AFAP1: Difference between revisions

VALUE_ERROR (nil)
Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

VisualWikitext

Latest revision as of 12:07, 10 January 2019

Actin filament-associated protein 1 is a protein that in humans is encoded by the AFAP1 gene.^[1]^[2]^[3]^[4]

The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Two alternative transcripts encoding the same protein have been identified.^[4]

References

↑ Qian Y, Gatesman AS, Baisden JM, Zot HG, Cherezova L, Qazi I, Mazloum N, Lee MY, Guappone-Koay A, Flynn DC (Feb 2004). "Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity". J Cell Biochem. 91 (3): 602–20. doi:10.1002/jcb.10725. PMID 14755689.
↑ Baisden JM, Gatesman AS, Cherezova L, Jiang BH, Flynn DC (Oct 2001). "The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases". Oncogene. 20 (45): 6607–16. doi:10.1038/sj.onc.1204802. PMID 11641786.
↑ Baisden JM, Qian Y, Zot HM, Flynn DC (Oct 2001). "The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity". Oncogene. 20 (44): 6435–47. doi:10.1038/sj.onc.1204784. PMID 11607843.
↑ ^4.0 ^4.1 "Entrez Gene: AFAP1 actin filament associated protein 1".

External links

Human AFAP1 genome location and AFAP1 gene details page in the UCSC Genome Browser.

Ishida Y, Hadano S, Nagayama T, et al. (1995). "Isolation and characterization of 21 novel expressed DNA sequences from the distal region of human chromosome 4p". Genomics. 22 (2): 302–12. doi:10.1006/geno.1994.1388. PMID 7545969.
Qian Y, Baisden JM, Westin EH, et al. (1998). "Src can regulate carboxy terminal interactions with AFAP-110, which influence self-association, cell localization and actin filament integrity". Oncogene. 16 (17): 2185–95. doi:10.1038/sj.onc.1201753. PMID 9619827.
Guappone AC, Weimer T, Flynn DC (1998). "Formation of a stable src-AFAP-110 complex through either an amino-terminal or a carboxy-terminal SH2-binding motif". Mol. Carcinog. 22 (2): 110–9. doi:10.1002/(SICI)1098-2744(199806)22:2<110::AID-MC6>3.0.CO;2-Q. PMID 9655255.
Qian Y, Baisden JM, Zot HG, et al. (2000). "The carboxy terminus of AFAP-110 modulates direct interactions with actin filaments and regulates its ability to alter actin filament integrity and induce lamellipodia formation". Exp. Cell Res. 255 (1): 102–13. doi:10.1006/excr.1999.4795. PMID 10666339.
Qian Y, Baisden JM, Cherezova L, et al. (2003). "PC phosphorylation increases the ability of AFAP-110 to cross-link actin filaments". Mol. Biol. Cell. 13 (7): 2311–22. doi:10.1091/mbc.E01-12-0148. PMC 117315. PMID 12134071.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Dorfleutner A, Stehlik C, Zhang J, et al. (2007). "AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB-231 breast cancer cells". J. Cell. Physiol. 213 (3): 740–9. doi:10.1002/jcp.21143. PMID 17520695.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[pmid14755689-1] Qian Y, Gatesman AS, Baisden JM, Zot HG, Cherezova L, Qazi I, Mazloum N, Lee MY, Guappone-Koay A, Flynn DC (Feb 2004). "Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity". J Cell Biochem. 91 (3): 602–20. doi:10.1002/jcb.10725. PMID 14755689.

[pmid11641786-2] Baisden JM, Gatesman AS, Cherezova L, Jiang BH, Flynn DC (Oct 2001). "The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases". Oncogene. 20 (45): 6607–16. doi:10.1038/sj.onc.1204802. PMID 11641786.

[pmid11607843-3] Baisden JM, Qian Y, Zot HM, Flynn DC (Oct 2001). "The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity". Oncogene. 20 (44): 6435–47. doi:10.1038/sj.onc.1204784. PMID 11607843.

[entrez-4] 4.0 ^4.1 "Entrez Gene: AFAP1 actin filament associated protein 1".

[1]

[2]

[3]

[4]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Actin filament-associated protein 1''' is a [[protein]] that in humans is encoded by the ''AFAP1'' [[gene]].<ref name="pmid14755689">{{cite journal | vauthors = Qian Y, Gatesman AS, Baisden JM, Zot HG, Cherezova L, Qazi I, Mazloum N, Lee MY, Guappone-Koay A, Flynn DC | title = Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity | journal = J Cell Biochem | volume = 91 | issue = 3 | pages = 602–20 |date=Feb 2004 | pmid = 14755689 | pmc =  | doi = 10.1002/jcb.10725 }}</ref><ref name="pmid11641786">{{cite journal | vauthors = Baisden JM, Gatesman AS, Cherezova L, Jiang BH, Flynn DC | title = The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases | journal = Oncogene | volume = 20 | issue = 45 | pages = 6607–16 |date=Oct 2001 | pmid = 11641786 | pmc =  | doi = 10.1038/sj.onc.1204802 }}</ref><ref name="pmid11607843">{{cite journal | vauthors = Baisden JM, Qian Y, Zot HM, Flynn DC | title = The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity | journal = Oncogene | volume = 20 | issue = 44 | pages = 6435–47 |date=Oct 2001 | pmid = 11607843 | pmc =  | doi = 10.1038/sj.onc.1204784 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AFAP1 actin filament associated protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=60312| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Actin filament associated protein 1
- | HGNCid = 24017
- | Symbol = AFAP1
- | AltSymbols =; AFAP; AFAP-110
- | OMIM = 608252
- | ECnumber =
- | Homologene = 11009
- | MGIid = 1917542
-  | GeneAtlas_image1 = PBB_GE_AFAP1_203563_at_tn.png
- | Function =
- | Component =
- | Process =
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 60312
-    | Hs_Ensembl = ENSG00000196526
-    | Hs_RefseqProtein = NP_067651
-    | Hs_RefseqmRNA = NM_021638
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 4
-    | Hs_GenLoc_start = 7811341
-    | Hs_GenLoc_end = 7992486
-    | Hs_Uniprot =
-    | Mm_EntrezGene = 70292
-    | Mm_Ensembl = ENSMUSG00000029094
-    | Mm_RefseqmRNA = NM_027373
-    | Mm_RefseqProtein = NP_081649
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 5
-    | Mm_GenLoc_start = 36210180
-    | Mm_GenLoc_end = 36320783
-    | Mm_Uniprot =
-  }}
-}}
-'''Actin filament associated protein 1''', also known as '''AFAP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AFAP1 actin filament associated protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=60312| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Two alternative transcripts encoding the same protein have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: AFAP1 actin filament associated protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=60312| accessdate = }}</ref>
+| summary_text = The protein encoded by this gene is a [[Proto-oncogene tyrosine-protein kinase Src|Src]] binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Two alternative transcripts encoding the same protein have been identified.<ref name="entrez"/>
 }}
 ==References==
-{{reflist|2}}
+{{reflist}}
+==External links==
+* {{UCSC gene info|AFAP1}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Baisden JM, Qian Y, Zot HM, Flynn DC |title=The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity. |journal=Oncogene |volume=20 |issue= 44 |pages= 6435-47 |year= 2001 |pmid= 11607843 |doi= 10.1038/sj.onc.1204784 }}
+*{{cite journal  | vauthors=Ishida Y, Hadano S, Nagayama T |title=Isolation and characterization of 21 novel expressed DNA sequences from the distal region of human chromosome 4p. |journal=Genomics |volume=22 |issue= 2 |pages= 302–12 |year= 1995 |pmid= 7545969 |doi=10.1006/geno.1994.1388  |display-authors=etal}}
-*{{cite journal  | author=Ishida Y, Hadano S, Nagayama T, ''et al.'' |title=Isolation and characterization of 21 novel expressed DNA sequences from the distal region of human chromosome 4p. |journal=Genomics |volume=22 |issue= 2 |pages= 302-12 |year= 1995 |pmid= 7545969 |doi=  }}
+*{{cite journal  | vauthors=Qian Y, Baisden JM, Westin EH |title=Src can regulate carboxy terminal interactions with AFAP-110, which influence self-association, cell localization and actin filament integrity. |journal=Oncogene |volume=16 |issue= 17 |pages= 2185–95 |year= 1998 |pmid= 9619827 |doi= 10.1038/sj.onc.1201753 |display-authors=etal}}
-*{{cite journal  | author=Qian Y, Baisden JM, Westin EH, ''et al.'' |title=Src can regulate carboxy terminal interactions with AFAP-110, which influence self-association, cell localization and actin filament integrity. |journal=Oncogene |volume=16 |issue= 17 |pages= 2185-95 |year= 1998 |pmid= 9619827 |doi= 10.1038/sj.onc.1201753 }}
+*{{cite journal  | vauthors=Guappone AC, Weimer T, Flynn DC |title=Formation of a stable src-AFAP-110 complex through either an amino-terminal or a carboxy-terminal SH2-binding motif. |journal=Mol. Carcinog. |volume=22 |issue= 2 |pages= 110–9 |year= 1998 |pmid= 9655255 |doi=10.1002/(SICI)1098-2744(199806)22:2<110::AID-MC6>3.0.CO;2-Q  }}
-*{{cite journal  | author=Guappone AC, Weimer T, Flynn DC |title=Formation of a stable src-AFAP-110 complex through either an amino-terminal or a carboxy-terminal SH2-binding motif. |journal=Mol. Carcinog. |volume=22 |issue= 2 |pages= 110-9 |year= 1998 |pmid= 9655255 |doi=  }}
+*{{cite journal  | vauthors=Qian Y, Baisden JM, Zot HG |title=The carboxy terminus of AFAP-110 modulates direct interactions with actin filaments and regulates its ability to alter actin filament integrity and induce lamellipodia formation. |journal=Exp. Cell Res. |volume=255 |issue= 1 |pages= 102–13 |year= 2000 |pmid= 10666339 |doi= 10.1006/excr.1999.4795 |display-authors=etal}}
-*{{cite journal  | author=Qian Y, Baisden JM, Zot HG, ''et al.'' |title=The carboxy terminus of AFAP-110 modulates direct interactions with actin filaments and regulates its ability to alter actin filament integrity and induce lamellipodia formation. |journal=Exp. Cell Res. |volume=255 |issue= 1 |pages= 102-13 |year= 2000 |pmid= 10666339 |doi= 10.1006/excr.1999.4795 }}
+*{{cite journal  | vauthors=Qian Y, Baisden JM, Cherezova L |title=PC phosphorylation increases the ability of AFAP-110 to cross-link actin filaments. |journal=Mol. Biol. Cell |volume=13 |issue= 7 |pages= 2311–22 |year= 2003 |pmid= 12134071 |doi= 10.1091/mbc.E01-12-0148  | pmc=117315 |display-authors=etal}}
-*{{cite journal  | author=Baisden JM, Gatesman AS, Cherezova L, ''et al.'' |title=The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases. |journal=Oncogene |volume=20 |issue= 45 |pages= 6607-16 |year= 2001 |pmid= 11641786 |doi= 10.1038/sj.onc.1204802 }}
+*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
-*{{cite journal  | author=Qian Y, Baisden JM, Cherezova L, ''et al.'' |title=PC phosphorylation increases the ability of AFAP-110 to cross-link actin filaments. |journal=Mol. Biol. Cell |volume=13 |issue= 7 |pages= 2311-22 |year= 2003 |pmid= 12134071 |doi= 10.1091/mbc.E01-12-0148 }}
+*{{cite journal  | vauthors=Brandenberger R, Wei H, Zhang S |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 |display-authors=etal}}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | vauthors=Ballif BA, Villén J, Beausoleil SA |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell. Proteomics |volume=3 |issue= 11 |pages= 1093–101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 |display-authors=etal}}
-*{{cite journal  | author=Qian Y, Gatesman AS, Baisden JM, ''et al.'' |title=Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity. |journal=J. Cell. Biochem. |volume=91 |issue= 3 |pages= 602-20 |year= 2004 |pmid= 14755689 |doi= 10.1002/jcb.10725 }}
+*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
-*{{cite journal  | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
+*{{cite journal  | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406  | pmc=1356129 |display-authors=etal}}
-*{{cite journal  | author=Ballif BA, Villén J, Beausoleil SA, ''et al.'' |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell Proteomics |volume=3 |issue= 11 |pages= 1093-101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 }}
+*{{cite journal  | vauthors=Dorfleutner A, Stehlik C, Zhang J |title=AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB-231 breast cancer cells. |journal=J. Cell. Physiol. |volume=213 |issue= 3 |pages= 740–9 |year= 2007 |pmid= 17520695 |doi= 10.1002/jcp.21143 |display-authors=etal}}
-*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
-*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
-*{{cite journal  | author=Dorfleutner A, Stehlik C, Zhang J, ''et al.'' |title=AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB-231 breast cancer cells. |journal=J. Cell. Physiol. |volume=213 |issue= 3 |pages= 740-9 |year= 2007 |pmid= 17520695 |doi= 10.1002/jcp.21143 }}
 }}
 {{refend}}
-{{protein-stub}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
-{{WikiDoc Sources}}
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
+{{gene-4-stub}}

AFAP1: Difference between revisions

Latest revision as of 12:07, 10 January 2019

References

External links

Further reading

Navigation menu

Search