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{{Infobox_gene}}
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'''Dolichyl-diphosphooligosaccharide—protein glycosyltransferase subunit DAD1''' is an [[enzyme]] that in humans is encoded by the ''DAD1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DAD1 defender against cell death 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1603| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Defender against cell death 1
| HGNCid = 2664
| Symbol = DAD1
| AltSymbols =; OST2
| OMIM = 600243
| ECnumber = 
| Homologene = 1027
| MGIid = 101912
| GeneAtlas_image1 = PBB_GE_DAD1_200047_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004579 |text = dolichyl-diphosphooligosaccharide-protein glycotransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0008250 |text = oligosaccharyl transferase complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0018279 |text = protein amino acid N-linked glycosylation via asparagine}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1603
    | Hs_Ensembl = ENSG00000129562
    | Hs_RefseqProtein = NP_001335
    | Hs_RefseqmRNA = NM_001344
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 22103647
    | Hs_GenLoc_end = 22127970
    | Hs_Uniprot = P61803
    | Mm_EntrezGene = 13135
    | Mm_Ensembl = ENSMUSG00000022174
    | Mm_RefseqmRNA = XM_988624
    | Mm_RefseqProtein = XP_993718
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 53193491
    | Mm_GenLoc_end = 53211919
    | Mm_Uniprot = P61804
  }}
}}
'''Defender against cell death 1''', also known as '''DAD1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DAD1 defender against cell death 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1603| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
DAD1, the defender against [[apoptotic]] cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line.  The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis.  DAD1 is believed to be a tightly associated subunit of [[oligosaccharyltransferase]] both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line.  The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis.  DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes.<ref name="entrez">{{cite web | title = Entrez Gene: DAD1 defender against cell death 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1603| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
DAD1 has been shown to [[Protein-protein interaction|interact]] with [[MCL1]].<ref name=pmid10965038>{{cite journal | vauthors = Makishima T, Yoshimi M, Komiyama S, Hara N, Nishimoto T | title = A subunit of the mammalian oligosaccharyltransferase, DAD1, interacts with Mcl-1, one of the bcl-2 protein family | journal = J. Biochem. | volume = 128 | issue = 3 | pages = 399–405  | date = September 2000 | pmid = 10965038 | doi = 10.1093/oxfordjournals.jbchem.a022767 }}</ref>
 
== References ==
{{reflist}}
{{Clear}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Yulug IG, See CG, Fisher EM, Ylug IG | title = The DAD1 protein, whose defect causes apoptotic cell death, maps to human chromosome 14 | journal = Genomics | volume = 26 | issue = 2 | pages = 433–5 | year = 1995 | pmid = 7601483 | doi = 10.1016/0888-7543(95)80241-D }}
| citations =
* {{cite journal | vauthors = Apte SS, Mattei MG, Seldin MF, Olsen BR | title = The highly conserved defender against the death 1 (DAD1) gene maps to human chromosome 14q11-q12 and mouse chromosome 14 and has plant and nematode homologs | journal = FEBS Lett. | volume = 363 | issue = 3 | pages = 304–6 | year = 1995 | pmid = 7737422 | doi = 10.1016/0014-5793(95)00321-Y }}
*{{cite journal | author=Yulug IG, See CG, Fisher EM, Ylug IG |title=The DAD1 protein, whose defect causes apoptotic cell death, maps to human chromosome 14. |journal=Genomics |volume=26 |issue= 2 |pages= 433-5 |year= 1995 |pmid= 7601483 |doi= }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Apte SS, Mattei MG, Seldin MF, Olsen BR |title=The highly conserved defender against the death 1 (DAD1) gene maps to human chromosome 14q11-q12 and mouse chromosome 14 and has plant and nematode homologs. |journal=FEBS Lett. |volume=363 |issue= 3 |pages= 304-6 |year= 1995 |pmid= 7737422 |doi= }}
* {{cite journal | vauthors = Nakashima T, Sekiguchi T, Kuraoka A, Fukushima K, Shibata Y, Komiyama S, Nishimoto T | title = Molecular cloning of a human cDNA encoding a novel protein, DAD1, whose defect causes apoptotic cell death in hamster BHK21 cells | journal = Mol. Cell. Biol. | volume = 13 | issue = 10 | pages = 6367–74 | year = 1993 | pmid = 8413235 | pmc = 364695 | doi =  10.1128/mcb.13.10.6367}}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Kelleher DJ, Gilmore R | title = DAD1, the defender against apoptotic cell death, is a subunit of the mammalian oligosaccharyltransferase | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 10 | pages = 4994–9 | year = 1997 | pmid = 9144178 | pmc = 24619 | doi = 10.1073/pnas.94.10.4994 }}
*{{cite journal | author=Nakashima T, Sekiguchi T, Kuraoka A, ''et al.'' |title=Molecular cloning of a human cDNA encoding a novel protein, DAD1, whose defect causes apoptotic cell death in hamster BHK21 cells. |journal=Mol. Cell. Biol. |volume=13 |issue= 10 |pages= 6367-74 |year= 1993 |pmid= 8413235 |doi=  }}
* {{cite journal | vauthors = Makishima T, Nakashima T, Nagata-Kuno K, Fukushima K, Iida H, Sakaguchi M, Ikehara Y, Komiyama S, Nishimoto T | title = The highly conserved DAD1 protein involved in apoptosis is required for N-linked glycosylation | journal = Genes Cells | volume = 2 | issue = 2 | pages = 129–41 | year = 1997 | pmid = 9167970 | doi = 10.1046/j.1365-2443.1997.1070303.x }}
*{{cite journal | author=Kelleher DJ, Gilmore R |title=DAD1, the defender against apoptotic cell death, is a subunit of the mammalian oligosaccharyltransferase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 10 |pages= 4994-9 |year= 1997 |pmid= 9144178 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Makishima T, Nakashima T, Nagata-Kuno K, ''et al.'' |title=The highly conserved DAD1 protein involved in apoptosis is required for N-linked glycosylation. |journal=Genes Cells |volume=2 |issue= 2 |pages= 129-41 |year= 1997 |pmid= 9167970 |doi= }}
* {{cite journal | vauthors = Zhong XP, Krangel MS | title = Enhancer-blocking activity within the DNase I hypersensitive site 2 to 6 region between the TCR alpha and Dad1 genes | journal = J. Immunol. | volume = 163 | issue = 1 | pages = 295–300 | year = 1999 | pmid = 10384128 | doi =  }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Makishima T, Yoshimi M, Komiyama S, Hara N, Nishimoto T | title = A subunit of the mammalian oligosaccharyltransferase, DAD1, interacts with Mcl-1, one of the bcl-2 protein family | journal = J. Biochem. | volume = 128 | issue = 3 | pages = 399–405 | year = 2000 | pmid = 10965038 | doi = 10.1093/oxfordjournals.jbchem.a022767 }}
*{{cite journal | author=Zhong XP, Krangel MS |title=Enhancer-blocking activity within the DNase I hypersensitive site 2 to 6 region between the TCR alpha and Dad1 genes. |journal=J. Immunol. |volume=163 |issue= 1 |pages= 295-300 |year= 1999 |pmid= 10384128 |doi=  }}
* {{cite journal | vauthors = Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J | title = Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides | journal = Nat. Biotechnol. | volume = 21 | issue = 5 | pages = 566–9 | year = 2003 | pmid = 12665801 | doi = 10.1038/nbt810 }}
*{{cite journal | author=Makishima T, Yoshimi M, Komiyama S, ''et al.'' |title=A subunit of the mammalian oligosaccharyltransferase, DAD1, interacts with Mcl-1, one of the bcl-2 protein family. |journal=J. Biochem. |volume=128 |issue= 3 |pages= 399-405 |year= 2000 |pmid= 10965038 |doi=  }}
* {{cite journal | vauthors = Shibatani T, David LL, McCormack AL, Frueh K, Skach WR | title = Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits | journal = Biochemistry | volume = 44 | issue = 16 | pages = 5982–92 | year = 2005 | pmid = 15835887 | doi = 10.1021/bi047328f }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Shibatani T, David LL, McCormack AL, ''et al.'' |title=Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits. |journal=Biochemistry |volume=44 |issue= 16 |pages= 5982-92 |year= 2005 |pmid= 15835887 |doi= 10.1021/bi047328f }}
}}
{{refend}}
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Latest revision as of 02:32, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Dolichyl-diphosphooligosaccharide—protein glycosyltransferase subunit DAD1 is an enzyme that in humans is encoded by the DAD1 gene.[1]

Function

DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes.[1]

Interactions

DAD1 has been shown to interact with MCL1.[2]

References

  1. ↑ 1.0 1.1 "Entrez Gene: DAD1 defender against cell death 1".
  2. ↑ Makishima T, Yoshimi M, Komiyama S, Hara N, Nishimoto T (September 2000). "A subunit of the mammalian oligosaccharyltransferase, DAD1, interacts with Mcl-1, one of the bcl-2 protein family". J. Biochem. 128 (3): 399–405. doi:10.1093/oxfordjournals.jbchem.a022767. PMID 10965038.

Further reading


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