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{{Infobox_gene}}
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'''Signal transduction protein CBL-C''' is a [[protein]] that in humans is encoded by the ''CBLC'' [[gene]].<ref name="pmid10362357">{{cite journal | vauthors = Keane MM, Ettenberg SA, Nau MM, Banerjee P, Cuello M, Penninger J, Lipkowitz S | title = cbl-3: a new mammalian cbl family protein | journal = Oncogene | volume = 18 | issue = 22 | pages = 3365–75 |date=Jun 1999 | pmid = 10362357 | pmc =  | doi = 10.1038/sj.onc.1202753 }}</ref><ref name="pmid10571044">{{cite journal | vauthors = Kim M, Tezuka T, Suziki Y, Sugano S, Hirai M, Yamamoto T | title = Molecular cloning and characterization of a novel cbl-family gene, cbl-c | journal = Gene | volume = 239 | issue = 1 | pages = 145–54 |date=Dec 1999 | pmid = 10571044 | pmc =  | doi =10.1016/S0378-1119(99)00356-X  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CBLC Cas-Br-M (murine) ecotropic retroviral transforming sequence c| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23624| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Cas-Br-M (murine) ecotropic retroviral transforming sequence c
| HGNCid = 15961
| Symbol = CBLC
| AltSymbols =; CBL-3; CBL-SL; RNF57
| OMIM = 608453
| ECnumber =
| Homologene = 8108
| MGIid = 1931457
| GeneAtlas_image1 = PBB_GE_CBLC_220638_s_at_tn.png
| Function =  
| Component =  
  | Process =  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23624
    | Hs_Ensembl = ENSG00000142273
    | Hs_RefseqProtein = NP_036248
    | Hs_RefseqmRNA = NM_012116
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 49972966
    | Hs_GenLoc_end = 49995736
    | Hs_Uniprot = Q9ULV8
    | Mm_EntrezGene = 80794
    | Mm_Ensembl = ENSMUSG00000040525
    | Mm_RefseqmRNA = XM_987284
    | Mm_RefseqProtein = XP_992378
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 18939488
    | Mm_GenLoc_end = 18955304
    | Mm_Uniprot = Q80XL1
  }}
}}
'''Cas-Br-M (murine) ecotropic retroviral transforming sequence c''', also known as '''CBLC''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CBLC Cas-Br-M (murine) ecotropic retroviral transforming sequence c| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23624| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = CBL proteins, such as CBLC, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC (MIM 190090) homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling (Keane et al., 1999).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: CBLC Cas-Br-M (murine) ecotropic retroviral transforming sequence c| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23624| accessdate = }}</ref>
| summary_text = CBL proteins, such as CBLC, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC (MIM 190090) homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling (Keane et al., 1999).[supplied by OMIM]<ref name="entrez" />
}}
}}
==Interactions==
CBLC has been shown to [[Protein-protein interaction|interact]] with [[FYN]]<ref name=autogenerated2>{{cite journal |last=Kim |first=M |author2=Tezuka T|author3=Suziki Y|author4=Sugano S|author5=Hirai M|author6=Yamamoto T |date=Oct 1999 |title=Molecular cloning and characterization of a novel cbl-family gene, cbl-c |journal=Gene |volume=239 |issue=1 |pages=145–54 |publisher= |location = NETHERLANDS| issn = 0378-1119| pmid = 10571044 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0378-1119(99)00356-X }}</ref> and [[Epidermal growth factor receptor]].<ref name=pmid10571044/><ref name=autogenerated1>{{cite journal |last=Keane |first=M M |author2=Ettenberg S A|author3=Nau M M|author4=Banerjee P|author5=Cuello M|author6=Penninger J|author7=Lipkowitz S |date=Jun 1999 |title=cbl-3: a new mammalian cbl family protein |journal=Oncogene |volume=18 |issue=22 |pages=3365–75 |publisher= |location = ENGLAND| issn = 0950-9232| pmid = 10362357 |doi = 10.1038/sj.onc.1202753 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CBLC}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Ollendorff V, Mattei M, Fournier E, ''et al.'' |title=A third human CBL gene is on chromosome 19. |journal=Int. J. Oncol. |volume=13 |issue= 6 |pages= 1159-61 |year= 1999 |pmid= 9824625 |doi=  }}
*{{cite journal  | vauthors=Ollendorff V, Mattei M, Fournier E |title=A third human CBL gene is on chromosome 19 |journal=Int. J. Oncol. |volume=13 |issue= 6 |pages= 1159–61 |year= 1999 |pmid= 9824625 |doi=  10.3892/ijo.13.6.1159|display-authors=etal}}
*{{cite journal  | author=Irby RB, Mao W, Coppola D, ''et al.'' |title=Activating SRC mutation in a subset of advanced human colon cancers. |journal=Nat. Genet. |volume=21 |issue= 2 |pages= 187-90 |year= 1999 |pmid= 9988270 |doi= 10.1038/5971 }}
*{{cite journal  | vauthors=Irby RB, Mao W, Coppola D |title=Activating SRC mutation in a subset of advanced human colon cancers |journal=Nat. Genet. |volume=21 |issue= 2 |pages= 187–90 |year= 1999 |pmid= 9988270 |doi= 10.1038/5971 |display-authors=etal}}
*{{cite journal  | author=Ettenberg SA, Keane MM, Nau MM, ''et al.'' |title=cbl-b inhibits epidermal growth factor receptor signaling. |journal=Oncogene |volume=18 |issue= 10 |pages= 1855-66 |year= 1999 |pmid= 10086340 |doi= 10.1038/sj.onc.1202499 }}
*{{cite journal  | vauthors=Ettenberg SA, Keane MM, Nau MM |title=Cbl-b inhibits epidermal growth factor receptor signaling |journal=Oncogene |volume=18 |issue= 10 |pages= 1855–66 |year= 1999 |pmid= 10086340 |doi= 10.1038/sj.onc.1202499 |display-authors=etal}}
*{{cite journal  | author=Keane MM, Ettenberg SA, Nau MM, ''et al.'' |title=cbl-3: a new mammalian cbl family protein. |journal=Oncogene |volume=18 |issue= 22 |pages= 3365-75 |year= 1999 |pmid= 10362357 |doi= 10.1038/sj.onc.1202753 }}
*{{cite journal  | vauthors=Loreto MP, Berry DM, McGlade CJ |title=Functional Cooperation between c-Cbl and Src-Like Adaptor Protein 2 in the Negative Regulation of T-Cell Receptor Signaling |journal=Mol. Cell. Biol. |volume=22 |issue= 12 |pages= 4241–55 |year= 2002 |pmid= 12024036 |doi=10.1128/MCB.22.12.4241-4255.2002  | pmc=133880 }}
*{{cite journal  | author=Kim M, Tezuka T, Suziki Y, ''et al.'' |title=Molecular cloning and characterization of a novel cbl-family gene, cbl-c. |journal=Gene |volume=239 |issue= 1 |pages= 145-54 |year= 1999 |pmid= 10571044 |doi= }}
*{{cite journal  | vauthors=Szymkiewicz I, Kowanetz K, Soubeyran P |title=CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases |journal=J. Biol. Chem. |volume=277 |issue= 42 |pages= 39666–72 |year= 2002 |pmid= 12177062 |doi= 10.1074/jbc.M205535200 |display-authors=etal}}
*{{cite journal  | author=Loreto MP, Berry DM, McGlade CJ |title=Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling. |journal=Mol. Cell. Biol. |volume=22 |issue= 12 |pages= 4241-55 |year= 2002 |pmid= 12024036 |doi=  }}
*{{cite journal  | vauthors=Courbard JR, Fiore F, Adélaïde J |title=Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 45267–75 |year= 2003 |pmid= 12226085 |doi= 10.1074/jbc.M206460200 |display-authors=etal}}
*{{cite journal  | author=Szymkiewicz I, Kowanetz K, Soubeyran P, ''et al.'' |title=CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases. |journal=J. Biol. Chem. |volume=277 |issue= 42 |pages= 39666-72 |year= 2002 |pmid= 12177062 |doi= 10.1074/jbc.M205535200 }}
*{{cite journal  | vauthors=Wong ES, Fong CW, Lim J |title=Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling |journal=EMBO J. |volume=21 |issue= 18 |pages= 4796–808 |year= 2002 |pmid= 12234920 |doi=10.1093/emboj/cdf493 | pmc=126289  |display-authors=etal}}
*{{cite journal  | author=Courbard JR, Fiore F, Adélaïde J, ''et al.'' |title=Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH. |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 45267-75 |year= 2003 |pmid= 12226085 |doi= 10.1074/jbc.M206460200 }}
*{{cite journal  | vauthors=Taher TE, Tjin EP, Beuling EA |title=C-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination |journal=J. Immunol. |volume=169 |issue= 7 |pages= 3793–800 |year= 2002 |pmid= 12244174 |doi=  10.4049/jimmunol.169.7.3793|display-authors=etal}}
*{{cite journal  | author=Wong ES, Fong CW, Lim J, ''et al.'' |title=Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling. |journal=EMBO J. |volume=21 |issue= 18 |pages= 4796-808 |year= 2002 |pmid= 12234920 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }}
*{{cite journal  | author=Taher TE, Tjin EP, Beuling EA, ''et al.'' |title=c-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination. |journal=J. Immunol. |volume=169 |issue= 7 |pages= 3793-800 |year= 2002 |pmid= 12244174 |doi=  }}
*{{cite journal  | vauthors=Nau MM, Lipkowitz S |title=Comparative genomic organization of the cbl genes |journal=Gene |volume=308 |issue=  |pages= 103–13 |year= 2003 |pmid= 12711395 |doi=10.1016/S0378-1119(03)00471-2 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Kim M, Tezuka T, Tanaka K, Yamamoto T |title=Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation |journal=Oncogene |volume=23 |issue= 9 |pages= 1645–55 |year= 2004 |pmid= 14661060 |doi= 10.1038/sj.onc.1207298 }}
*{{cite journal  | author=Nau MM, Lipkowitz S |title=Comparative genomic organization of the cbl genes. |journal=Gene |volume=308 |issue=  |pages= 103-13 |year= 2003 |pmid= 12711395 |doi=  }}
*{{cite journal  | vauthors=Kassenbrock CK, Anderson SM |title=Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28017–27 |year= 2004 |pmid= 15117950 |doi= 10.1074/jbc.M404114200 }}
*{{cite journal  | author=Kim M, Tezuka T, Tanaka K, Yamamoto T |title=Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation. |journal=Oncogene |volume=23 |issue= 9 |pages= 1645-55 |year= 2004 |pmid= 14661060 |doi= 10.1038/sj.onc.1207298 }}
*{{cite journal  | vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |display-authors=etal|bibcode=2004PNAS..10112130B }}
*{{cite journal  | author=Kassenbrock CK, Anderson SM |title=Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations. |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28017-27 |year= 2004 |pmid= 15117950 |doi= 10.1074/jbc.M404114200 }}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal|bibcode=2005Natur.437.1173R }}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
}}
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Latest revision as of 01:04, 23 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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RefSeq (mRNA)

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Wikidata
View/Edit Human

Signal transduction protein CBL-C is a protein that in humans is encoded by the CBLC gene.[1][2][3]

CBL proteins, such as CBLC, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC (MIM 190090) homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling (Keane et al., 1999).[supplied by OMIM][3]

Interactions

CBLC has been shown to interact with FYN[4] and Epidermal growth factor receptor.[2][5]

References

  1. ↑ Keane MM, Ettenberg SA, Nau MM, Banerjee P, Cuello M, Penninger J, Lipkowitz S (Jun 1999). "cbl-3: a new mammalian cbl family protein". Oncogene. 18 (22): 3365–75. doi:10.1038/sj.onc.1202753. PMID 10362357.
  2. ↑ 2.0 2.1 Kim M, Tezuka T, Suziki Y, Sugano S, Hirai M, Yamamoto T (Dec 1999). "Molecular cloning and characterization of a novel cbl-family gene, cbl-c". Gene. 239 (1): 145–54. doi:10.1016/S0378-1119(99)00356-X. PMID 10571044.
  3. ↑ 3.0 3.1 "Entrez Gene: CBLC Cas-Br-M (murine) ecotropic retroviral transforming sequence c".
  4. ↑ Kim, M; Tezuka T; Suziki Y; Sugano S; Hirai M; Yamamoto T (Oct 1999). "Molecular cloning and characterization of a novel cbl-family gene, cbl-c". Gene. NETHERLANDS. 239 (1): 145–54. doi:10.1016/S0378-1119(99)00356-X. ISSN 0378-1119. PMID 10571044.
  5. ↑ Keane, M M; Ettenberg S A; Nau M M; Banerjee P; Cuello M; Penninger J; Lipkowitz S (Jun 1999). "cbl-3: a new mammalian cbl family protein". Oncogene. ENGLAND. 18 (22): 3365–75. doi:10.1038/sj.onc.1202753. ISSN 0950-9232. PMID 10362357.

External links

Further reading



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