DLG5: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Disks large homolog 5''' is a [[protein]] that in humans is encoded by the ''DLG5'' [[gene]].<ref name="pmid9738934">{{cite journal | vauthors = Nakamura H, Sudo T, Tsuiki H, Miyake H, Morisaki T, Sasaki J, Masuko N, Kochi M, Ushio Y, Saya H | title = Identification of a novel human homolog of the Drosophila dlg, P-dlg, specifically expressed in the gland tissues and interacting with p55 | journal = FEBS Lett | volume = 433 | issue = 1-2 | pages = 63–7 |date=Sep 1998 | pmid = 9738934 | pmc =  | doi =10.1016/S0014-5793(98)00882-5  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DLG5 discs, large homolog 5 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9231| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_DLG5_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1uit.
| PDB = {{PDB2|1uit}}
| Name = Discs, large homolog 5 (Drosophila)
| HGNCid = 2904
| Symbol = DLG5
| AltSymbols =; KIAA0583; LP-DLG; P-DLG5; PDLG
| OMIM = 604090
| ECnumber = 
| Homologene = 3486
| MGIid = 1918478
| GeneAtlas_image1 = PBB_GE_DLG5_201681_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0030159 |text = receptor signaling complex scaffold activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0016337 |text = cell-cell adhesion}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9231
    | Hs_Ensembl = ENSG00000151208
    | Hs_RefseqProtein = NP_004738
    | Hs_RefseqmRNA = NM_004747
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 79220557
    | Hs_GenLoc_end = 79356384
    | Hs_Uniprot = Q8TDM6
    | Mm_EntrezGene = 71228
    | Mm_Ensembl = ENSMUSG00000021782
    | Mm_RefseqmRNA = XM_907765
    | Mm_RefseqProtein = XP_912858
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 22966420
    | Mm_GenLoc_end = 23077915
    | Mm_Uniprot = 
  }}
}}
'''Discs, large homolog 5 (Drosophila)''', also known as '''DLG5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DLG5 discs, large homolog 5 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9231| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the family of discs large (DLG) homologs, a subset of the [[membrane-associated guanylate kinase]] (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of [[adherens junctions]] and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: DLG5 discs, large homolog 5 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9231| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
DLG5 has been shown to [[Protein-protein interaction|interact]] with [[SORBS3]].<ref name="pmid12657639">{{cite journal | vauthors = Wakabayashi M, Ito T, Mitsushima M, Aizawa S, Ueda K, Amachi T, Kioka N | title = Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact | journal = J. Biol. Chem. | volume = 278 | issue = 24 | pages = 21709–14 | year = 2003 | pmid = 12657639 | doi = 10.1074/jbc.M211004200 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Newman B, Siminovitch KA |title=Recent advances in the genetics of inflammatory bowel disease. |journal=Curr. Opin. Gastroenterol. |volume=21 |issue= 4 |pages= 401–7 |year= 2005 |pmid= 15930978 |doi=  }}
| citations =
*{{cite journal  | vauthors=Funke L, Dakoji S, Bredt DS |title=Membrane-associated guanylate kinases regulate adhesion and plasticity at cell junctions. |journal=Annu. Rev. Biochem. |volume=74 |issue=  1|pages= 219–45 |year= 2005 |pmid= 15952887 |doi= 10.1146/annurev.biochem.74.082803.133339 }}
*{{cite journal  | author=Newman B, Siminovitch KA |title=Recent advances in the genetics of inflammatory bowel disease. |journal=Curr. Opin. Gastroenterol. |volume=21 |issue= 4 |pages= 401-7 |year= 2005 |pmid= 15930978 |doi=  }}
*{{cite journal  | vauthors=Friedrichs F, Stoll M |title=Role of discs large homolog 5. |journal=World J. Gastroenterol. |volume=12 |issue= 23 |pages= 3651–6 |year= 2006 |pmid= 16773680 |doi=  }}
*{{cite journal  | author=Funke L, Dakoji S, Bredt DS |title=Membrane-associated guanylate kinases regulate adhesion and plasticity at cell junctions. |journal=Annu. Rev. Biochem. |volume=74 |issue=  |pages= 219-45 |year= 2005 |pmid= 15952887 |doi= 10.1146/annurev.biochem.74.082803.133339 }}
*{{cite journal  | vauthors=Nagase T, Ishikawa K, Miyajima N |title=Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 1 |pages= 31–9 |year= 1998 |pmid= 9628581 |doi=10.1093/dnares/5.1.31  |display-authors=etal}}
*{{cite journal  | author=Friedrichs F, Stoll M |title=Role of discs large homolog 5. |journal=World J. Gastroenterol. |volume=12 |issue= 23 |pages= 3651-6 |year= 2006 |pmid= 16773680 |doi=  }}
*{{cite journal  | vauthors=Bowles KR, Abraham SE, Brugada R |title=Construction of a high-resolution physical map of the chromosome 10q22-q23 dilated cardiomyopathy locus and analysis of candidate genes. |journal=Genomics |volume=67 |issue= 2 |pages= 109–27 |year= 2000 |pmid= 10903836 |doi= 10.1006/geno.2000.6242 |display-authors=etal}}
*{{cite journal  | author=Nagase T, Ishikawa K, Miyajima N, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 1 |pages= 31-9 |year= 1998 |pmid= 9628581 |doi= }}
*{{cite journal  | vauthors=Shah G, Brugada R, Gonzalez O |title=The cloning, genomic organization and tissue expression profile of the human DLG5 gene. |journal=BMC Genomics |volume=3 |pages= 6 |year= 2003 |pmid= 11876824 |doi=10.1186/1471-2164-3-6  | pmc=77411 |display-authors=etal}}
*{{cite journal  | author=Nakamura H, Sudo T, Tsuiki H, ''et al.'' |title=Identification of a novel human homolog of the Drosophila dlg, P-dlg, specifically expressed in the gland tissues and interacting with p55. |journal=FEBS Lett. |volume=433 |issue= 1-2 |pages= 63-7 |year= 1998 |pmid= 9738934 |doi= }}
*{{cite journal  | vauthors=Purmonen S, Ahola TM, Pennanen P |title=HDLG5/KIAA0583, encoding a MAGUK-family protein, is a primary progesterone target gene in breast cancer cells. |journal=Int. J. Cancer |volume=102 |issue= 1 |pages= 1–6 |year= 2002 |pmid= 12353226 |doi= 10.1002/ijc.10665 |display-authors=etal}}
*{{cite journal  | author=Bowles KR, Abraham SE, Brugada R, ''et al.'' |title=Construction of a high-resolution physical map of the chromosome 10q22-q23 dilated cardiomyopathy locus and analysis of candidate genes. |journal=Genomics |volume=67 |issue= 2 |pages= 109-27 |year= 2000 |pmid= 10903836 |doi= 10.1006/geno.2000.6242 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Shah G, Brugada R, Gonzalez O, ''et al.'' |title=The cloning, genomic organization and tissue expression profile of the human DLG5 gene. |journal=BMC Genomics |volume=3 |issue= 1 |pages= 6 |year= 2003 |pmid= 11876824 |doi=  }}
*{{cite journal  | vauthors=Wakabayashi M, Ito T, Mitsushima M |title=Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact. |journal=J. Biol. Chem. |volume=278 |issue= 24 |pages= 21709–14 |year= 2003 |pmid= 12657639 |doi= 10.1074/jbc.M211004200 |display-authors=etal}}
*{{cite journal  | author=Purmonen S, Ahola TM, Pennanen P, ''et al.'' |title=HDLG5/KIAA0583, encoding a MAGUK-family protein, is a primary progesterone target gene in breast cancer cells. |journal=Int. J. Cancer |volume=102 |issue= 1 |pages= 1-6 |year= 2002 |pmid= 12353226 |doi= 10.1002/ijc.10665 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Stoll M, Corneliussen B, Costello CM |title=Genetic variation in DLG5 is associated with inflammatory bowel disease. |journal=Nat. Genet. |volume=36 |issue= 5 |pages= 476–80 |year= 2004 |pmid= 15107852 |doi= 10.1038/ng1345 |display-authors=etal}}
*{{cite journal  | author=Wakabayashi M, Ito T, Mitsushima M, ''et al.'' |title=Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact. |journal=J. Biol. Chem. |volume=278 |issue= 24 |pages= 21709-14 |year= 2003 |pmid= 12657639 |doi= 10.1074/jbc.M211004200 }}
*{{cite journal  | vauthors=Deloukas P, Earthrowl ME, Grafham DV |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Stoll M, Corneliussen B, Costello CM, ''et al.'' |title=Genetic variation in DLG5 is associated with inflammatory bowel disease. |journal=Nat. Genet. |volume=36 |issue= 5 |pages= 476-80 |year= 2004 |pmid= 15107852 |doi= 10.1038/ng1345 }}
*{{cite journal  | vauthors=Taniuchi K, Nakagawa H, Nakamura T |title=Down-regulation of RAB6KIFL/KIF20A, a kinesin involved with membrane trafficking of discs large homologue 5, can attenuate growth of pancreatic cancer cell. |journal=Cancer Res. |volume=65 |issue= 1 |pages= 105–12 |year= 2005 |pmid= 15665285 |doi=  |display-authors=etal}}
*{{cite journal  | author=Deloukas P, Earthrowl ME, Grafham DV, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375-81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 }}
*{{cite journal  | vauthors=Daly MJ, Pearce AV, Farwell L |title=Association of DLG5 R30Q variant with inflammatory bowel disease. |journal=Eur. J. Hum. Genet. |volume=13 |issue= 7 |pages= 835–9 |year= 2005 |pmid= 15841097 |doi= 10.1038/sj.ejhg.5201403 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Tenesa A, Noble C, Satsangi J, Dunlop M |title=Association of DLG5 and inflammatory bowel disease across populations. |journal=Eur. J. Hum. Genet. |volume=14 |issue= 3 |pages= 259–60; author reply 260–1 |year= 2006 |pmid= 16391570 |doi= 10.1038/sj.ejhg.5201516 }}
*{{cite journal  | author=Taniuchi K, Nakagawa H, Nakamura T, ''et al.'' |title=Down-regulation of RAB6KIFL/KIF20A, a kinesin involved with membrane trafficking of discs large homologue 5, can attenuate growth of pancreatic cancer cell. |journal=Cancer Res. |volume=65 |issue= 1 |pages= 105-12 |year= 2005 |pmid= 15665285 |doi=  }}
*{{cite journal  | vauthors=Gazouli M, Mantzaris G, Archimandritis AJ |title=Single nucleotide polymorphisms of OCTN1, OCTN2, and DLG5 genes in Greek patients with Crohn's disease. |journal=World J. Gastroenterol. |volume=11 |issue= 47 |pages= 7525–30 |year= 2006 |pmid= 16437728 |doi=  |display-authors=etal}}
*{{cite journal  | author=Daly MJ, Pearce AV, Farwell L, ''et al.'' |title=Association of DLG5 R30Q variant with inflammatory bowel disease. |journal=Eur. J. Hum. Genet. |volume=13 |issue= 7 |pages= 835-9 |year= 2005 |pmid= 15841097 |doi= 10.1038/sj.ejhg.5201403 }}
*{{cite journal  | author=Tenesa A, Noble C, Satsangi J, Dunlop M |title=Association of DLG5 and inflammatory bowel disease across populations. |journal=Eur. J. Hum. Genet. |volume=14 |issue= 3 |pages= 259-60; author reply 260-1 |year= 2006 |pmid= 16391570 |doi= 10.1038/sj.ejhg.5201516 }}
*{{cite journal  | author=Gazouli M, Mantzaris G, Archimandritis AJ, ''et al.'' |title=Single nucleotide polymorphisms of OCTN1, OCTN2, and DLG5 genes in Greek patients with Crohn's disease. |journal=World J. Gastroenterol. |volume=11 |issue= 47 |pages= 7525-30 |year= 2006 |pmid= 16437728 |doi=  }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=9231}}
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{{gene-10-stub}}

Latest revision as of 18:31, 30 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Disks large homolog 5 is a protein that in humans is encoded by the DLG5 gene.[1][2]

Function

This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined.[2]

Interactions

DLG5 has been shown to interact with SORBS3.[3]

References

  1. ↑ Nakamura H, Sudo T, Tsuiki H, Miyake H, Morisaki T, Sasaki J, Masuko N, Kochi M, Ushio Y, Saya H (Sep 1998). "Identification of a novel human homolog of the Drosophila dlg, P-dlg, specifically expressed in the gland tissues and interacting with p55". FEBS Lett. 433 (1–2): 63–7. doi:10.1016/S0014-5793(98)00882-5. PMID 9738934.
  2. ↑ 2.0 2.1 "Entrez Gene: DLG5 discs, large homolog 5 (Drosophila)".
  3. ↑ Wakabayashi M, Ito T, Mitsushima M, Aizawa S, Ueda K, Amachi T, Kioka N (2003). "Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact". J. Biol. Chem. 278 (24): 21709–14. doi:10.1074/jbc.M211004200. PMID 12657639.

Further reading


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