AKAP12: Difference between revisions
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{{ | '''A-kinase anchor protein 12, aka AKAP250,''' is an [[enzyme]] that in humans is encoded by the ''AKAP12'' [[gene]].<ref name="pmid9000000">{{cite journal | vauthors = Nauert JB, Klauck TM, Langeberg LK, Scott JD | title = Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein | journal = Curr. Biol. | volume = 7 | issue = 1 | pages = 52–62 | date = Mar 1997 | pmid = 9000000 | pmc = | doi = 10.1016/S0960-9822(06)00027-3 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AKAP12 A kinase (PRKA) anchor protein (gravin) 12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9590| accessdate = }}</ref> | ||
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== Function == | |||
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of [[protein kinase A]] (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in [[endothelial]] cells, cultured [[fibroblast]]s, and [[osteosarcoma]] cells. It associates with [[protein kinase A]] and [[protein kinase C|C]] and [[phosphatase]], and serves as a scaffold protein in [[signal transduction]]. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms.<ref name="entrez"/> | |||
== | == Interactions == | ||
{{protein- | AKAP12 has been shown to [[Protein-protein interaction|interact]] with [[Beta-2 adrenergic receptor]].<ref name = pmid11309381>{{cite journal | vauthors = Fan G, Shumay E, Wang H, Malbon CC | title = The scaffold protein gravin (cAMP-dependent protein kinase-anchoring protein 250) binds the beta 2-adrenergic receptor via the receptor cytoplasmic Arg-329 to Leu-413 domain and provides a mobile scaffold during desensitization | journal = J. Biol. Chem. | volume = 276 | issue = 26 | pages = 24005–14 | date = Jun 2001 | pmid = 11309381 | doi = 10.1074/jbc.M011199200 }}</ref><ref name = pmid9880537>{{cite journal | vauthors = Shih M, Lin F, Scott JD, Wang HY, Malbon CC | title = Dynamic complexes of beta2-adrenergic receptors with protein kinases and phosphatases and the role of gravin | journal = J. Biol. Chem. | volume = 274 | issue = 3 | pages = 1588–95 | date = Jan 1999 | pmid = 9880537 | doi = 10.1074/jbc.274.3.1588 }}</ref> | ||
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== References == | |||
{{Reflist}} | |||
==External links== | |||
* {{UCSC gene info|AKAP12}} | |||
== Further reading == | |||
{{Refbegin | 2}} | |||
* {{cite journal | vauthors = Lester LB, Scott JD | title = Anchoring and scaffold proteins for kinases and phosphatases | journal = Recent Prog. Horm. Res. | volume = 52 | issue = | pages = 409-29; discussion 429-30 | year = 1997 | pmid = 9238861 | doi = }} | |||
* {{cite journal | vauthors = Michel JJ, Scott JD | title = AKAP mediated signal transduction | journal = Annu. Rev. Pharmacol. Toxicol. | volume = 42 | issue = | pages = 235–57 | year = 2002 | pmid = 11807172 | doi = 10.1146/annurev.pharmtox.42.083101.135801 }} | |||
* {{cite journal | vauthors = Yildirim M, Paydas S, Tanriverdi K, Seydaoglu G, Disel U, Yavuz S | title = Gravin gene expression in acute leukaemias: clinical importance and review of the literature | journal = Leuk. Lymphoma | volume = 48 | issue = 6 | pages = 1167–72 | year = 2007 | pmid = 17577780 | doi = 10.1080/10428190701377055 }} | |||
* {{cite journal | vauthors = Gordon T, Grove B, Loftus JC, O'Toole T, McMillan R, Lindstrom J, Ginsberg MH | title = Molecular cloning and preliminary characterization of a novel cytoplasmic antigen recognized by myasthenia gravis sera | journal = J. Clin. Invest. | volume = 90 | issue = 3 | pages = 992–9 | year = 1992 | pmid = 1522245 | pmc = 329955 | doi = 10.1172/JCI115976 }} | |||
* {{cite journal | vauthors = Sato N, Kokame K, Shimokado K, Kato H, Miyata T | title = Changes of gene expression by lysophosphatidylcholine in vascular endothelial cells: 12 up-regulated distinct genes including 5 cell growth-related, 3 thrombosis-related, and 4 others | journal = J. Biochem. | volume = 123 | issue = 6 | pages = 1119–26 | year = 1998 | pmid = 9604001 | doi = 10.1093/oxfordjournals.jbchem.a022051 }} | |||
* {{cite journal | vauthors = Shih M, Lin F, Scott JD, Wang HY, Malbon CC | title = Dynamic complexes of beta2-adrenergic receptors with protein kinases and phosphatases and the role of gravin | journal = J. Biol. Chem. | volume = 274 | issue = 3 | pages = 1588–95 | year = 1999 | pmid = 9880537 | doi = 10.1074/jbc.274.3.1588 }} | |||
* {{cite journal | vauthors = Lin F, ((Wang Hy)), Malbon CC | title = Gravin-mediated formation of signaling complexes in beta 2-adrenergic receptor desensitization and resensitization | journal = J. Biol. Chem. | volume = 275 | issue = 25 | pages = 19025–34 | year = 2000 | pmid = 10858453 | doi = 10.1074/jbc.275.25.19025 }} | |||
* {{cite journal | vauthors = Fan G, Shumay E, Wang H, Malbon CC | title = The scaffold protein gravin (cAMP-dependent protein kinase-anchoring protein 250) binds the beta 2-adrenergic receptor via the receptor cytoplasmic Arg-329 to Leu-413 domain and provides a mobile scaffold during desensitization | journal = J. Biol. Chem. | volume = 276 | issue = 26 | pages = 24005–14 | year = 2001 | pmid = 11309381 | doi = 10.1074/jbc.M011199200 }} | |||
* {{cite journal | vauthors = Grove BD, Bruchey AK | title = Intracellular distribution of gravin, a PKA and PKC binding protein, in vascular endothelial cells | journal = J. Vasc. Res. | volume = 38 | issue = 2 | pages = 163–75 | year = 2001 | pmid = 11316952 | doi = 10.1159/000051043 }} | |||
* {{cite journal | vauthors = Sasaki H, Kunimatsu M, Fujii Y, Yamakawa Y, Fukai I, Kiriyama M, Nonaka M, Sasaki M | title = Autoantibody to gravin is expressed more strongly in younger and nonthymomatous patients with myasthenia gravis | journal = Surg. Today | volume = 31 | issue = 11 | pages = 1036–7 | year = 2001 | pmid = 11766078 | doi = 10.1007/s005950170020 }} | |||
* {{cite journal | vauthors = Piontek J, Brandt R | title = Differential and regulated binding of cAMP-dependent protein kinase and protein kinase C isoenzymes to gravin in human model neurons: Evidence that gravin provides a dynamic platform for the localization for kinases during neuronal development | journal = J. Biol. Chem. | volume = 278 | issue = 40 | pages = 38970–9 | year = 2003 | pmid = 12857743 | doi = 10.1074/jbc.M306749200 }} | |||
* {{cite journal | vauthors = Tao J, Wang HY, Malbon CC | title = Protein kinase A regulates AKAP250 (gravin) scaffold binding to the beta2-adrenergic receptor | journal = EMBO J. | volume = 22 | issue = 24 | pages = 6419–29 | year = 2003 | pmid = 14657015 | pmc = 291823 | doi = 10.1093/emboj/cdg628 }} | |||
* {{cite journal | vauthors = Choi MC, Jong HS, Kim TY, Song SH, Lee DS, Lee JW, Kim TY, Kim NK, Bang YJ | title = AKAP12/Gravin is inactivated by epigenetic mechanism in human gastric carcinoma and shows growth suppressor activity | journal = Oncogene | volume = 23 | issue = 42 | pages = 7095–103 | year = 2004 | pmid = 15258566 | doi = 10.1038/sj.onc.1207932 }} | |||
* {{cite journal | vauthors = Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP | title = Phosphoproteomic analysis of the developing mouse brain | journal = Mol. Cell. Proteomics | volume = 3 | issue = 11 | pages = 1093–101 | year = 2004 | pmid = 15345747 | doi = 10.1074/mcp.M400085-MCP200 }} | |||
* {{cite journal | vauthors = Streb JW, Miano JM | title = AKAP12alpha, an atypical serum response factor-dependent target gene | journal = J. Biol. Chem. | volume = 280 | issue = 6 | pages = 4125–34 | year = 2005 | pmid = 15590635 | doi = 10.1074/jbc.M412466200 }} | |||
* {{cite journal | vauthors = Streb JW, Miano JM | title = Cross-species sequence analysis reveals multiple charged residue-rich domains that regulate nuclear/cytoplasmic partitioning and membrane localization of a kinase anchoring protein 12 (SSeCKS/Gravin) | journal = J. Biol. Chem. | volume = 280 | issue = 30 | pages = 28007–14 | year = 2005 | pmid = 15923193 | doi = 10.1074/jbc.M414017200 }} | |||
{{Refend}} | |||
[[Category:A-kinase-anchoring proteins]] | |||
{{Gene-6-stub}} |
Latest revision as of 15:56, 24 December 2017
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
Wikidata | |||||||
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A-kinase anchor protein 12, aka AKAP250, is an enzyme that in humans is encoded by the AKAP12 gene.[1][2]
Function
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinase A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms.[2]
Interactions
AKAP12 has been shown to interact with Beta-2 adrenergic receptor.[3][4]
References
- ↑ Nauert JB, Klauck TM, Langeberg LK, Scott JD (Mar 1997). "Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein". Curr. Biol. 7 (1): 52–62. doi:10.1016/S0960-9822(06)00027-3. PMID 9000000.
- ↑ 2.0 2.1 "Entrez Gene: AKAP12 A kinase (PRKA) anchor protein (gravin) 12".
- ↑ Fan G, Shumay E, Wang H, Malbon CC (Jun 2001). "The scaffold protein gravin (cAMP-dependent protein kinase-anchoring protein 250) binds the beta 2-adrenergic receptor via the receptor cytoplasmic Arg-329 to Leu-413 domain and provides a mobile scaffold during desensitization". J. Biol. Chem. 276 (26): 24005–14. doi:10.1074/jbc.M011199200. PMID 11309381.
- ↑ Shih M, Lin F, Scott JD, Wang HY, Malbon CC (Jan 1999). "Dynamic complexes of beta2-adrenergic receptors with protein kinases and phosphatases and the role of gravin". J. Biol. Chem. 274 (3): 1588–95. doi:10.1074/jbc.274.3.1588. PMID 9880537.
External links
- Human AKAP12 genome location and AKAP12 gene details page in the UCSC Genome Browser.
Further reading
- Lester LB, Scott JD (1997). "Anchoring and scaffold proteins for kinases and phosphatases". Recent Prog. Horm. Res. 52: 409–29, discussion 429-30. PMID 9238861.
- Michel JJ, Scott JD (2002). "AKAP mediated signal transduction". Annu. Rev. Pharmacol. Toxicol. 42: 235–57. doi:10.1146/annurev.pharmtox.42.083101.135801. PMID 11807172.
- Yildirim M, Paydas S, Tanriverdi K, Seydaoglu G, Disel U, Yavuz S (2007). "Gravin gene expression in acute leukaemias: clinical importance and review of the literature". Leuk. Lymphoma. 48 (6): 1167–72. doi:10.1080/10428190701377055. PMID 17577780.
- Gordon T, Grove B, Loftus JC, O'Toole T, McMillan R, Lindstrom J, Ginsberg MH (1992). "Molecular cloning and preliminary characterization of a novel cytoplasmic antigen recognized by myasthenia gravis sera". J. Clin. Invest. 90 (3): 992–9. doi:10.1172/JCI115976. PMC 329955. PMID 1522245.
- Sato N, Kokame K, Shimokado K, Kato H, Miyata T (1998). "Changes of gene expression by lysophosphatidylcholine in vascular endothelial cells: 12 up-regulated distinct genes including 5 cell growth-related, 3 thrombosis-related, and 4 others". J. Biochem. 123 (6): 1119–26. doi:10.1093/oxfordjournals.jbchem.a022051. PMID 9604001.
- Shih M, Lin F, Scott JD, Wang HY, Malbon CC (1999). "Dynamic complexes of beta2-adrenergic receptors with protein kinases and phosphatases and the role of gravin". J. Biol. Chem. 274 (3): 1588–95. doi:10.1074/jbc.274.3.1588. PMID 9880537.
- Lin F, Wang Hy, Malbon CC (2000). "Gravin-mediated formation of signaling complexes in beta 2-adrenergic receptor desensitization and resensitization". J. Biol. Chem. 275 (25): 19025–34. doi:10.1074/jbc.275.25.19025. PMID 10858453.
- Fan G, Shumay E, Wang H, Malbon CC (2001). "The scaffold protein gravin (cAMP-dependent protein kinase-anchoring protein 250) binds the beta 2-adrenergic receptor via the receptor cytoplasmic Arg-329 to Leu-413 domain and provides a mobile scaffold during desensitization". J. Biol. Chem. 276 (26): 24005–14. doi:10.1074/jbc.M011199200. PMID 11309381.
- Grove BD, Bruchey AK (2001). "Intracellular distribution of gravin, a PKA and PKC binding protein, in vascular endothelial cells". J. Vasc. Res. 38 (2): 163–75. doi:10.1159/000051043. PMID 11316952.
- Sasaki H, Kunimatsu M, Fujii Y, Yamakawa Y, Fukai I, Kiriyama M, Nonaka M, Sasaki M (2001). "Autoantibody to gravin is expressed more strongly in younger and nonthymomatous patients with myasthenia gravis". Surg. Today. 31 (11): 1036–7. doi:10.1007/s005950170020. PMID 11766078.
- Piontek J, Brandt R (2003). "Differential and regulated binding of cAMP-dependent protein kinase and protein kinase C isoenzymes to gravin in human model neurons: Evidence that gravin provides a dynamic platform for the localization for kinases during neuronal development". J. Biol. Chem. 278 (40): 38970–9. doi:10.1074/jbc.M306749200. PMID 12857743.
- Tao J, Wang HY, Malbon CC (2003). "Protein kinase A regulates AKAP250 (gravin) scaffold binding to the beta2-adrenergic receptor". EMBO J. 22 (24): 6419–29. doi:10.1093/emboj/cdg628. PMC 291823. PMID 14657015.
- Choi MC, Jong HS, Kim TY, Song SH, Lee DS, Lee JW, Kim TY, Kim NK, Bang YJ (2004). "AKAP12/Gravin is inactivated by epigenetic mechanism in human gastric carcinoma and shows growth suppressor activity". Oncogene. 23 (42): 7095–103. doi:10.1038/sj.onc.1207932. PMID 15258566.
- Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (2004). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
- Streb JW, Miano JM (2005). "AKAP12alpha, an atypical serum response factor-dependent target gene". J. Biol. Chem. 280 (6): 4125–34. doi:10.1074/jbc.M412466200. PMID 15590635.
- Streb JW, Miano JM (2005). "Cross-species sequence analysis reveals multiple charged residue-rich domains that regulate nuclear/cytoplasmic partitioning and membrane localization of a kinase anchoring protein 12 (SSeCKS/Gravin)". J. Biol. Chem. 280 (30): 28007–14. doi:10.1074/jbc.M414017200. PMID 15923193.
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