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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Beta-Ala-His dipeptidase''' is an [[enzyme]] that in humans is encoded by the ''CNDP1'' [[gene]].<ref name="pmid12473676">{{cite journal | vauthors = Teufel M, Saudek V, Ledig JP, Bernhardt A, Boularand S, Carreau A, Cairns NJ, Carter C, Cowley DJ, Duverger D, Ganzhorn AJ, Guenet C, Heintzelmann B, Laucher V, Sauvage C, Smirnova T | title = Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase | journal = J Biol Chem | volume = 278 | issue = 8 | pages = 6521–31 |date=Feb 2003 | pmid = 12473676 | pmc =  | doi = 10.1074/jbc.M209764200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84735| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Carnosine dipeptidase 1 (metallopeptidase M20 family)
| HGNCid = 20675
| Symbol = CNDP1
| AltSymbols =; CN1; CPGL2; HsT2308; MGC102737; MGC10825; MGC142072
| OMIM =
| ECnumber =
| Homologene = 57178
| MGIid = 2451097
  | GeneAtlas_image1 = PBB_GE_CNDP1_gnf1h00863_at_tn.png
| Function =
| Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 84735
    | Hs_Ensembl = ENSG00000150656
    | Hs_RefseqProtein = NP_116038
    | Hs_RefseqmRNA = NM_032649
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 18
    | Hs_GenLoc_start = 70352817
    | Hs_GenLoc_end = 70403234
    | Hs_Uniprot = Q96KN2
    | Mm_EntrezGene = 338403
    | Mm_Ensembl = ENSMUSG00000056162
    | Mm_RefseqmRNA = NM_177450
    | Mm_RefseqProtein = NP_803233
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 84744708
    | Mm_GenLoc_end = 84784277
    | Mm_Uniprot = Q3TSF8
  }}
}}
'''Carnosine dipeptidase 1 (metallopeptidase M20 family)''', also known as '''CNDP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84735| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a member of the M20 metalloprotease family. The encoded protein is specifically expressed in the brain, is a homodimeric dipeptidase which was identified as human carnosinase. This gene contains trinucleotide (CTG) repeat length polymorphism in the coding region.<ref name="entrez">{{cite web | title = Entrez Gene: CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84735| accessdate = }}</ref>
| summary_text = This gene encodes a member of the M20 metalloprotease family. The encoded protein is specifically expressed in the brain, is a homodimeric dipeptidase which was identified as human carnosinase. This gene contains trinucleotide (CTG) repeat length polymorphism in the coding region.<ref name="entrez" />
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Lenney JF, Peppers SC, Kucera CM, Sjaastad O |title=Homocarnosinosis: lack of serum carnosinase is the defect probably responsible for elevated brain and CSF homocarnosine. |journal=Clin. Chim. Acta |volume=132 |issue= 2 |pages= 157-65 |year= 1983 |pmid= 6616870 |doi=  }}
*{{cite journal  | vauthors=Lenney JF, Peppers SC, Kucera CM, Sjaastad O |title=Homocarnosinosis: lack of serum carnosinase is the defect probably responsible for elevated brain and CSF homocarnosine |journal=Clin. Chim. Acta |volume=132 |issue= 2 |pages= 157–65 |year= 1983 |pmid= 6616870 |doi=10.1016/0009-8981(83)90243-7 }}
*{{cite journal  | author=Lenney JF, George RP, Weiss AM, ''et al.'' |title=Human serum carnosinase: characterization, distinction from cellular carnosinase, and activation by cadmium. |journal=Clin. Chim. Acta |volume=123 |issue= 3 |pages= 221-31 |year= 1982 |pmid= 7116644 |doi=  }}
*{{cite journal  | vauthors=Lenney JF, George RP, Weiss AM |title=Human serum carnosinase: characterization, distinction from cellular carnosinase, and activation by cadmium |journal=Clin. Chim. Acta |volume=123 |issue= 3 |pages= 221–31 |year= 1982 |pmid= 7116644 |doi=10.1016/0009-8981(82)90166-8 |display-authors=etal}}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Harrington JJ, Sherf B, Rundlett S, ''et al.'' |title=Creation of genome-wide protein expression libraries using random activation of gene expression. |journal=Nat. Biotechnol. |volume=19 |issue= 5 |pages= 440-5 |year= 2001 |pmid= 11329013 |doi= 10.1038/88107 }}
*{{cite journal  | vauthors=Harrington JJ, Sherf B, Rundlett S |title=Creation of genome-wide protein expression libraries using random activation of gene expression |journal=Nat. Biotechnol. |volume=19 |issue= 5 |pages= 440–5 |year= 2001 |pmid= 11329013 |doi= 10.1038/88107 |display-authors=etal}}
*{{cite journal  | author=Teufel M, Saudek V, Ledig JP, ''et al.'' |title=Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase. |journal=J. Biol. Chem. |volume=278 |issue= 8 |pages= 6521-31 |year= 2003 |pmid= 12473676 |doi= 10.1074/jbc.M209764200 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Clark HF, Gurney AL, Abaya E |title=The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 |display-authors=etal}}
*{{cite journal  | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal  | vauthors=Ghose S, Weickert CS, Colvin SM |title=Glutamate carboxypeptidase II gene expression in the human frontal and temporal lobe in schizophrenia |journal=Neuropsychopharmacology |volume=29 |issue= 1 |pages= 117–25 |year= 2004 |pmid= 14560319 |doi= 10.1038/sj.npp.1300304 |display-authors=etal}}
*{{cite journal  | author=Ghose S, Weickert CS, Colvin SM, ''et al.'' |title=Glutamate carboxypeptidase II gene expression in the human frontal and temporal lobe in schizophrenia. |journal=Neuropsychopharmacology |volume=29 |issue= 1 |pages= 117-25 |year= 2004 |pmid= 14560319 |doi= 10.1038/sj.npp.1300304 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Janssen B, Hohenadel D, Brinkkoetter P |title=Carnosine as a protective factor in diabetic nephropathy: association with a leucine repeat of the carnosinase gene CNDP1 |journal=Diabetes |volume=54 |issue= 8 |pages= 2320–7 |year= 2005 |pmid= 16046297 |doi=10.2337/diabetes.54.8.2320 |display-authors=etal}}
*{{cite journal  | author=Janssen B, Hohenadel D, Brinkkoetter P, ''et al.'' |title=Carnosine as a protective factor in diabetic nephropathy: association with a leucine repeat of the carnosinase gene CNDP1. |journal=Diabetes |volume=54 |issue= 8 |pages= 2320-7 |year= 2005 |pmid= 16046297 |doi=  }}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | vauthors=Liu T, Qian WJ, Gritsenko MA |title=Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 | pmc=1850943 |display-authors=etal}}
*{{cite journal  | author=Liu T, Qian WJ, Gritsenko MA, ''et al.'' |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070-80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 }}
*{{cite journal  | vauthors=Zschocke J, Nebel A, Wicks K |title=Allelic variation in the CNDP1 gene and its lack of association with longevity and coronary heart disease |journal=Mech. Ageing Dev. |volume=127 |issue= 11 |pages= 817–20 |year= 2007 |pmid= 16965804 |doi= 10.1016/j.mad.2006.08.002 |display-authors=etal}}
*{{cite journal  | author=Zschocke J, Nebel A, Wicks K, ''et al.'' |title=Allelic variation in the CNDP1 gene and its lack of association with longevity and coronary heart disease. |journal=Mech. Ageing Dev. |volume=127 |issue= 11 |pages= 817-20 |year= 2007 |pmid= 16965804 |doi= 10.1016/j.mad.2006.08.002 }}
*{{cite journal  | vauthors=Zhang P, Chan DW, Zhu Y |title=Identification of carboxypeptidase of glutamate like-B as a candidate suppressor in cell growth and metastasis in human hepatocellular carcinoma |journal=Clin. Cancer Res. |volume=12 |issue= 22 |pages= 6617–25 |year= 2007 |pmid= 17121880 |doi= 10.1158/1078-0432.CCR-06-1307 |display-authors=etal}}
*{{cite journal  | author=Zhang P, Chan DW, Zhu Y, ''et al.'' |title=Identification of carboxypeptidase of glutamate like-B as a candidate suppressor in cell growth and metastasis in human hepatocellular carcinoma. |journal=Clin. Cancer Res. |volume=12 |issue= 22 |pages= 6617-25 |year= 2007 |pmid= 17121880 |doi= 10.1158/1078-0432.CCR-06-1307 }}
*{{cite journal  | vauthors=Freedman BI, Hicks PJ, Sale MM |title=A leucine repeat in the carnosinase gene CNDP1 is associated with diabetic end-stage renal disease in European Americans |journal=Nephrol. Dial. Transplant. |volume=22 |issue= 4 |pages= 1131–5 |year= 2007 |pmid= 17205963 |doi= 10.1093/ndt/gfl717 |display-authors=etal}}
*{{cite journal  | author=Freedman BI, Hicks PJ, Sale MM, ''et al.'' |title=A leucine repeat in the carnosinase gene CNDP1 is associated with diabetic end-stage renal disease in European Americans. |journal=Nephrol. Dial. Transplant. |volume=22 |issue= 4 |pages= 1131-5 |year= 2007 |pmid= 17205963 |doi= 10.1093/ndt/gfl717 }}
*{{cite journal  | vauthors=Riedl E, Koeppel H, Brinkkoetter P |title=A CTG polymorphism in the CNDP1 gene determines the secretion of serum carnosinase in Cos-7 transfected cells |journal=Diabetes |volume=56 |issue= 9 |pages= 2410–3 |year= 2007 |pmid= 17601991 |doi= 10.2337/db07-0128 |display-authors=etal}}
*{{cite journal  | author=Riedl E, Koeppel H, Brinkkoetter P, ''et al.'' |title=A CTG polymorphism in the CNDP1 gene determines the secretion of serum carnosinase in Cos-7 transfected cells. |journal=Diabetes |volume=56 |issue= 9 |pages= 2410-3 |year= 2007 |pmid= 17601991 |doi= 10.2337/db07-0128 }}
*{{cite journal  | vauthors=Sauerhöfer S, Yuan G, Braun GS |title=L-carnosine, a substrate of carnosinase-1, influences glucose metabolism |journal=Diabetes |volume=56 |issue= 10 |pages= 2425–32 |year= 2007 |pmid= 17601992 |doi= 10.2337/db07-0177 |display-authors=etal}}
*{{cite journal  | author=Sauerhöfer S, Yuan G, Braun GS, ''et al.'' |title=L-carnosine, a substrate of carnosinase-1, influences glucose metabolism. |journal=Diabetes |volume=56 |issue= 10 |pages= 2425-32 |year= 2007 |pmid= 17601992 |doi= 10.2337/db07-0177 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC gene info|CNDP1}}
 
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Latest revision as of 09:03, 9 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Beta-Ala-His dipeptidase is an enzyme that in humans is encoded by the CNDP1 gene.[1][2]

This gene encodes a member of the M20 metalloprotease family. The encoded protein is specifically expressed in the brain, is a homodimeric dipeptidase which was identified as human carnosinase. This gene contains trinucleotide (CTG) repeat length polymorphism in the coding region.[2]

The metabolic disorder Carnosinemia may be caused by mutations in this gene.

References

  1. ↑ Teufel M, Saudek V, Ledig JP, Bernhardt A, Boularand S, Carreau A, Cairns NJ, Carter C, Cowley DJ, Duverger D, Ganzhorn AJ, Guenet C, Heintzelmann B, Laucher V, Sauvage C, Smirnova T (Feb 2003). "Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase". J Biol Chem. 278 (8): 6521–31. doi:10.1074/jbc.M209764200. PMID 12473676.
  2. ↑ 2.0 2.1 "Entrez Gene: CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family)".

Further reading

External links



Retrieved from "https://www.wikidoc.org/index.php?title=CNDP1&oldid=1517429"