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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Complexin-1''' is a [[protein]] that in humans is encoded by the ''CPLX1'' [[gene]].<ref name="pmid7553862">{{cite journal | vauthors = McMahon HT, Missler M, Li C, Südhof TC | title = Complexins: cytosolic proteins that regulate SNAP receptor function | journal = Cell | volume = 83 | issue = 1 | pages = 111–9 | date = Oct 1995 | pmid = 7553862 | pmc =  | doi = 10.1016/0092-8674(95)90239-2 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CPLX1 complexin 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10815| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_CPLX1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1kil.
| PDB = {{PDB2|1kil}}
| Name = Complexin 1
| HGNCid = 2309
| Symbol = CPLX1
| AltSymbols =; CPX-I; CPX1
| OMIM = 605032
| ECnumber = 
| Homologene = 21324
| MGIid = 104727
| GeneAtlas_image1 = PBB_GE_CPLX1_gnf1h00098_at_tn.png
| Function = {{GNF_GO|id=GO:0019905 |text = syntaxin binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006836 |text = neurotransmitter transport}} {{GNF_GO|id=GO:0006887 |text = exocytosis}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10815
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_006642
    | Hs_RefseqmRNA = NM_006651
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 12889
    | Mm_Ensembl = ENSMUSG00000033615
    | Mm_RefseqmRNA = NM_007756
    | Mm_RefseqProtein = NP_031782
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 108760431
    | Mm_GenLoc_end = 108765870
    | Mm_Uniprot = P63040
  }}
}}
'''Complexin 1''', also known as '''CPLX1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CPLX1 complexin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10815| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis.  These proteins bind syntaxin, part of the SNAP receptor.  The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release.<ref name="entrez">{{cite web | title = Entrez Gene: CPLX1 complexin 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10815| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis.  These proteins bind syntaxin, part of the SNAP receptor.  The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release.<ref name="entrez">{{cite web | title = Entrez Gene: CPLX1 complexin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10815| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
CPLX1 has been shown to [[Protein-protein_interaction|interact]] with [[SNAP-25]]<ref name=pmid11832227>{{cite journal | vauthors = Chen X, Tomchick DR, Kovrigin E, Araç D, Machius M, Südhof TC, Rizo J | title = Three-dimensional structure of the complexin/SNARE complex | journal = Neuron | volume = 33 | issue = 3 | pages = 397–409 | date = Jan 2002 | pmid = 11832227 | doi = 10.1016/S0896-6273(02)00583-4 }}</ref><ref name=pmid12200427>{{cite journal | vauthors = Hu K, Carroll J, Rickman C, Davletov B | title = Action of complexin on SNARE complex | journal = The Journal of Biological Chemistry | volume = 277 | issue = 44 | pages = 41652–6 | date = Nov 2002 | pmid = 12200427 | doi = 10.1074/jbc.M205044200 }}</ref> and [[STX1A]].<ref name=pmid10449403>{{cite journal | vauthors = Dulubova I, Sugita S, Hill S, Hosaka M, Fernandez I, Südhof TC, Rizo J | title = A conformational switch in syntaxin during exocytosis: role of munc18 | journal = The EMBO Journal | volume = 18 | issue = 16 | pages = 4372–82 | date = Aug 1999 | pmid = 10449403 | pmc = 1171512 | doi = 10.1093/emboj/18.16.4372 }}</ref><ref name=pmid11832227/><ref name=pmid12200427/>
{{refbegin | 2}}
 
{{PBB_Further_reading
== References ==
| citations =  
{{reflist}}
*{{cite journal | author=Abe T |title=[The mechanism of neurotransmitter release: role of synaphin/complexin in synaptic vesicle exocytosis] |journal=Tanpakushitsu Kakusan Koso |volume=47 |issue= 7 |pages= 794-800 |year= 2002 |pmid= 12058476 |doi= }}
{{-}}
*{{cite journal | author=McMahon HT, Missler M, Li C, Südhof TC |title=Complexins: cytosolic proteins that regulate SNAP receptor function. |journal=Cell |volume=83 |issue= 1 |pages= 111-9 |year= 1995 |pmid= 7553862 |doi=  }}
 
*{{cite journal | author=Ishizuka T, Saisu H, Odani S, Abe T |title=Synaphin: a protein associated with the docking/fusion complex in presynaptic terminals. |journal=Biochem. Biophys. Res. Commun. |volume=213 |issue= 3 |pages= 1107-14 |year= 1995 |pmid= 7654227 |doi= 10.1006/bbrc.1995.2241 }}
==External links==
*{{cite journal | author=Harrison PJ, Eastwood SL |title=Preferential involvement of excitatory neurons in medial temporal lobe in schizophrenia. |journal=Lancet |volume=352 |issue= 9141 |pages= 1669-73 |year= 1998 |pmid= 9853440 |doi= }}
* {{UCSC gene info|CPLX1}}
*{{cite journal | author=Ishizuka T, Saisu H, Odani S, ''et al.'' |title=Distinct regional distribution in the brain of messenger RNAs for the two isoforms of synaphin associated with the docking/fusion complex. |journal=Neuroscience |volume=88 |issue= 1 |pages= 295-306 |year= 1999 |pmid= 10051208 |doi= }}
 
*{{cite journal | author=Eastwood SL, Cotter D, Harrison PJ |title=Cerebellar synaptic protein expression in schizophrenia. |journal=Neuroscience |volume=105 |issue= 1 |pages= 219-29 |year= 2001 |pmid= 11483314 |doi= }}
== Further reading ==
*{{cite journal | author=Chen X, Tomchick DR, Kovrigin E, ''et al.'' |title=Three-dimensional structure of the complexin/SNARE complex. |journal=Neuron |volume=33 |issue= 3 |pages= 397-409 |year= 2002 |pmid= 11832227 |doi= }}
{{refbegin|33em}}
*{{cite journal | author=Sawada K, Young CE, Barr AM, ''et al.'' |title=Altered immunoreactivity of complexin protein in prefrontal cortex in severe mental illness. |journal=Mol. Psychiatry |volume=7 |issue= 5 |pages= 484-92 |year= 2002 |pmid= 12082566 |doi= 10.1038/sj.mp.4000978 }}
* {{cite journal | vauthors = Abe T | title = [The mechanism of neurotransmitter release: role of synaphin/complexin in synaptic vesicle exocytosis] | journal = Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme | volume = 47 | issue = 7 | pages = 794–800 | date = Jun 2002 | pmid = 12058476 | doi =  }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Ishizuka T, Saisu H, Odani S, Abe T | title = Synaphin: a protein associated with the docking/fusion complex in presynaptic terminals | journal = Biochemical and Biophysical Research Communications | volume = 213 | issue = 3 | pages = 1107–14 | date = Aug 1995 | pmid = 7654227 | doi = 10.1006/bbrc.1995.2241 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Harrison PJ, Eastwood SL | title = Preferential involvement of excitatory neurons in medial temporal lobe in schizophrenia | journal = Lancet | volume = 352 | issue = 9141 | pages = 1669–73 | date = Nov 1998 | pmid = 9853440 | doi = 10.1016/S0140-6736(98)03341-8 }}
*{{cite journal  | author=Basso M, Giraudo S, Corpillo D, ''et al.'' |title=Proteome analysis of human substantia nigra in Parkinson's disease. |journal=Proteomics |volume=4 |issue= 12 |pages= 3943-52 |year= 2005 |pmid= 15526345 |doi= 10.1002/pmic.200400848 }}
* {{cite journal | vauthors = Ishizuka T, Saisu H, Odani S, Kumanishi T, Abe T | title = Distinct regional distribution in the brain of messenger RNAs for the two isoforms of synaphin associated with the docking/fusion complex | journal = Neuroscience | volume = 88 | issue = 1 | pages = 295–306 | date = Jan 1999 | pmid = 10051208 | doi = 10.1016/S0306-4522(98)00223-1 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
* {{cite journal | vauthors = Eastwood SL, Cotter D, Harrison PJ | title = Cerebellar synaptic protein expression in schizophrenia | journal = Neuroscience | volume = 105 | issue = 1 | pages = 219–29 | year = 2001 | pmid = 11483314 | doi = 10.1016/S0306-4522(01)00141-5 }}
*{{cite journal | author=Giraudo CG, Eng WS, Melia TJ, Rothman JE |title=A clamping mechanism involved in SNARE-dependent exocytosis. |journal=Science |volume=313 |issue= 5787 |pages= 676-80 |year= 2006 |pmid= 16794037 |doi= 10.1126/science.1129450 }}
* {{cite journal | vauthors = Chen X, Tomchick DR, Kovrigin E, Araç D, Machius M, Südhof TC, Rizo J | title = Three-dimensional structure of the complexin/SNARE complex | journal = Neuron | volume = 33 | issue = 3 | pages = 397–409 | date = Jan 2002 | pmid = 11832227 | doi = 10.1016/S0896-6273(02)00583-4 }}
}}
* {{cite journal | vauthors = Sawada K, Young CE, Barr AM, Longworth K, Takahashi S, Arango V, Mann JJ, Dwork AJ, Falkai P, Phillips AG, Honer WG | title = Altered immunoreactivity of complexin protein in prefrontal cortex in severe mental illness | journal = Molecular Psychiatry | volume = 7 | issue = 5 | pages = 484–92 | year = 2002 | pmid = 12082566 | doi = 10.1038/sj.mp.4000978 }}
* {{cite journal | vauthors = Basso M, Giraudo S, Corpillo D, Bergamasco B, Lopiano L, Fasano M | title = Proteome analysis of human substantia nigra in Parkinson's disease | journal = Proteomics | volume = 4 | issue = 12 | pages = 3943–52 | date = Dec 2004 | pmid = 15526345 | doi = 10.1002/pmic.200400848 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
* {{cite journal | vauthors = Giraudo CG, Eng WS, Melia TJ, Rothman JE | title = A clamping mechanism involved in SNARE-dependent exocytosis | journal = Science | volume = 313 | issue = 5787 | pages = 676–80 | date = Aug 2006 | pmid = 16794037 | doi = 10.1126/science.1129450 }}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=10815}}


{{protein-stub}}
{{protein-stub}}
{{WikiDoc Sources}}

Latest revision as of 12:04, 10 January 2019

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Complexin-1 is a protein that in humans is encoded by the CPLX1 gene.[1][2]

Function

Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release.[2]

Interactions

CPLX1 has been shown to interact with SNAP-25[3][4] and STX1A.[5][3][4]

References

  1. ↑ McMahon HT, Missler M, Li C, Südhof TC (Oct 1995). "Complexins: cytosolic proteins that regulate SNAP receptor function". Cell. 83 (1): 111–9. doi:10.1016/0092-8674(95)90239-2. PMID 7553862.
  2. ↑ 2.0 2.1 "Entrez Gene: CPLX1 complexin 1".
  3. ↑ 3.0 3.1 Chen X, Tomchick DR, Kovrigin E, Araç D, Machius M, Südhof TC, Rizo J (Jan 2002). "Three-dimensional structure of the complexin/SNARE complex". Neuron. 33 (3): 397–409. doi:10.1016/S0896-6273(02)00583-4. PMID 11832227.
  4. ↑ 4.0 4.1 Hu K, Carroll J, Rickman C, Davletov B (Nov 2002). "Action of complexin on SNARE complex". The Journal of Biological Chemistry. 277 (44): 41652–6. doi:10.1074/jbc.M205044200. PMID 12200427.
  5. ↑ Dulubova I, Sugita S, Hill S, Hosaka M, Fernandez I, Südhof TC, Rizo J (Aug 1999). "A conformational switch in syntaxin during exocytosis: role of munc18". The EMBO Journal. 18 (16): 4372–82. doi:10.1093/emboj/18.16.4372. PMC 1171512. PMID 10449403.

External links

Further reading

  • Abe T (Jun 2002). "[The mechanism of neurotransmitter release: role of synaphin/complexin in synaptic vesicle exocytosis]". Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme. 47 (7): 794–800. PMID 12058476.
  • Ishizuka T, Saisu H, Odani S, Abe T (Aug 1995). "Synaphin: a protein associated with the docking/fusion complex in presynaptic terminals". Biochemical and Biophysical Research Communications. 213 (3): 1107–14. doi:10.1006/bbrc.1995.2241. PMID 7654227.
  • Harrison PJ, Eastwood SL (Nov 1998). "Preferential involvement of excitatory neurons in medial temporal lobe in schizophrenia". Lancet. 352 (9141): 1669–73. doi:10.1016/S0140-6736(98)03341-8. PMID 9853440.
  • Ishizuka T, Saisu H, Odani S, Kumanishi T, Abe T (Jan 1999). "Distinct regional distribution in the brain of messenger RNAs for the two isoforms of synaphin associated with the docking/fusion complex". Neuroscience. 88 (1): 295–306. doi:10.1016/S0306-4522(98)00223-1. PMID 10051208.
  • Eastwood SL, Cotter D, Harrison PJ (2001). "Cerebellar synaptic protein expression in schizophrenia". Neuroscience. 105 (1): 219–29. doi:10.1016/S0306-4522(01)00141-5. PMID 11483314.
  • Chen X, Tomchick DR, Kovrigin E, Araç D, Machius M, Südhof TC, Rizo J (Jan 2002). "Three-dimensional structure of the complexin/SNARE complex". Neuron. 33 (3): 397–409. doi:10.1016/S0896-6273(02)00583-4. PMID 11832227.
  • Sawada K, Young CE, Barr AM, Longworth K, Takahashi S, Arango V, Mann JJ, Dwork AJ, Falkai P, Phillips AG, Honer WG (2002). "Altered immunoreactivity of complexin protein in prefrontal cortex in severe mental illness". Molecular Psychiatry. 7 (5): 484–92. doi:10.1038/sj.mp.4000978. PMID 12082566.
  • Basso M, Giraudo S, Corpillo D, Bergamasco B, Lopiano L, Fasano M (Dec 2004). "Proteome analysis of human substantia nigra in Parkinson's disease". Proteomics. 4 (12): 3943–52. doi:10.1002/pmic.200400848. PMID 15526345.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Giraudo CG, Eng WS, Melia TJ, Rothman JE (Aug 2006). "A clamping mechanism involved in SNARE-dependent exocytosis". Science. 313 (5787): 676–80. doi:10.1126/science.1129450. PMID 16794037.
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