CCT6A: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: HTTP→HTTPS (v470))
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''T-complex protein 1 subunit zeta''' is a [[protein]] that in humans is encoded by the ''CCT6A'' [[gene]].<ref name="pmid1352881">{{cite journal | vauthors = Segel GB, Boal TR, Cardillo TS, Murant FG, Lichtman MA, Sherman F | title = Isolation of a gene encoding a chaperonin-like protein by complementation of yeast amino acid transport mutants with human cDNA | journal = Proc Natl Acad Sci U S A | volume = 89 | issue = 13 | pages = 6060–4 | date = August 1992 | pmid = 1352881 | pmc = 49437 | doi = 10.1073/pnas.89.13.6060 }}</ref><ref name="pmid8034610">{{cite journal | vauthors = Li WZ, Lin P, Frydman J, Boal TR, Cardillo TS, Richard LM, Toth D, Lichtman MA, Hartl FU, Sherman F | title = Tcp20, a subunit of the eukaryotic TRiC chaperonin from humans and yeast | journal = J Biol Chem | volume = 269 | issue = 28 | pages = 18616–22 | date = August 1994 | pmid = 8034610 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=908| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Chaperonin containing TCP1, subunit 6A (zeta 1)
| HGNCid = 1620
| Symbol = CCT6A
| AltSymbols =; CCT-zeta; CCT-zeta-1; CCT6; Cctz; HTR3; MGC126214; MGC126215; MoDP-2; TCP-1-zeta; TCP20; TCPZ; TTCP20
| OMIM = 104613
| ECnumber = 
| Homologene = 1336
| MGIid = 107943
| GeneAtlas_image1 = PBB_GE_CCT6A_201327_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CCT6A_201326_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0051082 |text = unfolded protein binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006457 |text = protein folding}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 908
    | Hs_Ensembl = ENSG00000146731
    | Hs_RefseqProtein = NP_001009186
    | Hs_RefseqmRNA = NM_001009186
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 56086872
    | Hs_GenLoc_end = 56099176
    | Hs_Uniprot = P40227
    | Mm_EntrezGene = 12466
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_009838
    | Mm_RefseqProtein = NP_033968
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Chaperonin containing TCP1, subunit 6A (zeta 1)''', also known as '''CCT6A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=908| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a molecular [[chaperone (protein)|chaperone]] that is member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including [[actin]] and [[tubulin]]. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a molecular chaperone that is member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.<ref name="entrez">{{cite web | title = Entrez Gene: CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=908| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
CCT6A has been shown to [[Protein-protein interaction|interact]] with [[PPP4C]].<ref name=pmid18715871>{{cite journal | vauthors = Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC | title = PP4R4/KIAA1622 Forms a Novel Stable Cytosolic Complex with Phosphoprotein Phosphatase 4 | language =  | journal = J. Biol. Chem. | volume = 283 | issue = 43 | pages = 29273–84 | date = October 2008 | pmid = 18715871 | pmc = 2662017 | doi = 10.1074/jbc.M803443200 }}</ref><ref name=pmid16085932>{{cite journal | vauthors = Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R | title = A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity | language =  | journal = Mol. Cell. Proteomics | volume = 4 | issue = 11 | pages = 1725–40 | date = November 2005 | pmid = 16085932 | doi = 10.1074/mcp.M500231-MCP200 }}</ref>
 
== References ==
{{reflist}}
{{Clear}}
 
==External links==
* {{UCSC gene info|CCT6A}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Dawson SJ, White LA | title = Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin | journal = J. Infect. | volume = 24 | issue = 3 | pages = 317–20 | year = 1992 | pmid = 1602151 | doi = 10.1016/S0163-4453(05)80037-4 }}
| citations =
* {{cite journal | vauthors = Kubota H, Hynes G, Carne A, Ashworth A, Willison K | title = Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin | journal = Curr. Biol. | volume = 4 | issue = 2 | pages = 89–99 | year = 1994 | pmid = 7953530 | doi = 10.1016/S0960-9822(94)00024-2 }}
*{{cite journal  | author=Segel GB, Boal TR, Cardillo TS, ''et al.'' |title=Isolation of a gene encoding a chaperonin-like protein by complementation of yeast amino acid transport mutants with human cDNA. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 13 |pages= 6060-4 |year= 1992 |pmid= 1352881 |doi=  }}
* {{cite journal | vauthors = Schwartz GJ, Kittelberger AM, Segel GB | title = Cloning of rabbit Cct6 and the distribution of the Cct complex in mammalian tissues | journal = Exp. Nephrol. | volume = 8 | issue = 3 | pages = 152–60 | year = 2000 | pmid = 10810232 | doi = 10.1159/000020663 }}
*{{cite journal | author=Dawson SJ, White LA |title=Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. |journal=J. Infect. |volume=24 |issue= 3 |pages= 317-20 |year= 1992 |pmid= 1602151 |doi= }}
* {{cite journal | vauthors = Yokota S, Yanagi H, Yura T, Kubota H | title = Cytosolic chaperonin-containing t-complex polypeptide 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell cycle | journal = Eur. J. Biochem. | volume = 268 | issue = 17 | pages = 4664–73 | year = 2001 | pmid = 11532003 | doi = 10.1046/j.1432-1327.2001.02393.x }}
*{{cite journal | author=Kubota H, Hynes G, Carne A, ''et al.'' |title=Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin. |journal=Curr. Biol. |volume=4 |issue= 2 |pages= 89-99 |year= 1994 |pmid= 7953530 |doi= }}
* {{cite journal | vauthors = Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J | title = Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides | journal = Nat. Biotechnol. | volume = 21 | issue = 5 | pages = 566–9 | year = 2004 | pmid = 12665801 | doi = 10.1038/nbt810 }}
*{{cite journal  | author=Li WZ, Lin P, Frydman J, ''et al.'' |title=Tcp20, a subunit of the eukaryotic TRiC chaperonin from humans and yeast. |journal=J. Biol. Chem. |volume=269 |issue= 28 |pages= 18616-22 |year= 1994 |pmid= 8034610 |doi=  }}
* {{cite journal | vauthors = Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R | title = A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death | journal = J. Biol. Chem. | volume = 278 | issue = 51 | pages = 51901–10 | year = 2004 | pmid = 14532270 | doi = 10.1074/jbc.M309655200 }}
*{{cite journal | author=Schwartz GJ, Kittelberger AM, Segel GB |title=Cloning of rabbit Cct6 and the distribution of the Cct complex in mammalian tissues. |journal=Exp. Nephrol. |volume=8 |issue= 3 |pages= 152-60 |year= 2000 |pmid= 10810232 |doi= }}
* {{cite journal | vauthors = Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G | title = A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway | journal = Nat. Cell Biol. | volume = 6 | issue = 2 | pages = 97–105 | year = 2004 | pmid = 14743216 | doi = 10.1038/ncb1086 }}
*{{cite journal | author=Yokota S, Yanagi H, Yura T, Kubota H |title=Cytosolic chaperonin-containing t-complex polypeptide 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell cycle. |journal=Eur. J. Biochem. |volume=268 |issue= 17 |pages= 4664-73 |year= 2001 |pmid= 11532003 |doi= }}
* {{cite journal | vauthors = Higo M, Uzawa K, Kouzu Y, Bukawa H, Nimura Y, Seki N, Tanzawa H | title = Identification of candidate radioresistant genes in human squamous cell carcinoma cells through gene expression analysis using DNA microarrays | journal = Oncol. Rep. | volume = 14 | issue = 5 | pages = 1293–8 | year = 2005 | pmid = 16211299 | doi = 10.3892/or.14.5.1293 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, Eizirik DL, She JX, Wang CY | title = Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress | journal = Biochem. Biophys. Res. Commun. | volume = 337 | issue = 4 | pages = 1308–18 | year = 2005 | pmid = 16236267 | doi = 10.1016/j.bbrc.2005.09.191 }}
*{{cite journal | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal  | author=Imai Y, Soda M, Murakami T, ''et al.'' |title=A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. |journal=J. Biol. Chem. |volume=278 |issue= 51 |pages= 51901-10 |year= 2004 |pmid= 14532270 |doi= 10.1074/jbc.M309655200 }}
*{{cite journal | author=Bouwmeester T, Bauch A, Ruffner H, ''et al.'' |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97-105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Higo M, Uzawa K, Kouzu Y, ''et al.'' |title=Identification of candidate radioresistant genes in human squamous cell carcinoma cells through gene expression analysis using DNA microarrays. |journal=Oncol. Rep. |volume=14 |issue= 5 |pages= 1293-8 |year= 2005 |pmid= 16211299 |doi= }}
*{{cite journal | author=Guo D, Han J, Adam BL, ''et al.'' |title=Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress. |journal=Biochem. Biophys. Res. Commun. |volume=337 |issue= 4 |pages= 1308-18 |year= 2005 |pmid= 16236267 |doi= 10.1016/j.bbrc.2005.09.191 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
{{WikiDoc Sources}}
{{gene-7-stub}}

Latest revision as of 02:31, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

T-complex protein 1 subunit zeta is a protein that in humans is encoded by the CCT6A gene.[1][2][3]

Function

This gene encodes a molecular chaperone that is member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.[3]

Interactions

CCT6A has been shown to interact with PPP4C.[4][5]

References

  1. ↑ Segel GB, Boal TR, Cardillo TS, Murant FG, Lichtman MA, Sherman F (August 1992). "Isolation of a gene encoding a chaperonin-like protein by complementation of yeast amino acid transport mutants with human cDNA". Proc Natl Acad Sci U S A. 89 (13): 6060–4. doi:10.1073/pnas.89.13.6060. PMC 49437. PMID 1352881.
  2. ↑ Li WZ, Lin P, Frydman J, Boal TR, Cardillo TS, Richard LM, Toth D, Lichtman MA, Hartl FU, Sherman F (August 1994). "Tcp20, a subunit of the eukaryotic TRiC chaperonin from humans and yeast". J Biol Chem. 269 (28): 18616–22. PMID 8034610.
  3. ↑ 3.0 3.1 "Entrez Gene: CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)".
  4. ↑ Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (October 2008). "PP4R4/KIAA1622 Forms a Novel Stable Cytosolic Complex with Phosphoprotein Phosphatase 4". J. Biol. Chem. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.
  5. ↑ Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (November 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Mol. Cell. Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.

External links

Further reading

  • Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
  • Kubota H, Hynes G, Carne A, Ashworth A, Willison K (1994). "Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin". Curr. Biol. 4 (2): 89–99. doi:10.1016/S0960-9822(94)00024-2. PMID 7953530.
  • Schwartz GJ, Kittelberger AM, Segel GB (2000). "Cloning of rabbit Cct6 and the distribution of the Cct complex in mammalian tissues". Exp. Nephrol. 8 (3): 152–60. doi:10.1159/000020663. PMID 10810232.
  • Yokota S, Yanagi H, Yura T, Kubota H (2001). "Cytosolic chaperonin-containing t-complex polypeptide 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell cycle". Eur. J. Biochem. 268 (17): 4664–73. doi:10.1046/j.1432-1327.2001.02393.x. PMID 11532003.
  • Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
  • Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R (2004). "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death". J. Biol. Chem. 278 (51): 51901–10. doi:10.1074/jbc.M309655200. PMID 14532270.
  • Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
  • Higo M, Uzawa K, Kouzu Y, Bukawa H, Nimura Y, Seki N, Tanzawa H (2005). "Identification of candidate radioresistant genes in human squamous cell carcinoma cells through gene expression analysis using DNA microarrays". Oncol. Rep. 14 (5): 1293–8. doi:10.3892/or.14.5.1293. PMID 16211299.
  • Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, Eizirik DL, She JX, Wang CY (2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. Commun. 337 (4): 1308–18. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.


Retrieved from "https://www.wikidoc.org/index.php?title=CCT6A&oldid=1421795"