ACIN1: Difference between revisions

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{{Infobox_gene}}
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'''Apoptotic chromatin condensation inducer in the nucleus''' is a [[protein]] that in [[human]]s is encoded by the ''ACIN1'' [[gene]].<ref name="pmid9734811">{{cite journal | vauthors = Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Res | volume = 5 | issue = 3 | pages = 169–76 |date=Dec 1998 | pmid = 9734811 | pmc = | doi =10.1093/dnares/5.3.169 }}</ref><ref name="pmid10490026">{{cite journal | vauthors = Sahara S, Aoto M, Eguchi Y, Imamoto N, Yoneda Y, Tsujimoto Y | title = Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation | journal = Nature | volume = 401 | issue = 6749 | pages = 168–73 |date=Sep 1999 | pmid = 10490026 | pmc =  | doi = 10.1038/43678 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ACIN1 apoptotic chromatin condensation inducer 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22985| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Apoptotic chromatin condensation inducer 1
| HGNCid = 17066
| Symbol = ACIN1
| AltSymbols =; ACN; ACINUS; DKFZp667N107; KIAA0670
| OMIM = 604562
| ECnumber = 
| Homologene = 22853
| MGIid = 1891824
| GeneAtlas_image1 = PBB_GE_ACIN1_201715_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0016887 |text = ATPase activity}} {{GNF_GO|id=GO:0019899 |text = enzyme binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005730 |text = nucleolus}}
  | Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0030218 |text = erythrocyte differentiation}} {{GNF_GO|id=GO:0030263 |text = apoptotic chromosome condensation}} {{GNF_GO|id=GO:0045657 |text = positive regulation of monocyte differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 22985
    | Hs_Ensembl = ENSG00000100813
    | Hs_RefseqProtein = NP_055792
    | Hs_RefseqmRNA = NM_014977
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 22597616
    | Hs_GenLoc_end = 22634663
    | Hs_Uniprot = Q9UKV3
    | Mm_EntrezGene = 56215
    | Mm_Ensembl = ENSMUSG00000022185
    | Mm_RefseqmRNA = NM_019567
    | Mm_RefseqProtein = NP_062513
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 53596372
    | Mm_GenLoc_end = 53641136
    | Mm_Uniprot = Q3UXT9
  }}
}}
'''Apoptotic chromatin condensation inducer 1''', also known as '''ACIN1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ACIN1 apoptotic chromatin condensation inducer 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22985| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|ACIN1}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading
| citations =  
| citations =
*{{cite journal  | author=Ishikawa K, Nagase T, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 3 |pages= 169-76 |year= 1998 |pmid= 9734811 |doi=  }}
*{{cite journal  | vauthors=Zermati Y, Garrido C, Amsellem S |title=Caspase activation is required for terminal erythroid differentiation. |journal=J. Exp. Med. |volume=193 |issue= 2 |pages= 247–54 |year= 2001 |pmid= 11208865 |doi=10.1084/jem.193.2.247 | pmc=2193347  |display-authors=etal}}
*{{cite journal  | author=Sahara S, Aoto M, Eguchi Y, ''et al.'' |title=Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation. |journal=Nature |volume=401 |issue= 6749 |pages= 168-73 |year= 1999 |pmid= 10490026 |doi= 10.1038/43678 }}
*{{cite journal  | vauthors=Sordet O, Rébé C, Plenchette S |title=Specific involvement of caspases in the differentiation of monocytes into macrophages. |journal=Blood |volume=100 |issue= 13 |pages= 4446–53 |year= 2003 |pmid= 12393560 |doi= 10.1182/blood-2002-06-1778 |display-authors=etal}}
*{{cite journal  | author=Zermati Y, Garrido C, Amsellem S, ''et al.'' |title=Caspase activation is required for terminal erythroid differentiation. |journal=J. Exp. Med. |volume=193 |issue= 2 |pages= 247-54 |year= 2001 |pmid= 11208865 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Sordet O, Rébé C, Plenchette S, ''et al.'' |title=Specific involvement of caspases in the differentiation of monocytes into macrophages. |journal=Blood |volume=100 |issue= 13 |pages= 4446-53 |year= 2003 |pmid= 12393560 |doi= 10.1182/blood-2002-06-1778 }}
*{{cite journal  | vauthors=Shu H, Chen S, Bi Q |title=Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line. |journal=Mol. Cell. Proteomics |volume=3 |issue= 3 |pages= 279–86 |year= 2004 |pmid= 14729942 |doi= 10.1074/mcp.D300003-MCP200 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |display-authors=etal}}
*{{cite journal  | author=Shu H, Chen S, Bi Q, ''et al.'' |title=Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line. |journal=Mol. Cell Proteomics |volume=3 |issue= 3 |pages= 279-86 |year= 2004 |pmid= 14729942 |doi= 10.1074/mcp.D300003-MCP200 }}
*{{cite journal  | vauthors=Jin J, Smith FD, Stark C |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 |display-authors=etal}}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal  | vauthors=Kim JE, Tannenbaum SR, White FM |title=Global phosphoproteome of HT-29 human colon adenocarcinoma cells. |journal=J. Proteome Res. |volume=4 |issue= 4 |pages= 1339–46 |year= 2005 |pmid= 16083285 |doi= 10.1021/pr050048h }}
*{{cite journal  | author=Jin J, Smith FD, Stark C, ''et al.'' |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436-50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
*{{cite journal  | vauthors=Hu Y, Yao J, Liu Z |title=Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation. |journal=EMBO J. |volume=24 |issue= 20 |pages= 3543–54 |year= 2005 |pmid= 16177823 |doi= 10.1038/sj.emboj.7600823 | pmc=1276706 |display-authors=etal}}
*{{cite journal  | author=Kim JE, Tannenbaum SR, White FM |title=Global phosphoproteome of HT-29 human colon adenocarcinoma cells. |journal=J. Proteome Res. |volume=4 |issue= 4 |pages= 1339-46 |year= 2005 |pmid= 16083285 |doi= 10.1021/pr050048h }}
*{{cite journal  | vauthors=Joselin AP, Schulze-Osthoff K, Schwerk C |title=Loss of Acinus inhibits oligonucleosomal DNA fragmentation but not chromatin condensation during apoptosis. |journal=J. Biol. Chem. |volume=281 |issue= 18 |pages= 12475–84 |year= 2006 |pmid= 16537548 |doi= 10.1074/jbc.M509859200 }}
*{{cite journal  | author=Hu Y, Yao J, Liu Z, ''et al.'' |title=Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation. |journal=EMBO J. |volume=24 |issue= 20 |pages= 3543-54 |year= 2005 |pmid= 16177823 |doi= 10.1038/sj.emboj.7600823 }}
*{{cite journal  | vauthors=Beausoleil SA, Villén J, Gerber SA |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |display-authors=etal}}
*{{cite journal  | author=Joselin AP, Schulze-Osthoff K, Schwerk C |title=Loss of Acinus inhibits oligonucleosomal DNA fragmentation but not chromatin condensation during apoptosis. |journal=J. Biol. Chem. |volume=281 |issue= 18 |pages= 12475-84 |year= 2006 |pmid= 16537548 |doi= 10.1074/jbc.M509859200 }}
*{{cite journal  | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
*{{cite journal  | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal  | vauthors=Shu Y, Iijima T, Sun W |title=The ACIN1 gene is hypermethylated in early stage lung adenocarcinoma. |journal=Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer |volume=1 |issue= 2 |pages= 160–7 |year= 2007 |pmid= 17409846 |doi=  10.1097/01243894-200602000-00010|display-authors=etal}}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Shu Y, Iijima T, Sun W, ''et al.'' |title=The ACIN1 gene is hypermethylated in early stage lung adenocarcinoma. |journal=Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer |volume=1 |issue= 2 |pages= 160-7 |year= 2007 |pmid= 17409846 |doi=  }}
}}
}}
{{refend}}
{{refend}}


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[[Category:Human proteins]]
 
 
{{gene-14-stub}}

Latest revision as of 17:43, 29 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Apoptotic chromatin condensation inducer in the nucleus is a protein that in humans is encoded by the ACIN1 gene.[1][2][3]


References

  1. ↑ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  2. ↑ Sahara S, Aoto M, Eguchi Y, Imamoto N, Yoneda Y, Tsujimoto Y (Sep 1999). "Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation". Nature. 401 (6749): 168–73. doi:10.1038/43678. PMID 10490026.
  3. ↑ "Entrez Gene: ACIN1 apoptotic chromatin condensation inducer 1".

External links

Further reading


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