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{{Infobox_gene}}
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'''Conserved oligomeric Golgi complex subunit 7''' is a [[protein]] that in humans is encoded by the ''COG7'' [[gene]].<ref name="pmid11980916">{{cite journal | vauthors = Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG | title = Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function | journal = J Cell Biol | volume = 157 | issue = 3 | pages = 405–15 |date=Apr 2002 | pmid = 11980916 | pmc = 2173297 | doi = 10.1083/jcb.200202016 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: COG7 component of oligomeric golgi complex 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=91949| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =  
| Name = Component of oligomeric golgi complex 7
| HGNCid = 18622
| Symbol = COG7
| AltSymbols =; CDG2E
| OMIM = 606978
| ECnumber =
| Homologene = 33431
| MGIid = 2685013
| GeneAtlas_image1 = PBB_GE_COG7_213190_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}  
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 91949
    | Hs_Ensembl = ENSG00000168434
    | Hs_RefseqProtein = NP_705831
    | Hs_RefseqmRNA = NM_153603
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 23307465
    | Hs_GenLoc_end = 23372000
    | Hs_Uniprot = P83436
    | Mm_EntrezGene = 233824
    | Mm_Ensembl = ENSMUSG00000034951
    | Mm_RefseqmRNA = NM_001033318
    | Mm_RefseqProtein = NP_001028490
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 121713991
    | Mm_GenLoc_end = 121772807
    | Mm_Uniprot = 
  }}
}}
'''Component of oligomeric golgi complex 7''', also known as '''COG7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: COG7 component of oligomeric golgi complex 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=91949| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG7 (Ungar et al., 2002).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: COG7 component of oligomeric golgi complex 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=91949| accessdate = }}</ref>
| summary_text = Multiprotein complexes are key determinants of [[Golgi apparatus]] structure and its capacity for [[intracellular transport]] and glycoprotein modification. Several complexes have been identified, including the [[Golgi transport complex]] (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the [[conserved oligomeric Golgi complex|conserved oligomeric Golgi (COG) complex]], which includes COG7 (Ungar et al., 2002).[supplied by OMIM]<ref name="entrez"/>
}}
}}
==Interactions==
COG7 has been shown to [[Protein-protein interaction|interact]] with [[COG4]]<ref name=pmid15047703>{{cite journal |last=Loh |first=Eva |author2=Hong Wanjin |date=Jun 2004 |title=The binary interacting network of the conserved oligomeric Golgi tethering complex |journal=J. Biol. Chem. |volume=279 |issue=23 |pages=24640–8 |publisher= |location = United States| issn = 0021-9258| pmid = 15047703 |doi = 10.1074/jbc.M400662200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[COG5]].<ref name=pmid15047703/>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal  | vauthors=Andersson B, Wentland MA, Ricafrente JY |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 |display-authors=etal}}
*{{cite journal  | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=  }}
*{{cite journal  | vauthors=Yu W, Andersson B, Worley KC |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=  10.1101/gr.7.4.353| pmc=139146  |display-authors=etal}}
*{{cite journal  | author=Loh E, Hong W |title=Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp. |journal=J. Biol. Chem. |volume=277 |issue= 24 |pages= 21955-61 |year= 2002 |pmid= 11929878 |doi= 10.1074/jbc.M202326200 }}
*{{cite journal  | vauthors=Loh E, Hong W |title=Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp. |journal=J. Biol. Chem. |volume=277 |issue= 24 |pages= 21955–61 |year= 2002 |pmid= 11929878 |doi= 10.1074/jbc.M202326200 }}
*{{cite journal  | author=Ungar D, Oka T, Brittle EE, ''et al.'' |title=Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function. |journal=J. Cell Biol. |volume=157 |issue= 3 |pages= 405-15 |year= 2002 |pmid= 11980916 |doi= 10.1083/jcb.200202016 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Clark HF, Gurney AL, Abaya E |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 |display-authors=etal}}
*{{cite journal  | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Loh E, Hong W |title=The binary interacting network of the conserved oligomeric Golgi tethering complex. |journal=J. Biol. Chem. |volume=279 |issue= 23 |pages= 24640–8 |year= 2004 |pmid= 15047703 |doi= 10.1074/jbc.M400662200 }}
*{{cite journal  | author=Loh E, Hong W |title=The binary interacting network of the conserved oligomeric Golgi tethering complex. |journal=J. Biol. Chem. |volume=279 |issue= 23 |pages= 24640-8 |year= 2004 |pmid= 15047703 |doi= 10.1074/jbc.M400662200 }}
*{{cite journal  | vauthors=Wu X, Steet RA, Bohorov O |title=Mutation of the COG complex subunit gene COG7 causes a lethal congenital disorder. |journal=Nat. Med. |volume=10 |issue= 5 |pages= 518–23 |year= 2004 |pmid= 15107842 |doi= 10.1038/nm1041 |display-authors=etal}}
*{{cite journal  | author=Wu X, Steet RA, Bohorov O, ''et al.'' |title=Mutation of the COG complex subunit gene COG7 causes a lethal congenital disorder. |journal=Nat. Med. |volume=10 |issue= 5 |pages= 518-23 |year= 2004 |pmid= 15107842 |doi= 10.1038/nm1041 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Oka T, Vasile E, Penman M |title=Genetic analysis of the subunit organization and function of the conserved oligomeric golgi (COG) complex: studies of COG5- and COG7-deficient mammalian cells. |journal=J. Biol. Chem. |volume=280 |issue= 38 |pages= 32736–45 |year= 2005 |pmid= 16051600 |doi= 10.1074/jbc.M505558200 |display-authors=etal}}
*{{cite journal  | author=Oka T, Vasile E, Penman M, ''et al.'' |title=Genetic analysis of the subunit organization and function of the conserved oligomeric golgi (COG) complex: studies of COG5- and COG7-deficient mammalian cells. |journal=J. Biol. Chem. |volume=280 |issue= 38 |pages= 32736-45 |year= 2005 |pmid= 16051600 |doi= 10.1074/jbc.M505558200 }}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal|bibcode=2005Natur.437.1173R }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | vauthors=Steet R, Kornfeld S |title=COG-7-deficient Human Fibroblasts Exhibit Altered Recycling of Golgi Proteins. |journal=Mol. Biol. Cell |volume=17 |issue= 5 |pages= 2312–21 |year= 2006 |pmid= 16510524 |doi= 10.1091/mbc.E05-08-0822 | pmc=1446086 }}
*{{cite journal  | author=Steet R, Kornfeld S |title=COG-7-deficient Human Fibroblasts Exhibit Altered Recycling of Golgi Proteins. |journal=Mol. Biol. Cell |volume=17 |issue= 5 |pages= 2312-21 |year= 2006 |pmid= 16510524 |doi= 10.1091/mbc.E05-08-0822 }}
*{{cite journal  | vauthors=Morava E, Zeevaert R, Korsch E |title=A common mutation in the COG7 gene with a consistent phenotype including microcephaly, adducted thumbs, growth retardation, VSD and episodes of hyperthermia. |journal=Eur. J. Hum. Genet. |volume=15 |issue= 6 |pages= 638–45 |year= 2007 |pmid= 17356545 |doi= 10.1038/sj.ejhg.5201813 |display-authors=etal}}
*{{cite journal  | author=Morava E, Zeevaert R, Korsch E, ''et al.'' |title=A common mutation in the COG7 gene with a consistent phenotype including microcephaly, adducted thumbs, growth retardation, VSD and episodes of hyperthermia. |journal=Eur. J. Hum. Genet. |volume=15 |issue= 6 |pages= 638-45 |year= 2007 |pmid= 17356545 |doi= 10.1038/sj.ejhg.5201813 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* [https://www.ncbi.nlm.nih.gov/books/NBK1332/  GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview]
* {{UCSC gene info|COG7}}
 
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Latest revision as of 09:20, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Conserved oligomeric Golgi complex subunit 7 is a protein that in humans is encoded by the COG7 gene.[1][2]

Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG7 (Ungar et al., 2002).[supplied by OMIM][2]

Interactions

COG7 has been shown to interact with COG4[3] and COG5.[3]

References

  1. ↑ Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG (Apr 2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function". J Cell Biol. 157 (3): 405–15. doi:10.1083/jcb.200202016. PMC 2173297. PMID 11980916.
  2. ↑ 2.0 2.1 "Entrez Gene: COG7 component of oligomeric golgi complex 7".
  3. ↑ 3.0 3.1 Loh, Eva; Hong Wanjin (Jun 2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. United States. 279 (23): 24640–8. doi:10.1074/jbc.M400662200. ISSN 0021-9258. PMID 15047703.

Further reading

External links



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