COP9 constitutive photomorphogenic homolog subunit 5: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)''', also known as COPS5 or Csn5, is a [[gene]] conserved from [[human]]s to [[Saccharomyces cerevisiae]].<ref name="entrez">{{cite web | title = Entrez Gene: COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10987| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)
| HGNCid = 2240
| Symbol = COPS5
| AltSymbols =; CSN5; JAB1; MGC3149; MOV-34; SGN5
| OMIM = 604850
| ECnumber = 
| Homologene = 55992
| MGIid = 1349415
| GeneAtlas_image1 = PBB_GE_COPS5_201652_at_tn.png
| GeneAtlas_image2 = PBB_GE_COPS5_gnf1h08492_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0003743 |text = translation initiation factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008237 |text = metallopeptidase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005852 |text = eukaryotic translation initiation factor 3 complex}} {{GNF_GO|id=GO:0008180 |text = signalosome}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006412 |text = translation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10987
    | Hs_Ensembl = ENSG00000121022
    | Hs_RefseqProtein = NP_006828
    | Hs_RefseqmRNA = NM_006837
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 68117871
    | Hs_GenLoc_end = 68136785
    | Hs_Uniprot = Q92905
    | Mm_EntrezGene = 26754
    | Mm_Ensembl = ENSMUSG00000025917
    | Mm_RefseqmRNA = NM_013715
    | Mm_RefseqProtein = NP_038743
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 10009816
    | Mm_GenLoc_end = 10023160
    | Mm_Uniprot = Q3V0K7
  }}
}}
'''COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)''', also known as '''COPS5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10987| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is one of the eight subunits of [[COP9 signalosome]], a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of  cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be a coactivator that increases the specificity of JUN/AP1 transcription factors.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of  cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be a coactivator that increases the specificity of JUN/AP1 transcription factors.<ref name="entrez">{{cite web | title = Entrez Gene: COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10987| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
COP9 constitutive photomorphogenic homolog subunit 5 has been shown to [[Protein-protein interaction|interact]] with [[Macrophage migration inhibitory factor]],<ref>{{cite journal |last1=Ghosh |first1=S |last2=Leaton |first2=LA |last3=Farr |first3=L |last4=Barfield |first4=A |last5=Moonah |first5=S |title=Interaction between parasite-encoded JAB1/CSN5 and macrophage migration inhibitory factor proteins attenuates its proinflammatory function |journal=Scientific Reports |date=6 July 2018 |volume=8 |issue=1 |pages=10241 |doi=10.1038/s41598-018-28625-1 |pmid=29980718}}</ref><ref name=pmid11089976>{{cite journal | vauthors = Kleemann R, Hausser A, Geiger G, Mischke R, Burger-Kentischer A, Flieger O, Johannes FJ, Roger T, Calandra T, Kapurniotu A, Grell M, Finkelmeier D, Brunner H, Bernhagen J | title = Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1 | journal = Nature | volume = 408 | issue = 6809 | pages = 211–6  | date = November 2000 | pmid = 11089976 | doi = 10.1038/35041591 }}</ref> [[GFER]],<ref name=pmid11709497>{{cite journal | vauthors = Lu C, Li Y, Zhao Y, Xing G, Tang F, Wang Q, Sun Y, Wei H, Yang X, Wu C, Chen J, Guan KL, Zhang C, Chen H, He F | title = Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway | journal = FASEB J. | volume = 16 | issue = 1 | pages = 90–2  | date = January 2002 | pmid = 11709497 | doi = 10.1096/fj.01-0506fje }}</ref> [[BCL3]],<ref name=pmid10362352>{{cite journal | vauthors = Dechend R, Hirano F, Lehmann K, Heissmeyer V, Ansieau S, Wulczyn FG, Scheidereit C, Leutz A | title = The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators | journal = Oncogene | volume = 18 | issue = 22 | pages = 3316–23  | date = June 1999 | pmid = 10362352 | doi = 10.1038/sj.onc.1202717 }}</ref> [[Ubiquitin carboxy-terminal hydrolase L1]],<ref name=pmid12082530>{{cite journal | vauthors = Caballero OL, Resto V, Patturajan M, Meerzaman D, Guo MZ, Engles J, Yochem R, Ratovitski E, Sidransky D, Jen J | title = Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1) | journal = Oncogene | volume = 21 | issue = 19 | pages = 3003–10  | date = May 2002 | pmid = 12082530 | doi = 10.1038/sj.onc.1205390 }}</ref> [[S100A7]]<ref name=pmid12702588>{{cite journal | vauthors = Emberley ED, Niu Y, Leygue E, Tomes L, Gietz RD, Murphy LC, Watson PH | title = Psoriasin interacts with Jab1 and influences breast cancer progression | journal = Cancer Res. | volume = 63 | issue = 8 | pages = 1954–61  | date = April 2003 | pmid = 12702588 }}</ref> and [[C-jun]].<ref name=pmid8837781>{{cite journal | vauthors = Claret FX, Hibi M, Dhut S, Toda T, Karin M | title = A new group of conserved coactivators that increase the specificity of AP-1 transcription factors | journal = Nature | volume = 383 | issue = 6599 | pages = 453–7  | date = October 1996 | pmid = 8837781 | doi = 10.1038/383453a0 }}</ref>
 
== See also ==
*[[GPS1|COPS1]]
*[[COPS2]]
*[[COPS3]]
*[[COPS4]]
*[[COPS6]]
*[[COPS7A]]
*[[COPS7B]]
*[[COPS8]]
 
== References ==
{{reflist}}
 
==External links==
* {{UCSC gene info|COPS5}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Wolf DA, Zhou C, Wee S | title = The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases? | journal = Nat. Cell Biol. | volume = 5 | issue = 12 | pages = 1029–33 | year = 2003 | pmid = 14647295 | doi = 10.1038/ncb1203-1029 }}
| citations =
* {{cite journal | vauthors = Claret FX, Hibi M, Dhut S, Toda T, Karin M | title = A new group of conserved coactivators that increase the specificity of AP-1 transcription factors | journal = Nature | volume = 383 | issue = 6599 | pages = 453–7 | year = 1996 | pmid = 8837781 | doi = 10.1038/383453a0 }}
*{{cite journal | author=Wolf DA, Zhou C, Wee S |title=The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases? |journal=Nat. Cell Biol. |volume=5 |issue= 12 |pages= 1029-33 |year= 2004 |pmid= 14647295 |doi= 10.1038/ncb1203-1029 }}
* {{cite journal | vauthors = Asano K, Vornlocher HP, Richter-Cook NJ, Merrick WC, Hinnebusch AG, Hershey JW | title = Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly | journal = J. Biol. Chem. | volume = 272 | issue = 43 | pages = 27042–52 | year = 1997 | pmid = 9341143 | doi = 10.1074/jbc.272.43.27042 }}
*{{cite journal | author=Claret FX, Hibi M, Dhut S, ''et al.'' |title=A new group of conserved coactivators that increase the specificity of AP-1 transcription factors. |journal=Nature |volume=383 |issue= 6599 |pages= 453-7 |year= 1996 |pmid= 8837781 |doi= 10.1038/383453a0 }}
* {{cite journal | vauthors = Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, Gordon C, Naumann M, Dubiel W | title = A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits | journal = FASEB J. | volume = 12 | issue = 6 | pages = 469–78 | year = 1998 | pmid = 9535219 | doi =  }}
*{{cite journal | author=Asano K, Vornlocher HP, Richter-Cook NJ, ''et al.'' |title=Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly. |journal=J. Biol. Chem. |volume=272 |issue= 43 |pages= 27042-52 |year= 1997 |pmid= 9341143 |doi= }}
* {{cite journal | vauthors = Wei N, Tsuge T, Serino G, Dohmae N, Takio K, Matsui M, Deng XW | title = The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex | journal = Curr. Biol. | volume = 8 | issue = 16 | pages = 919–22 | year = 1998 | pmid = 9707402 | doi = 10.1016/S0960-9822(07)00372-7 }}
*{{cite journal | author=Seeger M, Kraft R, Ferrell K, ''et al.'' |title=A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. |journal=FASEB J. |volume=12 |issue= 6 |pages= 469-78 |year= 1998 |pmid= 9535219 |doi=  }}
* {{cite journal | vauthors = Tomoda K, Kubota Y, Kato J | title = Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1 | journal = Nature | volume = 398 | issue = 6723 | pages = 160–5 | year = 1999 | pmid = 10086358 | doi = 10.1038/18230 }}
*{{cite journal | author=Wei N, Tsuge T, Serino G, ''et al.'' |title=The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. |journal=Curr. Biol. |volume=8 |issue= 16 |pages= 919-22 |year= 1998 |pmid= 9707402 |doi= }}
* {{cite journal | vauthors = Dechend R, Hirano F, Lehmann K, Heissmeyer V, Ansieau S, Wulczyn FG, Scheidereit C, Leutz A | title = The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators | journal = Oncogene | volume = 18 | issue = 22 | pages = 3316–23 | year = 1999 | pmid = 10362352 | doi = 10.1038/sj.onc.1202717 }}
*{{cite journal | author=Tomoda K, Kubota Y, Kato J |title=Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1. |journal=Nature |volume=398 |issue= 6723 |pages= 160-5 |year= 1999 |pmid= 10086358 |doi= 10.1038/18230 }}
* {{cite journal | vauthors = Chauchereau A, Georgiakaki M, Perrin-Wolff M, Milgrom E, Loosfelt H | title = JAB1 interacts with both the progesterone receptor and SRC-1 | journal = J. Biol. Chem. | volume = 275 | issue = 12 | pages = 8540–8 | year = 2000 | pmid = 10722692 | doi = 10.1074/jbc.275.12.8540 }}
*{{cite journal | author=Dechend R, Hirano F, Lehmann K, ''et al.'' |title=The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators. |journal=Oncogene |volume=18 |issue= 22 |pages= 3316-23 |year= 1999 |pmid= 10362352 |doi= 10.1038/sj.onc.1202717 }}
* {{cite journal | vauthors = Bianchi E, Denti S, Granata A, Bossi G, Geginat J, Villa A, Rogge L, Pardi R | title = Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity | journal = Nature | volume = 404 | issue = 6778 | pages = 617–21 | year = 2000 | pmid = 10766246 | doi = 10.1038/35007098 }}
*{{cite journal | author=Chauchereau A, Georgiakaki M, Perrin-Wolff M, ''et al.'' |title=JAB1 interacts with both the progesterone receptor and SRC-1. |journal=J. Biol. Chem. |volume=275 |issue= 12 |pages= 8540-8 |year= 2000 |pmid= 10722692 |doi= }}
* {{cite journal | vauthors = Kleemann R, Hausser A, Geiger G, Mischke R, Burger-Kentischer A, Flieger O, Johannes FJ, Roger T, Calandra T, Kapurniotu A, Grell M, Finkelmeier D, Brunner H, Bernhagen J | title = Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1 | journal = Nature | volume = 408 | issue = 6809 | pages = 211–6 | year = 2000 | pmid = 11089976 | doi = 10.1038/35041591 }}
*{{cite journal | author=Bianchi E, Denti S, Granata A, ''et al.'' |title=Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity. |journal=Nature |volume=404 |issue= 6778 |pages= 617-21 |year= 2000 |pmid= 10766246 |doi= 10.1038/35007098 }}
* {{cite journal | vauthors = Bech-Otschir D, Kraft R, Huang X, Henklein P, Kapelari B, Pollmann C, Dubiel W | title = COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system | journal = EMBO J. | volume = 20 | issue = 7 | pages = 1630–9 | year = 2001 | pmid = 11285227 | pmc = 145508 | doi = 10.1093/emboj/20.7.1630 }}
*{{cite journal | author=Kleemann R, Hausser A, Geiger G, ''et al.'' |title=Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1. |journal=Nature |volume=408 |issue= 6809 |pages= 211-6 |year= 2000 |pmid= 11089976 |doi= 10.1038/35041591 }}
* {{cite journal | vauthors = Lyapina S, Cope G, Shevchenko A, Serino G, Tsuge T, Zhou C, Wolf DA, Wei N, Shevchenko A, Deshaies RJ | title = Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome | journal = Science | volume = 292 | issue = 5520 | pages = 1382–5 | year = 2001 | pmid = 11337588 | doi = 10.1126/science.1059780 }}
*{{cite journal | author=Bech-Otschir D, Kraft R, Huang X, ''et al.'' |title=COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. |journal=EMBO J. |volume=20 |issue= 7 |pages= 1630-9 |year= 2001 |pmid= 11285227 |doi= 10.1093/emboj/20.7.1630 }}
* {{cite journal | vauthors = Tomoda K, Kubota Y, Arata Y, Mori S, Maeda M, Tanaka T, Yoshida M, Yoneda-Kato N, Kato JY | title = The cytoplasmic shuttling and subsequent degradation of p27Kip1 mediated by Jab1/CSN5 and the COP9 signalosome complex | journal = J. Biol. Chem. | volume = 277 | issue = 3 | pages = 2302–10 | year = 2002 | pmid = 11704659 | doi = 10.1074/jbc.M104431200 }}
*{{cite journal | author=Lyapina S, Cope G, Shevchenko A, ''et al.'' |title=Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. |journal=Science |volume=292 |issue= 5520 |pages= 1382-5 |year= 2001 |pmid= 11337588 |doi= 10.1126/science.1059780 }}
* {{cite journal | vauthors = Bae MK, Ahn MY, Jeong JW, Bae MH, Lee YM, Bae SK, Park JW, Kim KR, Kim KW | title = Jab1 interacts directly with HIF-1alpha and regulates its stability | journal = J. Biol. Chem. | volume = 277 | issue = 1 | pages = 9–12 | year = 2002 | pmid = 11707426 | doi = 10.1074/jbc.C100442200 }}
*{{cite journal | author=Tomoda K, Kubota Y, Arata Y, ''et al.'' |title=The cytoplasmic shuttling and subsequent degradation of p27Kip1 mediated by Jab1/CSN5 and the COP9 signalosome complex. |journal=J. Biol. Chem. |volume=277 |issue= 3 |pages= 2302-10 |year= 2002 |pmid= 11704659 |doi= 10.1074/jbc. M104431200 }}
* {{cite journal | vauthors = Lu C, Li Y, Zhao Y, Xing G, Tang F, Wang Q, Sun Y, Wei H, Yang X, Wu C, Chen J, Guan KL, Zhang C, Chen H, He F | title = Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway | journal = FASEB J. | volume = 16 | issue = 1 | pages = 90–2 | year = 2002 | pmid = 11709497 | doi = 10.1096/fj.01-0506fje }}
*{{cite journal | author=Bae MK, Ahn MY, Jeong JW, ''et al.'' |title=Jab1 interacts directly with HIF-1alpha and regulates its stability. |journal=J. Biol. Chem. |volume=277 |issue= 1 |pages= 9-12 |year= 2002 |pmid= 11707426 |doi= 10.1074/jbc. C100442200 }}
* {{cite journal | vauthors = Dai YS, Cserjesi P | title = The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer | journal = J. Biol. Chem. | volume = 277 | issue = 15 | pages = 12604–12 | year = 2002 | pmid = 11812799 | doi = 10.1074/jbc.M200283200 }}
*{{cite journal | author=Lu C, Li Y, Zhao Y, ''et al.'' |title=Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway. |journal=FASEB J. |volume=16 |issue= 1 |pages= 90-2 |year= 2002 |pmid= 11709497 |doi= 10.1096/fj.01-0506fje }}
* {{cite journal | vauthors = Wan M, Cao X, Wu Y, Bai S, Wu L, Shi X, Wang N, Cao X | title = Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation | journal = EMBO Rep. | volume = 3 | issue = 2 | pages = 171–6 | year = 2002 | pmid = 11818334 | pmc = 1083965 | doi = 10.1093/embo-reports/kvf024 }}
*{{cite journal | author=Dai YS, Cserjesi P |title=The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer. |journal=J. Biol. Chem. |volume=277 |issue= 15 |pages= 12604-12 |year= 2002 |pmid= 11812799 |doi= 10.1074/jbc. M200283200 }}
* {{cite journal | vauthors = Gemmill RM, Bemis LT, Lee JP, Sozen MA, Baron A, Zeng C, Erickson PF, Hooper JE, Drabkin HA | title = The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway | journal = Oncogene | volume = 21 | issue = 22 | pages = 3507–16 | year = 2002 | pmid = 12032852 | doi = 10.1038/sj.onc.1205437 }}
*{{cite journal | author=Wan M, Cao X, Wu Y, ''et al.'' |title=Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation. |journal=EMBO Rep. |volume=3 |issue= 2 |pages= 171-6 |year= 2002 |pmid= 11818334 |doi= 10.1093/embo-reports/kvf024 }}
* {{cite journal | vauthors = Caballero OL, Resto V, Patturajan M, Meerzaman D, Guo MZ, Engles J, Yochem R, Ratovitski E, Sidransky D, Jen J | title = Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1) | journal = Oncogene | volume = 21 | issue = 19 | pages = 3003–10 | year = 2002 | pmid = 12082530 | doi = 10.1038/sj.onc.1205390 }}
*{{cite journal | author=Gemmill RM, Bemis LT, Lee JP, ''et al.'' |title=The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway. |journal=Oncogene |volume=21 |issue= 22 |pages= 3507-16 |year= 2002 |pmid= 12032852 |doi= 10.1038/sj.onc.1205437 }}
* {{cite journal | vauthors = Chopra S, Fernandez De Mattos S, Lam EW, Mann DJ | title = Jab1 co-activation of c-Jun is abrogated by the serine 10-phosphorylated form of p27Kip1 | journal = J. Biol. Chem. | volume = 277 | issue = 36 | pages = 32413–6 | year = 2002 | pmid = 12119282 | doi = 10.1074/jbc.C200311200 }}
*{{cite journal  | author=Caballero OL, Resto V, Patturajan M, ''et al.'' |title=Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1). |journal=Oncogene |volume=21 |issue= 19 |pages= 3003-10 |year= 2002 |pmid= 12082530 |doi= 10.1038/sj.onc.1205390 }}
*{{cite journal | author=Chopra S, Fernandez De Mattos S, Lam EW, Mann DJ |title=Jab1 co-activation of c-Jun is abrogated by the serine 10-phosphorylated form of p27Kip1. |journal=J. Biol. Chem. |volume=277 |issue= 36 |pages= 32413-6 |year= 2002 |pmid= 12119282 |doi= 10.1074/jbc. C200311200 }}
}}
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Latest revision as of 08:41, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis), also known as COPS5 or Csn5, is a gene conserved from humans to Saccharomyces cerevisiae.[1]

Function

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be a coactivator that increases the specificity of JUN/AP1 transcription factors.[1]

Interactions

COP9 constitutive photomorphogenic homolog subunit 5 has been shown to interact with Macrophage migration inhibitory factor,[2][3] GFER,[4] BCL3,[5] Ubiquitin carboxy-terminal hydrolase L1,[6] S100A7[7] and C-jun.[8]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)".
  2. ↑ Ghosh, S; Leaton, LA; Farr, L; Barfield, A; Moonah, S (6 July 2018). "Interaction between parasite-encoded JAB1/CSN5 and macrophage migration inhibitory factor proteins attenuates its proinflammatory function". Scientific Reports. 8 (1): 10241. doi:10.1038/s41598-018-28625-1. PMID 29980718.
  3. ↑ Kleemann R, Hausser A, Geiger G, Mischke R, Burger-Kentischer A, Flieger O, Johannes FJ, Roger T, Calandra T, Kapurniotu A, Grell M, Finkelmeier D, Brunner H, Bernhagen J (November 2000). "Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1". Nature. 408 (6809): 211–6. doi:10.1038/35041591. PMID 11089976.
  4. ↑ Lu C, Li Y, Zhao Y, Xing G, Tang F, Wang Q, Sun Y, Wei H, Yang X, Wu C, Chen J, Guan KL, Zhang C, Chen H, He F (January 2002). "Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway". FASEB J. 16 (1): 90–2. doi:10.1096/fj.01-0506fje. PMID 11709497.
  5. ↑ Dechend R, Hirano F, Lehmann K, Heissmeyer V, Ansieau S, Wulczyn FG, Scheidereit C, Leutz A (June 1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene. 18 (22): 3316–23. doi:10.1038/sj.onc.1202717. PMID 10362352.
  6. ↑ Caballero OL, Resto V, Patturajan M, Meerzaman D, Guo MZ, Engles J, Yochem R, Ratovitski E, Sidransky D, Jen J (May 2002). "Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1)". Oncogene. 21 (19): 3003–10. doi:10.1038/sj.onc.1205390. PMID 12082530.
  7. ↑ Emberley ED, Niu Y, Leygue E, Tomes L, Gietz RD, Murphy LC, Watson PH (April 2003). "Psoriasin interacts with Jab1 and influences breast cancer progression". Cancer Res. 63 (8): 1954–61. PMID 12702588.
  8. ↑ Claret FX, Hibi M, Dhut S, Toda T, Karin M (October 1996). "A new group of conserved coactivators that increase the specificity of AP-1 transcription factors". Nature. 383 (6599): 453–7. doi:10.1038/383453a0. PMID 8837781.

External links

Further reading

  • Wolf DA, Zhou C, Wee S (2003). "The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?". Nat. Cell Biol. 5 (12): 1029–33. doi:10.1038/ncb1203-1029. PMID 14647295.
  • Claret FX, Hibi M, Dhut S, Toda T, Karin M (1996). "A new group of conserved coactivators that increase the specificity of AP-1 transcription factors". Nature. 383 (6599): 453–7. doi:10.1038/383453a0. PMID 8837781.
  • Asano K, Vornlocher HP, Richter-Cook NJ, Merrick WC, Hinnebusch AG, Hershey JW (1997). "Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly". J. Biol. Chem. 272 (43): 27042–52. doi:10.1074/jbc.272.43.27042. PMID 9341143.
  • Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, Gordon C, Naumann M, Dubiel W (1998). "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits". FASEB J. 12 (6): 469–78. PMID 9535219.
  • Wei N, Tsuge T, Serino G, Dohmae N, Takio K, Matsui M, Deng XW (1998). "The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex". Curr. Biol. 8 (16): 919–22. doi:10.1016/S0960-9822(07)00372-7. PMID 9707402.
  • Tomoda K, Kubota Y, Kato J (1999). "Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1". Nature. 398 (6723): 160–5. doi:10.1038/18230. PMID 10086358.
  • Dechend R, Hirano F, Lehmann K, Heissmeyer V, Ansieau S, Wulczyn FG, Scheidereit C, Leutz A (1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene. 18 (22): 3316–23. doi:10.1038/sj.onc.1202717. PMID 10362352.
  • Chauchereau A, Georgiakaki M, Perrin-Wolff M, Milgrom E, Loosfelt H (2000). "JAB1 interacts with both the progesterone receptor and SRC-1". J. Biol. Chem. 275 (12): 8540–8. doi:10.1074/jbc.275.12.8540. PMID 10722692.
  • Bianchi E, Denti S, Granata A, Bossi G, Geginat J, Villa A, Rogge L, Pardi R (2000). "Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity". Nature. 404 (6778): 617–21. doi:10.1038/35007098. PMID 10766246.
  • Kleemann R, Hausser A, Geiger G, Mischke R, Burger-Kentischer A, Flieger O, Johannes FJ, Roger T, Calandra T, Kapurniotu A, Grell M, Finkelmeier D, Brunner H, Bernhagen J (2000). "Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1". Nature. 408 (6809): 211–6. doi:10.1038/35041591. PMID 11089976.
  • Bech-Otschir D, Kraft R, Huang X, Henklein P, Kapelari B, Pollmann C, Dubiel W (2001). "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system". EMBO J. 20 (7): 1630–9. doi:10.1093/emboj/20.7.1630. PMC 145508. PMID 11285227.
  • Lyapina S, Cope G, Shevchenko A, Serino G, Tsuge T, Zhou C, Wolf DA, Wei N, Shevchenko A, Deshaies RJ (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science. 292 (5520): 1382–5. doi:10.1126/science.1059780. PMID 11337588.
  • Tomoda K, Kubota Y, Arata Y, Mori S, Maeda M, Tanaka T, Yoshida M, Yoneda-Kato N, Kato JY (2002). "The cytoplasmic shuttling and subsequent degradation of p27Kip1 mediated by Jab1/CSN5 and the COP9 signalosome complex". J. Biol. Chem. 277 (3): 2302–10. doi:10.1074/jbc.M104431200. PMID 11704659.
  • Bae MK, Ahn MY, Jeong JW, Bae MH, Lee YM, Bae SK, Park JW, Kim KR, Kim KW (2002). "Jab1 interacts directly with HIF-1alpha and regulates its stability". J. Biol. Chem. 277 (1): 9–12. doi:10.1074/jbc.C100442200. PMID 11707426.
  • Lu C, Li Y, Zhao Y, Xing G, Tang F, Wang Q, Sun Y, Wei H, Yang X, Wu C, Chen J, Guan KL, Zhang C, Chen H, He F (2002). "Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway". FASEB J. 16 (1): 90–2. doi:10.1096/fj.01-0506fje. PMID 11709497.
  • Dai YS, Cserjesi P (2002). "The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer". J. Biol. Chem. 277 (15): 12604–12. doi:10.1074/jbc.M200283200. PMID 11812799.
  • Wan M, Cao X, Wu Y, Bai S, Wu L, Shi X, Wang N, Cao X (2002). "Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation". EMBO Rep. 3 (2): 171–6. doi:10.1093/embo-reports/kvf024. PMC 1083965. PMID 11818334.
  • Gemmill RM, Bemis LT, Lee JP, Sozen MA, Baron A, Zeng C, Erickson PF, Hooper JE, Drabkin HA (2002). "The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway". Oncogene. 21 (22): 3507–16. doi:10.1038/sj.onc.1205437. PMID 12032852.
  • Caballero OL, Resto V, Patturajan M, Meerzaman D, Guo MZ, Engles J, Yochem R, Ratovitski E, Sidransky D, Jen J (2002). "Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1)". Oncogene. 21 (19): 3003–10. doi:10.1038/sj.onc.1205390. PMID 12082530.
  • Chopra S, Fernandez De Mattos S, Lam EW, Mann DJ (2002). "Jab1 co-activation of c-Jun is abrogated by the serine 10-phosphorylated form of p27Kip1". J. Biol. Chem. 277 (36): 32413–6. doi:10.1074/jbc.C200311200. PMID 12119282.
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