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'''Beta-casein''' is a [[protein]] that in humans is encoded by the ''CSN2'' [[gene]].<ref name="pmid1577486">{{cite journal | vauthors = Menon RS, Chang YF, Jeffers KF, Jones C, Ham RG | title = Regional localization of human beta-casein gene (CSN2) to 4pter-q21 | journal = Genomics | volume = 13 | issue = 1 | pages = 225–6 |date=Jun 1992 | pmid = 1577486 | pmc = | doi =10.1016/0888-7543(92)90227-J }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CSN2 casein beta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1447| accessdate = }}</ref> It is in the class of [[phosphoprotein]]s and generally occurs in [[mammalian]] milk.
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Casein beta
| HGNCid = 2447
| Symbol = CSN2
| AltSymbols =; CASB
| OMIM = 115460
| ECnumber =
| Homologene = 1426
| MGIid = 88541
| GeneAtlas_image1 = PBB_GE_CSN2_207951_at_tn.png
| Function = {{GNF_GO|id=GO:0004857 |text = enzyme inhibitor activity}} {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006816 |text = calcium ion transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1447
    | Hs_Ensembl = ENSG00000135222
    | Hs_RefseqProtein = NP_001882
    | Hs_RefseqmRNA = NM_001891
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 70855564
    | Hs_GenLoc_end = 70861315
    | Hs_Uniprot = P05814
    | Mm_EntrezGene = 12991
    | Mm_Ensembl = ENSMUSG00000063157
    | Mm_RefseqmRNA = NM_009972
    | Mm_RefseqProtein = NP_034102
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 88769035
    | Mm_GenLoc_end = 88773960
    | Mm_Uniprot = Q3TP33
  }}
}}
'''Casein beta''', also known as '''CSN2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CSN2 casein beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1447| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{Reflist}}
 
==External links==
* {{UCSC gene info|CSN2}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Letwin K, Mizzen L, Motro B, ''et al.'' |title=A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells. |journal=EMBO J. |volume=11 |issue= 10 |pages= 3521-31 |year= 1992 |pmid= 1382974 |doi= }}
*{{cite journal | vauthors=Letwin K, Mizzen L, Motro B |title=A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells. |journal=EMBO J. |volume=11 |issue= 10 |pages= 3521–31 |year= 1992 |pmid= 1382974 |doi= | pmc=556810 |display-authors=etal}}
*{{cite journal  | author=Menon RS, Chang YF, Jeffers KF, ''et al.'' |title=Regional localization of human beta-casein gene (CSN2) to 4pter-q21. |journal=Genomics |volume=13 |issue= 1 |pages= 225-6 |year= 1992 |pmid= 1577486 |doi= }}
*{{cite journal | vauthors=Lönnerdal B, Bergström S, Andersson Y |title=Cloning and sequencing of a cDNA encoding human milk beta-casein. |journal=FEBS Lett. |volume=269 |issue= 1 |pages= 153–6 |year= 1990 |pmid= 2387396 |doi=10.1016/0014-5793(90)81142-B |display-authors=etal}}
*{{cite journal | author=Lönnerdal B, Bergström S, Andersson Y, ''et al.'' |title=Cloning and sequencing of a cDNA encoding human milk beta-casein. |journal=FEBS Lett. |volume=269 |issue= 1 |pages= 153-6 |year= 1990 |pmid= 2387396 |doi= }}
*{{cite journal | vauthors=Menon RS, Ham RG |title=Human beta-casein: partial cDNA sequence and apparent polymorphism. |journal=Nucleic Acids Res. |volume=17 |issue= 7 |pages= 2869 |year= 1989 |pmid= 2717418 |doi=10.1093/nar/17.7.2869 | pmc=317677 }}
*{{cite journal | author=Menon RS, Ham RG |title=Human beta-casein: partial cDNA sequence and apparent polymorphism. |journal=Nucleic Acids Res. |volume=17 |issue= 7 |pages= 2869 |year= 1989 |pmid= 2717418 |doi= }}
*{{cite journal | vauthors=Greenberg R, Groves ML, Dower HJ |title=Human beta-casein. Amino acid sequence and identification of phosphorylation sites. |journal=J. Biol. Chem. |volume=259 |issue= 8 |pages= 5132–8 |year= 1984 |pmid= 6715339 |doi= }}
*{{cite journal | author=Greenberg R, Groves ML, Dower HJ |title=Human beta-casein. Amino acid sequence and identification of phosphorylation sites. |journal=J. Biol. Chem. |volume=259 |issue= 8 |pages= 5132-8 |year= 1984 |pmid= 6715339 |doi= }}
*{{cite journal | vauthors=Chen CS, Bejcek BE, Kersey JH |title=A mapping study of 13 genes on human chromosome bands 4q11→q25. |journal=Cytogenet. Cell Genet. |volume=69 |issue= 3–4 |pages= 260–5 |year= 1995 |pmid= 7698025 |doi=10.1159/000133976 }}
*{{cite journal | author=Chen CS, Bejcek BE, Kersey JH |title=A mapping study of 13 genes on human chromosome bands 4q11-->q25. |journal=Cytogenet. Cell Genet. |volume=69 |issue= 3-4 |pages= 260-5 |year= 1995 |pmid= 7698025 |doi= }}
*{{cite journal | vauthors=Hansson L, Edlund A, Johansson T |title=Structure of the human beta-casein encoding gene |journal=Gene |volume=139 |issue= 2 |pages= 193–9 |year= 1994 |pmid= 8112603 |doi=10.1016/0378-1119(94)90754-4 |display-authors=etal}}
*{{cite journal | author=Hansson L, Edlund A, Johansson T, ''et al.'' |title=Structure of the human beta-casein encoding gene. |journal=Gene |volume=139 |issue= 2 |pages= 193-9 |year= 1994 |pmid= 8112603 |doi= }}
*{{cite journal | vauthors=McConkey EH, Menon R, Williams G |title=Assignment of the gene for beta-casein (CSN2) to 4q13 → q21 in humans and 3p13 → p12 in chimpanzees |journal=Cytogenet. Cell Genet. |volume=72 |issue= 1 |pages= 60–2 |year= 1996 |pmid= 8565637 |doi=10.1159/000134163 |display-authors=etal}}
*{{cite journal | author=McConkey EH, Menon R, Williams G, ''et al.'' |title=Assignment of the gene for beta-casein (CSN2) to 4q13 --> q21 in humans and 3p13 --> p12 in chimpanzees. |journal=Cytogenet. Cell Genet. |volume=72 |issue= 1 |pages= 60-2 |year= 1996 |pmid= 8565637 |doi= }}
*{{cite journal | vauthors=Wilmouth RC, Clifton IJ, Robinson CV |title=Structure of a specific acyl-enzyme complex formed between beta-casomorphin-7 and porcine pancreatic elastase |journal=Nat. Struct. Biol. |volume=4 |issue= 6 |pages= 456–62 |year= 1997 |pmid= 9187653 |doi=10.1038/nsb0697-456 |display-authors=etal}}
*{{cite journal | author=Wilmouth RC, Clifton IJ, Robinson CV, ''et al.'' |title=Structure of a specific acyl-enzyme complex formed between beta-casomorphin-7 and porcine pancreatic elastase. |journal=Nat. Struct. Biol. |volume=4 |issue= 6 |pages= 456-62 |year= 1997 |pmid= 9187653 |doi= }}
*{{cite journal | vauthors=Winklehner-Jennewein P, Geymayer S, Lechner J |title=A distal enhancer region in the human beta-casein gene mediates the response to prolactin and glucocorticoid hormones |journal=Gene |volume=217 |issue= 1–2 |pages= 127–39 |year= 1998 |pmid= 9795185 |doi=10.1016/S0378-1119(98)00380-1 |display-authors=etal}}
*{{cite journal | author=Winklehner-Jennewein P, Geymayer S, Lechner J, ''et al.'' |title=A distal enhancer region in the human beta-casein gene mediates the response to prolactin and glucocorticoid hormones. |journal=Gene |volume=217 |issue= 1-2 |pages= 127-39 |year= 1998 |pmid= 9795185 |doi= }}
*{{cite journal | vauthors=Gray CW, Ward RV, Karran E |title=Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response |journal=Eur. J. Biochem. |volume=267 |issue= 18 |pages= 5699–710 |year= 2000 |pmid= 10971580 |doi=10.1046/j.1432-1327.2000.01589.x |display-authors=etal}}
*{{cite journal | author=Gray CW, Ward RV, Karran E, ''et al.'' |title=Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response. |journal=Eur. J. Biochem. |volume=267 |issue= 18 |pages= 5699-710 |year= 2000 |pmid= 10971580 |doi= }}
*{{cite journal | vauthors=Sood SM, Slatter CW |title=Suspension of the calcium-sensitive human beta-caseins by human kappa-casein |journal=J. Dairy Sci. |volume=85 |issue= 6 |pages= 1353–6 |year= 2003 |pmid= 12146463 |doi=10.3168/jds.S0022-0302(02)74200-8 }}
*{{cite journal | author=Sood SM, Slatter CW |title=Suspension of the calcium-sensitive human beta-caseins by human kappa-casein. |journal=J. Dairy Sci. |volume=85 |issue= 6 |pages= 1353-6 |year= 2003 |pmid= 12146463 |doi= }}
*{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | vauthors=Ohashi A, Murata E, Yamamoto K |title=New functions of lactoferrin and beta-casein in mammalian milk as cysteine protease inhibitors |journal=Biochem. Biophys. Res. Commun. |volume=306 |issue= 1 |pages= 98–103 |year= 2003 |pmid= 12788072 |doi=10.1016/S0006-291X(03)00917-3 |display-authors=etal}}
*{{cite journal | author=Ohashi A, Murata E, Yamamoto K, ''et al.'' |title=New functions of lactoferrin and beta-casein in mammalian milk as cysteine protease inhibitors. |journal=Biochem. Biophys. Res. Commun. |volume=306 |issue= 1 |pages= 98-103 |year= 2003 |pmid= 12788072 |doi= }}
*{{cite journal | vauthors=Reimer T, Weiwad M, Schierhorn A |title=Phosphorylation of the N-terminal domain regulates subcellular localization and DNA binding properties of the peptidyl-prolyl cis/trans isomerase hPar14 |journal=J. Mol. Biol. |volume=330 |issue= 5 |pages= 955–66 |year= 2003 |pmid= 12860119 |doi=10.1016/S0022-2836(03)00713-7 |display-authors=etal}}
*{{cite journal | author=Reimer T, Weiwad M, Schierhorn A, ''et al.'' |title=Phosphorylation of the N-terminal domain regulates subcellular localization and DNA binding properties of the peptidyl-prolyl cis/trans isomerase hPar14. |journal=J. Mol. Biol. |volume=330 |issue= 5 |pages= 955-66 |year= 2003 |pmid= 12860119 |doi= }}
*{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | vauthors=Miller SL, DeMaria JE, Freier DO |title=Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor |journal=Mol. Endocrinol. |volume=19 |issue= 4 |pages= 939–49 |year= 2005 |pmid= 15618286 |doi= 10.1210/me.2004-0443 |display-authors=etal}}
*{{cite journal | author=Miller SL, DeMaria JE, Freier DO, ''et al.'' |title=Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor. |journal=Mol. Endocrinol. |volume=19 |issue= 4 |pages= 939-49 |year= 2005 |pmid= 15618286 |doi= 10.1210/me.2004-0443 }}
*{{cite journal | vauthors=Sood SM, Lekic T, Jhawar H |title=Reconstituted micelle formation using reduced, carboxymethylated bovine kappa-casein and human beta-casein |journal=Protein J. |volume=25 |issue= 5 |pages= 352–60 |year= 2007 |pmid= 16947075 |doi= 10.1007/s10930-006-9022-7 |display-authors=etal}}
*{{cite journal | author=Sood SM, Lekic T, Jhawar H, ''et al.'' |title=Reconstituted micelle formation using reduced, carboxymethylated bovine kappa-casein and human beta-casein. |journal=Protein J. |volume=25 |issue= 5 |pages= 352-60 |year= 2007 |pmid= 16947075 |doi= 10.1007/s10930-006-9022-7 }}
*{{cite journal | vauthors=Buser AC, Gass-Handel EK, Wyszomierski SL |title=Progesterone receptor repression of prolactin/signal transducer and activator of transcription 5-mediated transcription of the beta-casein gene in mammary epithelial cells |journal=Mol. Endocrinol. |volume=21 |issue= 1 |pages= 106–25 |year= 2007 |pmid= 16973758 |doi= 10.1210/me.2006-0297 |display-authors=etal}}
*{{cite journal | author=Buser AC, Gass-Handel EK, Wyszomierski SL, ''et al.'' |title=Progesterone receptor repression of prolactin/signal transducer and activator of transcription 5-mediated transcription of the beta-casein gene in mammary epithelial cells. |journal=Mol. Endocrinol. |volume=21 |issue= 1 |pages= 106-25 |year= 2007 |pmid= 16973758 |doi= 10.1210/me.2006-0297 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 12:04, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

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Ensembl

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UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Beta-casein is a protein that in humans is encoded by the CSN2 gene.[1][2] It is in the class of phosphoproteins and generally occurs in mammalian milk.


References

  1. ↑ Menon RS, Chang YF, Jeffers KF, Jones C, Ham RG (Jun 1992). "Regional localization of human beta-casein gene (CSN2) to 4pter-q21". Genomics. 13 (1): 225–6. doi:10.1016/0888-7543(92)90227-J. PMID 1577486.
  2. ↑ "Entrez Gene: CSN2 casein beta".

External links

Further reading



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