Acromegaly history and symptoms: Difference between revisions

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Latest revision as of 21:54, 24 August 2017

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]

Overview

Common symptoms of acromegaly include enlarged hands and feet, headache, increase sweating, sexual dysfunction, skin thickening, deepening of the voice and, an enlarged tongue. Less common symptoms of acromegaly include visual defects and irregular menses in the women.

History and Symptoms

History

Patients with acromegaly may have a positive history of:

Rapid onset of acromegaly symptoms development
Increase in shoe size due to enlarged feet
Increase in ring size due to enlarged hand

Common Symptoms

Common symptoms of acromegaly include:^[1]^[2]

Enlarged hands and feet
Change in the facial features
Headache
Increase sweating
Paraesthesia
Sexual dysfunction
Skin thickening
Protrusion of the lower mandible
Deepening of voice
Enlarged tongue

Less Common Symptoms

Less common symptoms of acromegaly include:

Visual defects
In women, irregular menses

References

↑ Molitch ME (1992). "Clinical manifestations of acromegaly". Endocrinol Metab Clin North Am. 21 (3): 597–614. PMID 1521514.
↑ Melmed S (2009). "Acromegaly pathogenesis and treatment". J Clin Invest. 119 (11): 3189–202. doi:10.1172/JCI39375. PMC 2769196. PMID 19884662.

Template:WikiDoc Sources

[pmid1521514-1] Molitch ME (1992). "Clinical manifestations of acromegaly". Endocrinol Metab Clin North Am. 21 (3): 597–614. PMID 1521514.

[pmid19884662-2] Melmed S (2009). "Acromegaly pathogenesis and treatment". J Clin Invest. 119 (11): 3189–202. doi:10.1172/JCI39375. PMC 2769196. PMID 19884662.

[1]

[2]

@@ Line 1: / Line 1: @@
+__NOTOC__
 {{Acromegaly}}
-{{CMG}}
+{{CMG}}; {{AE}} {{AEL}}
-==Symptoms==
-Features that result from high level of hGH or expanding tumor include:
-* Soft tissue swelling of the hands and feet
-* Brow and lower jaw protrusion
-* Enlarging hands
-* Enlarging feet
-* [[Arthritis]] and [[carpal tunnel syndrome]]
-* Teeth spacing increase
-* [[Macroglossia]] [enlarged tongue]
-* [[Heart failure]]
-* [[Kidney failure]]
-* Compression of the [[optic chiasm]] leading to loss of vision in the outer visual fields (typically [[bitemporal hemianopia]])
-* [[Headache]]
-* [[Diabetes mellitus]]
-* [[Hypertension]]
-* Enlarging heart
-* Increased palmar sweating and [[sebum]] production over the face ([[seborrhea]]) are clinical indicators of active growth hormone (GH) producing pituitary tumours. These symptoms can also be used to monitor the activity of the tumour after surgery although biochemical monitoring is confirmatory.
+==Overview==
+Common symptoms of acromegaly include enlarged hands and feet, [[headache]], increase sweating, [[sexual dysfunction]], [[skin]] thickening, deepening of the voice and, an [[Macroglossia|enlarged tongue]].  Less common symptoms of acromegaly include visual defects and irregular menses in the women.
+==History and Symptoms==
+===History===
+Patients with acromegaly may have a positive history of:
+*Rapid onset of acromegaly symptoms development
+*Increase in shoe size due to enlarged [[feet]]
+*Increase in ring size due to enlarged [[hand]]
+===Common Symptoms===
+Common symptoms of acromegaly include:<ref name="pmid1521514">{{cite journal| author=Molitch ME| title=Clinical manifestations of acromegaly. | journal=Endocrinol Metab Clin North Am | year= 1992 | volume= 21 | issue= 3 | pages= 597-614 | pmid=1521514 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1521514  }} </ref><ref name="pmid19884662">{{cite journal| author=Melmed S| title=Acromegaly pathogenesis and treatment. | journal=J Clin Invest | year= 2009 | volume= 119 | issue= 11 | pages= 3189-202 | pmid=19884662 | doi=10.1172/JCI39375 | pmc=2769196 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19884662  }} </ref>
+*Enlarged hands and feet
+*Change in the facial features
+*[[Headache]]
+*Increase [[sweating]]
+*[[Paraesthesia]]
+*[[Sexual dysfunction]]
+*[[Skin]] thickening
+*Protrusion of the lower [[mandible]]
+*Deepening of voice
+*[[Macroglossia|Enlarged tongue]]
-(Image courtesy of Charlie Goldberg, M.D., UCSD School of Medicine and VA Medical Center, San Diego, California)
+===Less Common Symptoms===
+Less common symptoms of acromegaly include:
+*Visual defects
+*In women, irregular menses
-<div align="left">
-<gallery heights="175" widths="175">
-Image:acromegaly1.jpg|Facial changes secondary to elevated growth hormone levels.  Note in particular prominent supra-orbital ridge, jaw, and generally enlarged facial features.
-Image:Acromegaly3.jpg|Markedly enlarged hand resulting from excess growth hormone.  For reference purposes, the comparison hand is size 6 1/2.
-Image:acromegaly4.jpg|Facial changes secondary to elevated growth hormone levels.  Note in particular prominent supra-orbital ridge, jaw, and generally enlarged facial features.
-</gallery>
-</div>
-==Pituitary gigantism in children==
-This condition of growth hormone excess is rare in children and is referred to as [[gigantism|pituitary gigantism]], because the excessive growth hormone produces excessive growth of bones and the child can achieve excessive height. As an affected child becomes an adult, many of the adult problems can gradually develop. The distinction between gigantism (occurring in children) and acromegaly (occurring in adults) can be made by the occurrence of the adenoma in relation to the closure of the [[Bone#Formation|epiphyses]]. If elevated growth hormone levels occur before the closure of the epiphyses (i.e. in prepubertal children), then gigantism ensues.  If it occurs after the closure of the epiphyses (i.e., in adults) then acromegaly ensues.
 ==References==
 {{reflist|2}}
-[[Category:neuroendocrinology]]
-[[Category:Growth disorders]]
-[[Category:Growth hormones]]
-[[Category:Endocrinology]]
-[[bg:Акромегалия]]
-[[cs:Akromegalie]]
-[[de:Akromegalie]]
-[[es:Acromegalia]]
-[[fr:Acromégalie]]
-[[gl:Acromegalia]]
-[[it:Acromegalia]]
-[[he:אקרומגליה]]
-[[nl:Acromegalie]]
-[[ja:先端巨大症]]
-[[no:Akromegali]]
-[[pl:Akromegalia]]
-[[pt:Acromegalia]]
-[[sq:Akromegalia]]
-[[sk:Akromegália]]
-[[sr:Акромегалија]]
-[[fi:Akromegalia]]
-[[sv:Akromegali]]
-[[tr:Akromegali]]
-[[uk:Акромегалія]]
-[[zh:肢端肥大症]]
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