Dopachrome tautomerase: Difference between revisions

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{{Infobox_gene}}
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'''Dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)''', also known as '''DCT''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DCT dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1638| accessdate = }}</ref> Its expression is regulated by the [[microphthalmia-associated transcription factor]] (MITF).<ref name="pmid12032083">{{cite journal | vauthors = Yasumoto K, Takeda K, Saito H | title = Microphthalmia-associated transcription factor interacts with LEF-1, a mediator of Wnt signaling | journal = EMBO J. | volume = 21 | issue = 11 | pages = 2703–14 | year = 2002 | pmid = 12032083 | doi = 10.1093/emboj/21.11.2703| pmc = 126018 |display-authors=etal}}</ref><ref name="pmidunknown">{{cite journal | vauthors = Hoek KS, Schlegel NC, Eichhoff OM | title = Novel MITF targets identified using a two-step DNA microarray strategy | journal = Pigment Cell Melanoma Res. | volume = 21 | issue = 6 | pages = 665–76 | year = 2008 | pmid = 19067971| doi = 10.1111/j.1755-148X.2008.00505.x |display-authors=etal}}</ref>
| update_page = yes
 
| require_manual_inspection = no
== See also ==
| update_protein_box = yes
* [[Tyrosinase-related protein 1]] (TYRP1)
| update_summary = yes
* [[Dopachrome]], a cyclization product of [[L-DOPA]] and is an intermediate in the [[biosynthesis]] of [[melanin]].
| update_citations = yes
 
}}
==References==
{{Reflist}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==Further reading==
{{GNF_Protein_box
{{Refbegin|2}}
| image = 
{{PBB_Further_reading
| image_source =
| citations =  
  | PDB =  
*{{cite journal | vauthors=Jackson IJ, Chambers DM, Tsukamoto K |title=A second tyrosinase-related protein, TRP-2, maps to and is mutated at the mouse slaty locus |journal=EMBO J. |volume=11 |issue= 2 |pages= 527–35 |year= 1992 |pmid= 1537334 |doi=  | pmc=556483 |display-authors=etal}}
| Name = Dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)
*{{cite journal | vauthors=Tobin D, Quinn AG, Ito S, Thody AJ |title=The presence of tyrosinase and related proteins in human epidermis and their relationship to melanin type |journal=Pigment Cell Res. |volume=7 |issue= 4 |pages= 204–9 |year= 1995 |pmid= 7855064 |doi=10.1111/j.1600-0749.1994.tb00050.x  }}
| HGNCid = 2709
*{{cite journal | vauthors=Bernd A, Ramirez-Bosca A, Kippenberger S |title=Levels of dopachrome tautomerase in human melanocytes cultured in vitro |journal=Melanoma Res. |volume=4 |issue= 5 |pages= 287–91 |year= 1995 |pmid= 7858411 |doi=10.1097/00008390-199410000-00003  |display-authors=etal}}
| Symbol = DCT
*{{cite journal  | vauthors=Yokoyama K, Yasumoto K, Suzuki H, Shibahara S |title=Cloning of the human DOPAchrome tautomerase/tyrosinase-related protein 2 gene and identification of two regulatory regions required for its pigment cell-specific expression |journal=J. Biol. Chem. |volume=269 |issue= 43 |pages= 27080–7 |year= 1994 |pmid= 7929451 |doi= }}
| AltSymbols =; TYRP2
*{{cite journal  | vauthors=Orlow SJ, Zhou BK, Chakraborty AK |title=High-molecular-weight forms of tyrosinase and the tyrosinase-related proteins: evidence for a melanogenic complex |journal=J. Invest. Dermatol. |volume=103 |issue= 2 |pages= 196–201 |year= 1994 |pmid= 8040609 |doi=10.1111/1523-1747.ep12392743  |display-authors=etal}}
  | OMIM = 191275
*{{cite journal  | vauthors=Sturm RA, Baker E, Sutherland GR |title=Assignment of the tyrosinase-related protein-2 gene (TYRP2) to human chromosome 13q31-q32 by fluorescence in situ hybridization: extended synteny with mouse chromosome 14 |journal=Genomics |volume=21 |issue= 1 |pages= 293–6 |year= 1994 |pmid= 8088811 |doi= 10.1006/geno.1994.1266 }}
  | ECnumber =
*{{cite journal  | vauthors=Abdel-Malek Z, Swope V, Collins C |title=Contribution of melanogenic proteins to the heterogeneous pigmentation of human melanocytes |journal=J. Cell Sci. |volume=106 |issue=  4|pages= 1323–31 |year= 1994 |pmid= 8126111 |doi=  |display-authors=etal}}
  | Homologene = 1447
*{{cite journal  | vauthors=Yokoyama K, Suzuki H, Yasumoto K |title=Molecular cloning and functional analysis of a cDNA coding for human DOPAchrome tautomerase/tyrosinase-related protein-2 |journal=Biochim. Biophys. Acta |volume=1217 |issue= 3 |pages= 317–21 |year= 1994 |pmid= 8148378 |doi=  10.1016/0167-4781(94)90292-5|display-authors=etal}}
| MGIid = 102563
*{{cite journal | vauthors=Cassady JL, Sturm RA |title=Sequence of the human dopachrome tautomerase-encoding TRP-2 cDNA |journal=Gene |volume=143 |issue= 2 |pages= 295–8 |year= 1994 |pmid= 8206391 |doi=10.1016/0378-1119(94)90114-7  }}
| GeneAtlas_image1 = PBB_GE_DCT_205338_s_at_tn.png
*{{cite journal  | vauthors=Odh G, Hindemith A, Rosengren AM |title=Isolation of a new tautomerase monitored by the conversion of D-dopachrome to 5,6-dihydroxyindole |journal=Biochem. Biophys. Res. Commun. |volume=197 |issue= 2 |pages= 619–24 |year= 1994 |pmid= 8267597 |doi= 10.1006/bbrc.1993.2524 |display-authors=etal}}
| GeneAtlas_image2 = PBB_GE_DCT_205337_at_tn.png
*{{cite journal  | vauthors=Bouchard B, Del Marmol V, Jackson IJ |title=Molecular characterization of a human tyrosinase-related-protein-2 cDNA. Patterns of expression in melanocytic cells |journal=Eur. J. Biochem. |volume=219 |issue= 1–2 |pages= 127–34 |year= 1994 |pmid= 8306979 |doi=10.1111/j.1432-1033.1994.tb19922.x  |display-authors=etal}}
  | GeneAtlas_image3 = PBB_GE_DCT_216512_s_at_tn.png
*{{cite journal  | vauthors=Sturm RA, O'Sullivan BJ, Box NF |title=Chromosomal structure of the human TYRP1 and TYRP2 loci and comparison of the tyrosinase-related protein gene family |journal=Genomics |volume=29 |issue= 1 |pages= 24–34 |year= 1996 |pmid= 8530077 |doi= 10.1006/geno.1995.1211 |display-authors=etal}}
| Function = {{GNF_GO|id=GO:0004167 |text = dopachrome isomerase activity}} {{GNF_GO|id=GO:0005507 |text = copper ion binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0016853 |text = isomerase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}  
*{{cite journal  | vauthors=Björk P, Aman P, Hindemith A |title=A new enzyme activity in human blood cells and isolation of the responsible protein (D-dopachrome tautomerase) from erythrocytes |journal=Eur. J. Haematol. |volume=57 |issue= 3 |pages= 254–6 |year= 1996 |pmid= 8898931 |doi=10.1111/j.1600-0609.1996.tb01372.x  |display-authors=etal}}
  | Component = {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0042470 |text = melanosome}}  
*{{cite journal | vauthors=Smith-Thomas L, Richardson P, Thody AJ |title=Human ocular melanocytes and retinal pigment epithelial cells differ in their melanogenic properties in vivo and in vitro |journal=Curr. Eye Res. |volume=15 |issue= 11 |pages= 1079–91 |year= 1997 |pmid= 8950502 |doi=10.3109/02713689608995139  |display-authors=etal}}
  | Process = {{GNF_GO|id=GO:0006583 |text = melanin biosynthetic process from tyrosine}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0008544 |text = epidermis development}} {{GNF_GO|id=GO:0048066 |text = pigmentation during development}} {{GNF_GO|id=GO:0048468 |text = cell development}}  
*{{cite journal  | vauthors=Wang RF, Appella E, Kawakami Y |title=Identification of TRP-2 as a Human Tumor Antigen Recognized by Cytotoxic T Lymphocytes |journal=J. Exp. Med. |volume=184 |issue= 6 |pages= 2207–16 |year= 1997 |pmid= 8976176 |doi=10.1084/jem.184.6.2207  | pmc=2211562  |display-authors=etal}}
  | Orthologs = {{GNF_Ortholog_box
*{{cite journal  | vauthors=Chi DD, Merchant RE, Rand R |title=Molecular detection of tumor-associated antigens shared by human cutaneous melanomas and gliomas |journal=Am. J. Pathol. |volume=150 |issue= 6 |pages= 2143–52 |year= 1997 |pmid= 9176405 |doi=  | pmc=1858329  |display-authors=etal}}
    | Hs_EntrezGene = 1638
*{{cite journal  | vauthors=Sugimoto H, Taniguchi M, Nakagawa A |title=Crystallization and preliminary X-ray analysis of human D-dopachrome tautomerase |journal=J. Struct. Biol. |volume=120 |issue= 1 |pages= 105–8 |year= 1997 |pmid= 9356298 |doi= 10.1006/jsbi.1997.3904 |display-authors=etal}}
    | Hs_Ensembl = ENSG00000080166
*{{cite journal  | vauthors=Nishihira J, Fujinaga M, Kuriyama T |title=Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation |journal=Biochem. Biophys. Res. Commun. |volume=243 |issue= 2 |pages= 538–44 |year= 1998 |pmid= 9480844 |doi= 10.1006/bbrc.1998.8123 |display-authors=etal}}
    | Hs_RefseqProtein = NP_001913
*{{cite journal | vauthors=Kippenberger S, Loitsch S, Solano F |title=Quantification of tyrosinase, TRP-1, and Trp-2 transcripts in human melanocytes by reverse transcriptase-competitive multiplex PCR--regulation by steroid hormones |journal=J. Invest. Dermatol. |volume=110 |issue= 4 |pages= 364–7 |year= 1998 |pmid= 9540976 |doi= 10.1046/j.1523-1747.1998.00144.x |display-authors=etal}}
    | Hs_RefseqmRNA = NM_001922
*{{cite journal  | vauthors=Lupetti R, Pisarra P, Verrecchia A |title=Translation of a Retained Intron in Tyrosinase-related Protein (TRP) 2 mRNA Generates a New Cytotoxic T Lymphocyte (CTL)-defined and Shared Human Melanoma Antigen Not Expressed in Normal Cells of the Melanocytic Lineage |journal=J. Exp. Med. |volume=188 |issue= 6 |pages= 1005–16 |year= 1998 |pmid= 9743519 |doi=10.1084/jem.188.6.1005  | pmc=2212536  |display-authors=etal}}
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 13
    | Hs_GenLoc_start = 93887559
    | Hs_GenLoc_end = 93929924
    | Hs_Uniprot = P40126
    | Mm_EntrezGene = 13190
    | Mm_Ensembl = ENSMUSG00000022129
    | Mm_RefseqmRNA = XM_979031
    | Mm_RefseqProtein = XP_984125
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 116895153
    | Mm_GenLoc_end = 116934531
    | Mm_Uniprot = Q6NXI2
  }}
}}
}}
'''Dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)''', also known as '''DCT''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DCT dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1638| accessdate = }}</ref>
{{Refend}}


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}}
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==References==
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{reflist|2}}
{{PBB_Controls
==Further reading==
| update_page = yes
{{refbegin | 2}}
| require_manual_inspection = no
{{PBB_Further_reading
| update_protein_box = yes
| citations =
| update_summary = yes
*{{cite journal  | author=Jackson IJ, Chambers DM, Tsukamoto K, ''et al.'' |title=A second tyrosinase-related protein, TRP-2, maps to and is mutated at the mouse slaty locus. |journal=EMBO J. |volume=11 |issue= 2 |pages= 527-35 |year= 1992 |pmid= 1537334 |doi=  }}
| update_citations = yes
*{{cite journal  | author=Tobin D, Quinn AG, Ito S, Thody AJ |title=The presence of tyrosinase and related proteins in human epidermis and their relationship to melanin type. |journal=Pigment Cell Res. |volume=7 |issue= 4 |pages= 204-9 |year= 1995 |pmid= 7855064 |doi=  }}
*{{cite journal  | author=Bernd A, Ramirez-Bosca A, Kippenberger S, ''et al.'' |title=Levels of dopachrome tautomerase in human melanocytes cultured in vitro. |journal=Melanoma Res. |volume=4 |issue= 5 |pages= 287-91 |year= 1995 |pmid= 7858411 |doi=  }}
*{{cite journal  | author=Yokoyama K, Yasumoto K, Suzuki H, Shibahara S |title=Cloning of the human DOPAchrome tautomerase/tyrosinase-related protein 2 gene and identification of two regulatory regions required for its pigment cell-specific expression. |journal=J. Biol. Chem. |volume=269 |issue= 43 |pages= 27080-7 |year= 1994 |pmid= 7929451 |doi=  }}
*{{cite journal  | author=Orlow SJ, Zhou BK, Chakraborty AK, ''et al.'' |title=High-molecular-weight forms of tyrosinase and the tyrosinase-related proteins: evidence for a melanogenic complex. |journal=J. Invest. Dermatol. |volume=103 |issue= 2 |pages= 196-201 |year= 1994 |pmid= 8040609 |doi=  }}
*{{cite journal  | author=Sturm RA, Baker E, Sutherland GR |title=Assignment of the tyrosinase-related protein-2 gene (TYRP2) to human chromosome 13q31-q32 by fluorescence in situ hybridization: extended synteny with mouse chromosome 14. |journal=Genomics |volume=21 |issue= 1 |pages= 293-6 |year= 1994 |pmid= 8088811 |doi= 10.1006/geno.1994.1266 }}
*{{cite journal  | author=Abdel-Malek Z, Swope V, Collins C, ''et al.'' |title=Contribution of melanogenic proteins to the heterogeneous pigmentation of human melanocytes. |journal=J. Cell. Sci. |volume=106 ( Pt 4) |issue=  |pages= 1323-31 |year= 1994 |pmid= 8126111 |doi=  }}
*{{cite journal  | author=Yokoyama K, Suzuki H, Yasumoto K, ''et al.'' |title=Molecular cloning and functional analysis of a cDNA coding for human DOPAchrome tautomerase/tyrosinase-related protein-2. |journal=Biochim. Biophys. Acta |volume=1217 |issue= 3 |pages= 317-21 |year= 1994 |pmid= 8148378 |doi=  }}
*{{cite journal  | author=Cassady JL, Sturm RA |title=Sequence of the human dopachrome tautomerase-encoding TRP-2 cDNA. |journal=Gene |volume=143 |issue= 2 |pages= 295-8 |year= 1994 |pmid= 8206391 |doi=  }}
*{{cite journal  | author=Odh G, Hindemith A, Rosengren AM, ''et al.'' |title=Isolation of a new tautomerase monitored by the conversion of D-dopachrome to 5,6-dihydroxyindole. |journal=Biochem. Biophys. Res. Commun. |volume=197 |issue= 2 |pages= 619-24 |year= 1994 |pmid= 8267597 |doi= 10.1006/bbrc.1993.2524 }}
*{{cite journal  | author=Bouchard B, Del Marmol V, Jackson IJ, ''et al.'' |title=Molecular characterization of a human tyrosinase-related-protein-2 cDNA. Patterns of expression in melanocytic cells. |journal=Eur. J. Biochem. |volume=219 |issue= 1-2 |pages= 127-34 |year= 1994 |pmid= 8306979 |doi=  }}
*{{cite journal  | author=Sturm RA, O'Sullivan BJ, Box NF, ''et al.'' |title=Chromosomal structure of the human TYRP1 and TYRP2 loci and comparison of the tyrosinase-related protein gene family. |journal=Genomics |volume=29 |issue= 1 |pages= 24-34 |year= 1996 |pmid= 8530077 |doi= 10.1006/geno.1995.1211 }}
*{{cite journal  | author=Björk P, Aman P, Hindemith A, ''et al.'' |title=A new enzyme activity in human blood cells and isolation of the responsible protein (D-dopachrome tautomerase) from erythrocytes. |journal=Eur. J. Haematol. |volume=57 |issue= 3 |pages= 254-6 |year= 1996 |pmid= 8898931 |doi=  }}
*{{cite journal  | author=Smith-Thomas L, Richardson P, Thody AJ, ''et al.'' |title=Human ocular melanocytes and retinal pigment epithelial cells differ in their melanogenic properties in vivo and in vitro. |journal=Curr. Eye Res. |volume=15 |issue= 11 |pages= 1079-91 |year= 1997 |pmid= 8950502 |doi=  }}
*{{cite journal  | author=Wang RF, Appella E, Kawakami Y, ''et al.'' |title=Identification of TRP-2 as a human tumor antigen recognized by cytotoxic T lymphocytes. |journal=J. Exp. Med. |volume=184 |issue= 6 |pages= 2207-16 |year= 1997 |pmid= 8976176 |doi=  }}
*{{cite journal  | author=Chi DD, Merchant RE, Rand R, ''et al.'' |title=Molecular detection of tumor-associated antigens shared by human cutaneous melanomas and gliomas. |journal=Am. J. Pathol. |volume=150 |issue= 6 |pages= 2143-52 |year= 1997 |pmid= 9176405 |doi=  }}
*{{cite journal  | author=Sugimoto H, Taniguchi M, Nakagawa A, ''et al.'' |title=Crystallization and preliminary X-ray analysis of human D-dopachrome tautomerase. |journal=J. Struct. Biol. |volume=120 |issue= 1 |pages= 105-8 |year= 1997 |pmid= 9356298 |doi= 10.1006/jsbi.1997.3904 }}
*{{cite journal  | author=Nishihira J, Fujinaga M, Kuriyama T, ''et al.'' |title=Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation. |journal=Biochem. Biophys. Res. Commun. |volume=243 |issue= 2 |pages= 538-44 |year= 1998 |pmid= 9480844 |doi= 10.1006/bbrc.1998.8123 }}
*{{cite journal  | author=Kippenberger S, Loitsch S, Solano F, ''et al.'' |title=Quantification of tyrosinase, TRP-1, and Trp-2 transcripts in human melanocytes by reverse transcriptase-competitive multiplex PCR--regulation by steroid hormones. |journal=J. Invest. Dermatol. |volume=110 |issue= 4 |pages= 364-7 |year= 1998 |pmid= 9540976 |doi= 10.1046/j.1523-1747.1998.00144.x }}
*{{cite journal  | author=Lupetti R, Pisarra P, Verrecchia A, ''et al.'' |title=Translation of a retained intron in tyrosinase-related protein (TRP) 2 mRNA generates a new cytotoxic T lymphocyte (CTL)-defined and shared human melanoma antigen not expressed in normal cells of the melanocytic lineage. |journal=J. Exp. Med. |volume=188 |issue= 6 |pages= 1005-16 |year= 1998 |pmid= 9743519 |doi= }}
}}
}}
{{refend}}


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{{gene-13-stub}}

Latest revision as of 19:49, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2), also known as DCT, is a human gene.[1] Its expression is regulated by the microphthalmia-associated transcription factor (MITF).[2][3]

See also

References

  1. ↑ "Entrez Gene: DCT dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)".
  2. ↑ Yasumoto K, Takeda K, Saito H, et al. (2002). "Microphthalmia-associated transcription factor interacts with LEF-1, a mediator of Wnt signaling". EMBO J. 21 (11): 2703–14. doi:10.1093/emboj/21.11.2703. PMC 126018. PMID 12032083.
  3. ↑ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

Further reading




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