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{{Infobox gene}}
{{PBB_Controls
'''CD2 antigen cytoplasmic tail-binding protein 2''' is a [[protein]] that in humans is encoded by the ''CD2BP2'' [[gene]].<ref name="pmid9843987">{{cite journal | vauthors = Nishizawa K, Freund C, Li J, Wagner G, Reinherz EL | title = Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation | journal = Proc Natl Acad Sci U S A | volume = 95 | issue = 25 | pages = 14897–902 |date=Jan 1999 | pmid = 9843987 | pmc = 24547 | doi =10.1073/pnas.95.25.14897 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CD2BP2 CD2 (cytoplasmic tail) binding protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10421| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CD2BP2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1gyf.
| PDB = {{PDB2|1gyf}}, {{PDB2|1l2z}}, {{PDB2|1syx}}
| Name = CD2 (cytoplasmic tail) binding protein 2
| HGNCid = 1656
| Symbol = CD2BP2
| AltSymbols =; FWP010; LIN1; Snu40
| OMIM = 604470
| ECnumber =
| Homologene = 4455
| MGIid = 1917483
| GeneAtlas_image1 = PBB_GE_CD2BP2_202256_at_tn.png
| GeneAtlas_image2 = PBB_GE_CD2BP2_202257_s_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
  | Process = {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10421
    | Hs_Ensembl = ENSG00000169217
    | Hs_RefseqProtein = NP_006101
    | Hs_RefseqmRNA = NM_006110
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 30271670
    | Hs_GenLoc_end = 30274128
    | Hs_Uniprot = O95400
    | Mm_EntrezGene = 70233
    | Mm_Ensembl = ENSMUSG00000042502
    | Mm_RefseqmRNA = NM_027353
    | Mm_RefseqProtein = NP_081629
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 126982808
    | Mm_GenLoc_end = 126987148
    | Mm_Uniprot = Q3U4A3
  }}
}}
'''CD2 (cytoplasmic tail) binding protein 2''', also known as '''CD2BP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CD2BP2 CD2 (cytoplasmic tail) binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10421| accessdate = }}</ref>
 
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| summary_text =  
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==Interactions==
CD2BP2 has been shown to [[Protein-protein interaction|interact]] with [[CD2]].<ref name=pmid9843987 />


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
*{{cite journal  | vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 |display-authors=etal}}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Laggerbauer B, Liu S, Makarov E, ''et al.'' |title=The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation. |journal=RNA |volume=11 |issue= 5 |pages= 598-608 |year= 2005 |pmid= 15840814 |doi= 10.1261/rna.2300805 }}
*{{cite journal  | vauthors=Laggerbauer B, Liu S, Makarov E |title=The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation. |journal=RNA |volume=11 |issue= 5 |pages= 598–608 |year= 2005 |pmid= 15840814 |doi= 10.1261/rna.2300805 | pmc=1370748 |display-authors=etal}}
*{{cite journal  | author=Cohavy O, Zhou J, Ware CF, Targan SR |title=LIGHT is constitutively expressed on T and NK cells in the human gut and can be induced by CD2-mediated signaling. |journal=J. Immunol. |volume=174 |issue= 2 |pages= 646-53 |year= 2005 |pmid= 15634882 |doi=  }}
*{{cite journal  | vauthors=Cohavy O, Zhou J, Ware CF, Targan SR |title=LIGHT is constitutively expressed on T and NK cells in the human gut and can be induced by CD2-mediated signaling. |journal=J. Immunol. |volume=174 |issue= 2 |pages= 646–53 |year= 2005 |pmid= 15634882 |doi=  10.4049/jimmunol.174.2.646}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Kofler M, Heuer K, Zech T, Freund C |title=Recognition sequences for the GYF domain reveal a possible spliceosomal function of CD2BP2. |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28292-7 |year= 2004 |pmid= 15105431 |doi= 10.1074/jbc.M402008200 }}
*{{cite journal  | vauthors=Kofler M, Heuer K, Zech T, Freund C |title=Recognition sequences for the GYF domain reveal a possible spliceosomal function of CD2BP2. |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28292–7 |year= 2004 |pmid= 15105431 |doi= 10.1074/jbc.M402008200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Freund C, Kühne R, Yang H, ''et al.'' |title=Dynamic interaction of CD2 with the GYF and the SH3 domain of compartmentalized effector molecules. |journal=EMBO J. |volume=21 |issue= 22 |pages= 5985-95 |year= 2003 |pmid= 12426371 |doi=  }}
*{{cite journal  | vauthors=Freund C, Kühne R, Yang H |title=Dynamic interaction of CD2 with the GYF and the SH3 domain of compartmentalized effector molecules. |journal=EMBO J. |volume=21 |issue= 22 |pages= 5985–95 |year= 2003 |pmid= 12426371 |doi=10.1093/emboj/cdf602  | pmc=137194 |display-authors=etal}}
*{{cite journal  | author=Hirosawa M, Nagase T, Ishikawa K, ''et al.'' |title=Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. |journal=DNA Res. |volume=6 |issue= 5 |pages= 329-36 |year= 2000 |pmid= 10574461 |doi=  }}
*{{cite journal  | vauthors=Hirosawa M, Nagase T, Ishikawa K |title=Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. |journal=DNA Res. |volume=6 |issue= 5 |pages= 329–36 |year= 2000 |pmid= 10574461 |doi=10.1093/dnares/6.5.329 |display-authors=etal}}
*{{cite journal  | author=Freund C, Dötsch V, Nishizawa K, ''et al.'' |title=The GYF domain is a novel structural fold that is involved in lymphoid signaling through proline-rich sequences. |journal=Nat. Struct. Biol. |volume=6 |issue= 7 |pages= 656-60 |year= 1999 |pmid= 10404223 |doi= 10.1038/10712 }}
*{{cite journal  | vauthors=Freund C, Dötsch V, Nishizawa K |title=The GYF domain is a novel structural fold that is involved in lymphoid signaling through proline-rich sequences. |journal=Nat. Struct. Biol. |volume=6 |issue= 7 |pages= 656–60 |year= 1999 |pmid= 10404223 |doi= 10.1038/10712 |display-authors=etal}}
*{{cite journal  | author=Nishizawa K, Freund C, Li J, ''et al.'' |title=Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 25 |pages= 14897-902 |year= 1999 |pmid= 9843987 |doi=  }}
}}
}}
{{refend}}
{{refend}}
==External links==
* {{UCSC gene info|CD2BP2}}
{{PDB Gallery|geneid=10421}}
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Latest revision as of 09:22, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

CD2 antigen cytoplasmic tail-binding protein 2 is a protein that in humans is encoded by the CD2BP2 gene.[1][2]


Interactions

CD2BP2 has been shown to interact with CD2.[1]

References

  1. ↑ 1.0 1.1 Nishizawa K, Freund C, Li J, Wagner G, Reinherz EL (Jan 1999). "Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation". Proc Natl Acad Sci U S A. 95 (25): 14897–902. doi:10.1073/pnas.95.25.14897. PMC 24547. PMID 9843987.
  2. ↑ "Entrez Gene: CD2BP2 CD2 (cytoplasmic tail) binding protein 2".

Further reading

External links



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