Henoch-Schönlein purpura laboratory findings: Difference between revisions
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{{ | {{Henoch-Schönlein purpura}} | ||
{{CMG}} | {{CMG}} | ||
==Overview== | ==Overview== | ||
There is no specific diagnostic test available for HSP. Platelet count, [[coagulation]] studies such as [[PT]], [[aPTT]], and [[Bleeding time|BT]] are done to rule out other diseases like [[coagulopathies]]. They are usually normal. [[Urinalysis]] is done to check for any blood in the urine or [[proteinuria]] for renal involvement. Serum [[IgA]] levels are elevated in the majority of patients with HSP, and in patients with [[renal]] involvement higher [[IgA]] levels are detected. | |||
==Laboratory findings== | ==Laboratory findings== | ||
*Laboratory findings of HSP:<ref name="pmid11552081">{{cite journal |vauthors=Calviño MC, Llorca J, García-Porrúa C, Fernández-Iglesias JL, Rodriguez-Ledo P, González-Gay MA |title=Henoch-Schönlein purpura in children from northwestern Spain: a 20-year epidemiologic and clinical study |journal=Medicine (Baltimore) |volume=80 |issue=5 |pages=279–90 |date=September 2001 |pmid=11552081 |doi= |url=}}</ref><ref name="pmid5003905">{{cite journal |vauthors=Trygstad CW, Stiehm ER |title=Elevated serum IgA globulin in anaphylactoid purpura |journal=Pediatrics |volume=47 |issue=6 |pages=1023–8 |date=June 1971 |pmid=5003905 |doi= |url=}}</ref><ref name="pmid11231337">{{cite journal |vauthors=Davin JC, Ten Berge IJ, Weening JJ |title=What is the difference between IgA nephropathy and Henoch-Schönlein purpura nephritis? |journal=Kidney Int. |volume=59 |issue=3 |pages=823–34 |date=March 2001 |pmid=11231337 |doi=10.1046/j.1523-1755.2001.059003823.x |url=}}</ref><ref name="pmid22271365">{{cite journal |vauthors=Lin Q, Min Y, Li Y, Zhu Y, Song X, Xu Q, Wang L, Cheng J, Feng Q, Li X |title=Henoch-Schönlein purpura with hypocomplementemia |journal=Pediatr. Nephrol. |volume=27 |issue=5 |pages=801–6 |date=May 2012 |pmid=22271365 |doi=10.1007/s00467-011-2070-z |url=}}</ref> | |||
*There is no specific diagnostic test available for HSP. | |||
*[[Platelet count]], [[coagulation studies]] such as [[PT]], [[aPTT]], and BT is done to rule out other diseases like [[coagulopathies]]. They are usually normal. | |||
*[[Urinalysis]], is done to check for any blood in the urine or [[proteinuria]] for renal involvement. | |||
*Serum [[IgA]] levels are elevated in the majority of patients with HSP, and in patients with [[renal]] involvement higher [[IgA]] levels are detected. | |||
*The routine blood tests [[CBC]] (complete blood count), [[metabolic profile]], [[urinalysis]] are usually inconclusive. | |||
*Patients with occult [[Gastrointestinal bleeding|GI bleeding]] may have anemia. | |||
*Since HSP is a type-III [[hypersensitivity]] reaction complements are consumed by the [[immune complexes]] eventually leading to [[hypocomplementemia]] (decreased C3 and C4). | |||
*[[Leukocytosis]] and elevated acute phase reactants are noted in patients with HSP secondary to [[bacterial]] infections. | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Disease]] | |||
[[Category:Rheumatology]] | |||
[[Category:Pediatrics]] | |||
[[Category:Nephrology]] | |||
[[Category:Autoimmune diseases]] | |||
[[Category:Hematology]] | |||
[[Category:Mature chapter]] | |||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
Latest revision as of 20:33, 15 April 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
There is no specific diagnostic test available for HSP. Platelet count, coagulation studies such as PT, aPTT, and BT are done to rule out other diseases like coagulopathies. They are usually normal. Urinalysis is done to check for any blood in the urine or proteinuria for renal involvement. Serum IgA levels are elevated in the majority of patients with HSP, and in patients with renal involvement higher IgA levels are detected.
Laboratory findings
- Laboratory findings of HSP:[1][2][3][4]
- There is no specific diagnostic test available for HSP.
- Platelet count, coagulation studies such as PT, aPTT, and BT is done to rule out other diseases like coagulopathies. They are usually normal.
- Urinalysis, is done to check for any blood in the urine or proteinuria for renal involvement.
- Serum IgA levels are elevated in the majority of patients with HSP, and in patients with renal involvement higher IgA levels are detected.
- The routine blood tests CBC (complete blood count), metabolic profile, urinalysis are usually inconclusive.
- Patients with occult GI bleeding may have anemia.
- Since HSP is a type-III hypersensitivity reaction complements are consumed by the immune complexes eventually leading to hypocomplementemia (decreased C3 and C4).
- Leukocytosis and elevated acute phase reactants are noted in patients with HSP secondary to bacterial infections.
References
- ↑ Calviño MC, Llorca J, García-Porrúa C, Fernández-Iglesias JL, Rodriguez-Ledo P, González-Gay MA (September 2001). "Henoch-Schönlein purpura in children from northwestern Spain: a 20-year epidemiologic and clinical study". Medicine (Baltimore). 80 (5): 279–90. PMID 11552081.
- ↑ Trygstad CW, Stiehm ER (June 1971). "Elevated serum IgA globulin in anaphylactoid purpura". Pediatrics. 47 (6): 1023–8. PMID 5003905.
- ↑ Davin JC, Ten Berge IJ, Weening JJ (March 2001). "What is the difference between IgA nephropathy and Henoch-Schönlein purpura nephritis?". Kidney Int. 59 (3): 823–34. doi:10.1046/j.1523-1755.2001.059003823.x. PMID 11231337.
- ↑ Lin Q, Min Y, Li Y, Zhu Y, Song X, Xu Q, Wang L, Cheng J, Feng Q, Li X (May 2012). "Henoch-Schönlein purpura with hypocomplementemia". Pediatr. Nephrol. 27 (5): 801–6. doi:10.1007/s00467-011-2070-z. PMID 22271365.