CUL5: Difference between revisions

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{{Infobox_gene}}
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'''Cullin-5''' is a [[protein]] that in humans is encoded by the ''CUL5'' [[gene]].<ref name="pmid8681378">{{cite journal | vauthors = Kipreos ET, Lander LE, Wing JP, He WW, Hedgecock EM | title = cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family | journal = Cell | volume = 85 | issue = 6 | pages = 829–39 |date=Aug 1996 | pmid = 8681378 | pmc =  | doi =10.1016/S0092-8674(00)81267-2  }}</ref><ref name="pmid9037604">{{cite journal | vauthors = Byrd PJ, Stankovic T, McConville CM, Smith AD, Cooper PR, Taylor AM | title = Identification and analysis of expression of human VACM-1, a cullin gene family member located on chromosome 11q22-23 | journal = Genome Res | volume = 7 | issue = 1 | pages = 71–5 |date=May 1997 | pmid = 9037604 | pmc =  | doi =10.1101/gr.7.1.71  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CUL5 cullin 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8065| accessdate = }}</ref>
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==Discovery==
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The mammalian gene product was originally discovered by [[expression cloning]], due to the protein's ability to mobilize intracellular calcium in response to the peptide hormone [[arginine vasopressin]].  It was first titled VACM-1, for vasopressin-activated, calcium-mobilizing receptor.<ref>{{cite journal  | vauthors=Burnatowska-Hledin MA, Spielman WS, Smith WL |title=Expression cloning of an AVP-activated, calcium-mobilizing receptor from rabbit kidney medulla |journal=Am J Physiol |volume=268 |issue= 6 |pages= F1198–210 |year= 1995 |pmid= 7611460 |doi=  |display-authors=etal}}</ref> Since then, VACM-1 has been shown to be homologous to the [[Cullin]] family of proteins, and was subsequently dubbed cul5.
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==Tissue distribution==
}}
Studies have shown that the cul5 protein is expressed at its highest levels in heart and skeletal tissue, and is specifically expressed in vascular [[endothelium]] and renal [[collecting tubules]].<ref>{{cite journal  | vauthors= Burnatowska-Hledin M, Lazdins IB, Listenberger L |title=VACM-1 receptor is specifically expressed in rabbit vascular endothelium and renal collecting tubule |journal=Am J Physiol |volume=276 |issue= 2 Pt 2 |pages=F199–209 |year= 1999 |pmid= 9950950 |doi=  |display-authors=etal}}</ref>
 
==Function==
Cul5 inhibits cellular proliferation, potentially through its involvement in the [[SOCS]]/ BC-box/ eloBC/ cul5/ RING E3 ligase complex, which functions as part of the [[ubiquitin]] system for protein degradation.<ref>{{cite journal  | vauthors= Petroski MD, Deshaies RJ |title=Function and regulation of cullin-RING E3 ligases |journal=Nature Reviews Molecular Cell Biology  |volume=6 |issue= 1 |pages= 9–21 |year= 2005 |pmid= 15688063 |doi=10.1038/nrm1547  }}</ref>
 
One study have shown that Cul5 plays a role in [[Reelin]] signaling cascade, participating in the [[DAB1]] degradation and thus ensuring the negative feedback mechanism of Reelin signaling during corticogenesis.<!--


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
--><ref name="pmid17974915">{{cite journal |vauthors=Feng L, Allen NS, Simo S, Cooper JA |title=Cullin 5 regulates Dab1 protein levels and neuron positioning during cortical development |journal=[[Genes Dev.]] |volume=21 |issue=21 |pages=2717–30 |date=November 2007 |pmid=17974915 |pmc=2045127 |doi=10.1101/gad.1604207 |url=http://www.genesdev.org/cgi/pmidlookup?view=long&pmid=17974915}}</ref>
{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Cullin 5
| HGNCid = 2556
| Symbol = CUL5
| AltSymbols =; VACM-1; VACM1
| OMIM = 601741
| ECnumber =
| Homologene = 2597
| MGIid = 1922967
| GeneAtlas_image1 = PBB_GE_CUL5_203531_at_tn.png
| GeneAtlas_image2 = PBB_GE_CUL5_203532_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_CUL5_203533_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005262 |text = calcium channel activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component =
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0000082 |text = G1/S transition of mitotic cell cycle}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007050 |text = cell cycle arrest}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0008629 |text = induction of apoptosis by intracellular signals}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8065
    | Hs_Ensembl = ENSG00000166266
    | Hs_RefseqProtein = NP_003469
    | Hs_RefseqmRNA = NM_003478
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 107384618
    | Hs_GenLoc_end = 107483676
    | Hs_Uniprot = Q93034
    | Mm_EntrezGene = 75717
    | Mm_Ensembl = ENSMUSG00000032030
    | Mm_RefseqmRNA = NM_027807
    | Mm_RefseqProtein = NP_082083
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 53379265
    | Mm_GenLoc_end = 53421096
    | Mm_Uniprot = Q05CY9
  }}
}}
'''Cullin 5''', also known as '''CUL5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CUL5 cullin 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8065| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==Interactions==
{{PBB_Summary
CUL5 has been shown to [[Protein-protein interaction|interact]] with [[RBX1]].<ref name=pmid18805092>{{cite journal |last=Duda |first=David M |author2=Borg Laura A |author3=Scott Daniel C |author4=Hunt Harold W |author5=Hammel Michal |author6=Schulman Brenda A |date=Sep 2008 |title=Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation |journal=Cell |volume=134 |issue=6 |pages=995–1006 |publisher= |location = United States| pmid = 18805092 |doi = 10.1016/j.cell.2008.07.022 |pmc=2628631  }}</ref><ref name=pmid10230407>{{cite journal |last=Ohta |first=T |author2=Michel J J |author3=Schottelius A J |author4=Xiong Y  |date=Apr 1999 |title=ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity |journal=Mol. Cell |volume=3 |issue=4 |pages=535–41 |publisher= |location = UNITED STATES| issn = 1097-2765| pmid = 10230407 |doi=10.1016/S1097-2765(00)80482-7 }}</ref>
| section_title =  
| summary_text =  
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CUL5}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Kipreos ET, Lander LE, Wing JP, ''et al.'' |title=cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. |journal=Cell |volume=85 |issue= 6 |pages= 829-39 |year= 1996 |pmid= 8681378 |doi= }}
*{{cite journal  | vauthors=Hillier LD, Lennon G, Becker M |title=Generation and analysis of 280,000 human expressed sequence tags |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=10.1101/gr.6.9.807  |display-authors=etal}}
*{{cite journal  | author=Hillier LD, Lennon G, Becker M, ''et al.'' |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807-28 |year= 1997 |pmid= 8889549 |doi= }}
*{{cite journal  | vauthors=Stankovic T, Byrd PJ, Cooper PR |title=Construction of a transcription map around the gene for ataxia telangiectasia: identification of at least four novel genes |journal=Genomics |volume=40 |issue= 2 |pages= 267–76 |year= 1997 |pmid= 9119394 |doi= 10.1006/geno.1996.4595 |display-authors=etal}}
*{{cite journal  | author=Byrd PJ, Stankovic T, McConville CM, ''et al.'' |title=Identification and analysis of expression of human VACM-1, a cullin gene family member located on chromosome 11q22-23. |journal=Genome Res. |volume=7 |issue= 1 |pages= 71-5 |year= 1997 |pmid= 9037604 |doi=  }}
*{{cite journal  | vauthors=North WG, Fay MJ, Longo KA, Du J |title=Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide |journal=Cancer Res. |volume=58 |issue= 9 |pages= 1866–71 |year= 1998 |pmid= 9581826 |doi=  }}
*{{cite journal  | author=Stankovic T, Byrd PJ, Cooper PR, ''et al.'' |title=Construction of a transcription map around the gene for ataxia telangiectasia: identification of at least four novel genes. |journal=Genomics |volume=40 |issue= 2 |pages= 267-76 |year= 1997 |pmid= 9119394 |doi= 10.1006/geno.1996.4595 }}
*{{cite journal  | vauthors=Burnatowska-Hledin M, Lazdins IB, Listenberger L |title=VACM-1 receptor is specifically expressed in rabbit vascular endothelium and renal collecting tubule |journal=Am. J. Physiol. |volume=276 |issue= 2 Pt 2 |pages= F199–209 |year= 1999 |pmid= 9950950 |doi= |display-authors=etal}}
*{{cite journal  | author=North WG, Fay MJ, Longo KA, Du J |title=Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide. |journal=Cancer Res. |volume=58 |issue= 9 |pages= 1866-71 |year= 1998 |pmid= 9581826 |doi= }}
*{{cite journal  | vauthors=Wada H, Yeh ET, Kamitani T |title=Identification of NEDD8-conjugation site in human cullin-2 |journal=Biochem. Biophys. Res. Commun. |volume=257 |issue= 1 |pages= 100–5 |year= 1999 |pmid= 10092517 |doi= 10.1006/bbrc.1999.0339 }}
*{{cite journal  | author=Burnatowska-Hledin M, Lazdins IB, Listenberger L, ''et al.'' |title=VACM-1 receptor is specifically expressed in rabbit vascular endothelium and renal collecting tubule. |journal=Am. J. Physiol. |volume=276 |issue= 2 Pt 2 |pages= F199-209 |year= 1999 |pmid= 9950950 |doi=  }}
*{{cite journal  | vauthors=Ohta T, Michel JJ, Schottelius AJ, Xiong Y |title=ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity |journal=Mol. Cell |volume=3 |issue= 4 |pages= 535–41 |year= 1999 |pmid= 10230407 |doi=10.1016/S1097-2765(00)80482-7 }}
*{{cite journal  | author=Wada H, Yeh ET, Kamitani T |title=Identification of NEDD8-conjugation site in human cullin-2. |journal=Biochem. Biophys. Res. Commun. |volume=257 |issue= 1 |pages= 100-5 |year= 1999 |pmid= 10092517 |doi= 10.1006/bbrc.1999.0339 }}
*{{cite journal  | vauthors=Hori T, Osaka F, Chiba T |title=Covalent modification of all members of human cullin family proteins by NEDD8 |journal=Oncogene |volume=18 |issue= 48 |pages= 6829–34 |year= 2000 |pmid= 10597293 |doi= 10.1038/sj.onc.1203093 |display-authors=etal}}
*{{cite journal  | author=Ohta T, Michel JJ, Schottelius AJ, Xiong Y |title=ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. |journal=Mol. Cell |volume=3 |issue= 4 |pages= 535-41 |year= 1999 |pmid= 10230407 |doi=  }}
*{{cite journal  | vauthors=Burnatowska-Hledin M, Zhao P, Capps B |title=VACM-1, a cullin gene family member, regulates cellular signaling |journal=Am. J. Physiol., Cell Physiol. |volume=279 |issue= 1 |pages= C266–73 |year= 2000 |pmid= 10898738 |doi=  |display-authors=etal}}
*{{cite journal  | author=Hori T, Osaka F, Chiba T, ''et al.'' |title=Covalent modification of all members of human cullin family proteins by NEDD8. |journal=Oncogene |volume=18 |issue= 48 |pages= 6829-34 |year= 2000 |pmid= 10597293 |doi= 10.1038/sj.onc.1203093 }}
*{{cite journal  | vauthors=Kamura T, Burian D, Yan Q |title=Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase |journal=J. Biol. Chem. |volume=276 |issue= 32 |pages= 29748–53 |year= 2001 |pmid= 11384984 |doi= 10.1074/jbc.M103093200 |display-authors=etal}}
*{{cite journal  | author=Burnatowska-Hledin M, Zhao P, Capps B, ''et al.'' |title=VACM-1, a cullin gene family member, regulates cellular signaling. |journal=Am. J. Physiol., Cell Physiol. |volume=279 |issue= 1 |pages= C266-73 |year= 2000 |pmid= 10898738 |doi=  }}
*{{cite journal  | vauthors=Burnatowska-Hledin M, Zeneberg A, Roulo A |title=Expression of VACM-1 protein in cultured rat adrenal endothelial cells is linked to the cell cycle |journal=Endothelium |volume=8 |issue= 1 |pages= 49–63 |year= 2001 |pmid= 11409851 |doi=  |display-authors=etal}}
*{{cite journal  | author=Kamura T, Burian D, Yan Q, ''et al.'' |title=Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase. |journal=J. Biol. Chem. |volume=276 |issue= 32 |pages= 29748-53 |year= 2001 |pmid= 11384984 |doi= 10.1074/jbc.M103093200 }}
*{{cite journal  | vauthors=Harada JN, Shevchenko A, Shevchenko A |title=Analysis of the Adenovirus E1B-55K-Anchored Proteome Reveals Its Link to Ubiquitination Machinery |journal=J. Virol. |volume=76 |issue= 18 |pages= 9194–206 |year= 2002 |pmid= 12186903 |doi=10.1128/JVI.76.18.9194-9206.2002  | pmc=136464  |display-authors=etal}}
*{{cite journal  | author=Burnatowska-Hledin , Zeneberg A, Roulo A, ''et al.'' |title=Expression of VACM-1 protein in cultured rat adrenal endothelial cells is linked to the cell cycle. |journal=Endothelium |volume=8 |issue= 1 |pages= 49-63 |year= 2001 |pmid= 11409851 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Harada JN, Shevchenko A, Shevchenko A, ''et al.'' |title=Analysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery. |journal=J. Virol. |volume=76 |issue= 18 |pages= 9194-206 |year= 2002 |pmid= 12186903 |doi= }}
*{{cite journal  | vauthors=Liu J, Furukawa M, Matsumoto T, Xiong Y |title=NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases |journal=Mol. Cell |volume=10 |issue= 6 |pages= 1511–8 |year= 2003 |pmid= 12504025 |doi=10.1016/S1097-2765(02)00783-9  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Van Dort C, Zhao P, Parmelee K |title=VACM-1, a cul-5 gene, inhibits cellular growth by a mechanism that involves MAPK and p53 signaling pathways |journal=Am. J. Physiol., Cell Physiol. |volume=285 |issue= 6 |pages= C1386–96 |year= 2004 |pmid= 12917106 |doi= 10.1152/ajpcell.00338.2002 |display-authors=etal}}
*{{cite journal  | author=Liu J, Furukawa M, Matsumoto T, Xiong Y |title=NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases. |journal=Mol. Cell |volume=10 |issue= 6 |pages= 1511-8 |year= 2003 |pmid= 12504025 |doi= }}
*{{cite journal  | vauthors=Yu X, Yu Y, Liu B |title=Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex |journal=Science |volume=302 |issue= 5647 |pages= 1056–60 |year= 2003 |pmid= 14564014 |doi= 10.1126/science.1089591 |display-authors=etal}}
*{{cite journal  | author=Van Dort C, Zhao P, Parmelee K, ''et al.'' |title=VACM-1, a cul-5 gene, inhibits cellular growth by a mechanism that involves MAPK and p53 signaling pathways. |journal=Am. J. Physiol., Cell Physiol. |volume=285 |issue= 6 |pages= C1386-96 |year= 2004 |pmid= 12917106 |doi= 10.1152/ajpcell.00338.2002 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Yu X, Yu Y, Liu B, ''et al.'' |title=Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex. |journal=Science |volume=302 |issue= 5647 |pages= 1056-60 |year= 2003 |pmid= 14564014 |doi= 10.1126/science.1089591 }}
*{{cite journal  | vauthors=Burnatowska-Hledin MA, Kossoris JB, Van Dort CJ |title=T47D breast cancer cell growth is inhibited by expression of VACM-1, a cul-5 gene |journal=Biochem. Biophys. Res. Commun. |volume=319 |issue= 3 |pages= 817–25 |year= 2004 |pmid= 15184056 |doi= 10.1016/j.bbrc.2004.05.057 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal | author=Burnatowska-Hledin MA, Kossoris JB, Van Dort CJ, ''et al.'' |title=T47D breast cancer cell growth is inhibited by expression of VACM-1, a cul-5 gene. |journal=Biochem. Biophys. Res. Commun. |volume=319 |issue= 3 |pages= 817-25 |year= 2004 |pmid= 15184056 |doi= 10.1016/j.bbrc.2004.05.057 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
}}
{{refend}}
{{refend}}


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{{gene-11-stub}}

Latest revision as of 10:11, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Cullin-5 is a protein that in humans is encoded by the CUL5 gene.[1][2][3]

Discovery

The mammalian gene product was originally discovered by expression cloning, due to the protein's ability to mobilize intracellular calcium in response to the peptide hormone arginine vasopressin. It was first titled VACM-1, for vasopressin-activated, calcium-mobilizing receptor.[4] Since then, VACM-1 has been shown to be homologous to the Cullin family of proteins, and was subsequently dubbed cul5.

Tissue distribution

Studies have shown that the cul5 protein is expressed at its highest levels in heart and skeletal tissue, and is specifically expressed in vascular endothelium and renal collecting tubules.[5]

Function

Cul5 inhibits cellular proliferation, potentially through its involvement in the SOCS/ BC-box/ eloBC/ cul5/ RING E3 ligase complex, which functions as part of the ubiquitin system for protein degradation.[6]

One study have shown that Cul5 plays a role in Reelin signaling cascade, participating in the DAB1 degradation and thus ensuring the negative feedback mechanism of Reelin signaling during corticogenesis.[7]

Interactions

CUL5 has been shown to interact with RBX1.[8][9]

References

  1. ↑ Kipreos ET, Lander LE, Wing JP, He WW, Hedgecock EM (Aug 1996). "cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family". Cell. 85 (6): 829–39. doi:10.1016/S0092-8674(00)81267-2. PMID 8681378.
  2. ↑ Byrd PJ, Stankovic T, McConville CM, Smith AD, Cooper PR, Taylor AM (May 1997). "Identification and analysis of expression of human VACM-1, a cullin gene family member located on chromosome 11q22-23". Genome Res. 7 (1): 71–5. doi:10.1101/gr.7.1.71. PMID 9037604.
  3. ↑ "Entrez Gene: CUL5 cullin 5".
  4. ↑ Burnatowska-Hledin MA, Spielman WS, Smith WL, et al. (1995). "Expression cloning of an AVP-activated, calcium-mobilizing receptor from rabbit kidney medulla". Am J Physiol. 268 (6): F1198–210. PMID 7611460.
  5. ↑ Burnatowska-Hledin M, Lazdins IB, Listenberger L, et al. (1999). "VACM-1 receptor is specifically expressed in rabbit vascular endothelium and renal collecting tubule". Am J Physiol. 276 (2 Pt 2): F199–209. PMID 9950950.
  6. ↑ Petroski MD, Deshaies RJ (2005). "Function and regulation of cullin-RING E3 ligases". Nature Reviews Molecular Cell Biology. 6 (1): 9–21. doi:10.1038/nrm1547. PMID 15688063.
  7. ↑ Feng L, Allen NS, Simo S, Cooper JA (November 2007). "Cullin 5 regulates Dab1 protein levels and neuron positioning during cortical development". Genes Dev. 21 (21): 2717–30. doi:10.1101/gad.1604207. PMC 2045127. PMID 17974915.
  8. ↑ Duda, David M; Borg Laura A; Scott Daniel C; Hunt Harold W; Hammel Michal; Schulman Brenda A (Sep 2008). "Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation". Cell. United States. 134 (6): 995–1006. doi:10.1016/j.cell.2008.07.022. PMC 2628631. PMID 18805092.
  9. ↑ Ohta, T; Michel J J; Schottelius A J; Xiong Y (Apr 1999). "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity". Mol. Cell. UNITED STATES. 3 (4): 535–41. doi:10.1016/S1097-2765(00)80482-7. ISSN 1097-2765. PMID 10230407.

External links

Further reading



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