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{{Infobox_gene}}
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'''Bromodomain-containing protein 8''' is a [[protein]] that in humans is encoded by the ''BRD8'' [[gene]].<ref name="pmid8611617">{{cite journal | vauthors = Nielsen MS, Petersen CM, Gliemann J, Madsen P | title = Cloning and sequencing of a human cDNA encoding a putative transcription factor containing a bromodomain | journal = Biochim Biophys Acta | volume = 1306 | issue = 1 | pages = 14–6 |date=Jun 1996 | pmid = 8611617 | pmc =  | doi =  10.1016/0167-4781(95)00239-1}}</ref><ref name="pmid9368056">{{cite journal | vauthors = Monden T, Wondisford FE, Hollenberg AN | title = Isolation and characterization of a novel ligand-dependent thyroid hormone receptor-coactivating protein | journal = J Biol Chem | volume = 272 | issue = 47 | pages = 29834–41 |date=Dec 1997 | pmid = 9368056 | pmc =  | doi =10.1074/jbc.272.47.29834 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: BRD8 bromodomain containing 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10902| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Bromodomain containing 8
| HGNCid = 19874
| Symbol = BRD8
| AltSymbols =; p120; SMAP; SMAP2
| OMIM = 602848
| ECnumber =
| Homologene = 41790
| MGIid = 1925906
  | GeneAtlas_image1 = PBB_GE_BRD8_202227_s_at_tn.png
  | GeneAtlas_image2 = PBB_GE_BRD8_210352_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003706 |text = ligand-regulated transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0004887 |text = thyroid hormone receptor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001558 |text = regulation of cell growth}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0016568 |text = chromatin modification}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10902
    | Hs_Ensembl = ENSG00000112983
    | Hs_RefseqProtein = NP_006687
    | Hs_RefseqmRNA = NM_006696
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 137503364
    | Hs_GenLoc_end = 137542257
    | Hs_Uniprot = Q9H0E9
    | Mm_EntrezGene = 78656
    | Mm_Ensembl = ENSMUSG00000003778
    | Mm_RefseqmRNA = XM_908662
    | Mm_RefseqProtein = XP_913755
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 34723416
    | Mm_GenLoc_end = 34749611
    | Mm_Uniprot = Q8R3B7
  }}
}}
'''Bromodomain containing 8''', also known as '''BRD8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BRD8 bromodomain containing 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10902| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Three alternatively spliced transcript variants that encode distinct isoforms have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: BRD8 bromodomain containing 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10902| accessdate = }}</ref>
| summary_text = The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Three alternatively spliced transcript variants that encode distinct isoforms have been identified.<ref name="entrez" />
}}
}}
==Interactions==
BRD8 has been shown to [[Protein-protein interaction|interact]] with [[Thyroid hormone receptor beta]]<ref name=pmid9368056 /> and [[Retinoid X receptor alpha]].<ref name=pmid10517671>{{cite journal |last=Monden |first=T |author2=Kishi M |author3=Hosoya T |author4=Satoh T |author5=Wondisford F E |author6=Hollenberg A N |author7=Yamada M |author8=Mori M  |date=Oct 1999 |title=p120 acts as a specific coactivator for 9-cis-retinoic acid receptor (RXR) on peroxisome proliferator-activated receptor-gamma/RXR heterodimers |journal=Mol. Endocrinol. |volume=13 |issue=10 |pages=1695–703 |publisher= |location = UNITED STATES| issn = 0888-8809| pmid = 10517671 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1210/me.13.10.1695 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|BRD8}}
* {{UCSC gene info|SMAP2}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Doyon Y, Côté J |title=The highly conserved and multifunctional NuA4 HAT complex. |journal=Curr. Opin. Genet. Dev. |volume=14 |issue= 2 |pages= 147-54 |year= 2004 |pmid= 15196461 |doi= 10.1016/j.gde.2004.02.009 }}
*{{cite journal  | vauthors=Doyon Y, Côté J |title=The highly conserved and multifunctional NuA4 HAT complex |journal=Curr. Opin. Genet. Dev. |volume=14 |issue= 2 |pages= 147–54 |year= 2004 |pmid= 15196461 |doi= 10.1016/j.gde.2004.02.009 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Nielsen MS, Petersen CM, Gliemann J, Madsen P |title=Cloning and sequencing of a human cDNA encoding a putative transcription factor containing a bromodomain. |journal=Biochim. Biophys. Acta |volume=1306 |issue= 1 |pages= 14-6 |year= 1996 |pmid= 8611617 |doi=  }}
*{{cite journal  | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
*{{cite journal  | author=Monden T, Wondisford FE, Hollenberg AN |title=Isolation and characterization of a novel ligand-dependent thyroid hormone receptor-coactivating protein. |journal=J. Biol. Chem. |volume=272 |issue= 47 |pages= 29834-41 |year= 1997 |pmid= 9368056 |doi=  }}
*{{cite journal  | vauthors=Monden T, Kishi M, Hosoya T |title=p120 acts as a specific coactivator for 9-cis-retinoic acid receptor (RXR) on peroxisome proliferator-activated receptor-gamma/RXR heterodimers |journal=Mol. Endocrinol. |volume=13 |issue= 10 |pages= 1695–703 |year= 1999 |pmid= 10517671 |doi=10.1210/me.13.10.1695 |display-authors=etal}}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal  | vauthors=Lai F, Godley LA, Joslin J |title=Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q) |journal=Genomics |volume=71 |issue= 2 |pages= 235–45 |year= 2001 |pmid= 11161817 |doi= 10.1006/geno.2000.6414 |display-authors=etal}}
*{{cite journal  | author=Monden T, Kishi M, Hosoya T, ''et al.'' |title=p120 acts as a specific coactivator for 9-cis-retinoic acid receptor (RXR) on peroxisome proliferator-activated receptor-gamma/RXR heterodimers. |journal=Mol. Endocrinol. |volume=13 |issue= 10 |pages= 1695-703 |year= 1999 |pmid= 10517671 |doi=  }}
*{{cite journal  | vauthors=Wiemann S, Weil B, Wellenreuther R |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072 |display-authors=etal}}
*{{cite journal  | author=Lai F, Godley LA, Joslin J, ''et al.'' |title=Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q). |journal=Genomics |volume=71 |issue= 2 |pages= 235-45 |year= 2001 |pmid= 11161817 |doi= 10.1006/geno.2000.6414 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }}
*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal  | vauthors=Cai Y, Jin J, Tomomori-Sato C |title=Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex |journal=J. Biol. Chem. |volume=278 |issue= 44 |pages= 42733–6 |year= 2003 |pmid= 12963728 |doi= 10.1074/jbc.C300389200 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Doyon Y, Selleck W, Lane WS |title=Structural and Functional Conservation of the NuA4 Histone Acetyltransferase Complex from Yeast to Humans |journal=Mol. Cell. Biol. |volume=24 |issue= 5 |pages= 1884–96 |year= 2004 |pmid= 14966270 |doi=10.1128/MCB.24.5.1884-1896.2004  | pmc=350560  |display-authors=etal}}
*{{cite journal  | author=Cai Y, Jin J, Tomomori-Sato C, ''et al.'' |title=Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. |journal=J. Biol. Chem. |volume=278 |issue= 44 |pages= 42733-6 |year= 2003 |pmid= 12963728 |doi= 10.1074/jbc.C300389200 }}
*{{cite journal  | vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101  | pmc=514446 |display-authors=etal|bibcode=2004PNAS..10112130B }}
*{{cite journal  | author=Doyon Y, Selleck W, Lane WS, ''et al.'' |title=Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. |journal=Mol. Cell. Biol. |volume=24 |issue= 5 |pages= 1884-96 |year= 2004 |pmid= 14966270 |doi=  }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal  | vauthors=Cai Y, Jin J, Florens L |title=The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes |journal=J. Biol. Chem. |volume=280 |issue= 14 |pages= 13665–70 |year= 2005 |pmid= 15647280 |doi= 10.1074/jbc.M500001200 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Benevolenskaya EV, Murray HL, Branton P |title=Binding of pRB to the PHD protein RBP2 promotes cellular differentiation |journal=Mol. Cell |volume=18 |issue= 6 |pages= 623–35 |year= 2005 |pmid= 15949438 |doi= 10.1016/j.molcel.2005.05.012 |display-authors=etal}}
*{{cite journal  | author=Cai Y, Jin J, Florens L, ''et al.'' |title=The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes. |journal=J. Biol. Chem. |volume=280 |issue= 14 |pages= 13665-70 |year= 2005 |pmid= 15647280 |doi= 10.1074/jbc.M500001200 }}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal|bibcode=2005Natur.437.1173R }}
*{{cite journal  | author=Benevolenskaya EV, Murray HL, Branton P, ''et al.'' |title=Binding of pRB to the PHD protein RBP2 promotes cellular differentiation. |journal=Mol. Cell |volume=18 |issue= 6 |pages= 623-35 |year= 2005 |pmid= 15949438 |doi= 10.1016/j.molcel.2005.05.012 }}
*{{cite journal  | vauthors=Natsume W, Tanabe K, Kon S |title=SMAP2, a Novel ARF GTPase-activating Protein, Interacts with Clathrin and Clathrin Assembly Protein and Functions on the AP-1–positive Early Endosome/Trans-Golgi Network |journal=Mol. Biol. Cell |volume=17 |issue= 6 |pages= 2592–603 |year= 2006 |pmid= 16571680 |doi= 10.1091/mbc.E05-10-0909  | pmc=1475504 |display-authors=etal}}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | vauthors=Beausoleil SA, Villén J, Gerber SA |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |display-authors=etal}}
*{{cite journal  | author=Natsume W, Tanabe K, Kon S, ''et al.'' |title=SMAP2, a novel ARF GTPase-activating protein, interacts with clathrin and clathrin assembly protein and functions on the AP-1-positive early endosome/trans-Golgi network. |journal=Mol. Biol. Cell |volume=17 |issue= 6 |pages= 2592-603 |year= 2006 |pmid= 16571680 |doi= 10.1091/mbc.E05-10-0909 }}
*{{cite journal  | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
*{{cite journal  | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 21:58, 22 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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Wikidata
View/Edit Human

Bromodomain-containing protein 8 is a protein that in humans is encoded by the BRD8 gene.[1][2][3]

The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Three alternatively spliced transcript variants that encode distinct isoforms have been identified.[3]

Interactions

BRD8 has been shown to interact with Thyroid hormone receptor beta[2] and Retinoid X receptor alpha.[4]

References

  1. ↑ Nielsen MS, Petersen CM, Gliemann J, Madsen P (Jun 1996). "Cloning and sequencing of a human cDNA encoding a putative transcription factor containing a bromodomain". Biochim Biophys Acta. 1306 (1): 14–6. doi:10.1016/0167-4781(95)00239-1. PMID 8611617.
  2. ↑ 2.0 2.1 Monden T, Wondisford FE, Hollenberg AN (Dec 1997). "Isolation and characterization of a novel ligand-dependent thyroid hormone receptor-coactivating protein". J Biol Chem. 272 (47): 29834–41. doi:10.1074/jbc.272.47.29834. PMID 9368056.
  3. ↑ 3.0 3.1 "Entrez Gene: BRD8 bromodomain containing 8".
  4. ↑ Monden, T; Kishi M; Hosoya T; Satoh T; Wondisford F E; Hollenberg A N; Yamada M; Mori M (Oct 1999). "p120 acts as a specific coactivator for 9-cis-retinoic acid receptor (RXR) on peroxisome proliferator-activated receptor-gamma/RXR heterodimers". Mol. Endocrinol. UNITED STATES. 13 (10): 1695–703. doi:10.1210/me.13.10.1695. ISSN 0888-8809. PMID 10517671.

External links

Further reading



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