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{{Infobox_gene}}
{{PBB_Controls
'''Acyl-CoA-binding protein''' in humans belongs to the family of [[Acyl-CoA-binding protein]]s.<ref name="pmid1440058">{{cite journal | vauthors = Todd S, Naylor SL | title = New chromosomal mapping assignments for argininosuccinate synthetase pseudogene 1, interferon-beta 3 gene, and the diazepam binding inhibitor gene | journal = Somat Cell Mol Genet | volume = 18 | issue = 4 | pages = 381–5 |date=Dec 1992 | pmid = 1440058 | pmc =  | doi =10.1007/BF01235761 }}</ref><ref name="entrez"/>  
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{{GNF_Protein_box
| image = PBB_Protein_DBI_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1aca.
| PDB = {{PDB2|1aca}}, {{PDB2|1hb6}}, {{PDB2|1hb8}}, {{PDB2|1nti}}, {{PDB2|1nvl}}, {{PDB2|2abd}}, {{PDB2|2cb8}}, {{PDB2|2fj9}}
| Name = Diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)
| HGNCid = 2690
| Symbol = DBI
| AltSymbols =; ACBP; ACBD1; CCK-RP; EP; MGC70414
| OMIM = 125950
| ECnumber =
| Homologene = 39086
| MGIid = 94865
| GeneAtlas_image1 = PBB_GE_DBI_202428_x_at_tn.png
  | GeneAtlas_image2 = PBB_GE_DBI_209389_x_at_tn.png
  | GeneAtlas_image3 = PBB_GE_DBI_211070_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000062 |text = acyl-CoA binding}} {{GNF_GO|id=GO:0005488 |text = binding}} {{GNF_GO|id=GO:0008289 |text = lipid binding}} {{GNF_GO|id=GO:0030156 |text = benzodiazepine receptor binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006810 |text = transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1622
    | Hs_Ensembl = ENSG00000155368
    | Hs_RefseqProtein = NP_001073331
    | Hs_RefseqmRNA = NM_001079862
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 119841055
    | Hs_GenLoc_end = 119846586
    | Hs_Uniprot = P07108
    | Mm_EntrezGene = 13167
    | Mm_Ensembl = ENSMUSG00000026385
    | Mm_RefseqmRNA = NM_001037999
    | Mm_RefseqProtein = NP_001033088
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 121940826
    | Mm_GenLoc_end = 121948625
    | Mm_Uniprot = Q3ULV8
  }}
}}
'''Diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)''', also known as '''DBI''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DBI diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1622| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: DBI diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1622| accessdate = }}</ref>
| summary_text = This gene encodes diazepam binding inhibitor, a protein that is regulated by [[hormone]]s and is involved in [[lipid metabolism]] and the displacement of [[beta-carboline]]s and [[benzodiazepine]]s, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain [[synapse]]s. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain [[acetyl-CoA|acyl-Coenzyme A esters]]. Diazepam binding inhibitor also mediates the feedback regulation of pancreatic secretion and the postprandial release of [[cholecystokinin]], in addition to its role as a mediator in corticotropin-dependent synthesis of steroids in the [[adrenal gland]].  
Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have also been described for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: DBI diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1622| accessdate = }}</ref>
}}
}}
==See also==
* [[Diazepam]]


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Papadopoulos V, Brown AS |title=Role of the peripheral-type benzodiazepine receptor and the polypeptide diazepam binding inhibitor in steroidogenesis. |journal=J. Steroid Biochem. Mol. Biol. |volume=53 |issue= 1-6 |pages= 103-10 |year= 1995 |pmid= 7626442 |doi=  }}
*{{cite journal  | vauthors=Papadopoulos V, Brown AS |title=Role of the peripheral-type benzodiazepine receptor and the polypeptide diazepam binding inhibitor in steroidogenesis. |journal=J. Steroid Biochem. Mol. Biol. |volume=53 |issue= 1–6 |pages= 103–10 |year= 1995 |pmid= 7626442 |doi=10.1016/0960-0760(95)00027-W }}
*{{cite journal  | author=Costa E, Auta J, Guidotti A, ''et al.'' |title=The pharmacology of neurosteroidogenesis. |journal=J. Steroid Biochem. Mol. Biol. |volume=49 |issue= 4-6 |pages= 385-9 |year= 1994 |pmid= 8043504 |doi= }}
*{{cite journal  | vauthors=Costa E, Auta J, Guidotti A |title=The pharmacology of neurosteroidogenesis |journal=J. Steroid Biochem. Mol. Biol. |volume=49 |issue= 4–6 |pages= 385–9 |year= 1994 |pmid= 8043504 |doi=10.1016/0960-0760(94)90284-4 |display-authors=etal}}
*{{cite journal  | author=Todd S, Naylor SL |title=New chromosomal mapping assignments for argininosuccinate synthetase pseudogene 1, interferon-beta 3 gene, and the diazepam binding inhibitor gene. |journal=Somat. Cell Mol. Genet. |volume=18 |issue= 4 |pages= 381-5 |year= 1992 |pmid= 1440058 |doi=  }}
*{{cite journal  | vauthors=Mandrup S, Hummel R, Ravn S |title=Acyl-CoA-binding protein/diazepam-binding inhibitor gene and pseudogenes. A typical housekeeping gene family |journal=J. Mol. Biol. |volume=228 |issue= 3 |pages= 1011–22 |year= 1993 |pmid= 1469708 |doi=10.1016/0022-2836(92)90888-Q |display-authors=etal}}
*{{cite journal  | author=Mandrup S, Hummel R, Ravn S, ''et al.'' |title=Acyl-CoA-binding protein/diazepam-binding inhibitor gene and pseudogenes. A typical housekeeping gene family. |journal=J. Mol. Biol. |volume=228 |issue= 3 |pages= 1011-22 |year= 1993 |pmid= 1469708 |doi=  }}
*{{cite journal  | vauthors=Webb NR, Rose TM, Malik N |title=Bovine and human cDNA sequences encoding a putative benzodiazepine receptor ligand |journal=DNA |volume=6 |issue= 1 |pages= 71–9 |year= 1987 |pmid= 2881742 |doi=10.1089/dna.1987.6.71 |display-authors=etal}}
*{{cite journal  | author=Webb NR, Rose TM, Malik N, ''et al.'' |title=Bovine and human cDNA sequences encoding a putative benzodiazepine receptor ligand. |journal=DNA |volume=6 |issue= 1 |pages= 71-9 |year= 1987 |pmid= 2881742 |doi=  }}
*{{cite journal  | vauthors=Gray PW, Glaister D, Seeburg PH |title=Cloning and expression of cDNA for human diazepam binding inhibitor, a natural ligand of an allosteric regulatory site of the gamma-aminobutyric acid type A receptor |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 19 |pages= 7547–51 |year= 1986 |pmid= 3020548 |doi=10.1073/pnas.83.19.7547  | pmc=386756 |display-authors=etal}}
*{{cite journal  | author=Gray PW, Glaister D, Seeburg PH, ''et al.'' |title=Cloning and expression of cDNA for human diazepam binding inhibitor, a natural ligand of an allosteric regulatory site of the gamma-aminobutyric acid type A receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 19 |pages= 7547-51 |year= 1986 |pmid= 3020548 |doi=  }}
*{{cite journal  | vauthors=DeBernardi MA, Crowe RR, Mocchetti I |title=Chromosomal localization of the human diazepam binding inhibitor gene |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 17 |pages= 6561–5 |year= 1988 |pmid= 3413112 |doi=10.1073/pnas.85.17.6561  | pmc=282013 |display-authors=etal}}
*{{cite journal  | author=DeBernardi MA, Crowe RR, Mocchetti I, ''et al.'' |title=Chromosomal localization of the human diazepam binding inhibitor gene. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 17 |pages= 6561-5 |year= 1988 |pmid= 3413112 |doi=  }}
*{{cite journal  | vauthors=Marquardt H, Todaro GJ, Shoyab M |title=Complete amino acid sequences of bovine and human endozepines. Homology with rat diazepam binding inhibitor |journal=J. Biol. Chem. |volume=261 |issue= 21 |pages= 9727–31 |year= 1986 |pmid= 3525533 |doi=  }}
*{{cite journal  | author=Marquardt H, Todaro GJ, Shoyab M |title=Complete amino acid sequences of bovine and human endozepines. Homology with rat diazepam binding inhibitor. |journal=J. Biol. Chem. |volume=261 |issue= 21 |pages= 9727-31 |year= 1986 |pmid= 3525533 |doi=  }}
*{{cite journal  | vauthors=Swinnen JV, Esquenet M, Heyns W |title=Androgen regulation of the messenger RNA encoding diazepam-binding inhibitor/acyl-CoA-binding protein in the human prostatic adenocarcinoma cell line LNCaP |journal=Mol. Cell. Endocrinol. |volume=104 |issue= 2 |pages= 153–62 |year= 1995 |pmid= 7527352 |doi=10.1016/0303-7207(94)90118-X |display-authors=etal}}
*{{cite journal  | author=Swinnen JV, Esquenet M, Heyns W, ''et al.'' |title=Androgen regulation of the messenger RNA encoding diazepam-binding inhibitor/acyl-CoA-binding protein in the human prostatic adenocarcinoma cell line LNCaP. |journal=Mol. Cell. Endocrinol. |volume=104 |issue= 2 |pages= 153-62 |year= 1995 |pmid= 7527352 |doi=  }}
*{{cite journal  | vauthors=Kolmer M, Rovio A, Alho H |title=The characterization of two diazepam binding inhibitor (DBI) transcripts in humans |journal=Biochem. J. |volume=306 |issue=  Pt 2|pages= 327–30 |year= 1995 |pmid= 7534063 |doi= | pmc=1136524 }}
*{{cite journal  | author=Kolmer M, Rovio A, Alho H |title=The characterization of two diazepam binding inhibitor (DBI) transcripts in humans. |journal=Biochem. J. |volume=306 ( Pt 2) |issue=  |pages= 327-30 |year= 1995 |pmid= 7534063 |doi=  }}
*{{cite journal  | vauthors=Gersuk VH, Rose TM, Todaro GJ |title=Molecular cloning and chromosomal localization of a pseudogene related to the human acyl-CoA binding protein/diazepam binding inhibitor |journal=Genomics |volume=25 |issue= 2 |pages= 469–76 |year= 1995 |pmid= 7789980 |doi=10.1016/0888-7543(95)80047-P }}
*{{cite journal  | author=Gersuk VH, Rose TM, Todaro GJ |title=Molecular cloning and chromosomal localization of a pseudogene related to the human acyl-CoA binding protein/diazepam binding inhibitor. |journal=Genomics |volume=25 |issue= 2 |pages= 469-76 |year= 1995 |pmid= 7789980 |doi=  }}
*{{cite journal  | vauthors=Alho H, Kolmer M, Harjuntausta T, Helén P |title=Increased expression of diazepam binding inhibitor in human brain tumors |journal=Cell Growth Differ. |volume=6 |issue= 3 |pages= 309–14 |year= 1995 |pmid= 7794798 |doi=  }}
*{{cite journal  | author=Alho H, Kolmer M, Harjuntausta T, Helén P |title=Increased expression of diazepam binding inhibitor in human brain tumors. |journal=Cell Growth Differ. |volume=6 |issue= 3 |pages= 309-14 |year= 1995 |pmid= 7794798 |doi=  }}
*{{cite journal  | vauthors=Alho H, Vaalasti A, Podkletnova I, Rechardt L |title=Expression of diazepam-binding inhibitor peptide in human skin: an immunohistochemical and ultrastructural study |journal=J. Invest. Dermatol. |volume=101 |issue= 6 |pages= 800–3 |year= 1994 |pmid= 8245508 |doi=10.1111/1523-1747.ep12371698 }}
*{{cite journal  | author=Alho H, Vaalasti A, Podkletnova I, Rechardt L |title=Expression of diazepam-binding inhibitor peptide in human skin: an immunohistochemical and ultrastructural study. |journal=J. Invest. Dermatol. |volume=101 |issue= 6 |pages= 800-3 |year= 1994 |pmid= 8245508 |doi=  }}
*{{cite journal  | vauthors=Cavallaro S, Pani L, Guidotti A, Costa E |title=ACTH-induced mitochondrial DBI receptor (MDR) and diazepam binding inhibitor (DBI) expression in adrenals of hypophysectomized rats is not cause-effect related to its immediate steroidogenic action |journal=Life Sci. |volume=53 |issue= 14 |pages= 1137–47 |year= 1993 |pmid= 8396705 |doi=10.1016/0024-3205(93)90550-M }}
*{{cite journal  | author=Cavallaro S, Pani L, Guidotti A, Costa E |title=ACTH-induced mitochondrial DBI receptor (MDR) and diazepam binding inhibitor (DBI) expression in adrenals of hypophysectomized rats is not cause-effect related to its immediate steroidogenic action. |journal=Life Sci. |volume=53 |issue= 14 |pages= 1137-47 |year= 1993 |pmid= 8396705 |doi=  }}
*{{cite journal  | vauthors=Swinnen JV, Esquenet M, Rosseels J |title=A human gene encoding diazepam-binding inhibitor/acy1-CoA-binding protein: transcription and hormonal regulation in the androgen-sensitive human prostatic adenocarcinoma cell line LNCaP |journal=DNA Cell Biol. |volume=15 |issue= 3 |pages= 197–208 |year= 1996 |pmid= 8634149 |doi=10.1089/dna.1996.15.197 |display-authors=etal}}
*{{cite journal  | author=Swinnen JV, Esquenet M, Rosseels J, ''et al.'' |title=A human gene encoding diazepam-binding inhibitor/acy1-CoA-binding protein: transcription and hormonal regulation in the androgen-sensitive human prostatic adenocarcinoma cell line LNCaP. |journal=DNA Cell Biol. |volume=15 |issue= 3 |pages= 197-208 |year= 1996 |pmid= 8634149 |doi=  }}
*{{cite journal  | vauthors=Krøll JB, Nøhr J, Gregersen N |title=Structure of the rat gene encoding the multifunctional acyl-CoA-binding protein: conservation of intron 1 sequences in rodents and man. Addendum |journal=Gene |volume=173 |issue= 2 |pages= 239–40 |year= 1996 |pmid= 8964506 |doi=10.1016/0378-1119(96)00214-4 |display-authors=etal}}
*{{cite journal  | author=Krøll JB, Nøhr J, Gregersen N, ''et al.'' |title=Structure of the rat gene encoding the multifunctional acyl-CoA-binding protein: conservation of intron 1 sequences in rodents and man. Addendum. |journal=Gene |volume=173 |issue= 2 |pages= 239-40 |year= 1996 |pmid= 8964506 |doi=  }}
*{{cite journal  | vauthors=Kolmer M, Pelto-Huikko M, Parvinen M |title=The transcriptional and translational control of diazepam binding inhibitor expression in rat male germ-line cells |journal=DNA Cell Biol. |volume=16 |issue= 1 |pages= 59–72 |year= 1997 |pmid= 9022045 |doi=10.1089/dna.1997.16.59 |display-authors=etal}}
*{{cite journal  | author=Kolmer M, Pelto-Huikko M, Parvinen M, ''et al.'' |title=The transcriptional and translational control of diazepam binding inhibitor expression in rat male germ-line cells. |journal=DNA Cell Biol. |volume=16 |issue= 1 |pages= 59-72 |year= 1997 |pmid= 9022045 |doi=  }}
*{{cite journal  | vauthors=Ferrarese C, Cogliati T, Tortorella R |title=Diazepam binding inhibitor (DBI) in the plasma of pediatric and adult epileptic patients |journal=Epilepsy Res. |volume=29 |issue= 2 |pages= 129–34 |year= 1998 |pmid= 9477145 |doi=10.1016/S0920-1211(97)00074-0 |display-authors=etal}}
*{{cite journal  | author=Ferrarese C, Cogliati T, Tortorella R, ''et al.'' |title=Diazepam binding inhibitor (DBI) in the plasma of pediatric and adult epileptic patients. |journal=Epilepsy Res. |volume=29 |issue= 2 |pages= 129-34 |year= 1998 |pmid= 9477145 |doi=  }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=1622}}
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{{protein-stub}}
{{gene-2-stub}}

Latest revision as of 03:51, 15 August 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Acyl-CoA-binding protein in humans belongs to the family of Acyl-CoA-binding proteins.[1][2]

This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor also mediates the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent synthesis of steroids in the adrenal gland. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have also been described for this gene.[2]

See also

References

  1. ↑ Todd S, Naylor SL (Dec 1992). "New chromosomal mapping assignments for argininosuccinate synthetase pseudogene 1, interferon-beta 3 gene, and the diazepam binding inhibitor gene". Somat Cell Mol Genet. 18 (4): 381–5. doi:10.1007/BF01235761. PMID 1440058.
  2. ↑ 2.0 2.1 "Entrez Gene: DBI diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)".

Further reading



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