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{{ | '''Conserved oligomeric Golgi complex subunit 3''' is a [[protein]] that in humans is encoded by the ''COG3'' [[gene]].<ref name="pmid11980916">{{cite journal | vauthors = Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG | title = Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function | journal = J Cell Biol | volume = 157 | issue = 3 | pages = 405–15 |date=Apr 2002 | pmid = 11980916 | pmc = 2173297 | doi = 10.1083/jcb.200202016 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: COG3 component of oligomeric golgi complex 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83548| accessdate = }}</ref> | ||
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| summary_text = The protein encoded by this gene has similarity to a yeast protein. It seems to be part of a peripheral membrane protein complex localized on cis/medial Golgi cisternae where it may participate in tethering intra-Golgi transport vesicles.<ref name="entrez" | | summary_text = The protein encoded by this gene has similarity to a yeast protein. It seems to be part of a peripheral membrane protein complex localized on cis/medial Golgi cisternae where it may participate in tethering intra-Golgi transport vesicles.<ref name="entrez" /> | ||
}} | }} | ||
==Interactions== | |||
COG3 has been shown to [[Protein-protein interaction|interact]] with [[COG2]]<ref name=pmid11929878>{{cite journal |last=Loh |first=Eva |author2=Hong Wanjin |date=Jun 2002 |title=Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp |journal=J. Biol. Chem. |volume=277 |issue=24 |pages=21955–61 | issn = 0021-9258| pmid = 11929878 |doi = 10.1074/jbc.M202326200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[COG1]].<ref name=pmid11929878/> | |||
==References== | ==References== | ||
{{reflist| | {{reflist}} | ||
==External links== | |||
* {{UCSC gene info|COG3}} | |||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Andersson B, Wentland MA, Ricafrente JY |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Yu W, Andersson B, Worley KC |title=Large-scale concatenation cDNA sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Kim DW, Sacher M, Scarpa A |title=High-copy suppressor analysis reveals a physical interaction between Sec34p and Sec35p, a protein implicated in vesicle docking |journal=Mol. Biol. Cell |volume=10 |issue= 10 |pages= 3317–29 |year= 1999 |pmid= 10512869 |doi= 10.1091/mbc.10.10.3317| pmc=25597 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=VanRheenen SM, Cao X, Sapperstein SK |title=Sec34p, a protein required for vesicle tethering to the yeast Golgi apparatus, is in a complex with Sec35p |journal=J. Cell Biol. |volume=147 |issue= 4 |pages= 729–42 |year= 1999 |pmid= 10562277 |doi=10.1083/jcb.147.4.729 | pmc=2156162 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Suvorova ES, Kurten RC, Lupashin VV |title=Identification of a human orthologue of Sec34p as a component of the cis-Golgi vesicle tethering machinery |journal=J. Biol. Chem. |volume=276 |issue= 25 |pages= 22810–8 |year= 2001 |pmid= 11292827 |doi= 10.1074/jbc.M011624200 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Loh E, Hong W |title=Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp |journal=J. Biol. Chem. |volume=277 |issue= 24 |pages= 21955–61 |year= 2002 |pmid= 11929878 |doi= 10.1074/jbc.M202326200 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }} | ||
*{{cite journal | vauthors=Gevaert K, Goethals M, Martens L |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 |display-authors=etal}} | |||
*{{cite journal | | *{{cite journal | vauthors=Loh E, Hong W |title=The binary interacting network of the conserved oligomeric Golgi tethering complex |journal=J. Biol. Chem. |volume=279 |issue= 23 |pages= 24640–8 |year= 2004 |pmid= 15047703 |doi= 10.1074/jbc.M400662200 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Dunham A, Matthews LH, Burton J |title=The DNA sequence and analysis of human chromosome 13 |journal=Nature |volume=428 |issue= 6982 |pages= 522–8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 | pmc=2665288 |display-authors=etal|bibcode=2004Natur.428..522D }} | ||
*{{cite journal | | *{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} | ||
*{{cite journal | | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
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{{gene-13-stub}} |
Latest revision as of 11:33, 9 January 2019
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External IDs | GeneCards: [1] | ||||||
Orthologs | |||||||
Species | Human | Mouse | |||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
Wikidata | |||||||
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Conserved oligomeric Golgi complex subunit 3 is a protein that in humans is encoded by the COG3 gene.[1][2]
The protein encoded by this gene has similarity to a yeast protein. It seems to be part of a peripheral membrane protein complex localized on cis/medial Golgi cisternae where it may participate in tethering intra-Golgi transport vesicles.[2]
Interactions
COG3 has been shown to interact with COG2[3] and COG1.[3]
References
- ↑ Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG (Apr 2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function". J Cell Biol. 157 (3): 405–15. doi:10.1083/jcb.200202016. PMC 2173297. PMID 11980916.
- ↑ 2.0 2.1 "Entrez Gene: COG3 component of oligomeric golgi complex 3".
- ↑ 3.0 3.1 Loh, Eva; Hong Wanjin (Jun 2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". J. Biol. Chem. 277 (24): 21955–61. doi:10.1074/jbc.M202326200. ISSN 0021-9258. PMID 11929878.
External links
- Human COG3 genome location and COG3 gene details page in the UCSC Genome Browser.
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Kim DW, Sacher M, Scarpa A, et al. (1999). "High-copy suppressor analysis reveals a physical interaction between Sec34p and Sec35p, a protein implicated in vesicle docking". Mol. Biol. Cell. 10 (10): 3317–29. doi:10.1091/mbc.10.10.3317. PMC 25597. PMID 10512869.
- VanRheenen SM, Cao X, Sapperstein SK, et al. (1999). "Sec34p, a protein required for vesicle tethering to the yeast Golgi apparatus, is in a complex with Sec35p". J. Cell Biol. 147 (4): 729–42. doi:10.1083/jcb.147.4.729. PMC 2156162. PMID 10562277.
- Suvorova ES, Kurten RC, Lupashin VV (2001). "Identification of a human orthologue of Sec34p as a component of the cis-Golgi vesicle tethering machinery". J. Biol. Chem. 276 (25): 22810–8. doi:10.1074/jbc.M011624200. PMID 11292827.
- Loh E, Hong W (2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". J. Biol. Chem. 277 (24): 21955–61. doi:10.1074/jbc.M202326200. PMID 11929878.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
- Loh E, Hong W (2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. 279 (23): 24640–8. doi:10.1074/jbc.M400662200. PMID 15047703.
- Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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