Alpha 1-antitrypsin deficiency laboratory tests: Difference between revisions
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{{Alpha 1-antitrypsin deficiency}} | {{Alpha 1-antitrypsin deficiency}} | ||
{{CMG}} {{AE}} | |||
==Overview== | |||
==Laboratory Findings== | |||
The diagnosis of alpha-1 AT deficiency should be suspected in any patient who: | |||
# Develops [[emphysema]] younger than 45 years old, if they are a non/minimal smoker, or if they have primarily basilar disease OR | |||
# Has a history of [[panniculitis]] or | |||
# Has or has a family history of unexplained liver disease (especially [[cirrhosis]] or [[hepatoma]]). <br> | |||
* In suspected individuals the initial step is to measure the serum alpha-1 AT concentration. | |||
* In general, phenotyping should be reserved for patients who have low or borderline low alpha-1 AT levels. | |||
* PFTs-pulmonary function tests (spirometry pre and post bronchodilators, lung volumes and diffusing capacity), | |||
* LFTs (liver function test) | |||
* ABG-arterial blood gases (usually) | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category: | [[Category:Gastroenterology]] | ||
[[Category:Pulmonology]] | |||
[[Category:Hepatology]] | |||
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Latest revision as of 15:26, 1 June 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:
Overview
Laboratory Findings
The diagnosis of alpha-1 AT deficiency should be suspected in any patient who:
- Develops emphysema younger than 45 years old, if they are a non/minimal smoker, or if they have primarily basilar disease OR
- Has a history of panniculitis or
- Has or has a family history of unexplained liver disease (especially cirrhosis or hepatoma).
- In suspected individuals the initial step is to measure the serum alpha-1 AT concentration.
- In general, phenotyping should be reserved for patients who have low or borderline low alpha-1 AT levels.
- PFTs-pulmonary function tests (spirometry pre and post bronchodilators, lung volumes and diffusing capacity),
- LFTs (liver function test)
- ABG-arterial blood gases (usually)