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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Centrosome-associated protein CEP250''' is a [[protein]] that in humans is encoded by the ''CEP250'' [[gene]].<ref name="pmid9506584">{{cite journal | vauthors = Mack GJ, Rees J, Sandblom O, Balczon R, Fritzler MJ, Rattner JB | title = Autoantibodies to a group of centrosomal proteins in human autoimmune sera reactive with the centrosome | journal = Arthritis Rheum | volume = 41 | issue = 3 | pages = 551–8 |date=Apr 1998 | pmid = 9506584 | pmc =  | doi = 10.1002/1529-0131(199803)41:3<551::AID-ART22>3.0.CO;2-X }}</ref><ref name="pmid9647649">{{cite journal | vauthors = Fry AM, Mayor T, Meraldi P, Stierhof YD, Tanaka K, Nigg EA | title = C-Nap1, a Novel Centrosomal Coiled-Coil Protein and Candidate Substrate of the Cell Cycle–regulated Protein Kinase Nek2 | journal = J Cell Biol | volume = 141 | issue = 7 | pages = 1563–74 |date=Aug 1998 | pmid = 9647649 | pmc = 2133000 | doi =10.1083/jcb.141.7.1563  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CEP250 centrosomal protein 250kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11190| accessdate = }}</ref>
| update_page = yes
This gene encodes a core [[centrosome|centrosomal]] protein required for [[centriole]]-centriole cohesion during [[interphase]] of the [[cell cycle]]. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of [[mitosis]]. The protein associates with and is [[Phosphorylation|phosphorylated]] by [[NEK2|NIMA-related kinase 2]], which is also associated with the centrosome.<ref name="entrez" /> Furthermore, [[CEP135]] is also required for the centriolar localization of CEP250.<ref name="pmid18851962">{{cite journal | vauthors = Kim K, Lee S, Chang J, Rhee K | title = A novel function of CEP135 as a platform protein of C-NAP1 for its centriolar localization | journal = Exp. Cell Res. | volume = 314 | issue = 20 | pages = 3692–700 |date=December 2008 | pmid = 18851962 | doi = 10.1016/j.yexcr.2008.09.016  }}</ref>
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==References==
{{GNF_Protein_box
{{reflist}}
| image = 
| image_source = 
| PDB =
| Name = Centrosomal protein 250kDa
| HGNCid = 1859
| Symbol = CEP250
| AltSymbols =; CEP2; C-NAP1; MGC88542
| OMIM = 609689
| ECnumber = 
| Homologene = 38286
| MGIid = 108084
| GeneAtlas_image1 = PBB_GE_CEP250_210894_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CEP250_209495_at_tn.png
| Function = {{GNF_GO|id=GO:0019901 |text = protein kinase binding}}
| Component = {{GNF_GO|id=GO:0005813 |text = centrosome}}
| Process = {{GNF_GO|id=GO:0000278 |text = mitotic cell cycle}} {{GNF_GO|id=GO:0030997 |text = regulation of centriole-centriole cohesion}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11190
    | Hs_Ensembl = ENSG00000126001
    | Hs_RefseqProtein = NP_001030595
    | Hs_RefseqmRNA = NM_001035518
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 33506564
    | Hs_GenLoc_end = 33563218
    | Hs_Uniprot = Q9BV73
    | Mm_EntrezGene = 16328
    | Mm_Ensembl = ENSMUSG00000038241
    | Mm_RefseqmRNA = NM_008383
    | Mm_RefseqProtein = NP_032409
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 155648013
    | Mm_GenLoc_end = 155690144
    | Mm_Uniprot = Q8BZX9
  }}
}}
'''Centrosomal protein 250kDa''', also known as '''CEP250''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CEP250 centrosomal protein 250kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11190| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==External links==
{{PBB_Summary
* {{UCSC gene info|CEP250}}
| section_title =  
| summary_text = This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome. Alternately spliced transcript variants encoding different isoforms have been described.<ref name="entrez">{{cite web | title = Entrez Gene: CEP250 centrosomal protein 250kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11190| accessdate = }}</ref>
}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
| citations =
*{{cite journal  | vauthors=Jin J, Smith FD, Stark C |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Colland F, Jacq X, Trouplin V |title=Functional Proteomics Mapping of a Human Signaling Pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 |display-authors=etal}}
*{{cite journal  | author=Jin J, Smith FD, Stark C, ''et al.'' |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436-50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
*{{cite journal  | vauthors=Faragher AJ, Fry AM |title=Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles |journal=Mol. Biol. Cell |volume=14 |issue= 7 |pages= 2876–89 |year= 2004 |pmid= 12857871 |doi= 10.1091/mbc.E03-02-0108 | pmc=165683 }}
*{{cite journal  | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Faragher AJ, Fry AM |title=Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles. |journal=Mol. Biol. Cell |volume=14 |issue= 7 |pages= 2876-89 |year= 2004 |pmid= 12857871 |doi= 10.1091/mbc.E03-02-0108 }}
*{{cite journal  | vauthors=Mayor T, Hacker U, Stierhof YD, Nigg EA |title=The mechanism regulating the dissociation of the centrosomal protein C-Nap1 from mitotic spindle poles |journal=J. Cell Sci. |volume=115 |issue= Pt 16 |pages= 3275–84 |year= 2003 |pmid= 12140259 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Deloukas P, Matthews LH, Ashurst J |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |display-authors=etal}}
*{{cite journal  | author=Mayor T, Hacker U, Stierhof YD, Nigg EA |title=The mechanism regulating the dissociation of the centrosomal protein C-Nap1 from mitotic spindle poles. |journal=J. Cell. Sci. |volume=115 |issue= Pt 16 |pages= 3275-84 |year= 2003 |pmid= 12140259 |doi=  }}
*{{cite journal  | vauthors=Mayor T, Stierhof YD, Tanaka K |title=The Centrosomal Protein C-Nap1 Is Required for Cell Cycle–Regulated Centrosome Cohesion |journal=J. Cell Biol. |volume=151 |issue= 4 |pages= 837–46 |year= 2000 |pmid= 11076968 |doi=10.1083/jcb.151.4.837  | pmc=2169446 |display-authors=etal}}
*{{cite journal  | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal  | vauthors=Hirsch DS, Pirone DM, Burbelo PD |title=A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes |journal=J. Biol. Chem. |volume=276 |issue= 2 |pages= 875–83 |year= 2001 |pmid= 11035016 |doi= 10.1074/jbc.M007039200 }}
*{{cite journal  | author=Mayor T, Stierhof YD, Tanaka K, ''et al.'' |title=The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion. |journal=J. Cell Biol. |volume=151 |issue= 4 |pages= 837-46 |year= 2000 |pmid= 11076968 |doi=  }}
*{{cite journal  | vauthors=Helps NR, Luo X, Barker HM, Cohen PT |title=NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1 |journal=Biochem. J. |volume=349 |issue= Pt 2 |pages= 509–18 |year= 2001 |pmid= 10880350 |doi=10.1042/0264-6021:3490509  | pmc=1221174 }}
*{{cite journal  | author=Hirsch DS, Pirone DM, Burbelo PD |title=A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes. |journal=J. Biol. Chem. |volume=276 |issue= 2 |pages= 875-83 |year= 2001 |pmid= 11035016 |doi= 10.1074/jbc.M007039200 }}
*{{cite journal  | author=Helps NR, Luo X, Barker HM, Cohen PT |title=NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1. |journal=Biochem. J. |volume=349 |issue= Pt 2 |pages= 509-18 |year= 2001 |pmid= 10880350 |doi= }}
*{{cite journal  | author=Fry AM, Mayor T, Meraldi P, ''et al.'' |title=C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2. |journal=J. Cell Biol. |volume=141 |issue= 7 |pages= 1563-74 |year= 1998 |pmid= 9647649 |doi=  }}
*{{cite journal  | author=Mack GJ, Rees J, Sandblom O, ''et al.'' |title=Autoantibodies to a group of centrosomal proteins in human autoimmune sera reactive with the centrosome. |journal=Arthritis Rheum. |volume=41 |issue= 3 |pages= 551-8 |year= 1998 |pmid= 9506584 |doi= 10.1002/1529-0131(199803)41:3<551::AID-ART22>3.0.CO;2-X }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{centrosome}}
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Latest revision as of 19:33, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Centrosome-associated protein CEP250 is a protein that in humans is encoded by the CEP250 gene.[1][2][3] This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome.[3] Furthermore, CEP135 is also required for the centriolar localization of CEP250.[4]

References

  1. ↑ Mack GJ, Rees J, Sandblom O, Balczon R, Fritzler MJ, Rattner JB (Apr 1998). "Autoantibodies to a group of centrosomal proteins in human autoimmune sera reactive with the centrosome". Arthritis Rheum. 41 (3): 551–8. doi:10.1002/1529-0131(199803)41:3<551::AID-ART22>3.0.CO;2-X. PMID 9506584.
  2. ↑ Fry AM, Mayor T, Meraldi P, Stierhof YD, Tanaka K, Nigg EA (Aug 1998). "C-Nap1, a Novel Centrosomal Coiled-Coil Protein and Candidate Substrate of the Cell Cycle–regulated Protein Kinase Nek2". J Cell Biol. 141 (7): 1563–74. doi:10.1083/jcb.141.7.1563. PMC 2133000. PMID 9647649.
  3. ↑ 3.0 3.1 "Entrez Gene: CEP250 centrosomal protein 250kDa".
  4. ↑ Kim K, Lee S, Chang J, Rhee K (December 2008). "A novel function of CEP135 as a platform protein of C-NAP1 for its centriolar localization". Exp. Cell Res. 314 (20): 3692–700. doi:10.1016/j.yexcr.2008.09.016. PMID 18851962.

External links

Further reading


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