CDC16: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Cell division cycle protein 16 homolog''' is a [[protein]] that in humans is encoded by the ''CDC16'' [[gene]].<ref name="pmid7736578">{{cite journal | vauthors = Tugendreich S, Tomkiel J, Earnshaw W, Hieter P | title = CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition | journal = Cell | volume = 81 | issue = 2 | pages = 261–8 | date = Apr 1995 | pmid = 7736578 | pmc =  | doi = 10.1016/0092-8674(95)90336-4 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CDC16 cell division cycle 16 homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8881| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cell division cycle 16 homolog (S. cerevisiae)
| HGNCid = 1720
| Symbol = CDC16
| AltSymbols =; APC6
| OMIM = 603461
| ECnumber = 
| Homologene = 2899
| MGIid = 1917207
| GeneAtlas_image1 = PBB_GE_CDC16_202717_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CDC16_209659_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_CDC16_209658_at_tn.png
| Function = {{GNF_GO|id=GO:0005488 |text = binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005813 |text = centrosome}} {{GNF_GO|id=GO:0005876 |text = spindle microtubule}}
| Process = {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007088 |text = regulation of mitosis}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8881
    | Hs_Ensembl = ENSG00000130177
    | Hs_RefseqProtein = NP_001072113
    | Hs_RefseqmRNA = NM_001078645
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 13
    | Hs_GenLoc_start = 114018476
    | Hs_GenLoc_end = 114056300
    | Hs_Uniprot = Q13042
    | Mm_EntrezGene = 69957
    | Mm_Ensembl = ENSMUSG00000038416
    | Mm_RefseqmRNA = NM_027276
    | Mm_RefseqProtein = NP_081552
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 13757667
    | Mm_GenLoc_end = 13781859
    | Mm_Uniprot = Q3TI84
  }}
}}
'''Cell division cycle 16 homolog (S. cerevisiae)''', also known as '''CDC16''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CDC16 cell division cycle 16 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8881| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a component protein of the APC complex, which is composed of eight proteins and functions as a protein ubiquitin ligase. The APC complex is a cyclin degradation system that governs exit from mitosis. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein and two other APC complex proteins, CDC23 and CDC27, contain a tetratricopeptide repeat (TPR), a protein domain that may be involved in protein-protein interaction. Multiple alternatively spliced variants, encoding the same protein, have been identified.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a component protein of the APC complex, which is composed of eight proteins and functions as a protein ubiquitin ligase. The APC complex is a cyclin degradation system that governs exit from mitosis. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein and two other APC complex proteins, CDC23 and CDC27, contain a tetratricopeptide repeat (TPR), a protein domain that may be involved in protein-protein interaction. Multiple alternatively spliced variants, encoding the same protein, have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: CDC16 cell division cycle 16 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8881| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
CDC16 has been shown to [[Protein-protein interaction|interact]] with [[CDC27]]<ref name=pmid12956947>{{cite journal | vauthors = Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM | title = TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1 | journal = Current Biology | volume = 13 | issue = 17 | pages = 1459–68 | date = Sep 2003 | pmid = 12956947 | doi = 10.1016/S0960-9822(03)00581-5 }}</ref><ref name=pmid9405394>{{cite journal | vauthors = Ollendorff V, Donoghue DJ | title = The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex | journal = The Journal of Biological Chemistry | volume = 272 | issue = 51 | pages = 32011–8 | date = Dec 1997 | pmid = 9405394 | doi = 10.1074/jbc.272.51.32011 }}</ref><ref name=pmid9628895>{{cite journal | vauthors = Kallio M, Weinstein J, Daum JR, Burke DJ, Gorbsky GJ | title = Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events | journal = The Journal of Cell Biology | volume = 141 | issue = 6 | pages = 1393–406 | date = Jun 1998 | pmid = 9628895 | pmc = 2132789 | doi = 10.1083/jcb.141.6.1393 }}</ref><ref name=pmid10922056>{{cite journal | vauthors = Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM | title = The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 16 | pages = 8973–8 | date = Aug 2000 | pmid = 10922056 | pmc = 16806 | doi = 10.1073/pnas.97.16.8973 }}</ref> and [[CDC20]].<ref name=pmid12956947/><ref name=pmid9628895/><ref name=pmid12196507>{{cite journal | vauthors = Kallio MJ, Beardmore VA, Weinstein J, Gorbsky GJ | title = Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells | journal = The Journal of Cell Biology | volume = 158 | issue = 5 | pages = 841–7 | date = Sep 2002 | pmid = 12196507 | pmc = 2173153 | doi = 10.1083/jcb.200201135 }}</ref><ref name=pmid18997788>{{cite journal | vauthors = Nilsson J, Yekezare M, Minshull J, Pines J | title = The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction | journal = Nature Cell Biology | volume = 10 | issue = 12 | pages = 1411–20 | date = Dec 2008 | pmid = 18997788 | pmc = 2635557 | doi = 10.1038/ncb1799 }}</ref>
 
== References ==
{{reflist}}
 
==External links==
* {{UCSC gene info|CDC16}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Ollendorff V, Donoghue DJ | title = The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex | journal = The Journal of Biological Chemistry | volume = 272 | issue = 51 | pages = 32011–8 | date = Dec 1997 | pmid = 9405394 | doi = 10.1074/jbc.272.51.32011 }}
| citations =
* {{cite journal | vauthors = Yu H, Peters JM, King RW, Page AM, Hieter P, Kirschner MW | title = Identification of a cullin homology region in a subunit of the anaphase-promoting complex | journal = Science | volume = 279 | issue = 5354 | pages = 1219–22 | date = Feb 1998 | pmid = 9469815 | doi = 10.1126/science.279.5354.1219 }}
*{{cite journal  | author=Tugendreich S, Tomkiel J, Earnshaw W, Hieter P |title=CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition. |journal=Cell |volume=81 |issue= 2 |pages= 261-8 |year= 1995 |pmid= 7736578 |doi=  }}
* {{cite journal | vauthors = Kallio M, Weinstein J, Daum JR, Burke DJ, Gorbsky GJ | title = Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events | journal = The Journal of Cell Biology | volume = 141 | issue = 6 | pages = 1393–406 | date = Jun 1998 | pmid = 9628895 | pmc = 2132789 | doi = 10.1083/jcb.141.6.1393 }}
*{{cite journal | author=Ollendorff V, Donoghue DJ |title=The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex. |journal=J. Biol. Chem. |volume=272 |issue= 51 |pages= 32011-8 |year= 1998 |pmid= 9405394 |doi= }}
* {{cite journal | vauthors = Grossberger R, Gieffers C, Zachariae W, Podtelejnikov AV, Schleiffer A, Nasmyth K, Mann M, Peters JM | title = Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex | journal = The Journal of Biological Chemistry | volume = 274 | issue = 20 | pages = 14500–7 | date = May 1999 | pmid = 10318877 | doi = 10.1074/jbc.274.20.14500 }}
*{{cite journal | author=Yu H, Peters JM, King RW, ''et al.'' |title=Identification of a cullin homology region in a subunit of the anaphase-promoting complex. |journal=Science |volume=279 |issue= 5354 |pages= 1219-22 |year= 1998 |pmid= 9469815 |doi= }}
* {{cite journal | vauthors = Chan GK, Jablonski SA, Sudakin V, Hittle JC, Yen TJ | title = Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC | journal = The Journal of Cell Biology | volume = 146 | issue = 5 | pages = 941–54 | date = Sep 1999 | pmid = 10477750 | pmc = 2169490 | doi = 10.1083/jcb.146.5.941 }}
*{{cite journal | author=Kallio M, Weinstein J, Daum JR, ''et al.'' |title=Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events. |journal=J. Cell Biol. |volume=141 |issue= 6 |pages= 1393-406 |year= 1998 |pmid= 9628895 |doi= }}
* {{cite journal | vauthors = Gieffers C, Peters BH, Kramer ER, Dotti CG, Peters JM | title = Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 20 | pages = 11317–22 | date = Sep 1999 | pmid = 10500174 | pmc = 18031 | doi = 10.1073/pnas.96.20.11317 }}
*{{cite journal | author=Grossberger R, Gieffers C, Zachariae W, ''et al.'' |title=Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex. |journal=J. Biol. Chem. |volume=274 |issue= 20 |pages= 14500-7 |year= 1999 |pmid= 10318877 |doi= }}
* {{cite journal | vauthors = Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM | title = The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 16 | pages = 8973–8 | date = Aug 2000 | pmid = 10922056 | pmc = 16806 | doi = 10.1073/pnas.97.16.8973 }}
*{{cite journal | author=Chan GK, Jablonski SA, Sudakin V, ''et al.'' |title=Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC. |journal=J. Cell Biol. |volume=146 |issue= 5 |pages= 941-54 |year= 1999 |pmid= 10477750 |doi= }}
* {{cite journal | vauthors = Jörgensen PM, Gräslund S, Betz R, Ståhl S, Larsson C, Höög C | title = Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex | journal = Gene | volume = 262 | issue = 1-2 | pages = 51–9 | date = Jan 2001 | pmid = 11179667 | doi = 10.1016/S0378-1119(00)00511-4 }}
*{{cite journal | author=Gieffers C, Peters BH, Kramer ER, ''et al.'' |title=Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 20 |pages= 11317-22 |year= 1999 |pmid= 10500174 |doi= }}
* {{cite journal | vauthors = Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S | title = Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing | journal = EMBO Reports | volume = 1 | issue = 3 | pages = 287–92 | date = Sep 2000 | pmid = 11256614 | pmc = 1083732 | doi = 10.1093/embo-reports/kvd058 }}
*{{cite journal | author=Gmachl M, Gieffers C, Podtelejnikov AV, ''et al.'' |title=The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 16 |pages= 8973-8 |year= 2000 |pmid= 10922056 |doi= }}
* {{cite journal | vauthors = Stroschein SL, Bonni S, Wrana JL, Luo K | title = Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN | journal = Genes & Development | volume = 15 | issue = 21 | pages = 2822–36 | date = Nov 2001 | pmid = 11691834 | pmc = 312804 | doi = 10.1101/gad.912901 }}
*{{cite journal | author=Jörgensen PM, Gräslund S, Betz R, ''et al.'' |title=Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex. |journal=Gene |volume=262 |issue= 1-2 |pages= 51-9 |year= 2001 |pmid= 11179667 |doi= }}
* {{cite journal | vauthors = Yasui K, Arii S, Zhao C, Imoto I, Ueda M, Nagai H, Emi M, Inazawa J | title = TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas | journal = Hepatology | volume = 35 | issue = 6 | pages = 1476–84 | date = Jun 2002 | pmid = 12029633 | doi = 10.1053/jhep.2002.33683 }}
*{{cite journal | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
* {{cite journal | vauthors = Kallio MJ, Beardmore VA, Weinstein J, Gorbsky GJ | title = Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells | journal = The Journal of Cell Biology | volume = 158 | issue = 5 | pages = 841–7 | date = Sep 2002 | pmid = 12196507 | pmc = 2173153 | doi = 10.1083/jcb.200201135 }}
*{{cite journal | author=Stroschein SL, Bonni S, Wrana JL, Luo K |title=Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN. |journal=Genes Dev. |volume=15 |issue= 21 |pages= 2822-36 |year= 2001 |pmid= 11691834 |doi= 10.1101/gad.912901 }}
* {{cite journal | vauthors = Wang Q, Moyret-Lalle C, Couzon F, Surbiguet-Clippe C, Saurin JC, Lorca T, Navarro C, Puisieux A | title = Alterations of anaphase-promoting complex genes in human colon cancer cells | journal = Oncogene | volume = 22 | issue = 10 | pages = 1486–90 | date = Mar 2003 | pmid = 12629511 | doi = 10.1038/sj.onc.1206224 }}
*{{cite journal | author=Yasui K, Arii S, Zhao C, ''et al.'' |title=TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas. |journal=Hepatology |volume=35 |issue= 6 |pages= 1476-84 |year= 2002 |pmid= 12029633 |doi= 10.1053/jhep.2002.33683 }}
* {{cite journal | vauthors = Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM | title = TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1 | journal = Current Biology | volume = 13 | issue = 17 | pages = 1459–68 | date = Sep 2003 | pmid = 12956947 | doi = 10.1016/S0960-9822(03)00581-5 }}
*{{cite journal | author=Kallio MJ, Beardmore VA, Weinstein J, Gorbsky GJ |title=Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells. |journal=J. Cell Biol. |volume=158 |issue= 5 |pages= 841-7 |year= 2002 |pmid= 12196507 |doi= 10.1083/jcb.200201135 }}
* {{cite journal | vauthors = Kraft C, Herzog F, Gieffers C, Mechtler K, Hagting A, Pines J, Peters JM | title = Mitotic regulation of the human anaphase-promoting complex by phosphorylation | journal = The EMBO Journal | volume = 22 | issue = 24 | pages = 6598–609 | date = Dec 2003 | pmid = 14657031 | pmc = 291822 | doi = 10.1093/emboj/cdg627 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 14 | pages = 5391–6 | date = Apr 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 }}
*{{cite journal  | author=Wang Q, Moyret-Lalle C, Couzon F, ''et al.'' |title=Alterations of anaphase-promoting complex genes in human colon cancer cells. |journal=Oncogene |volume=22 |issue= 10 |pages= 1486-90 |year= 2003 |pmid= 12629511 |doi= 10.1038/sj.onc.1206224 }}
*{{cite journal | author=Vodermaier HC, Gieffers C, Maurer-Stroh S, ''et al.'' |title=TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1. |journal=Curr. Biol. |volume=13 |issue= 17 |pages= 1459-68 |year= 2004 |pmid= 12956947 |doi= }}
*{{cite journal | author=Kraft C, Herzog F, Gieffers C, ''et al.'' |title=Mitotic regulation of the human anaphase-promoting complex by phosphorylation. |journal=EMBO J. |volume=22 |issue= 24 |pages= 6598-609 |year= 2004 |pmid= 14657031 |doi= 10.1093/emboj/cdg627 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Nousiainen M, Silljé HH, Sauer G, ''et al.'' |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391-6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{gene-13-stub}}
{{WikiDoc Sources}}

Latest revision as of 09:25, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cell division cycle protein 16 homolog is a protein that in humans is encoded by the CDC16 gene.[1][2]

Function

This gene encodes a component protein of the APC complex, which is composed of eight proteins and functions as a protein ubiquitin ligase. The APC complex is a cyclin degradation system that governs exit from mitosis. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein and two other APC complex proteins, CDC23 and CDC27, contain a tetratricopeptide repeat (TPR), a protein domain that may be involved in protein-protein interaction. Multiple alternatively spliced variants, encoding the same protein, have been identified.[2]

Interactions

CDC16 has been shown to interact with CDC27[3][4][5][6] and CDC20.[3][5][7][8]

References

  1. ↑ Tugendreich S, Tomkiel J, Earnshaw W, Hieter P (Apr 1995). "CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition". Cell. 81 (2): 261–8. doi:10.1016/0092-8674(95)90336-4. PMID 7736578.
  2. ↑ 2.0 2.1 "Entrez Gene: CDC16 cell division cycle 16 homolog (S. cerevisiae)".
  3. ↑ 3.0 3.1 Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (Sep 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology. 13 (17): 1459–68. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947.
  4. ↑ Ollendorff V, Donoghue DJ (Dec 1997). "The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex". The Journal of Biological Chemistry. 272 (51): 32011–8. doi:10.1074/jbc.272.51.32011. PMID 9405394.
  5. ↑ 5.0 5.1 Kallio M, Weinstein J, Daum JR, Burke DJ, Gorbsky GJ (Jun 1998). "Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events". The Journal of Cell Biology. 141 (6): 1393–406. doi:10.1083/jcb.141.6.1393. PMC 2132789. PMID 9628895.
  6. ↑ Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (Aug 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (16): 8973–8. doi:10.1073/pnas.97.16.8973. PMC 16806. PMID 10922056.
  7. ↑ Kallio MJ, Beardmore VA, Weinstein J, Gorbsky GJ (Sep 2002). "Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells". The Journal of Cell Biology. 158 (5): 841–7. doi:10.1083/jcb.200201135. PMC 2173153. PMID 12196507.
  8. ↑ Nilsson J, Yekezare M, Minshull J, Pines J (Dec 2008). "The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction". Nature Cell Biology. 10 (12): 1411–20. doi:10.1038/ncb1799. PMC 2635557. PMID 18997788.

External links

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=CDC16&oldid=1416250"