COPS4: Difference between revisions
Jump to navigation
Jump to search
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}})) |
Matt Pijoan (talk | contribs) m (1 revision imported) |
||
| (2 intermediate revisions by 2 users not shown) | |||
| Line 1: | Line 1: | ||
{{Infobox_gene}} | |||
{{ | '''COP9 signalosome complex subunit 4''' is a [[protein]] that in humans is encoded by the ''COPS4'' [[gene]].<ref name="pmid9707402">{{cite journal | vauthors = Wei N, Tsuge T, Serino G, Dohmae N, Takio K, Matsui M, Deng XW | title = The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex | journal = Curr Biol | volume = 8 | issue = 16 | pages = 919–924 |date=Oct 1998 | pmid = 9707402 | pmc = | doi =10.1016/S0960-9822(07)00372-7 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: COPS4 COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51138| accessdate = }}</ref> | ||
}} | |||
| | |||
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. --> | <!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. --> | ||
{{PBB_Summary | {{PBB_Summary | ||
| section_title = | | section_title = | ||
| summary_text = This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases.<ref name="entrez" | | summary_text = This gene encodes one of eight subunits composing [[COP9 signalosome]], a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases.<ref name="entrez"/> | ||
}} | }} | ||
==References== | ==References== | ||
{{reflist| | {{reflist}} | ||
==External links== | |||
* {{UCSC gene info|COPS4}} | |||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal | vauthors=Schwechheimer C, Deng XW |title=COP9 signalosome revisited: a novel mediator of protein degradation |journal=Trends Cell Biol. |volume=11 |issue= 10 |pages= 420–426 |year= 2001 |pmid= 11567875 |doi=10.1016/S0962-8924(01)02091-8 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Wolf DA, Zhou C, Wee S |title=The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases? |journal=Nat. Cell Biol. |volume=5 |issue= 12 |pages= 1029–1033 |year= 2004 |pmid= 14647295 |doi= 10.1038/ncb1203-1029 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–174 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }} | ||
*{{cite journal | author=Suzuki Y | *{{cite journal | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–156 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |name-list-format=vanc| author2=Yoshitomo-Nakagawa K | author3=Maruyama K | display-authors=3 | last4=Suyama | first4=A | last5=Sugano | first5=S }} | ||
*{{cite journal | author=Seeger M |title=A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits |journal=FASEB J. |volume=12 |issue= 6 |pages= 469–78 |year= 1998 |pmid= 9535219 |doi= |name-list-format=vanc| author2=Kraft R | author3=Ferrell K | display-authors=3 | last4=Bech-Otschir | first4=D | last5=Dumdey | first5=R | last6=Schade | first6=R | last7=Gordon | first7=C | last8=Naumann | first8=M | last9=Dubiel | first9=W }} | |||
*{{cite journal |title=Toward a complete human genome sequence |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi= 10.1101/gr.8.11.1097}} | |||
*{{cite journal | *{{cite journal | author=Naumann M |title=COP9 signalosome-directed c-Jun activation/stabilization is independent of JNK |journal=J. Biol. Chem. |volume=274 |issue= 50 |pages= 35297–35300 |year= 2000 |pmid= 10585392 |doi=10.1074/jbc.274.50.35297 |name-list-format=vanc| author2=Bech-Otschir D | author3=Huang X | display-authors=3 | last4=Ferrell | first4=K | last5=Dubiel | first5=W |url=http://www.jbc.org/content/274/50/35297.full.pdf}} | ||
*{{cite journal | author=Naumann M | *{{cite journal | author=Cohen H |title=Interaction between [[Interferon Consensus Sequence-binding protein]] and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome |journal=J. Biol. Chem. |volume=275 |issue= 50 |pages= 39081–39089 |year= 2001 |pmid= 10991940 |doi= 10.1074/jbc.M004900200 |name-list-format=vanc| author2=Azriel A | author3=Cohen T | display-authors=3 | last4=Meraro | first4=D | last5=Hashmueli | first5=S | last6=Bech-Otschir | first6=D | last7=Kraft | first7=R | last8=Dubiel | first8=W | last9=Levi | first9=BZ }} | ||
*{{cite journal | vauthors=Tsuge T, Matsui M, Wei N |title=The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain |journal=J. Mol. Biol. |volume=305 |issue= 1 |pages= 1–9 |year= 2001 |pmid= 11114242 |doi= 10.1006/jmbi.2000.4288 }} | |||
*{{cite journal | author= | *{{cite journal | author=Bech-Otschir D |title=COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system |journal=EMBO J. |volume=20 |issue= 7 |pages= 1630–1639 |year= 2001 |pmid= 11285227 |doi= 10.1093/emboj/20.7.1630 | pmc=145508 |name-list-format=vanc| author2=Kraft R | author3=Huang X | display-authors=3 | last4=Henklein | first4=P | last5=Kapelari | first5=B | last6=Pollmann | first6=C | last7=Dubiel | first7=W }} | ||
*{{cite journal | author=Lyapina S |title=Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome |journal=Science |volume=292 |issue= 5520 |pages= 1382–1385 |year= 2001 |pmid= 11337588 |doi= 10.1126/science.1059780 |name-list-format=vanc| author2=Cope G | author3=Shevchenko A | display-authors=3 | last4=Serino | first4=G | last5=Tsuge | first5=T | last6=Zhou | first6=C | last7=Wolf | first7=DA | last8=Wei | first8=N | last9=Shevchenko | first9=A }} | |||
*{{cite journal | | *{{cite journal | author=Peyrl A |title=Aberrant expression of signaling-related proteins 14-3-3 gamma and RACK1 in fetal Down syndrome brain (trisomy 21) |journal=Electrophoresis |volume=23 |issue= 1 |pages= 152–7 |year= 2003 |pmid= 11824616 |doi= 10.1002/1522-2683(200201)23:1<152::AID-ELPS152>3.0.CO;2-T |name-list-format=vanc| author2=Weitzdoerfer R | author3=Gulesserian T | display-authors=3 | last4=Fountoulakis | first4=Michael | last5=Lubec | first5=Gert }} | ||
*{{cite journal | author= | *{{cite journal | vauthors=Hoareau Alves K, Bochard V, Réty S, Jalinot P |title=Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome |journal=FEBS Lett. |volume=527 |issue= 1–3 |pages= 15–21 |year= 2002 |pmid= 12220626 |doi=10.1016/S0014-5793(02)03147-2 }} | ||
*{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }} | |||
*{{cite journal | author= | *{{cite journal | author=Serino G |title=Characterization of the last subunit of the Arabidopsis COP9 signalosome: implications for the overall structure and origin of the complex |journal=Plant Cell |volume=15 |issue= 3 |pages= 719–731 |year= 2003 |pmid= 12615944 |doi=10.1105/tpc.009092 | pmc=150025 |name-list-format=vanc| author2=Su H | author3=Peng Z | display-authors=3 | last4=Tsuge | first4=T | last5=Wei | first5=N | last6=Gu | first6=H | last7=Deng | first7=XW }} | ||
*{{cite journal | author=Uhle S |title=Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome |journal=EMBO J. |volume=22 |issue= 6 |pages= 1302–1312 |year= 2003 |pmid= 12628923 |doi= 10.1093/emboj/cdg127 | pmc=151059 |name-list-format=vanc| author2=Medalia O | author3=Waldron R | display-authors=3 | last4=Dumdey | first4=R | last5=Henklein | first5=P | last6=Bech-Otschir | first6=D | last7=Huang | first7=X | last8=Berse | first8=M | last9=Sperling | first9=J }} | |||
*{{cite journal | author= | *{{cite journal | author=Groisman R |title=The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage |journal=Cell |volume=113 |issue= 3 |pages= 357–367 |year= 2003 |pmid= 12732143 |doi=10.1016/S0092-8674(03)00316-7 |name-list-format=vanc| author2=Polanowska J | author3=Kuraoka I | display-authors=3 | last4=Sawada | first4=Jun-Ichi | last5=Saijo | first5=Masafumi | last6=Drapkin | first6=Ronny | last7=Kisselev | first7=Alexei F. | last8=Tanaka | first8=Kiyoji | last9=Nakatani | first9=Yoshihiro }} | ||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{PDB Gallery|geneid=51138}} | |||
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. --> | |||
{{PBB_Controls | |||
| update_page = yes | |||
| require_manual_inspection = no | |||
| update_protein_box = yes | |||
| update_summary = yes | |||
| update_citations = yes | |||
}} | |||
{{ | {{gene-4-stub}} | ||
Latest revision as of 12:00, 10 January 2019
| VALUE_ERROR (nil) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Aliases | |||||||
| External IDs | GeneCards: [1] | ||||||
| Orthologs | |||||||
| Species | Human | Mouse | |||||
| Entrez |
|
| |||||
| Ensembl |
|
| |||||
| UniProt |
|
| |||||
| RefSeq (mRNA) |
|
| |||||
| RefSeq (protein) |
|
| |||||
| Location (UCSC) | n/a | n/a | |||||
| PubMed search | n/a | n/a | |||||
| Wikidata | |||||||
| |||||||
COP9 signalosome complex subunit 4 is a protein that in humans is encoded by the COPS4 gene.[1][2]
This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases.[2]
References
- ↑ Wei N, Tsuge T, Serino G, Dohmae N, Takio K, Matsui M, Deng XW (Oct 1998). "The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex". Curr Biol. 8 (16): 919–924. doi:10.1016/S0960-9822(07)00372-7. PMID 9707402.
- ↑ 2.0 2.1 "Entrez Gene: COPS4 COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)".
External links
- Human COPS4 genome location and COPS4 gene details page in the UCSC Genome Browser.
Further reading
- Schwechheimer C, Deng XW (2001). "COP9 signalosome revisited: a novel mediator of protein degradation". Trends Cell Biol. 11 (10): 420–426. doi:10.1016/S0962-8924(01)02091-8. PMID 11567875.
- Wolf DA, Zhou C, Wee S (2004). "The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?". Nat. Cell Biol. 5 (12): 1029–1033. doi:10.1038/ncb1203-1029. PMID 14647295.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Seeger M, Kraft R, Ferrell K, et al. (1998). "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits". FASEB J. 12 (6): 469–78. PMID 9535219.
- "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
- Naumann M, Bech-Otschir D, Huang X, et al. (2000). "COP9 signalosome-directed c-Jun activation/stabilization is independent of JNK" (PDF). J. Biol. Chem. 274 (50): 35297–35300. doi:10.1074/jbc.274.50.35297. PMID 10585392.
- Cohen H, Azriel A, Cohen T, et al. (2001). "Interaction between Interferon Consensus Sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome". J. Biol. Chem. 275 (50): 39081–39089. doi:10.1074/jbc.M004900200. PMID 10991940.
- Tsuge T, Matsui M, Wei N (2001). "The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain". J. Mol. Biol. 305 (1): 1–9. doi:10.1006/jmbi.2000.4288. PMID 11114242.
- Bech-Otschir D, Kraft R, Huang X, et al. (2001). "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system". EMBO J. 20 (7): 1630–1639. doi:10.1093/emboj/20.7.1630. PMC 145508. PMID 11285227.
- Lyapina S, Cope G, Shevchenko A, et al. (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science. 292 (5520): 1382–1385. doi:10.1126/science.1059780. PMID 11337588.
- Peyrl A, Weitzdoerfer R, Gulesserian T, et al. (2003). "Aberrant expression of signaling-related proteins 14-3-3 gamma and RACK1 in fetal Down syndrome brain (trisomy 21)". Electrophoresis. 23 (1): 152–7. doi:10.1002/1522-2683(200201)23:1<152::AID-ELPS152>3.0.CO;2-T. PMID 11824616.
- Hoareau Alves K, Bochard V, Réty S, Jalinot P (2002). "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome". FEBS Lett. 527 (1–3): 15–21. doi:10.1016/S0014-5793(02)03147-2. PMID 12220626.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Serino G, Su H, Peng Z, et al. (2003). "Characterization of the last subunit of the Arabidopsis COP9 signalosome: implications for the overall structure and origin of the complex". Plant Cell. 15 (3): 719–731. doi:10.1105/tpc.009092. PMC 150025. PMID 12615944.
- Uhle S, Medalia O, Waldron R, et al. (2003). "Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome". EMBO J. 22 (6): 1302–1312. doi:10.1093/emboj/cdg127. PMC 151059. PMID 12628923.
- Groisman R, Polanowska J, Kuraoka I, et al. (2003). "The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage". Cell. 113 (3): 357–367. doi:10.1016/S0092-8674(03)00316-7. PMID 12732143.
 | This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it. |