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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Creatine kinase, mitochondrial 1B''' also known as '''CKMT1B''' is one of two [[gene]]s which encode the ubiquitous mitochondrial [[creatine kinase]] ('''ubiquitous mtCK''' or '''CKMT1''').<ref name="entrez"/>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_CKMT1B_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1qk1.
| PDB = {{PDB2|1qk1}}
| Name = Creatine kinase, mitochondrial 1B
| HGNCid = 1995
| Symbol = CKMT1B
| AltSymbols =; CKMT; CKMT1; UMTCK
| OMIM = 123290
| ECnumber = 
| Homologene = 69058
| MGIid = 99441
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004111 |text = creatine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1159
    | Hs_Ensembl = 
    | Hs_RefseqProtein = XP_001128529
    | Hs_RefseqmRNA = XM_001128529
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 12716
    | Mm_Ensembl = ENSMUSG00000000308
    | Mm_RefseqmRNA = NM_009897
    | Mm_RefseqProtein = NP_034027
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 121049241
    | Mm_GenLoc_end = 121055178
    | Mm_Uniprot = Q545N7
  }}
}}
'''Creatine kinase, mitochondrial 1B''', also known as '''CKMT1B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CKMT1B creatine kinase, mitochondrial 1B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1159| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from [[mitochondria]] to the cytosolic carrier, [[creatine]]. It belongs to the [[creatine kinase]] isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK ([[CKMT2]]) and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 ([[CKMT1A]] and CKMT1B (this gene)) have been identified which encode identical mitochondrial creatine kinase proteins.<ref name="entrez">{{cite web | title = Entrez Gene: CKMT1B creatine kinase, mitochondrial 1B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1159| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins.<ref name="entrez">{{cite web | title = Entrez Gene: CKMT1B creatine kinase, mitochondrial 1B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1159| accessdate = }}</ref>
}}


==References==
== Clinical significance ==
{{reflist|2}}
 
==Further reading==
Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis.<ref name="entrez"/>
 
== References ==
{{reflist}}
 
==External links==
* {{UCSC gene info|CKMT1B}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Payne RM, Strauss AW | title = Expression of the mitochondrial creatine kinase genes | journal = Mol. Cell. Biochem. | volume = 133-134 | issue =  | pages = 235–43 | year = 1995 | pmid = 7808456 | doi = 10.1007/BF01267957 }}
| citations =
* {{cite journal | vauthors = Qin W, Khuchua Z, Cheng J, Boero J, Payne RM, Strauss AW | title = Molecular characterization of the creatine kinases and some historical perspectives | journal = Mol. Cell. Biochem. | volume = 184 | issue = 1–2 | pages = 153–67 | year = 1998 | pmid = 9746319 | doi = 10.1023/A:1006807515892 }}
*{{cite journal | author=Payne RM, Strauss AW |title=Expression of the mitochondrial creatine kinase genes. |journal=Mol. Cell. Biochem. |volume=133-134 |issue=  |pages= 235-43 |year= 1995 |pmid= 7808456 |doi= }}
* {{cite journal | vauthors = Haas RC, Strauss AW | title = Separate nuclear genes encode sarcomere-specific and ubiquitous human mitochondrial creatine kinase isoenzymes | journal = J. Biol. Chem. | volume = 265 | issue = 12 | pages = 6921–7 | year = 1990 | pmid = 2324105 | doi =  }}
*{{cite journal | author=Qin W, Khuchua Z, Cheng J, ''et al.'' |title=Molecular characterization of the creatine kinases and some historical perspectives. |journal=Mol. Cell. Biochem. |volume=184 |issue= 1-2 |pages= 153-67 |year= 1998 |pmid= 9746319 |doi= }}
* {{cite journal | vauthors = Haas RC, Korenfeld C, Zhang ZF, Perryman B, Roman D, Strauss AW | title = Isolation and characterization of the gene and cDNA encoding human mitochondrial creatine kinase | journal = J. Biol. Chem. | volume = 264 | issue = 5 | pages = 2890–7 | year = 1989 | pmid = 2914937 | doi =  }}
*{{cite journal | author=Haas RC, Strauss AW |title=Separate nuclear genes encode sarcomere-specific and ubiquitous human mitochondrial creatine kinase isoenzymes. |journal=J. Biol. Chem. |volume=265 |issue= 12 |pages= 6921-7 |year= 1990 |pmid= 2324105 |doi=  }}
* {{cite journal | vauthors = Stallings RL, Olson E, Strauss AW, Thompson LH, Bachinski LL, Siciliano MJ | title = Human creatine kinase genes on chromosomes 15 and 19, and proximity of the gene for the muscle form to the genes for apolipoprotein C2 and excision repair | journal = Am. J. Hum. Genet. | volume = 43 | issue = 2 | pages = 144–51 | year = 1988 | pmid = 3400641 | pmc = 1715361 | doi =  }}
*{{cite journal | author=Haas RC, Korenfeld C, Zhang ZF, ''et al.'' |title=Isolation and characterization of the gene and cDNA encoding human mitochondrial creatine kinase. |journal=J. Biol. Chem. |volume=264 |issue= 5 |pages= 2890-7 |year= 1989 |pmid= 2914937 |doi=  }}
* {{cite journal | vauthors = Jacobus WE, Moreadith RW, Vandegaer KM | title = Control of heart oxidative phosphorylation by creatine kinase in mitochondrial membranes | journal = Ann. N. Y. Acad. Sci. | volume = 414 | issue =  1| pages = 73–89 | year = 1984 | pmid = 6584077 | doi = 10.1111/j.1749-6632.1983.tb31676.x | bibcode = 1983NYASA.414...73J }}
*{{cite journal | author=Stallings RL, Olson E, Strauss AW, ''et al.'' |title=Human creatine kinase genes on chromosomes 15 and 19, and proximity of the gene for the muscle form to the genes for apolipoprotein C2 and excision repair. |journal=Am. J. Hum. Genet. |volume=43 |issue= 2 |pages= 144-51 |year= 1988 |pmid= 3400641 |doi=  }}
* {{cite journal | vauthors = Brdiczka D, Kaldis P, Wallimann T | title = In vitro complex formation between the octamer of mitochondrial creatine kinase and porin | journal = J. Biol. Chem. | volume = 269 | issue = 44 | pages = 27640–4 | year = 1994 | pmid = 7525559 | doi =  }}
*{{cite journal | author=Jacobus WE, Moreadith RW, Vandegaer KM |title=Control of heart oxidative phosphorylation by creatine kinase in mitochondrial membranes. |journal=Ann. N. Y. Acad. Sci. |volume=414 |issue=  |pages= 73-89 |year= 1984 |pmid= 6584077 |doi= }}
* {{cite journal | vauthors = Steeghs K, Merkx G, Wieringa B | title = The ubiquitous mitochondrial creatine kinase gene maps to a conserved region on human chromosome 15q15 and mouse chromosome 2 bands F1-F3 | journal = Genomics | volume = 24 | issue = 1 | pages = 193–5 | year = 1995 | pmid = 7896282 | doi = 10.1006/geno.1994.1604 }}
*{{cite journal | author=Brdiczka D, Kaldis P, Wallimann T |title=In vitro complex formation between the octamer of mitochondrial creatine kinase and porin. |journal=J. Biol. Chem. |volume=269 |issue= 44 |pages= 27640-4 |year= 1994 |pmid= 7525559 |doi=  }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Steeghs K, Merkx G, Wieringa B |title=The ubiquitous mitochondrial creatine kinase gene maps to a conserved region on human chromosome 15q15 and mouse chromosome 2 bands F1-F3. |journal=Genomics |volume=24 |issue= 1 |pages= 193-5 |year= 1995 |pmid= 7896282 |doi= 10.1006/geno.1994.1604 }}
* {{cite journal | vauthors = Fritz-Wolf K, Schnyder T, Wallimann T, Kabsch W | title = Structure of mitochondrial creatine kinase | journal = Nature | volume = 381 | issue = 6580 | pages = 341–5 | year = 1996 | pmid = 8692275 | doi = 10.1038/381341a0 | bibcode = 1996Natur.381..341F }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1997 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
*{{cite journal | author=Fritz-Wolf K, Schnyder T, Wallimann T, Kabsch W |title=Structure of mitochondrial creatine kinase. |journal=Nature |volume=381 |issue= 6580 |pages= 341-5 |year= 1996 |pmid= 8692275 |doi= 10.1038/381341a0 }}
* {{cite journal | vauthors = Thomure MF, Gast MJ, Srivastava N, Payne RM | title = Regulation of creatine kinase isoenzymes in human placenta during early, mid-, and late gestation | journal = J. Soc. Gynecol. Investig. | volume = 3 | issue = 6 | pages = 322–7 | year = 1997 | pmid = 8923416 | doi = 10.1016/S1071-5576(96)00043-3 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Thomure MF, Gast MJ, Srivastava N, Payne RM |title=Regulation of creatine kinase isoenzymes in human placenta during early, mid-, and late gestation. |journal=J. Soc. Gynecol. Investig. |volume=3 |issue= 6 |pages= 322-7 |year= 1997 |pmid= 8923416 |doi= }}
* {{cite journal | vauthors = Eder M, Fritz-Wolf K, Kabsch W, Wallimann T, Schlattner U | title = Crystal structure of human ubiquitous mitochondrial creatine kinase | journal = Proteins | volume = 39 | issue = 3 | pages = 216–25 | year = 2000 | pmid = 10737943 | doi = 10.1002/(SICI)1097-0134(20000515)39:3<216::AID-PROT40>3.0.CO;2-# | doi-broken-date = <!-- not broken --> }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Schlattner U, Wallimann T | title = Octamers of mitochondrial creatine kinase isoenzymes differ in stability and membrane binding | journal = J. Biol. Chem. | volume = 275 | issue = 23 | pages = 17314–20 | year = 2000 | pmid = 10748055 | doi = 10.1074/jbc.M001919200 }}
*{{cite journal | author=Eder M, Fritz-Wolf K, Kabsch W, ''et al.'' |title=Crystal structure of human ubiquitous mitochondrial creatine kinase. |journal=Proteins |volume=39 |issue= 3 |pages= 216-25 |year= 2000 |pmid= 10737943 |doi=  }}
* {{cite journal | vauthors = Schlattner U, Dolder M, Wallimann T, Tokarska-Schlattner M | title = Mitochondrial creatine kinase and mitochondrial outer membrane porin show a direct interaction that is modulated by calcium | journal = J. Biol. Chem. | volume = 276 | issue = 51 | pages = 48027–30 | year = 2002 | pmid = 11602586 | doi = 10.1074/jbc.M106524200 }}
*{{cite journal | author=Schlattner U, Wallimann T |title=Octamers of mitochondrial creatine kinase isoenzymes differ in stability and membrane binding. |journal=J. Biol. Chem. |volume=275 |issue= 23 |pages= 17314-20 |year= 2000 |pmid= 10748055 |doi= 10.1074/jbc.M001919200 }}
* {{cite journal | vauthors = Schlattner U, Wallimann T | title = A quantitative approach to membrane binding of human ubiquitous mitochondrial creatine kinase using surface plasmon resonance | journal = J. Bioenerg. Biomembr. | volume = 32 | issue = 1 | pages = 123–31 | year = 2002 | pmid = 11768757 | doi = 10.1023/A:1005576831968 }}
*{{cite journal | author=Schlattner U, Dolder M, Wallimann T, Tokarska-Schlattner M |title=Mitochondrial creatine kinase and mitochondrial outer membrane porin show a direct interaction that is modulated by calcium. |journal=J. Biol. Chem. |volume=276 |issue= 51 |pages= 48027-30 |year= 2002 |pmid= 11602586 |doi= 10.1074/jbc.M106524200 }}
* {{cite journal | vauthors = Schlattner U, Möckli N, Speer O, Werner S, Wallimann T | title = Creatine kinase and creatine transporter in normal, wounded, and diseased skin | journal = J. Invest. Dermatol. | volume = 118 | issue = 3 | pages = 416–23 | year = 2002 | pmid = 11874479 | doi = 10.1046/j.0022-202x.2001.01697.x }}
*{{cite journal | author=Schlattner U, Wallimann T |title=A quantitative approach to membrane binding of human ubiquitous mitochondrial creatine kinase using surface plasmon resonance. |journal=J. Bioenerg. Biomembr. |volume=32 |issue= 1 |pages= 123-31 |year= 2002 |pmid= 11768757 |doi= }}
*{{cite journal | author=Schlattner U, Möckli N, Speer O, ''et al.'' |title=Creatine kinase and creatine transporter in normal, wounded, and diseased skin. |journal=J. Invest. Dermatol. |volume=118 |issue= 3 |pages= 416-23 |year= 2002 |pmid= 11874479 |doi= 10.1046/j.0022-202x.2001.01697.x }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=1159}}


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{{protein-stub}}
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Latest revision as of 12:42, 9 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Creatine kinase, mitochondrial 1B also known as CKMT1B is one of two genes which encode the ubiquitous mitochondrial creatine kinase (ubiquitous mtCK or CKMT1).[1]

Function

Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK (CKMT2) and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 (CKMT1A and CKMT1B (this gene)) have been identified which encode identical mitochondrial creatine kinase proteins.[1]

Clinical significance

Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis.[1]

References

  1. ↑ 1.0 1.1 1.2 "Entrez Gene: CKMT1B creatine kinase, mitochondrial 1B".

External links

Further reading


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