AHCYL1: Difference between revisions

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{{Infobox_gene}}
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'''Putative adenosylhomocysteinase 2''' is an [[enzyme]] that in humans is encoded by the ''AHCYL1'' [[gene]].<ref name="pmid11904675">{{cite journal | vauthors = Dekker JW, Budhia S, Angel NZ, Cooper BJ, Clark GJ, Hart DN, Kato M | title = Identification of an S-adenosylhomocysteine hydrolase-like transcript induced during dendritic cell differentiation | journal = Immunogenetics | volume = 53 | issue = 12 | pages = 993–1001 |date=Mar 2002 | pmid = 11904675 | pmc =  | doi = 10.1007/s00251-001-0402-z }}</ref><ref name="pmid16754674">{{cite journal | vauthors = Cooper BJ, Key B, Carter A, Angel NZ, Hart DN, Kato M | title = Suppression and overexpression of adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) influences zebrafish embryo development: a possible role for AHCYL1 in inositol phospholipid signaling | journal = J Biol Chem | volume = 281 | issue = 32 | pages = 22471–84 |date=Aug 2006 | pmid = 16754674 | pmc = | doi = 10.1074/jbc.M602520200 }}</ref><ref name="pmid12525476">{{cite journal | vauthors = Ando H, Mizutani A, Matsu-ura T, Mikoshiba K | title = IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor | journal = J Biol Chem | volume = 278 | issue = 12 | pages = 10602–12 |date=Mar 2003 | pmid = 12525476 | pmc =  | doi = 10.1074/jbc.M210119200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AHCYL1 S-adenosylhomocysteine hydrolase-like 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10768| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = S-adenosylhomocysteine hydrolase-like 1
| HGNCid = 344
| Symbol = AHCYL1
| AltSymbols =; DCAL; IRBIT; PRO0233; XPVKONA
| OMIM = 607826
| ECnumber =
| Homologene = 77353
| MGIid = 2385184
| GeneAtlas_image1 = PBB_GE_AHCYL1_200850_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_AHCYL1_200848_at_tn.png
  | GeneAtlas_image3 = PBB_GE_AHCYL1_200849_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004013 |text = adenosylhomocysteinase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}}
| Process = {{GNF_GO|id=GO:0006730 |text = one-carbon compound metabolic process}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10768
    | Hs_Ensembl = ENSG00000168710
    | Hs_RefseqProtein = NP_006612
    | Hs_RefseqmRNA = NM_006621
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 110328831
    | Hs_GenLoc_end = 110367880
    | Hs_Uniprot = O43865
    | Mm_EntrezGene = 229709
    | Mm_Ensembl = ENSMUSG00000027893
    | Mm_RefseqmRNA = NM_145542
    | Mm_RefseqProtein = NP_663517
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 107793568
    | Mm_GenLoc_end = 107824333
    | Mm_Uniprot = Q80SW1
  }}
}}
'''S-adenosylhomocysteine hydrolase-like 1''', also known as '''AHCYL1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AHCYL1 S-adenosylhomocysteine hydrolase-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10768| accessdate = }}</ref>


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| summary_text =  
}}
}}
==Interactions==
AHCYL1 has been shown to [[Protein-protein interaction|interact]] with [[ITPR1]].<ref name=pmid12525476 />


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|AHCYL1}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Pawlak A, Toussaint C, Lévy I, ''et al.'' |title=Characterization of a large population of mRNAs from human testis. |journal=Genomics |volume=26 |issue= 1 |pages= 151-8 |year= 1995 |pmid= 7782076 |doi=  }}
*{{cite journal  | vauthors=Pawlak A, Toussaint C, Lévy I |title=Characterization of a large population of mRNAs from human testis. |journal=Genomics |volume=26 |issue= 1 |pages= 151–8 |year= 1995 |pmid= 7782076 |doi=10.1016/0888-7543(95)80096-5 |display-authors=etal}}
*{{cite journal  | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal  | vauthors=Andersson B, Wentland MA, Ricafrente JY |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 |display-authors=etal}}
*{{cite journal  | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=  }}
*{{cite journal  | vauthors=Yu W, Andersson B, Worley KC |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=  10.1101/gr.7.4.353| pmc=139146  |display-authors=etal}}
*{{cite journal  | author=Cleaver JE, Afzal V, Feeney L, ''et al.'' |title=Increased ultraviolet sensitivity and chromosomal instability related to P53 function in the xeroderma pigmentosum variant. |journal=Cancer Res. |volume=59 |issue= 5 |pages= 1102-8 |year= 1999 |pmid= 10070969 |doi=  }}
*{{cite journal  | vauthors=Cleaver JE, Afzal V, Feeney L |title=Increased ultraviolet sensitivity and chromosomal instability related to P53 function in the xeroderma pigmentosum variant. |journal=Cancer Res. |volume=59 |issue= 5 |pages= 1102–8 |year= 1999 |pmid= 10070969 |doi=  |display-authors=etal}}
*{{cite journal  | author=Dekker JW, Budhia S, Angel NZ, ''et al.'' |title=Identification of an S-adenosylhomocysteine hydrolase-like transcript induced during dendritic cell differentiation. |journal=Immunogenetics |volume=53 |issue= 12 |pages= 993-1001 |year= 2002 |pmid= 11904675 |doi= 10.1007/s00251-001-0402-z }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Imabayashi H, Mori T, Gojo S |title=Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis. |journal=Exp. Cell Res. |volume=288 |issue= 1 |pages= 35–50 |year= 2003 |pmid= 12878157 |doi=10.1016/S0014-4827(03)00130-7 |display-authors=etal}}
*{{cite journal | author=Ando H, Mizutani A, Matsu-ura T, Mikoshiba K |title=IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor. |journal=J. Biol. Chem. |volume=278 |issue= 12 |pages= 10602-12 |year= 2003 |pmid= 12525476 |doi= 10.1074/jbc.M210119200 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Imabayashi H, Mori T, Gojo S, ''et al.'' |title=Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis. |journal=Exp. Cell Res. |volume=288 |issue= 1 |pages= 35-50 |year= 2003 |pmid= 12878157 |doi=  }}
*{{cite journal  | vauthors=Zhang Y, Wolf-Yadlin A, Ross PL |title=Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. |journal=Mol. Cell. Proteomics |volume=4 |issue= 9 |pages= 1240–50 |year= 2005 |pmid= 15951569 |doi= 10.1074/mcp.M500089-MCP200 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Gregory SG, Barlow KF, McLay KE |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |display-authors=etal}}
*{{cite journal  | author=Zhang Y, Wolf-Yadlin A, Ross PL, ''et al.'' |title=Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. |journal=Mol. Cell Proteomics |volume=4 |issue= 9 |pages= 1240-50 |year= 2005 |pmid= 15951569 |doi= 10.1074/mcp.M500089-MCP200 }}
*{{cite journal  | vauthors=Shirakabe K, Priori G, Yamada H |title=IRBIT, an inositol 1,4,5-trisphosphate receptor-binding protein, specifically binds to and activates pancreas-type Na+/HCO3- cotransporter 1 (pNBC1). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 25 |pages= 9542–7 |year= 2006 |pmid= 16769890 |doi= 10.1073/pnas.0602250103 | pmc=1480443 |display-authors=etal}}
*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal  | author=Cooper BJ, Key B, Carter A, ''et al.'' |title=Suppression and overexpression of adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) influences zebrafish embryo development: a possible role for AHCYL1 in inositol phospholipid signaling. |journal=J. Biol. Chem. |volume=281 |issue= 32 |pages= 22471-84 |year= 2006 |pmid= 16754674 |doi= 10.1074/jbc.M602520200 }}
*{{cite journal  | author=Shirakabe K, Priori G, Yamada H, ''et al.'' |title=IRBIT, an inositol 1,4,5-trisphosphate receptor-binding protein, specifically binds to and activates pancreas-type Na+/HCO3- cotransporter 1 (pNBC1). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 25 |pages= 9542-7 |year= 2006 |pmid= 16769890 |doi= 10.1073/pnas.0602250103 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 17:53, 29 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Putative adenosylhomocysteinase 2 is an enzyme that in humans is encoded by the AHCYL1 gene.[1][2][3][4]


Interactions

AHCYL1 has been shown to interact with ITPR1.[3]

References

  1. ↑ Dekker JW, Budhia S, Angel NZ, Cooper BJ, Clark GJ, Hart DN, Kato M (Mar 2002). "Identification of an S-adenosylhomocysteine hydrolase-like transcript induced during dendritic cell differentiation". Immunogenetics. 53 (12): 993–1001. doi:10.1007/s00251-001-0402-z. PMID 11904675.
  2. ↑ Cooper BJ, Key B, Carter A, Angel NZ, Hart DN, Kato M (Aug 2006). "Suppression and overexpression of adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) influences zebrafish embryo development: a possible role for AHCYL1 in inositol phospholipid signaling". J Biol Chem. 281 (32): 22471–84. doi:10.1074/jbc.M602520200. PMID 16754674.
  3. ↑ 3.0 3.1 Ando H, Mizutani A, Matsu-ura T, Mikoshiba K (Mar 2003). "IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor". J Biol Chem. 278 (12): 10602–12. doi:10.1074/jbc.M210119200. PMID 12525476.
  4. ↑ "Entrez Gene: AHCYL1 S-adenosylhomocysteine hydrolase-like 1".

External links

Further reading



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