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{{Infobox_gene}}
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'''Drebrin''' is a [[protein]] that in humans is encoded by the ''DBN1'' [[gene]].<ref name="pmid8216329">{{cite journal | vauthors = Toda M, Shirao T, Minoshima S, Shimizu N, Toya S, Uyemura K | title = Molecular cloning of cDNA encoding human drebrin E and chromosomal mapping of its gene | journal = Biochem Biophys Res Commun | volume = 196 | issue = 1 | pages = 468–72 |date=Nov 1993 | pmid = 8216329 | pmc =  | doi = 10.1006/bbrc.1993.2273 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DBN1 drebrin 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1627| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Drebrin 1
| HGNCid = 2695
| Symbol = DBN1
| AltSymbols =; D0S117E; DKFZp434D064
| OMIM = 126660
| ECnumber = 
| Homologene = 3236
| MGIid = 1931838
| GeneAtlas_image1 = PBB_GE_DBN1_202806_at_tn.png
| GeneAtlas_image2 = PBB_GE_DBN1_217025_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005522 |text = profilin binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}} {{GNF_GO|id=GO:0030425 |text = dendrite}} {{GNF_GO|id=GO:0042641 |text = actomyosin}}
| Process = {{GNF_GO|id=GO:0007015 |text = actin filament organization}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0048168 |text = regulation of neuronal synaptic plasticity}} {{GNF_GO|id=GO:0050773 |text = regulation of dendrite development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1627
    | Hs_Ensembl = ENSG00000113758
    | Hs_RefseqProtein = NP_004386
    | Hs_RefseqmRNA = NM_004395
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 176816220
    | Hs_GenLoc_end = 176833271
    | Hs_Uniprot = Q16643
    | Mm_EntrezGene = 56320
    | Mm_Ensembl = ENSMUSG00000034675
    | Mm_RefseqmRNA = NM_019813
    | Mm_RefseqProtein = NP_062787
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 55483409
    | Mm_GenLoc_end = 55497790
    | Mm_Uniprot = Q9QXS6
  }}
}}
'''Drebrin 1''', also known as '''DBN1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DBN1 drebrin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1627| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: DBN1 drebrin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1627| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene.<ref name="entrez" />
}}
}}
==Model organisms==
[[Model organism]]s have been used in the study of DBN1 function. A conditional [[knockout mouse]] line called ''Dbn1<sup>tm1b(KOMP)Wtsi</sup>'' was generated at the [[Wellcome Trust Sanger Institute]].<ref name="mgp_reference">{{cite journal |title=The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice |author=Gerdin AK |year=2010 |journal=Acta Ophthalmologica|volume=88 |pages=925–7|doi=10.1111/j.1755-3768.2010.4142.x }}</ref> Male and female animals underwent a standardized [[phenotypic screen]]<ref name="IMPCsearch_ref">{{cite web |url=http://www.mousephenotype.org/data/search?q=Dbn1#fq=*:*&facet=gene |title=International Mouse Phenotyping Consortium}}</ref> to determine the effects of deletion.<ref name="pmid21677750">{{cite journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–42 | date = Jun 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}</ref><ref name="mouse_library">{{cite journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | date = Jun 2011 | pmid = 21677718 | doi = 10.1038/474262a }}</ref><ref name="mouse_for_all_reasons">{{cite journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9–13 | date = Jan 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}</ref><ref name="pmid23870131">{{cite journal | vauthors = White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, ((Sanger Institute Mouse Genetics Project)), Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP | title = Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes | journal = Cell | volume = 154 | issue = 2 | pages = 452–64 | year = 2013 | pmid = 23870131 | doi = 10.1016/j.cell.2013.06.022 | pmc=3717207}}</ref> Additional screens performed:  - In-depth immunological phenotyping<ref name="iii_ref">{{cite web |url= http://www.immunophenotyping.org/data/search?keys=Dbn1&field_gene_construct_tid=All |title=Infection and Immunity Immunophenotyping (3i) Consortium}}</ref>
{| class="wikitable sortable collapsible collapsed" border="1" cellpadding="2" style="float: left;" |
|+ ''Dbn1'' knockout mouse phenotype
|-
! Characteristic!! Phenotype
|-
| colspan=2; style="text-align: center;" | All data available at.<ref name="IMPCsearch_ref"/><ref name="iii_ref" />
|-
| Peripheral blood leukocytes 6 Weeks || bgcolor="#488ED3"|Normal
|-
| ''[[Haematology]]'' 6 Weeks || bgcolor="#488ED3"|Normal
|-
| Homozygous viability at P14 || bgcolor="#C40000"|Abnormal
|-
| [[Recessive]] lethal study || bgcolor="#488ED3"|Normal
|-
| Body weight || bgcolor="#488ED3"|Normal
|-
| Neurological assessment || bgcolor="#488ED3"|Normal
|-
| Grip strength || bgcolor="#488ED3"|Normal
|-
| [[Dysmorphology]] || bgcolor="#488ED3"|Normal
|-
| [[Indirect calorimetry]] || bgcolor="#488ED3"|Normal
|-
| [[Glucose tolerance test]] || bgcolor="#488ED3"|Normal
|-
| [[Auditory brainstem response]] || bgcolor="#488ED3"|Normal
|-
| [[Dual-energy X-ray absorptiometry|DEXA]] || bgcolor="#488ED3"|Normal
|-
| [[Radiography]] || bgcolor="#488ED3"|Normal
|-
| Eye morphology || bgcolor="#488ED3"|Normal
|-
| [[Clinical chemistry]] || bgcolor="#488ED3"|Normal
|-
| ''[[Haematology]]'' 16 Weeks || bgcolor="#488ED3"|Normal
|-
| Peripheral blood leukocytes 16 Weeks || bgcolor="#488ED3"|Normal
|-
| Heart weight || bgcolor="#488ED3"|Normal
|-
| ''[[Salmonella]]'' infection || bgcolor="#488ED3"|Normal
|-
| Cytotoxic T Cell Function || bgcolor="#488ED3"|Normal
|-
| Spleen Immunophenotyping || bgcolor="#488ED3"|Normal
|-
| Mesenteric Lymph Node Immunophenotyping || bgcolor="#488ED3"|Normal
|-
| Bone Marrow Immunophenotyping || bgcolor="#488ED3"|Normal
|-
| Epidermal Immune Composition || bgcolor="#488ED3"|Normal
|-
| Trichuris Challenge || bgcolor="#488ED3"|Normal
|-
|}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Shirao T |title=The roles of microfilament-associated proteins, drebrins, in brain morphogenesis: a review. |journal=J. Biochem. |volume=117 |issue= 2 |pages= 231-6 |year= 1995 |pmid= 7608104 |doi=  }}
*{{cite journal  | author=Shirao T |title=The roles of microfilament-associated proteins, drebrins, in brain morphogenesis: a review |journal=J. Biochem. |volume=117 |issue= 2 |pages= 231–6 |year= 1995 |pmid= 7608104 |doi=10.1093/jb/117.2.231 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
*{{cite journal  | author=Toda M, Shirao T, Minoshima S, ''et al.'' |title=Molecular cloning of cDNA encoding human drebrin E and chromosomal mapping of its gene. |journal=Biochem. Biophys. Res. Commun. |volume=196 |issue= 1 |pages= 468-72 |year= 1993 |pmid= 8216329 |doi= 10.1006/bbrc.1993.2273 }}
*{{cite journal  | vauthors=Harigaya Y, Shoji M, Shirao T, Hirai S |title=Disappearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer's disease |journal=J. Neurosci. Res. |volume=43 |issue= 1 |pages= 87–92 |year= 1996 |pmid= 8838578 |doi= 10.1002/jnr.490430111 }}
*{{cite journal  | author=Harigaya Y, Shoji M, Shirao T, Hirai S |title=Disappearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer's disease. |journal=J. Neurosci. Res. |volume=43 |issue= 1 |pages= 87-92 |year= 1996 |pmid= 8838578 |doi= 10.1002/jnr.490430111 }}
*{{cite journal  | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | vauthors=Mammoto A, Sasaki T, Asakura T |title=Interactions of drebrin and gephyrin with profilin |journal=Biochem. Biophys. Res. Commun. |volume=243 |issue= 1 |pages= 86–9 |year= 1998 |pmid= 9473484 |doi= 10.1006/bbrc.1997.8068 |display-authors=etal}}
*{{cite journal  | author=Mammoto A, Sasaki T, Asakura T, ''et al.'' |title=Interactions of drebrin and gephyrin with profilin. |journal=Biochem. Biophys. Res. Commun. |volume=243 |issue= 1 |pages= 86-9 |year= 1998 |pmid= 9473484 |doi= 10.1006/bbrc.1997.8068 }}
*{{cite journal  | vauthors=Hayashi K, Ishikawa R, Kawai-Hirai R |title=Domain analysis of the actin-binding and actin-remodeling activities of drebrin |journal=Exp. Cell Res. |volume=253 |issue= 2 |pages= 673–80 |year= 2000 |pmid= 10585290 |doi= 10.1006/excr.1999.4663 |display-authors=etal}}
*{{cite journal  | author=Hayashi K, Ishikawa R, Kawai-Hirai R, ''et al.'' |title=Domain analysis of the actin-binding and actin-remodeling activities of drebrin. |journal=Exp. Cell Res. |volume=253 |issue= 2 |pages= 673-80 |year= 2000 |pmid= 10585290 |doi= 10.1006/excr.1999.4663 }}
*{{cite journal  | vauthors=Peitsch WK, Grund C, Kuhn C |title=Drebrin is a widespread actin-associating protein enriched at junctional plaques, defining a specific microfilament anchorage system in polar epithelial cells |journal=Eur. J. Cell Biol. |volume=78 |issue= 11 |pages= 767–78 |year= 2000 |pmid= 10604653 |doi=  10.1016/s0171-9335(99)80027-2|display-authors=etal}}
*{{cite journal  | author=Peitsch WK, Grund C, Kuhn C, ''et al.'' |title=Drebrin is a widespread actin-associating protein enriched at junctional plaques, defining a specific microfilament anchorage system in polar epithelial cells. |journal=Eur. J. Cell Biol. |volume=78 |issue= 11 |pages= 767-78 |year= 2000 |pmid= 10604653 |doi=  }}
*{{cite journal  | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal  | vauthors=Wiemann S, Weil B, Wellenreuther R |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072 |display-authors=etal}}
*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal  | vauthors=Simpson JC, Wellenreuther R, Poustka A |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 | pmc=1083732 |display-authors=etal}}
*{{cite journal  | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
*{{cite journal  | vauthors=Kobayashi S, Shirao T, Sasaki T |title=Drebrin expression is increased in spinal motoneurons of rats after axotomy |journal=Neurosci. Lett. |volume=311 |issue= 3 |pages= 165–8 |year= 2001 |pmid= 11578820 |doi=10.1016/S0304-3940(01)02155-3 }}
*{{cite journal  | author=Kobayashi S, Shirao T, Sasaki T |title=Drebrin expression is increased in spinal motoneurons of rats after axotomy. |journal=Neurosci. Lett. |volume=311 |issue= 3 |pages= 165-8 |year= 2001 |pmid= 11578820 |doi=  }}
*{{cite journal  | vauthors=Shim KS, Lubec G |title=Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome |journal=Neurosci. Lett. |volume=324 |issue= 3 |pages= 209–12 |year= 2002 |pmid= 12009525 |doi=10.1016/S0304-3940(02)00210-0 }}
*{{cite journal  | author=Shim KS, Lubec G |title=Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome. |journal=Neurosci. Lett. |volume=324 |issue= 3 |pages= 209-12 |year= 2002 |pmid= 12009525 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Gevaert K, Goethals M, Martens L |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 |display-authors=etal}}
*{{cite journal  | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal  | vauthors=Shiraishi Y, Mizutani A, Mikoshiba K, Furuichi T |title=Coincidence in dendritic clustering and synaptic targeting of homer proteins and NMDA receptor complex proteins NR2B and PSD95 during development of cultured hippocampal neurons |journal=Mol. Cell. Neurosci. |volume=22 |issue= 2 |pages= 188–201 |year= 2003 |pmid= 12676529 |doi=10.1016/S1044-7431(03)00037-X }}
*{{cite journal  | author=Shiraishi Y, Mizutani A, Mikoshiba K, Furuichi T |title=Coincidence in dendritic clustering and synaptic targeting of homer proteins and NMDA receptor complex proteins NR2B and PSD95 during development of cultured hippocampal neurons. |journal=Mol. Cell. Neurosci. |volume=22 |issue= 2 |pages= 188-201 |year= 2003 |pmid= 12676529 |doi=  }}
*{{cite journal  | vauthors=Peitsch WK, Hofmann I, Endlich N |title=Cell biological and biochemical characterization of drebrin complexes in mesangial cells and podocytes of renal glomeruli |journal=J. Am. Soc. Nephrol. |volume=14 |issue= 6 |pages= 1452–63 |year= 2003 |pmid= 12761245 |doi=10.1097/01.ASN.0000069222.63700.DE |display-authors=etal}}
*{{cite journal  | author=Peitsch WK, Hofmann I, Endlich N, ''et al.'' |title=Cell biological and biochemical characterization of drebrin complexes in mesangial cells and podocytes of renal glomeruli. |journal=J. Am. Soc. Nephrol. |volume=14 |issue= 6 |pages= 1452-63 |year= 2003 |pmid= 12761245 |doi=  }}
*{{cite journal  | vauthors=Salazar MA, Kwiatkowski AV, Pellegrini L |title=Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton |journal=J. Biol. Chem. |volume=278 |issue= 49 |pages= 49031–43 |year= 2004 |pmid= 14506234 |doi= 10.1074/jbc.M308104200 |display-authors=etal}}
*{{cite journal  | author=Salazar MA, Kwiatkowski AV, Pellegrini L, ''et al.'' |title=Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton. |journal=J. Biol. Chem. |volume=278 |issue= 49 |pages= 49031-43 |year= 2004 |pmid= 14506234 |doi= 10.1074/jbc.M308104200 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 18:15, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Drebrin is a protein that in humans is encoded by the DBN1 gene.[1][2]

The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene.[2]

Model organisms

Model organisms have been used in the study of DBN1 function. A conditional knockout mouse line called Dbn1tm1b(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute.[3] Male and female animals underwent a standardized phenotypic screen[4] to determine the effects of deletion.[5][6][7][8] Additional screens performed: - In-depth immunological phenotyping[9]

References

  1. ↑ Toda M, Shirao T, Minoshima S, Shimizu N, Toya S, Uyemura K (Nov 1993). "Molecular cloning of cDNA encoding human drebrin E and chromosomal mapping of its gene". Biochem Biophys Res Commun. 196 (1): 468–72. doi:10.1006/bbrc.1993.2273. PMID 8216329.
  2. ↑ 2.0 2.1 "Entrez Gene: DBN1 drebrin 1".
  3. ↑ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  4. ↑ 4.0 4.1 "International Mouse Phenotyping Consortium".
  5. ↑ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  6. ↑ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  7. ↑ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  8. ↑ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Sanger Institute Mouse Genetics Project, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
  9. ↑ 9.0 9.1 "Infection and Immunity Immunophenotyping (3i) Consortium".

Further reading


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