Acute basophilic leukemia: Difference between revisions
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==Overview== | ==Overview== | ||
Acute basophilic leukemia is a rare form of [[acute myeloid leukemia]] where blasts are accompanied by abnormal [[basophil]]s in all stages of differentiation. It would most likely be classified as M0 without electron microscopic confirmation of basophil lineage.<ref>Liu pp; Hajara A; Wijmengac C; Collins fs. Molecular pathogenesis of chromosome 16 inversion in the M4E0 subtypes of acute myeloid leukemia.Blood;1995;85:2289-2302.</ref> | |||
==Pathophysiology== | |||
===Microscopic Pathology=== | |||
== | Differentiated (basophilic granules by light microscopy) and poorly differentiated cases ; Majority are poorly differentiated. MPO negative by light microscopy; granules positive in a speckled pattern by [[electron microscope|electron microscopy]]. Myeloid [[antigen]]s are expressed. Diagnosis of poorly differentiated cases made by electron microscopy. May manifest basophil and mast cell granules by EM. Cytogeneticcally heterogeneous but frequently associated with [[Philadelphia chromosome]]. There is no clinically distinguishing features but may be more common in children and young adults and carry a poor prognosis.<ref>Duchayne E; Rubier H; Robert A;Dastugue N.Diagnosis of acute basophilic leukemia.Leuk Lymphoma 1999.Jan;32(3-4)269-78.PMID: 10037023</ref> | ||
Differentiated (basophilic granules by light microscopy) and poorly differentiated cases ; Majority are poorly differentiated. MPO negative by light microscopy; granules positive in a speckled pattern by electron microscopy. Myeloid | |||
==References== | ==References== | ||
Latest revision as of 16:37, 26 February 2013
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Acute basophilic leukemia is a rare form of acute myeloid leukemia where blasts are accompanied by abnormal basophils in all stages of differentiation. It would most likely be classified as M0 without electron microscopic confirmation of basophil lineage.[1]
Pathophysiology
Microscopic Pathology
Differentiated (basophilic granules by light microscopy) and poorly differentiated cases ; Majority are poorly differentiated. MPO negative by light microscopy; granules positive in a speckled pattern by electron microscopy. Myeloid antigens are expressed. Diagnosis of poorly differentiated cases made by electron microscopy. May manifest basophil and mast cell granules by EM. Cytogeneticcally heterogeneous but frequently associated with Philadelphia chromosome. There is no clinically distinguishing features but may be more common in children and young adults and carry a poor prognosis.[2]
References
- ↑ Liu pp; Hajara A; Wijmengac C; Collins fs. Molecular pathogenesis of chromosome 16 inversion in the M4E0 subtypes of acute myeloid leukemia.Blood;1995;85:2289-2302.
- ↑ Duchayne E; Rubier H; Robert A;Dastugue N.Diagnosis of acute basophilic leukemia.Leuk Lymphoma 1999.Jan;32(3-4)269-78.PMID: 10037023
External link
- http://www.meds.com/leukemia/flow/flow with flow cytometry in AML. Atlas .html