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| __NOTOC__
| | #redirect:[[Glomerular disease]] |
| {{Infobox_Disease |
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| Name = {{PAGENAME}} |
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| Image = Acute GN 2.jpg|
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| Caption = Acute Glomerulonephritis: Micro H&E high mag; an excellent example of acute exudative glomerulonephritis. <br> <small> [http://www.peir.net Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology] </small>|
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| DiseasesDB = 5245 |
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| ICD10 = N00, N01, N03, N18 |
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| ICD9 = {{ICD9|580}}-{{ICD9|582}} |
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| ICDO = |
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| OMIM = |
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| MedlinePlus = |
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| MeshID = D005921 |
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| }}
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| {{Glomerulonephritis}}
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| {{CMG}}; '''Associate Editor-In-Chief:''' {{CZ}}
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| {{SK}} GN; glomerular nephritis
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| ==Overview==
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| '''Glomerulonephritis''', also known as '''glomerular nephritis''' and abbreviated '''GN'''', is a primary or secondary immune-mediated [[kidney|renal]] disease characterized by [[inflammation]] of the [[glomerulus|glomeruli]], or small blood vessels in the kidneys. It may present with isolated [[hematuria]] and/or [[proteinuria]] (blood resp. protein in the [[urine]]); or as a [[nephrotic syndrome]], a [[nephritic syndrome]], [[acute renal failure]], or [[chronic renal failure]].
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| They are categorized into several different pathological patterns, which are broadly grouped into non-proliferative or proliferative types. Diagnosing the pattern of GN is important because the outcome and treatment differs in different types. Primary causes are one which are intrinsic to the [[kidney]], whilst secondary causes are associated with certain infections (bacterial, viral or parasitic pathogens), [[drug]]s, systemic disorders ([[SLE]], [[vasculitis]]) or [[cancers]].
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| =====Histopathology=====
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| The majority of glomeruli present "crescents". Formation of crescents is initiated by passage of fibrin into the Bowman space as a result of increased permeability of glomerular basement membrane. Fibrin stimulates the proliferation of parietal cells of Bowman capsule, and an influx of [[monocyte]]s. Rapid growing and fibrosis of crescents compresses the capillary loops and decreases the Bowman space which leads to renal failure within weeks or months.
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| [http://www.peir.net Images shown below are courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology]
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| <div align="left">
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| <gallery heights="175" widths="175">
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| image:Acute GN 1.jpg|Glomerulonephritis: Micro H&E med mag; an excellent example of AGN with many neutrophils
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| image:Acute GN 2.jpg|Acute Glomerulonephritis: Micro H&E high mag; an excellent example of acute exudative glomerulonephritis.
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| </gallery>
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| </div>
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| <br>
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| ==Glomerulonephritis Videos==
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| ====Rapidly progressive glomerulonephritis====
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| {{#ev:youtube|CqSyj4cVZPE}}
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| ====Chronic glomerulonephritis====
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| {{#ev:youtube|eA1vYarRAWo}}
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| ==Pathological Findings: A Case Example==
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| ====Clinical Summary====
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| A 17-year-old white male had end-stage renal disease requiring hemodialysis for 10 years. For the previous four years he had hypertension which slowly increased to about 180/120 mm Hg. Laboratory findings included a greatly elevated BUN and creatinine. He was admitted for bilateral nephrectomy and discharged in satisfactory condition on the 10th postoperative day. He was to be contacted in the future for transplantation.
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| ====Autopsy Findings====
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| The left (97 grams) and right (88 grams) kidneys were of similar appearance. Cortices were pale, diffusely granular with a few 1-2 mm cysts. On being sectioned, the cortex of each kidney was thin (4-5 mm) and pale. Renal medullae were pale yellow-tan in color and there was abundant peripelvic fat. The ureters, pelvis, calyces and hilar vessels showed no abnormalities.
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| [http://www.peir.net Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology]
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| <div align="left">
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| <gallery heights="175" widths="175">
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| Image:Glomerulonephritis case 1.jpg|This is a low-power photomicrograph of a saggital section of end stage chronic glomerulonephritis (GN). Note the marked thinning of the cortex (arrow).
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| Image:Glomerulonephritis case 2.jpg|This is a higher-power photomicrograph of hyalinized glomeruli (arrows) and glomeruli with thick basement membranes.
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| </gallery>
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| </div>
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| <div align="left">
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| <gallery heights="175" widths="175">
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| Image:Glomerulonephritis case 3.jpg|This is a higher-power photomicrograph of hyalinized glomeruli (1) and glomeruli with thickened basement membranes (2).
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| Image:Glomerulonephritis case 4.jpg|This is a photomicrograph of interstitial and vascular lesions in end stage renal disease.
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| </gallery>
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| </div>
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| <div align="left">
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| <gallery heights="175" widths="175">
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| Image:Glomerulonephritis case 5.jpg|This is an immunofluorescent photomicrograph of granular membranous immunofluorescence (immune complex disease). The antibody used for these studies was specific for IgG.
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| Image:Glomerulonephritis case 6.jpg|This is an electron micrograph of subepithelial granular electron dense deposits (arrows) which correspond to the granular immunofluorescence seen in the previous image.
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| </gallery>
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| </div>
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| <div align="left">
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| <gallery heights="175" widths="175">
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| Image:Glomerulonephritis case 7.jpg|This is a photomicrograph of a glomerulus from another case with acute poststreptococcal glomerulonephritis. In this case the immune complex glomerular disease is ongoing with necrosis and accumulation of neutrophils in the glomerulus.
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| Image:Glomerulonephritis case 8.jpg|This immunofluorescent photomicrograph of a glomerulus from a case of acute poststreptococcal glomerulonephritis shows a granular immunofluorescence pattern consistent with immune complex disease. The primary antibody used for this staining was specific for IgG; however antibodies for complement would show a similar pattern.
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| </gallery>
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| </div>
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| <div align="left">
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| <gallery heights="175" widths="175">
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| Image:Glomerulonephritis case 9.jpg|This electron micrograph demonstrates scattered subepithelial dense deposits (arrows) and a polymorphonuclear leukocyte in the lumen.
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| Image:Glomerulonephritis case 10.jpg|For comparison this is an immunofluorescent photomicrograph of a glomerulus from a patient with Goodpasture's syndrome. The linear (arrows) immunofluorescence is characteristic of Goodpasture's syndrome.
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| </gallery>
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| </div>
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| ==Related chapters==
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| * [[Nephritic syndrome]]
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| * [[Nephritis]]
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| ==Resources==
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| ===Images:===
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| *[http://www.pathologyatlas.ro/Proliferative%20Glomerulonephritis.html Proliferative GN]
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| *[http://www.pathologyatlas.ro/Crescentic%20Glomerulonephritis.html Crescentic GN]
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| *[http://www.pathologyatlas.ro/Chronic%20Glomerulonephritis1.html Chronic GN]
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| ===HDCN===
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| *[http://www.hdcn.com/ch/nephr/nephr.htm HDCN Nephritis Channel] - Collection of lectures and links pertaining to glomerulonephritis on the HDCN (Hypertension, Dialysis, and Clinical Nephrology) on-line journal.
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| *[http://www.mayoclinic.com/health/post-infectious-glomerulonephritis/AN00629 Post-infectious glomerulonephritis] - mayoclinic.com.
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| *[http://www.niaid.nih.gov/factsheets/strep.htm Group A Streptococcal Infections] - National Institute of Allergy and Infectious Diseases.
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| ==References==
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| {{reflist|2}}
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| {{Nephrology}}
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| [[Category:Disease]]
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| [[Category:Organ disorders]]
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| [[Category:Inflammations]]
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| [[Category:Kidney diseases]]
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| [[de:Glomerulonephritis]]
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| [[es:Glomerulonefritis]]
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| [[fr:Glomérulonéphrite]]
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| [[nl:Glomerulonefritis]]
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| [[ja:糸球体腎炎]]
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| [[pl:Kłębuszkowe zapalenie nerek]]
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| [[pt:Glomerulonefrite]]
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| [[sv:Glomerulonefrit]]
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