ASAH2: Difference between revisions

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{{Infobox_gene}}
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'''Neutral ceramidase''' is an [[enzyme]] that in humans is encoded by the ''ASAH2'' [[gene]].<ref name="pmid10781606">{{cite journal | vauthors = El Bawab S, Roddy P, Qian T, Bielawska A, Lemasters JJ, Hannun YA | title = Molecular cloning and characterization of a human mitochondrial ceramidase | journal = J Biol Chem | volume = 275 | issue = 28 | pages = 21508–13 |date=Aug 2000 | pmid = 10781606 | pmc =  | doi = 10.1074/jbc.M002522200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56624| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
| HGNCid = 18860
| Symbol = ASAH2
| AltSymbols =; HNAC1; MGC129777
| OMIM = 
| ECnumber = 
| Homologene = 10310
| MGIid = 1859310
| Function = {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0017040 |text = ceramidase activity}}
  | Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006665 |text = sphingolipid metabolic process}} {{GNF_GO|id=GO:0006672 |text = ceramide metabolic process}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 56624
    | Hs_Ensembl = ENSG00000188611
    | Hs_RefseqProtein = XP_001125770
    | Hs_RefseqmRNA = XM_001125770
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 51614627
    | Hs_GenLoc_end = 51678319
    | Hs_Uniprot = Q9NR71
    | Mm_EntrezGene = 54447
    | Mm_Ensembl = ENSMUSG00000024887
    | Mm_RefseqmRNA = NM_018830
    | Mm_RefseqProtein = NP_061300
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 32050631
    | Mm_GenLoc_end = 32127401
    | Mm_Uniprot = Q9JHE3
  }}
}}
'''N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2''', also known as '''ASAH2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56624| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|ASAH2}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Matoba R, Okubo K, Hori N, ''et al.'' |title=The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression. |journal=Gene |volume=146 |issue= 2 |pages= 199-207 |year= 1994 |pmid= 8076819 |doi=  }}
*{{cite journal  | vauthors=Matoba R, Okubo K, Hori N |title=The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression. |journal=Gene |volume=146 |issue= 2 |pages= 199–207 |year= 1994 |pmid= 8076819 |doi=10.1016/0378-1119(94)90293-3 |display-authors=etal}}
*{{cite journal  | author=Tani M, Okino N, Mori K, ''et al.'' |title=Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases. |journal=J. Biol. Chem. |volume=275 |issue= 15 |pages= 11229-34 |year= 2000 |pmid= 10753931 |doi= }}
*{{cite journal  | vauthors=Tani M, Okino N, Mori K |title=Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases. |journal=J. Biol. Chem. |volume=275 |issue= 15 |pages= 11229–34 |year= 2000 |pmid= 10753931 |doi=10.1074/jbc.275.15.11229  |display-authors=etal}}
*{{cite journal  | author=El Bawab S, Roddy P, Qian T, ''et al.'' |title=Molecular cloning and characterization of a human mitochondrial ceramidase. |journal=J. Biol. Chem. |volume=275 |issue= 28 |pages= 21508-13 |year= 2000 |pmid= 10781606 |doi= 10.1074/jbc.M002522200 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Choi MS, Anderson MA, Zhang Z |title=Neutral ceramidase gene: role in regulating ceramide-induced apoptosis. |journal=Gene |volume=315 |issue=  |pages= 113–22 |year= 2004 |pmid= 14557071 |doi=10.1016/S0378-1119(03)00721-2 |display-authors=etal}}
*{{cite journal  | author=Choi MS, Anderson MA, Zhang Z, ''et al.'' |title=Neutral ceramidase gene: role in regulating ceramide-induced apoptosis. |journal=Gene |volume=315 |issue=  |pages= 113-22 |year= 2004 |pmid= 14557071 |doi=  }}
*{{cite journal  | vauthors=Deloukas P, Earthrowl ME, Grafham DV |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 |display-authors=etal}}
*{{cite journal  | author=Deloukas P, Earthrowl ME, Grafham DV, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375-81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 }}
*{{cite journal  | vauthors=Monick MM, Mallampalli RK, Bradford M |title=Cooperative prosurvival activity by ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activity. |journal=J. Immunol. |volume=173 |issue= 1 |pages= 123–35 |year= 2004 |pmid= 15210766 |doi=  10.4049/jimmunol.173.1.123|display-authors=etal}}
*{{cite journal  | author=Monick MM, Mallampalli RK, Bradford M, ''et al.'' |title=Cooperative prosurvival activity by ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activity. |journal=J. Immunol. |volume=173 |issue= 1 |pages= 123-35 |year= 2004 |pmid= 15210766 |doi=  }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Hwang YH, Tani M, Nakagawa T |title=Subcellular localization of human neutral ceramidase expressed in HEK293 cells. |journal=Biochem. Biophys. Res. Commun. |volume=331 |issue= 1 |pages= 37–42 |year= 2005 |pmid= 15845354 |doi= 10.1016/j.bbrc.2005.03.134 |display-authors=etal}}
*{{cite journal  | author=Hwang YH, Tani M, Nakagawa T, ''et al.'' |title=Subcellular localization of human neutral ceramidase expressed in HEK293 cells. |journal=Biochem. Biophys. Res. Commun. |volume=331 |issue= 1 |pages= 37-42 |year= 2005 |pmid= 15845354 |doi= 10.1016/j.bbrc.2005.03.134 }}
*{{cite journal  | vauthors=Osawa Y, Uchinami H, Bielawski J |title=Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. |journal=J. Biol. Chem. |volume=280 |issue= 30 |pages= 27879–87 |year= 2005 |pmid= 15946935 |doi= 10.1074/jbc.M503002200 |display-authors=etal}}
*{{cite journal  | author=Osawa Y, Uchinami H, Bielawski J, ''et al.'' |title=Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. |journal=J. Biol. Chem. |volume=280 |issue= 30 |pages= 27879-87 |year= 2005 |pmid= 15946935 |doi= 10.1074/jbc.M503002200 }}
*{{cite journal  | vauthors=Tani M, Sano T, Ito M, Igarashi Y |title=Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets. |journal=J. Lipid Res. |volume=46 |issue= 11 |pages= 2458–67 |year= 2006 |pmid= 16061940 |doi= 10.1194/jlr.M500268-JLR200 }}
*{{cite journal  | author=Tani M, Sano T, Ito M, Igarashi Y |title=Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets. |journal=J. Lipid Res. |volume=46 |issue= 11 |pages= 2458-67 |year= 2006 |pmid= 16061940 |doi= 10.1194/jlr.M500268-JLR200 }}
*{{cite journal  | vauthors=Galadari S, Wu BX, Mao C |title=Identification of a novel amidase motif in neutral ceramidase. |journal=Biochem. J. |volume=393 |issue= Pt 3 |pages= 687–95 |year= 2006 |pmid= 16229686 |doi= 10.1042/BJ20050682 | pmc=1360721 |display-authors=etal}}
*{{cite journal  | author=Galadari S, Wu BX, Mao C, ''et al.'' |title=Identification of a novel amidase motif in neutral ceramidase. |journal=Biochem. J. |volume=393 |issue= Pt 3 |pages= 687-95 |year= 2006 |pmid= 16229686 |doi= 10.1042/BJ20050682 }}
*{{cite journal  | vauthors=Xu R, Jin J, Hu W |title=Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P. |journal=FASEB J. |volume=20 |issue= 11 |pages= 1813–25 |year= 2006 |pmid= 16940153 |doi= 10.1096/fj.05-5689com |display-authors=etal}}
*{{cite journal  | author=Xu R, Jin J, Hu W, ''et al.'' |title=Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P. |journal=FASEB J. |volume=20 |issue= 11 |pages= 1813-25 |year= 2006 |pmid= 16940153 |doi= 10.1096/fj.05-5689com }}
*{{cite journal  | vauthors=Avramopoulos D, Wang R, Valle D |title=A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease. |journal=Neurogenetics |volume=8 |issue= 2 |pages= 111–20 |year=  2007|pmid= 17334805 |doi= 10.1007/s10048-007-0081-5 |display-authors=etal}}
*{{cite journal  | author=Avramopoulos D, Wang R, Valle D, ''et al.'' |title=A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease. |journal=Neurogenetics |volume=8 |issue= 2 |pages= 111-20 |year=  |pmid= 17334805 |doi= 10.1007/s10048-007-0081-5 }}
*{{cite journal  | vauthors=Ohlsson L, Palmberg C, Duan RD |title=Purification and characterization of human intestinal neutral ceramidase. |journal=Biochimie |volume=89 |issue= 8 |pages= 950–60 |year= 2007 |pmid= 17475390 |doi= 10.1016/j.biochi.2007.03.009 |display-authors=etal}}
*{{cite journal  | author=Ohlsson L, Palmberg C, Duan RD, ''et al.'' |title=Purification and characterization of human intestinal neutral ceramidase. |journal=Biochimie |volume=89 |issue= 8 |pages= 950-60 |year= 2007 |pmid= 17475390 |doi= 10.1016/j.biochi.2007.03.009 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 18:18, 29 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Neutral ceramidase is an enzyme that in humans is encoded by the ASAH2 gene.[1][2]


References

  1. ↑ El Bawab S, Roddy P, Qian T, Bielawska A, Lemasters JJ, Hannun YA (Aug 2000). "Molecular cloning and characterization of a human mitochondrial ceramidase". J Biol Chem. 275 (28): 21508–13. doi:10.1074/jbc.M002522200. PMID 10781606.
  2. ↑ "Entrez Gene: ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2".

External links

Further reading



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