DYRK1A: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Dual specificity tyrosine-phosphorylation-regulated kinase 1A''' is an [[enzyme]] that in humans is encoded by the ''DYRK1A'' [[gene]].<ref name="pmid9284911">{{cite journal | vauthors = Guimera J, Pritchard M, Nadal M, Estivill X | title = Minibrain (MNBH) is a single copy gene mapping to human chromosome 21q22.2 | journal = Cytogenet Cell Genet | volume = 77 | issue = 3–4 | pages = 182–4 |date=Sep 1997 | pmid = 9284911 | pmc =  | doi =10.1159/000134571  }}</ref> Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region.<ref name="Bol_2011">{{cite journal | vauthors = Bol SM, Moerland PD, Limou S, van Remmerden Y, Coulonges C, van Manen D, Herbeck JT, Fellay J, Sieberer M, Sietzema JG, van 't Slot R, Martinson J, Zagury JF, Schuitemaker H, van 't Wout AB | title = Genome-wide association study identifies single nucleotide polymorphism in DYRK1A associated with replication of HIV-1 in monocyte-derived macrophages | journal = PLoS ONE | volume = 6 | issue = 2 | pages = e17190 | year = 2011 | pmid = 21364930 | pmc = 3045405 | doi = 10.1371/journal.pone.0017190 | url = }}</ref> These variants encode at least five different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1859| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
| HGNCid = 3091
| Symbol = DYRK1A
| AltSymbols =; DYRK; DYRK1; HP86; MNB; MNBH
| OMIM = 600855
| ECnumber = 
| Homologene = 55576
| MGIid = 1330299
| GeneAtlas_image1 = PBB_GE_DYRK1A_211079_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_DYRK1A_209033_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_DYRK1A_211541_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004715 |text = non-membrane spanning protein tyrosine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0043621 |text = protein self-association}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0016607 |text = nuclear speck}}
| Process = {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0018108 |text = peptidyl-tyrosine phosphorylation}} {{GNF_GO|id=GO:0046777 |text = protein amino acid autophosphorylation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1859
    | Hs_Ensembl = ENSG00000157540
    | Hs_RefseqProtein = NP_001387
    | Hs_RefseqmRNA = NM_001396
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 21
    | Hs_GenLoc_start = 37713077
    | Hs_GenLoc_end = 37809347
    | Hs_Uniprot = Q13627
    | Mm_EntrezGene = 13548
    | Mm_Ensembl = ENSMUSG00000022897
    | Mm_RefseqmRNA = NM_007890
    | Mm_RefseqProtein = NP_031916
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 94720258
    | Mm_GenLoc_end = 94801197
    | Mm_Uniprot = Q61158
  }}
}}
'''Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A''', also known as '''DYRK1A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1859| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
DYRK1A is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a [[nuclear targeting signal]] sequence, a [[protein kinase]] domain, a [[leucine zipper]] motif, and a highly conservative 13-consecutive-[[histidine]] repeat. It catalyzes its [[autophosphorylation]] on [[serine]]/[[threonine]] and [[tyrosine]] residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene.<ref name="entrez" />
{{PBB_Summary
 
| section_title =
Dyrk1a has also been shown to modulate plasma [[homocysteine]] level in a mouse model of overexpression.<ref name="pmid19844572">{{cite journal | vauthors = Noll C, Planque C, Ripoll C, Guedj F, Diez A, Ducros V, Belin N, Duchon A, Paul JL, Badel A, de Freminville B, Grattau Y, Bléhaut H, Herault Y, Janel N, Delabar JM | title = DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase | journal = PLoS ONE | volume = 4 | issue = 10 | pages = e7540 | year = 2009 | pmid = 19844572 | pmc = 2760102 | doi = 10.1371/journal.pone.0007540 }}</ref>
| summary_text = This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1859| accessdate = }}</ref>
 
}}
== Clinical significance ==
 
DYRK1A is localized in the [[Down syndrome]] critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome.<ref name="entrez"/> In addition, a polymorphism (SNP) in ''DYRK1A'' was found to be associated with HIV-1 replication in monocyte-derived macrophages, as well as with slower progression to AIDS in two independent cohorts of HIV-1-infected individuals.<ref name="Bol_2011"/>  Mutations in DYRK1A are also associated with [[Autism spectrum disorder]].<ref name="pmid23160955">{{cite journal | vauthors = O'Roak BJ, Vives L, Fu W, Egertson JD, Stanaway IB, Phelps IG, Carvill G, Kumar A, Lee C, Ankenman K, Munson J, Hiatt JB, Turner EH, Levy R, O'Day DR, Krumm N, Coe BP, Martin BK, Borenstein E, Nickerson DA, Mefford HC, Doherty D, Akey JM, Bernier R, Eichler EE, Shendure J | title = Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders | journal = Science | volume = 338 | issue = 6114 | pages = 1619–22 |date=December 2012 | pmid = 23160955 | doi = 10.1126/science.1227764 | pmc=3528801}}</ref>
 
==Interactions==
DYRK1A has been shown to [[Protein-protein interaction|interact]] with [[WDR68]].<ref name="pmid14593110">{{cite journal | vauthors = Skurat AV, Dietrich AD | title = Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases | journal = J. Biol. Chem. | volume = 279 | issue = 4 | pages = 2490–8 |date=January 2004 | pmid = 14593110 | doi = 10.1074/jbc.M301769200 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Hämmerle B, Elizalde C, Galceran J |title=The MNB/DYRK1A protein kinase: neurobiological functions and Down syndrome implications |journal=J. Neural Transm. Suppl. |volume= |issue= 67 |pages= 129–37 |year= 2004 |pmid= 15068245 |doi=  10.1007/978-3-7091-6721-2_11|display-authors=etal}}
| citations =
*{{cite journal  | vauthors=Galceran J, de Graaf K, Tejedor FJ, Becker W |title=The MNB/DYRK1A protein kinase: genetic and biochemical properties |journal=J. Neural Transm. Suppl. |volume= |issue= 67 |pages= 139–48 |year= 2004 |pmid= 15068246 |doi=  10.1007/978-3-7091-6721-2_12}}
*{{cite journal  | author=Hämmerle B, Elizalde C, Galceran J, ''et al.'' |title=The MNB/DYRK1A protein kinase: neurobiological functions and Down syndrome implications. |journal=J. Neural Transm. Suppl. |volume= |issue= 67 |pages= 129-37 |year= 2004 |pmid= 15068245 |doi=  }}
*{{cite journal  | vauthors=Schultz SJ, Nigg EA |title=Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans |journal=Cell Growth Differ. |volume=4 |issue= 10 |pages= 821–30 |year= 1994 |pmid= 8274451 |doi=  }}
*{{cite journal  | author=Galceran J, de Graaf K, Tejedor FJ, Becker W |title=The MNB/DYRK1A protein kinase: genetic and biochemical properties. |journal=J. Neural Transm. Suppl. |volume= |issue= 67 |pages= 139-48 |year= 2004 |pmid= 15068246 |doi=  }}
*{{cite journal  | vauthors=Shindoh N, Kudoh J, Maeda H |title=Cloning of a human homolog of the Drosophila minibrain/rat Dyrk gene from "the Down syndrome critical region" of chromosome 21 |journal=Biochem. Biophys. Res. Commun. |volume=225 |issue= 1 |pages= 92–9 |year= 1996 |pmid= 8769099 |doi= 10.1006/bbrc.1996.1135 |display-authors=etal}}
*{{cite journal  | author=Schultz SJ, Nigg EA |title=Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans. |journal=Cell Growth Differ. |volume=4 |issue= 10 |pages= 821-30 |year= 1994 |pmid= 8274451 |doi=  }}
*{{cite journal  | vauthors=Guimerá J, Casas C, Pucharcòs C |title=A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region |journal=Hum. Mol. Genet. |volume=5 |issue= 9 |pages= 1305–10 |year= 1997 |pmid= 8872470 |doi=10.1093/hmg/5.9.1305 |display-authors=etal}}
*{{cite journal  | author=Shindoh N, Kudoh J, Maeda H, ''et al.'' |title=Cloning of a human homolog of the Drosophila minibrain/rat Dyrk gene from "the Down syndrome critical region" of chromosome 21. |journal=Biochem. Biophys. Res. Commun. |volume=225 |issue= 1 |pages= 92-9 |year= 1996 |pmid= 8769099 |doi= 10.1006/bbrc.1996.1135 }}
*{{cite journal  | vauthors=Song WJ, Sternberg LR, Kasten-Sportès C |title=Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome "critical region" |journal=Genomics |volume=38 |issue= 3 |pages= 331–9 |year= 1997 |pmid= 8975710 |doi= 10.1006/geno.1996.0636 |display-authors=etal}}
*{{cite journal  | author=Guimerá J, Casas C, Pucharcòs C, ''et al.'' |title=A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region. |journal=Hum. Mol. Genet. |volume=5 |issue= 9 |pages= 1305-10 |year= 1997 |pmid= 8872470 |doi=  }}
*{{cite journal  | vauthors=Ohira M, Seki N, Nagase T |title=Gene identification in 1.6-Mb region of the Down syndrome region on chromosome 21 |journal=Genome Res. |volume=7 |issue= 1 |pages= 47–58 |year= 1997 |pmid= 9037601 |doi=10.1101/gr.7.1.47  |display-authors=etal}}
*{{cite journal  | author=Song WJ, Sternberg LR, Kasten-Sportès C, ''et al.'' |title=Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome "critical region". |journal=Genomics |volume=38 |issue= 3 |pages= 331-9 |year= 1997 |pmid= 8975710 |doi= 10.1006/geno.1996.0636 }}
*{{cite journal  | vauthors=Chen H, Antonarakis SE |title=Localisation of a human homologue of the Drosophila mnb and rat Dyrk genes to chromosome 21q22.2 |journal=Hum. Genet. |volume=99 |issue= 2 |pages= 262–5 |year= 1997 |pmid= 9048932 |doi=10.1007/s004390050350 }}
*{{cite journal  | author=Ohira M, Seki N, Nagase T, ''et al.'' |title=Gene identification in 1.6-Mb region of the Down syndrome region on chromosome 21. |journal=Genome Res. |volume=7 |issue= 1 |pages= 47-58 |year= 1997 |pmid= 9037601 |doi= }}
*{{cite journal  | vauthors=Smith DJ, Stevens ME, Sudanagunta SP |title=Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome |journal=Nat. Genet. |volume=16 |issue= 1 |pages= 28–36 |year= 1997 |pmid= 9140392 |doi= 10.1038/ng0597-28 |display-authors=etal}}
*{{cite journal  | author=Chen H, Antonarakis SE |title=Localisation of a human homologue of the Drosophila mnb and rat Dyrk genes to chromosome 21q22.2. |journal=Hum. Genet. |volume=99 |issue= 2 |pages= 262-5 |year= 1997 |pmid= 9048932 |doi=  }}
*{{cite journal  | vauthors=Dahmane N, Ghezala GA, Gosset P |title=Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome |journal=Genomics |volume=48 |issue= 1 |pages= 12–23 |year= 1998 |pmid= 9503011 |doi= 10.1006/geno.1997.5146 |display-authors=etal}}
*{{cite journal  | author=Smith DJ, Stevens ME, Sudanagunta SP, ''et al.'' |title=Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome. |journal=Nat. Genet. |volume=16 |issue= 1 |pages= 28-36 |year= 1997 |pmid= 9140392 |doi= 10.1038/ng0597-28 }}
*{{cite journal  | vauthors=Xu X, Rich ES, Seldin DC |title=Murine protein kinase CK2 alpha': cDNA and genomic cloning and chromosomal mapping |journal=Genomics |volume=48 |issue= 1 |pages= 79–86 |year= 1998 |pmid= 9503019 |doi= 10.1006/geno.1997.5154 }}
*{{cite journal  | author=Guimera J, Pritchard M, Nadal M, Estivill X |title=Minibrain (MNBH) is a single copy gene mapping to human chromosome 21q22.2. |journal=Cytogenet. Cell Genet. |volume=77 |issue= 3-4 |pages= 182-4 |year= 1997 |pmid= 9284911 |doi= }}
*{{cite journal  | vauthors=Becker W, Weber Y, Wetzel K |title=Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 25893–902 |year= 1998 |pmid= 9748265 |doi=10.1074/jbc.273.40.25893  |display-authors=etal}}
*{{cite journal  | author=Dahmane N, Ghezala GA, Gosset P, ''et al.'' |title=Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome. |journal=Genomics |volume=48 |issue= 1 |pages= 12-23 |year= 1998 |pmid= 9503011 |doi= 10.1006/geno.1997.5146 }}
*{{cite journal  | vauthors=Wang J, Kudoh J, Shintani A |title=Identification of two novel 5' noncoding exons in human MNB/DYRK gene and alternatively spliced transcripts |journal=Biochem. Biophys. Res. Commun. |volume=250 |issue= 3 |pages= 704–10 |year= 1998 |pmid= 9784410 |doi= 10.1006/bbrc.1998.9392 |display-authors=etal}}
*{{cite journal  | author=Xu X, Rich ES, Seldin DC |title=Murine protein kinase CK2 alpha': cDNA and genomic cloning and chromosomal mapping. |journal=Genomics |volume=48 |issue= 1 |pages= 79-86 |year= 1998 |pmid= 9503019 |doi= 10.1006/geno.1997.5154 }}
*{{cite journal  | vauthors=Guimera J, Casas C, Estivill X, Pritchard M |title=Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome |journal=Genomics |volume=57 |issue= 3 |pages= 407–18 |year= 1999 |pmid= 10329007 |doi= 10.1006/geno.1999.5775 }}
*{{cite journal  | author=Becker W, Weber Y, Wetzel K, ''et al.'' |title=Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 25893-902 |year= 1998 |pmid= 9748265 |doi= }}
*{{cite journal  | vauthors=Hattori M, Fujiyama A, Taylor TD |title=The DNA sequence of human chromosome 21 |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518 |display-authors=etal}}
*{{cite journal  | author=Wang J, Kudoh J, Shintani A, ''et al.'' |title=Identification of two novel 5' noncoding exons in human MNB/DYRK gene and alternatively spliced transcripts. |journal=Biochem. Biophys. Res. Commun. |volume=250 |issue= 3 |pages= 704-10 |year= 1998 |pmid= 9784410 |doi= 10.1006/bbrc.1998.9392 }}
*{{cite journal  | vauthors=Woods YL, Rena G, Morrice N |title=The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site |journal=Biochem. J. |volume=355 |issue= Pt 3 |pages= 597–607 |year= 2001 |pmid= 11311120 |doi= | pmc=1221773  |display-authors=etal}}
*{{cite journal  | author=Guimera J, Casas C, Estivill X, Pritchard M |title=Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome. |journal=Genomics |volume=57 |issue= 3 |pages= 407-18 |year= 1999 |pmid= 10329007 |doi= 10.1006/geno.1999.5775 }}
*{{cite journal  | vauthors=Mao J, Maye P, Kogerman P |title=Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1 |journal=J. Biol. Chem. |volume=277 |issue= 38 |pages= 35156–61 |year= 2002 |pmid= 12138125 |doi= 10.1074/jbc.M206743200 |display-authors=etal}}
*{{cite journal  | author=Hattori M, Fujiyama A, Taylor TD, ''et al.'' |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311-9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Woods YL, Rena G, Morrice N, ''et al.'' |title=The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site. |journal=Biochem. J. |volume=355 |issue= Pt 3 |pages= 597-607 |year= 2001 |pmid= 11311120 |doi= }}
*{{cite journal  | vauthors=Martí E, Altafaj X, Dierssen M |title=Dyrk1A expression pattern supports specific roles of this kinase in the adult central nervous system |journal=Brain Res. |volume=964 |issue= 2 |pages= 250–63 |year= 2003 |pmid= 12576186 |doi=10.1016/S0006-8993(02)04069-6  |display-authors=etal}}
*{{cite journal  | author=Mao J, Maye P, Kogerman P, ''et al.'' |title=Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1. |journal=J. Biol. Chem. |volume=277 |issue= 38 |pages= 35156-61 |year= 2002 |pmid= 12138125 |doi= 10.1074/jbc.M206743200 }}
*{{cite journal  | vauthors=Jarhad DB, Mashelkar KK, Kim HR, Noh M, Jeong LS |title=Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors as potential therapeutics |journal=Journal of medicinal chemistry |volume=61 |issue= 22 |pages= 9791-9810 |year= 2018 |pmid=  |doi= 10.1021/acs.jmedchem.8b00185 |}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Martí E, Altafaj X, Dierssen M, ''et al.'' |title=Dyrk1A expression pattern supports specific roles of this kinase in the adult central nervous system. |journal=Brain Res. |volume=964 |issue= 2 |pages= 250-63 |year= 2003 |pmid= 12576186 |doi=  }}
}}
{{refend}}
{{refend}}
 
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Latest revision as of 17:20, 6 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Dual specificity tyrosine-phosphorylation-regulated kinase 1A is an enzyme that in humans is encoded by the DYRK1A gene.[1] Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region.[2] These variants encode at least five different isoforms.[3]

Function

DYRK1A is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene.[3]

Dyrk1a has also been shown to modulate plasma homocysteine level in a mouse model of overexpression.[4]

Clinical significance

DYRK1A is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome.[3] In addition, a polymorphism (SNP) in DYRK1A was found to be associated with HIV-1 replication in monocyte-derived macrophages, as well as with slower progression to AIDS in two independent cohorts of HIV-1-infected individuals.[2] Mutations in DYRK1A are also associated with Autism spectrum disorder.[5]

Interactions

DYRK1A has been shown to interact with WDR68.[6]

References

  1. ↑ Guimera J, Pritchard M, Nadal M, Estivill X (Sep 1997). "Minibrain (MNBH) is a single copy gene mapping to human chromosome 21q22.2". Cytogenet Cell Genet. 77 (3–4): 182–4. doi:10.1159/000134571. PMID 9284911.
  2. ↑ 2.0 2.1 Bol SM, Moerland PD, Limou S, van Remmerden Y, Coulonges C, van Manen D, Herbeck JT, Fellay J, Sieberer M, Sietzema JG, van 't Slot R, Martinson J, Zagury JF, Schuitemaker H, van 't Wout AB (2011). "Genome-wide association study identifies single nucleotide polymorphism in DYRK1A associated with replication of HIV-1 in monocyte-derived macrophages". PLoS ONE. 6 (2): e17190. doi:10.1371/journal.pone.0017190. PMC 3045405. PMID 21364930.
  3. ↑ 3.0 3.1 3.2 "Entrez Gene: DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A".
  4. ↑ Noll C, Planque C, Ripoll C, Guedj F, Diez A, Ducros V, Belin N, Duchon A, Paul JL, Badel A, de Freminville B, Grattau Y, Bléhaut H, Herault Y, Janel N, Delabar JM (2009). "DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase". PLoS ONE. 4 (10): e7540. doi:10.1371/journal.pone.0007540. PMC 2760102. PMID 19844572.
  5. ↑ O'Roak BJ, Vives L, Fu W, Egertson JD, Stanaway IB, Phelps IG, Carvill G, Kumar A, Lee C, Ankenman K, Munson J, Hiatt JB, Turner EH, Levy R, O'Day DR, Krumm N, Coe BP, Martin BK, Borenstein E, Nickerson DA, Mefford HC, Doherty D, Akey JM, Bernier R, Eichler EE, Shendure J (December 2012). "Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders". Science. 338 (6114): 1619–22. doi:10.1126/science.1227764. PMC 3528801. PMID 23160955.
  6. ↑ Skurat AV, Dietrich AD (January 2004). "Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases". J. Biol. Chem. 279 (4): 2490–8. doi:10.1074/jbc.M301769200. PMID 14593110.

Further reading

  • Hämmerle B, Elizalde C, Galceran J, et al. (2004). "The MNB/DYRK1A protein kinase: neurobiological functions and Down syndrome implications". J. Neural Transm. Suppl. (67): 129–37. doi:10.1007/978-3-7091-6721-2_11. PMID 15068245.
  • Galceran J, de Graaf K, Tejedor FJ, Becker W (2004). "The MNB/DYRK1A protein kinase: genetic and biochemical properties". J. Neural Transm. Suppl. (67): 139–48. doi:10.1007/978-3-7091-6721-2_12. PMID 15068246.
  • Schultz SJ, Nigg EA (1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30. PMID 8274451.
  • Shindoh N, Kudoh J, Maeda H, et al. (1996). "Cloning of a human homolog of the Drosophila minibrain/rat Dyrk gene from "the Down syndrome critical region" of chromosome 21". Biochem. Biophys. Res. Commun. 225 (1): 92–9. doi:10.1006/bbrc.1996.1135. PMID 8769099.
  • Guimerá J, Casas C, Pucharcòs C, et al. (1997). "A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region". Hum. Mol. Genet. 5 (9): 1305–10. doi:10.1093/hmg/5.9.1305. PMID 8872470.
  • Song WJ, Sternberg LR, Kasten-Sportès C, et al. (1997). "Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome "critical region"". Genomics. 38 (3): 331–9. doi:10.1006/geno.1996.0636. PMID 8975710.
  • Ohira M, Seki N, Nagase T, et al. (1997). "Gene identification in 1.6-Mb region of the Down syndrome region on chromosome 21". Genome Res. 7 (1): 47–58. doi:10.1101/gr.7.1.47. PMID 9037601.
  • Chen H, Antonarakis SE (1997). "Localisation of a human homologue of the Drosophila mnb and rat Dyrk genes to chromosome 21q22.2". Hum. Genet. 99 (2): 262–5. doi:10.1007/s004390050350. PMID 9048932.
  • Smith DJ, Stevens ME, Sudanagunta SP, et al. (1997). "Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome". Nat. Genet. 16 (1): 28–36. doi:10.1038/ng0597-28. PMID 9140392.
  • Dahmane N, Ghezala GA, Gosset P, et al. (1998). "Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome". Genomics. 48 (1): 12–23. doi:10.1006/geno.1997.5146. PMID 9503011.
  • Xu X, Rich ES, Seldin DC (1998). "Murine protein kinase CK2 alpha': cDNA and genomic cloning and chromosomal mapping". Genomics. 48 (1): 79–86. doi:10.1006/geno.1997.5154. PMID 9503019.
  • Becker W, Weber Y, Wetzel K, et al. (1998). "Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases". J. Biol. Chem. 273 (40): 25893–902. doi:10.1074/jbc.273.40.25893. PMID 9748265.
  • Wang J, Kudoh J, Shintani A, et al. (1998). "Identification of two novel 5' noncoding exons in human MNB/DYRK gene and alternatively spliced transcripts". Biochem. Biophys. Res. Commun. 250 (3): 704–10. doi:10.1006/bbrc.1998.9392. PMID 9784410.
  • Guimera J, Casas C, Estivill X, Pritchard M (1999). "Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome". Genomics. 57 (3): 407–18. doi:10.1006/geno.1999.5775. PMID 10329007.
  • Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
  • Woods YL, Rena G, Morrice N, et al. (2001). "The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site". Biochem. J. 355 (Pt 3): 597–607. PMC 1221773. PMID 11311120.
  • Mao J, Maye P, Kogerman P, et al. (2002). "Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1". J. Biol. Chem. 277 (38): 35156–61. doi:10.1074/jbc.M206743200. PMID 12138125.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Martí E, Altafaj X, Dierssen M, et al. (2003). "Dyrk1A expression pattern supports specific roles of this kinase in the adult central nervous system". Brain Res. 964 (2): 250–63. doi:10.1016/S0006-8993(02)04069-6. PMID 12576186.
  • Jarhad DB, Mashelkar KK, Kim HR, Noh M, Jeong LS (2018). "Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors as potential therapeutics". Journal of medicinal chemistry. 61 (22): 9791–9810. doi:10.1021/acs.jmedchem.8b00185.
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