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{{ | '''Cullin-2''' is a [[protein]] that in humans is encoded by the ''CUL2'' [[gene]].<ref name="pmid8681378">{{cite journal | vauthors = Kipreos ET, Lander LE, Wing JP, He WW, Hedgecock EM | title = cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family | journal = Cell | volume = 85 | issue = 6 | pages = 829–39 | date = Aug 1996 | pmid = 8681378 | pmc = | doi = 10.1016/S0092-8674(00)81267-2 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CUL2 cullin 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8453| accessdate = }}</ref> | ||
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== Interactions == | |||
< | CUL2 has been shown to [[Protein-protein interaction|interact]] with: | ||
{{ | {{div col|colwidth=20em}} | ||
| | * [[CAND1]],<ref name = pmid18173839/><ref name = pmid12609982>{{cite journal | vauthors = Min KW, Hwang JW, Lee JS, Park Y, Tamura TA, Yoon JB | title = TIP120A associates with cullins and modulates ubiquitin ligase activity | journal = J. Biol. Chem. | volume = 278 | issue = 18 | pages = 15905–10 | date = May 2003 | pmid = 12609982 | doi = 10.1074/jbc.M213070200 }}</ref> | ||
| | * [[DCUN1D1]],<ref name = pmid18826954>{{cite journal | vauthors = Kim AY, Bommeljé CC, Lee BE, Yonekawa Y, Choi L, Morris LG, Huang G, Kaufman A, Ryan RJ, Hao B, Ramanathan Y, Singh B | title = SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation | journal = J. Biol. Chem. | volume = 283 | issue = 48 | pages = 33211–20 | date = Nov 2008 | pmid = 18826954 | pmc = 2586271 | doi = 10.1074/jbc.M804440200 }}</ref> | ||
}} | * [[RBX1]],<ref name = pmid12481031>{{cite journal | vauthors = Dias DC, Dolios G, Wang R, Pan ZQ | title = CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 26 | pages = 16601–6 | date = Dec 2002 | pmid = 12481031 | pmc = 139190 | doi = 10.1073/pnas.252646399 }}</ref><ref name = pmid10230407>{{cite journal | vauthors = Ohta T, Michel JJ, Schottelius AJ, Xiong Y | title = ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity | journal = Mol. Cell | volume = 3 | issue = 4 | pages = 535–41 | date = Apr 1999 | pmid = 10230407 | doi = 10.1016/s1097-2765(00)80482-7}}</ref> | ||
* [[SAP130]],<ref name = pmid18173839>{{cite journal | vauthors = Menon S, Tsuge T, Dohmae N, Takio K, Wei N | title = Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome | journal = BMC Biochem. | volume = 9 | issue = | pages = 1 | pmid = 18173839 | pmc = 2265268 | doi = 10.1186/1471-2091-9-1 }}</ref> | |||
* [[TCEB2]]<ref name = pmid18173839/><ref name = pmid11384984>{{cite journal | vauthors = Kamura T, Burian D, Yan Q, Schmidt SL, Lane WS, Querido E, Branton PE, Shilatifard A, Conaway RC, Conaway JW | title = Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase | journal = J. Biol. Chem. | volume = 276 | issue = 32 | pages = 29748–53 | date = Aug 2001 | pmid = 11384984 | doi = 10.1074/jbc.M103093200 }}</ref> and | |||
* [[Von Hippel-Lindau tumor suppressor]].<ref name = pmid18173839/><ref name = pmid11384984/><ref name = pmid17353931>{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = | pages = 89 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}</ref><ref name = pmid10587522>{{cite journal | vauthors = Ohh M, Takagi Y, Aso T, Stebbins CE, Pavletich NP, Zbar B, Conaway RC, Conaway JW, Kaelin WG | title = Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein | journal = J. Clin. Invest. | volume = 104 | issue = 11 | pages = 1583–91 | date = Dec 1999 | pmid = 10587522 | pmc = 481054 | doi = 10.1172/JCI8161 }}</ref><ref name = pmid19030229>{{cite journal | vauthors = Hacker KE, Lee CM, Rathmell WK | title = VHL type 2B mutations retain VBC complex form and function | journal = PLoS ONE | volume = 3 | issue = 11 | pages = e3801 | pmid = 19030229 | pmc = 2583047 | doi = 10.1371/journal.pone.0003801 | editor1-last = Zhang | editor1-first = Baohong }}</ref> | |||
{{Div col end}} | |||
==References== | == References == | ||
{{reflist| | {{reflist}} | ||
==Further reading== | |||
==External links== | |||
* {{UCSC gene info|CUL2}} | |||
== Further reading == | |||
{{refbegin | 2}} | {{refbegin | 2}} | ||
* {{cite journal | vauthors = Kibel A, Iliopoulos O, DeCaprio JA, Kaelin WG | title = Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C | journal = Science | volume = 269 | issue = 5229 | pages = 1444–6 | year = 1995 | pmid = 7660130 | doi = 10.1126/science.7660130 }} | |||
* {{cite journal | vauthors = Pause A, Lee S, Worrell RA, Chen DY, Burgess WH, Linehan WM, Klausner RD | title = The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 6 | pages = 2156–61 | year = 1997 | pmid = 9122164 | pmc = 20057 | doi = 10.1073/pnas.94.6.2156 }} | |||
*{{cite journal | * {{cite journal | vauthors = Lonergan KM, Iliopoulos O, Ohh M, Kamura T, Conaway RC, Conaway JW, Kaelin WG | title = Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2 | journal = Mol. Cell. Biol. | volume = 18 | issue = 2 | pages = 732–41 | year = 1998 | pmid = 9447969 | pmc = 108784 | doi = }} | ||
*{{cite journal | * {{cite journal | vauthors = Wada H, Yeh ET, Kamitani T | title = Identification of NEDD8-conjugation site in human cullin-2 | journal = Biochem. Biophys. Res. Commun. | volume = 257 | issue = 1 | pages = 100–5 | year = 1999 | pmid = 10092517 | doi = 10.1006/bbrc.1999.0339 }} | ||
*{{cite journal | * {{cite journal | vauthors = Ohta T, Michel JJ, Schottelius AJ, Xiong Y | title = ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity | journal = Mol. Cell | volume = 3 | issue = 4 | pages = 535–41 | year = 1999 | pmid = 10230407 | doi = 10.1016/S1097-2765(00)80482-7 }} | ||
*{{cite journal | * {{cite journal | vauthors = Pause A, Peterson B, Schaffar G, Stearman R, Klausner RD | title = Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 17 | pages = 9533–8 | year = 1999 | pmid = 10449727 | pmc = 22243 | doi = 10.1073/pnas.96.17.9533 }} | ||
*{{cite journal | * {{cite journal | vauthors = Iwai K, Yamanaka K, Kamura T, Minato N, Conaway RC, Conaway JW, Klausner RD, Pause A | title = Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 22 | pages = 12436–41 | year = 1999 | pmid = 10535940 | pmc = 22941 | doi = 10.1073/pnas.96.22.12436 }} | ||
*{{cite journal | * {{cite journal | vauthors = Hori T, Osaka F, Chiba T, Miyamoto C, Okabayashi K, Shimbara N, Kato S, Tanaka K | title = Covalent modification of all members of human cullin family proteins by NEDD8 | journal = Oncogene | volume = 18 | issue = 48 | pages = 6829–34 | year = 2000 | pmid = 10597293 | doi = 10.1038/sj.onc.1203093 }} | ||
*{{cite journal | * {{cite journal | vauthors = Kamura T, Sato S, Iwai K, Czyzyk-Krzeska M, Conaway RC, Conaway JW | title = Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 19 | pages = 10430–5 | year = 2000 | pmid = 10973499 | pmc = 27041 | doi = 10.1073/pnas.190332597 }} | ||
*{{cite journal | * {{cite journal | vauthors = Lyapina S, Cope G, Shevchenko A, Serino G, Tsuge T, Zhou C, Wolf DA, Wei N, Shevchenko A, Deshaies RJ | title = Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome | journal = Science | volume = 292 | issue = 5520 | pages = 1382–5 | year = 2001 | pmid = 11337588 | doi = 10.1126/science.1059780 }} | ||
*{{cite journal | * {{cite journal | vauthors = Kamura T, Burian D, Yan Q, Schmidt SL, Lane WS, Querido E, Branton PE, Shilatifard A, Conaway RC, Conaway JW | title = Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase | journal = J. Biol. Chem. | volume = 276 | issue = 32 | pages = 29748–53 | year = 2001 | pmid = 11384984 | doi = 10.1074/jbc.M103093200 }} | ||
*{{cite journal | * {{cite journal | vauthors = Ohh M, Kim WY, Moslehi JJ, Chen Y, Chau V, Read MA, Kaelin WG | title = An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells | journal = EMBO Rep. | volume = 3 | issue = 2 | pages = 177–82 | year = 2002 | pmid = 11818338 | pmc = 1083969 | doi = 10.1093/embo-reports/kvf028 }} | ||
*{{cite journal | * {{cite journal | vauthors = Min JH, Yang H, Ivan M, Gertler F, Kaelin WG, Pavletich NP | title = Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling | journal = Science | volume = 296 | issue = 5574 | pages = 1886–9 | year = 2002 | pmid = 12004076 | doi = 10.1126/science.1073440 }} | ||
*{{cite journal | * {{cite journal | vauthors = Brower CS, Sato S, Tomomori-Sato C, Kamura T, Pause A, Stearman R, Klausner RD, Malik S, Lane WS, Sorokina I, Roeder RG, Conaway JW, Conaway RC | title = Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 16 | pages = 10353–8 | year = 2002 | pmid = 12149480 | pmc = 124918 | doi = 10.1073/pnas.162424199 }} | ||
*{{cite journal | * {{cite journal | vauthors = Min KW, Hwang JW, Lee JS, Park Y, Tamura TA, Yoon JB | title = TIP120A associates with cullins and modulates ubiquitin ligase activity | journal = J. Biol. Chem. | volume = 278 | issue = 18 | pages = 15905–10 | year = 2003 | pmid = 12609982 | doi = 10.1074/jbc.M213070200 }} | ||
*{{cite journal | * {{cite journal | vauthors = Yan Q, Kamura T, Cai Y, Jin J, Ivan M, Mushegian A, Conaway RC, Conaway JW | title = Identification of Elongin C and Skp1 sequences that determine Cullin selection | journal = J. Biol. Chem. | volume = 279 | issue = 41 | pages = 43019–26 | year = 2004 | pmid = 15280393 | doi = 10.1074/jbc.M408018200 }} | ||
*{{cite journal | |||
*{{cite journal | |||
}} | |||
{{refend}} | {{refend}} | ||
{{ | |||
{{gene-10-stub}} |
Latest revision as of 10:11, 30 August 2017
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Identifiers | |||||||
Aliases | |||||||
External IDs | GeneCards: [1] | ||||||
Orthologs | |||||||
Species | Human | Mouse | |||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
Wikidata | |||||||
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Cullin-2 is a protein that in humans is encoded by the CUL2 gene.[1][2]
Interactions
CUL2 has been shown to interact with:
References
- ↑ Kipreos ET, Lander LE, Wing JP, He WW, Hedgecock EM (Aug 1996). "cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family". Cell. 85 (6): 829–39. doi:10.1016/S0092-8674(00)81267-2. PMID 8681378.
- ↑ "Entrez Gene: CUL2 cullin 2".
- ↑ 3.0 3.1 3.2 3.3 Menon S, Tsuge T, Dohmae N, Takio K, Wei N. "Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome". BMC Biochem. 9: 1. doi:10.1186/1471-2091-9-1. PMC 2265268. PMID 18173839.
- ↑ Min KW, Hwang JW, Lee JS, Park Y, Tamura TA, Yoon JB (May 2003). "TIP120A associates with cullins and modulates ubiquitin ligase activity". J. Biol. Chem. 278 (18): 15905–10. doi:10.1074/jbc.M213070200. PMID 12609982.
- ↑ Kim AY, Bommeljé CC, Lee BE, Yonekawa Y, Choi L, Morris LG, Huang G, Kaufman A, Ryan RJ, Hao B, Ramanathan Y, Singh B (Nov 2008). "SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation". J. Biol. Chem. 283 (48): 33211–20. doi:10.1074/jbc.M804440200. PMC 2586271. PMID 18826954.
- ↑ Dias DC, Dolios G, Wang R, Pan ZQ (Dec 2002). "CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16601–6. doi:10.1073/pnas.252646399. PMC 139190. PMID 12481031.
- ↑ Ohta T, Michel JJ, Schottelius AJ, Xiong Y (Apr 1999). "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity". Mol. Cell. 3 (4): 535–41. doi:10.1016/s1097-2765(00)80482-7. PMID 10230407.
- ↑ 8.0 8.1 Kamura T, Burian D, Yan Q, Schmidt SL, Lane WS, Querido E, Branton PE, Shilatifard A, Conaway RC, Conaway JW (Aug 2001). "Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase". J. Biol. Chem. 276 (32): 29748–53. doi:10.1074/jbc.M103093200. PMID 11384984.
- ↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D. "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
- ↑ Ohh M, Takagi Y, Aso T, Stebbins CE, Pavletich NP, Zbar B, Conaway RC, Conaway JW, Kaelin WG (Dec 1999). "Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein". J. Clin. Invest. 104 (11): 1583–91. doi:10.1172/JCI8161. PMC 481054. PMID 10587522.
- ↑ Hacker KE, Lee CM, Rathmell WK. Zhang B, ed. "VHL type 2B mutations retain VBC complex form and function". PLoS ONE. 3 (11): e3801. doi:10.1371/journal.pone.0003801. PMC 2583047. PMID 19030229.
External links
- Human CUL2 genome location and CUL2 gene details page in the UCSC Genome Browser.
Further reading
- Kibel A, Iliopoulos O, DeCaprio JA, Kaelin WG (1995). "Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C". Science. 269 (5229): 1444–6. doi:10.1126/science.7660130. PMID 7660130.
- Pause A, Lee S, Worrell RA, Chen DY, Burgess WH, Linehan WM, Klausner RD (1997). "The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins". Proc. Natl. Acad. Sci. U.S.A. 94 (6): 2156–61. doi:10.1073/pnas.94.6.2156. PMC 20057. PMID 9122164.
- Lonergan KM, Iliopoulos O, Ohh M, Kamura T, Conaway RC, Conaway JW, Kaelin WG (1998). "Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2". Mol. Cell. Biol. 18 (2): 732–41. PMC 108784. PMID 9447969.
- Wada H, Yeh ET, Kamitani T (1999). "Identification of NEDD8-conjugation site in human cullin-2". Biochem. Biophys. Res. Commun. 257 (1): 100–5. doi:10.1006/bbrc.1999.0339. PMID 10092517.
- Ohta T, Michel JJ, Schottelius AJ, Xiong Y (1999). "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity". Mol. Cell. 3 (4): 535–41. doi:10.1016/S1097-2765(00)80482-7. PMID 10230407.
- Pause A, Peterson B, Schaffar G, Stearman R, Klausner RD (1999). "Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9533–8. doi:10.1073/pnas.96.17.9533. PMC 22243. PMID 10449727.
- Iwai K, Yamanaka K, Kamura T, Minato N, Conaway RC, Conaway JW, Klausner RD, Pause A (1999). "Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex". Proc. Natl. Acad. Sci. U.S.A. 96 (22): 12436–41. doi:10.1073/pnas.96.22.12436. PMC 22941. PMID 10535940.
- Hori T, Osaka F, Chiba T, Miyamoto C, Okabayashi K, Shimbara N, Kato S, Tanaka K (2000). "Covalent modification of all members of human cullin family proteins by NEDD8". Oncogene. 18 (48): 6829–34. doi:10.1038/sj.onc.1203093. PMID 10597293.
- Kamura T, Sato S, Iwai K, Czyzyk-Krzeska M, Conaway RC, Conaway JW (2000). "Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex". Proc. Natl. Acad. Sci. U.S.A. 97 (19): 10430–5. doi:10.1073/pnas.190332597. PMC 27041. PMID 10973499.
- Lyapina S, Cope G, Shevchenko A, Serino G, Tsuge T, Zhou C, Wolf DA, Wei N, Shevchenko A, Deshaies RJ (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science. 292 (5520): 1382–5. doi:10.1126/science.1059780. PMID 11337588.
- Kamura T, Burian D, Yan Q, Schmidt SL, Lane WS, Querido E, Branton PE, Shilatifard A, Conaway RC, Conaway JW (2001). "Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase". J. Biol. Chem. 276 (32): 29748–53. doi:10.1074/jbc.M103093200. PMID 11384984.
- Ohh M, Kim WY, Moslehi JJ, Chen Y, Chau V, Read MA, Kaelin WG (2002). "An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells". EMBO Rep. 3 (2): 177–82. doi:10.1093/embo-reports/kvf028. PMC 1083969. PMID 11818338.
- Min JH, Yang H, Ivan M, Gertler F, Kaelin WG, Pavletich NP (2002). "Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling". Science. 296 (5574): 1886–9. doi:10.1126/science.1073440. PMID 12004076.
- Brower CS, Sato S, Tomomori-Sato C, Kamura T, Pause A, Stearman R, Klausner RD, Malik S, Lane WS, Sorokina I, Roeder RG, Conaway JW, Conaway RC (2002). "Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase". Proc. Natl. Acad. Sci. U.S.A. 99 (16): 10353–8. doi:10.1073/pnas.162424199. PMC 124918. PMID 12149480.
- Min KW, Hwang JW, Lee JS, Park Y, Tamura TA, Yoon JB (2003). "TIP120A associates with cullins and modulates ubiquitin ligase activity". J. Biol. Chem. 278 (18): 15905–10. doi:10.1074/jbc.M213070200. PMID 12609982.
- Yan Q, Kamura T, Cai Y, Jin J, Ivan M, Mushegian A, Conaway RC, Conaway JW (2004). "Identification of Elongin C and Skp1 sequences that determine Cullin selection". J. Biol. Chem. 279 (41): 43019–26. doi:10.1074/jbc.M408018200. PMID 15280393.
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