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{{ | '''Cbp/p300-interacting transactivator 2''' is a [[protein]] that in humans is encoded by the ''CITED2'' [[gene]].<ref name="pmid8901575">{{cite journal | vauthors = Shioda T, Fenner MH, Isselbacher KJ | title = msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 22 | pages = 12298–303 | date = Oct 1996 | pmid = 8901575 | pmc = 37985 | doi = 10.1073/pnas.93.22.12298 }}</ref><ref name="pmid10552932">{{cite journal | vauthors = Leung MK, Jones T, Michels CL, Livingston DM, Bhattacharya S | title = Molecular cloning and chromosomal localization of the human CITED2 gene encoding p35srj/Mrg1 | journal = Genomics | volume = 61 | issue = 3 | pages = 307–13 | date = Nov 1999 | pmid = 10552932 | pmc = | doi = 10.1006/geno.1999.5970 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10370| accessdate = }}</ref> | ||
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== Interactions == | |||
< | CITED2 has been shown to [[Protein-protein interaction|interact]] with [[EP300]],<ref name=pmid9887100>{{cite journal | vauthors = Bhattacharya S, Michels CL, Leung MK, Arany ZP, Kung AL, Livingston DM | title = Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1 | journal = Genes & Development | volume = 13 | issue = 1 | pages = 64–75 | date = Jan 1999 | pmid = 9887100 | pmc = 316375 | doi = 10.1101/gad.13.1.64 }}</ref><ref name=pmid12586840>{{cite journal | vauthors = Bragança J, Eloranta JJ, Bamforth SD, Ibbitt JC, Hurst HC, Bhattacharya S | title = Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 18 | pages = 16021–9 | date = May 2003 | pmid = 12586840 | doi = 10.1074/jbc.M208144200 }}</ref><ref name=pmid11744733>{{cite journal | vauthors = Bragança J, Swingler T, Marques FI, Jones T, Eloranta JJ, Hurst HC, Shioda T, Bhattacharya S | title = Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 10 | pages = 8559–65 | date = Mar 2002 | pmid = 11744733 | doi = 10.1074/jbc.M110850200 }}</ref><ref name=pmid10593900>{{cite journal | vauthors = Glenn DJ, Maurer RA | title = MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression | journal = The Journal of Biological Chemistry | volume = 274 | issue = 51 | pages = 36159–67 | date = Dec 1999 | pmid = 10593900 | doi = 10.1074/jbc.274.51.36159 }}</ref> [[LHX2]],<ref name=pmid10593900/> [[TFAP2A]],<ref name=pmid12586840/><ref name=pmid11744733/> and [[WT1]].<ref name=pmid17537799>{{cite journal | vauthors = Val P, Martinez-Barbera JP, Swain A | title = Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage | journal = Development | volume = 134 | issue = 12 | pages = 2349–58 | date = Jun 2007 | pmid = 17537799 | doi = 10.1242/dev.004390 }}</ref> | ||
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==References== | == References == | ||
{{reflist | {{reflist}} | ||
==Further reading== | |||
== Further reading == | |||
{{refbegin | 2}} | {{refbegin | 2}} | ||
* {{cite journal | vauthors = Haase M, Schott M, Bornstein SR, Malendowicz LK, Scherbaum WA, Willenberg HS | title = CITED2 is expressed in human adrenocortical cells and regulated by basic fibroblast growth factor | journal = The Journal of Endocrinology | volume = 192 | issue = 2 | pages = 459–65 | date = Feb 2007 | pmid = 17283246 | doi = 10.1677/JOE-06-0083 }} | |||
* {{cite journal | vauthors = Shioda T, Fenner MH, Isselbacher KJ | title = MSG1 and its related protein MRG1 share a transcription activating domain | journal = Gene | volume = 204 | issue = 1-2 | pages = 235–41 | date = Dec 1997 | pmid = 9434189 | doi = 10.1016/S0378-1119(97)00551-9 }} | |||
*{{cite journal | * {{cite journal | vauthors = Sun HB, Zhu YX, Yin T, Sledge G, Yang YC | title = MRG1, the product of a melanocyte-specific gene related gene, is a cytokine-inducible transcription factor with transformation activity | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 23 | pages = 13555–60 | date = Nov 1998 | pmid = 9811838 | pmc = 24857 | doi = 10.1073/pnas.95.23.13555 }} | ||
*{{cite journal | * {{cite journal | vauthors = Bhattacharya S, Michels CL, Leung MK, Arany ZP, Kung AL, Livingston DM | title = Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1 | journal = Genes & Development | volume = 13 | issue = 1 | pages = 64–75 | date = Jan 1999 | pmid = 9887100 | pmc = 316375 | doi = 10.1101/gad.13.1.64 }} | ||
*{{cite journal | * {{cite journal | vauthors = Glenn DJ, Maurer RA | title = MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression | journal = The Journal of Biological Chemistry | volume = 274 | issue = 51 | pages = 36159–67 | date = Dec 1999 | pmid = 10593900 | doi = 10.1074/jbc.274.51.36159 }} | ||
*{{cite journal | * {{cite journal | vauthors = Bragança J, Swingler T, Marques FI, Jones T, Eloranta JJ, Hurst HC, Shioda T, Bhattacharya S | title = Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 10 | pages = 8559–65 | date = Mar 2002 | pmid = 11744733 | doi = 10.1074/jbc.M110850200 }} | ||
* {{cite journal | vauthors = Bragança J, Eloranta JJ, Bamforth SD, Ibbitt JC, Hurst HC, Bhattacharya S | title = Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 18 | pages = 16021–9 | date = May 2003 | pmid = 12586840 | doi = 10.1074/jbc.M208144200 }} | |||
*{{cite journal | * {{cite journal | vauthors = Liu L, Amy V, Liu G, McKeehan WL | title = Novel complex integrating mitochondria and the microtubular cytoskeleton with chromosome remodeling and tumor suppressor RASSF1 deduced by in silico homology analysis, interaction cloning in yeast, and colocalization in cultured cells | journal = In Vitro Cellular & Developmental Biology. Animal | volume = 38 | issue = 10 | pages = 582–94 | year = 2003 | pmid = 12762840 | pmc = 3225227 | doi = 10.1290/1543-706X(2002)38<582:NCIMAT>2.0.CO;2 }} | ||
*{{cite journal | * {{cite journal | vauthors = Yokota H, Goldring MB, Sun HB | title = CITED2-mediated regulation of MMP-1 and MMP-13 in human chondrocytes under flow shear | journal = The Journal of Biological Chemistry | volume = 278 | issue = 47 | pages = 47275–80 | date = Nov 2003 | pmid = 12960175 | doi = 10.1074/jbc.M304652200 }} | ||
*{{cite journal | * {{cite journal | vauthors = Bhakat KK, Izumi T, Yang SH, Hazra TK, Mitra S | title = Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene | journal = The EMBO Journal | volume = 22 | issue = 23 | pages = 6299–309 | date = Dec 2003 | pmid = 14633989 | pmc = 291836 | doi = 10.1093/emboj/cdg595 }} | ||
* {{cite journal | vauthors = Tien ES, Davis JW, Vanden Heuvel JP | title = Identification of the CREB-binding protein/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator | journal = The Journal of Biological Chemistry | volume = 279 | issue = 23 | pages = 24053–63 | date = Jun 2004 | pmid = 15051727 | doi = 10.1074/jbc.M401489200 }} | |||
*{{cite journal | * {{cite journal | vauthors = Sperling S, Grimm CH, Dunkel I, Mebus S, Sperling HP, Ebner A, Galli R, Lehrach H, Fusch C, Berger F, Hammer S | title = Identification and functional analysis of CITED2 mutations in patients with congenital heart defects | journal = Human Mutation | volume = 26 | issue = 6 | pages = 575–82 | date = Dec 2005 | pmid = 16287139 | doi = 10.1002/humu.20262 }} | ||
*{{cite journal | * {{cite journal | vauthors = Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS | title = Transcriptome analysis of human gastric cancer | journal = Mammalian Genome | volume = 16 | issue = 12 | pages = 942–54 | date = Dec 2005 | pmid = 16341674 | doi = 10.1007/s00335-005-0075-2 }} | ||
*{{cite journal | * {{cite journal | vauthors = Chou YT, Yang YC | title = Post-transcriptional control of Cited2 by transforming growth factor beta. Regulation via Smads and Cited2 coding region | journal = The Journal of Biological Chemistry | volume = 281 | issue = 27 | pages = 18451–62 | date = Jul 2006 | pmid = 16675452 | doi = 10.1074/jbc.M601720200 }} | ||
*{{cite journal | * {{cite journal | vauthors = Qu X, Lam E, Doughman YQ, Chen Y, Chou YT, Lam M, Turakhia M, Dunwoodie SL, Watanabe M, Xu B, Duncan SA, Yang YC | title = Cited2, a coactivator of HNF4alpha, is essential for liver development | journal = The EMBO Journal | volume = 26 | issue = 21 | pages = 4445–56 | date = Oct 2007 | pmid = 17932483 | pmc = 2063472 | doi = 10.1038/sj.emboj.7601883 }} | ||
*{{cite journal | |||
*{{cite journal | |||
*{{cite journal | |||
*{{cite journal | |||
}} | |||
{{refend}} | {{refend}} | ||
{{ | == External links == | ||
{{ | * {{UCSC genome browser|CITED2}} | ||
* {{UCSC gene details|CITED2}} | |||
{{PDB Gallery|geneid=10370}} | |||
{{gene-6-stub}} |
Latest revision as of 02:18, 27 October 2017
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
Wikidata | |||||||
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Cbp/p300-interacting transactivator 2 is a protein that in humans is encoded by the CITED2 gene.[1][2][3]
Interactions
CITED2 has been shown to interact with EP300,[4][5][6][7] LHX2,[7] TFAP2A,[5][6] and WT1.[8]
References
- ↑ Shioda T, Fenner MH, Isselbacher KJ (Oct 1996). "msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation". Proceedings of the National Academy of Sciences of the United States of America. 93 (22): 12298–303. doi:10.1073/pnas.93.22.12298. PMC 37985. PMID 8901575.
- ↑ Leung MK, Jones T, Michels CL, Livingston DM, Bhattacharya S (Nov 1999). "Molecular cloning and chromosomal localization of the human CITED2 gene encoding p35srj/Mrg1". Genomics. 61 (3): 307–13. doi:10.1006/geno.1999.5970. PMID 10552932.
- ↑ "Entrez Gene: CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2".
- ↑ Bhattacharya S, Michels CL, Leung MK, Arany ZP, Kung AL, Livingston DM (Jan 1999). "Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1". Genes & Development. 13 (1): 64–75. doi:10.1101/gad.13.1.64. PMC 316375. PMID 9887100.
- ↑ 5.0 5.1 Bragança J, Eloranta JJ, Bamforth SD, Ibbitt JC, Hurst HC, Bhattacharya S (May 2003). "Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2". The Journal of Biological Chemistry. 278 (18): 16021–9. doi:10.1074/jbc.M208144200. PMID 12586840.
- ↑ 6.0 6.1 Bragança J, Swingler T, Marques FI, Jones T, Eloranta JJ, Hurst HC, Shioda T, Bhattacharya S (Mar 2002). "Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2". The Journal of Biological Chemistry. 277 (10): 8559–65. doi:10.1074/jbc.M110850200. PMID 11744733.
- ↑ 7.0 7.1 Glenn DJ, Maurer RA (Dec 1999). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression". The Journal of Biological Chemistry. 274 (51): 36159–67. doi:10.1074/jbc.274.51.36159. PMID 10593900.
- ↑ Val P, Martinez-Barbera JP, Swain A (Jun 2007). "Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage". Development. 134 (12): 2349–58. doi:10.1242/dev.004390. PMID 17537799.
Further reading
- Haase M, Schott M, Bornstein SR, Malendowicz LK, Scherbaum WA, Willenberg HS (Feb 2007). "CITED2 is expressed in human adrenocortical cells and regulated by basic fibroblast growth factor". The Journal of Endocrinology. 192 (2): 459–65. doi:10.1677/JOE-06-0083. PMID 17283246.
- Shioda T, Fenner MH, Isselbacher KJ (Dec 1997). "MSG1 and its related protein MRG1 share a transcription activating domain". Gene. 204 (1–2): 235–41. doi:10.1016/S0378-1119(97)00551-9. PMID 9434189.
- Sun HB, Zhu YX, Yin T, Sledge G, Yang YC (Nov 1998). "MRG1, the product of a melanocyte-specific gene related gene, is a cytokine-inducible transcription factor with transformation activity". Proceedings of the National Academy of Sciences of the United States of America. 95 (23): 13555–60. doi:10.1073/pnas.95.23.13555. PMC 24857. PMID 9811838.
- Bhattacharya S, Michels CL, Leung MK, Arany ZP, Kung AL, Livingston DM (Jan 1999). "Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1". Genes & Development. 13 (1): 64–75. doi:10.1101/gad.13.1.64. PMC 316375. PMID 9887100.
- Glenn DJ, Maurer RA (Dec 1999). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression". The Journal of Biological Chemistry. 274 (51): 36159–67. doi:10.1074/jbc.274.51.36159. PMID 10593900.
- Bragança J, Swingler T, Marques FI, Jones T, Eloranta JJ, Hurst HC, Shioda T, Bhattacharya S (Mar 2002). "Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2". The Journal of Biological Chemistry. 277 (10): 8559–65. doi:10.1074/jbc.M110850200. PMID 11744733.
- Bragança J, Eloranta JJ, Bamforth SD, Ibbitt JC, Hurst HC, Bhattacharya S (May 2003). "Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2". The Journal of Biological Chemistry. 278 (18): 16021–9. doi:10.1074/jbc.M208144200. PMID 12586840.
- Liu L, Amy V, Liu G, McKeehan WL (2003). "Novel complex integrating mitochondria and the microtubular cytoskeleton with chromosome remodeling and tumor suppressor RASSF1 deduced by in silico homology analysis, interaction cloning in yeast, and colocalization in cultured cells". In Vitro Cellular & Developmental Biology. Animal. 38 (10): 582–94. doi:10.1290/1543-706X(2002)38<582:NCIMAT>2.0.CO;2. PMC 3225227. PMID 12762840.
- Yokota H, Goldring MB, Sun HB (Nov 2003). "CITED2-mediated regulation of MMP-1 and MMP-13 in human chondrocytes under flow shear". The Journal of Biological Chemistry. 278 (47): 47275–80. doi:10.1074/jbc.M304652200. PMID 12960175.
- Bhakat KK, Izumi T, Yang SH, Hazra TK, Mitra S (Dec 2003). "Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene". The EMBO Journal. 22 (23): 6299–309. doi:10.1093/emboj/cdg595. PMC 291836. PMID 14633989.
- Tien ES, Davis JW, Vanden Heuvel JP (Jun 2004). "Identification of the CREB-binding protein/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator". The Journal of Biological Chemistry. 279 (23): 24053–63. doi:10.1074/jbc.M401489200. PMID 15051727.
- Sperling S, Grimm CH, Dunkel I, Mebus S, Sperling HP, Ebner A, Galli R, Lehrach H, Fusch C, Berger F, Hammer S (Dec 2005). "Identification and functional analysis of CITED2 mutations in patients with congenital heart defects". Human Mutation. 26 (6): 575–82. doi:10.1002/humu.20262. PMID 16287139.
- Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (Dec 2005). "Transcriptome analysis of human gastric cancer". Mammalian Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
- Chou YT, Yang YC (Jul 2006). "Post-transcriptional control of Cited2 by transforming growth factor beta. Regulation via Smads and Cited2 coding region". The Journal of Biological Chemistry. 281 (27): 18451–62. doi:10.1074/jbc.M601720200. PMID 16675452.
- Qu X, Lam E, Doughman YQ, Chen Y, Chou YT, Lam M, Turakhia M, Dunwoodie SL, Watanabe M, Xu B, Duncan SA, Yang YC (Oct 2007). "Cited2, a coactivator of HNF4alpha, is essential for liver development". The EMBO Journal. 26 (21): 4445–56. doi:10.1038/sj.emboj.7601883. PMC 2063472. PMID 17932483.
External links
- CITED2 human gene location in the UCSC Genome Browser.
- CITED2 human gene details in the UCSC Genome Browser.
This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it. |