EIF2A: Difference between revisions

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Latest revision as of 09:13, 3 January 2018

Eukaryotic translation initiation factor 2A (eIF2A) is a protein that in humans is encoded by the EIF2A gene.^[1]^[2]^[3] The eIF2A protein is not to be confused with eIF2α, a subunit of the heterotrimeric eIF2 complex. Instead, eIF2A functions by a separate mechanism in eukaryotic translation.

Function

eIF2A is a 65 kDa protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002).[supplied by OMIM]^[3] It may be important for translation initiation mediated by the HCV IRES under stress conditions, but this result has been debated.^[4]^[5]

References

↑ Zoll WL, Horton LE, Komar AA, Hensold JO, Merrick WC (Oct 2002). "Characterization of mammalian eIF2A and identification of the yeast homolog". The Journal of Biological Chemistry. 277 (40): 37079–87. doi:10.1074/jbc.M207109200. PMID 12133843.
↑ Merrick WC (Jun 1992). "Mechanism and regulation of eukaryotic protein synthesis". Microbiological Reviews. 56 (2): 291–315. PMC 372869. PMID 1620067.
↑ ^3.0 ^3.1 "Entrez Gene: EIF2A eukaryotic translation initiation factor 2A, 38kDa".
↑ Kim JH, Park SM, Park JH, Keum SJ, Jang SK (Jun 2011). "eIF2A mediates translation of hepatitis C viral mRNA under stress conditions". The EMBO Journal. 30 (12): 2454–64. doi:10.1038/emboj.2011.146. PMC 3116280. PMID 21556050.
↑ Jaafar ZA, Oguro A, Nakamura Y, Kieft JS (December 2016). "Translation initiation by the hepatitis C virus IRES requires eIF1A and ribosomal complex remodeling". eLife. 5: e21198. doi:10.7554/elife.21198. PMID 28009256.

Koumenis C, Naczki C, Koritzinsky M, Rastani S, Diehl A, Sonenberg N, Koromilas A, Wouters BG (Nov 2002). "Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha". Molecular and Cellular Biology. 22 (21): 7405–16. doi:10.1128/MCB.22.21.7405-7416.2002. PMC 135664. PMID 12370288.
Page AB, Owen CR, Kumar R, Miller JM, Rafols JA, White BC, DeGracia DJ, Krause GS (Jul 2003). "Persistent eIF2alpha(P) is colocalized with cytoplasmic cytochrome c in vulnerable hippocampal neurons after 4 hours of reperfusion following 10-minute complete brain ischemia". Acta Neuropathologica. 106 (1): 8–16. doi:10.1007/s00401-003-0693-2. PMID 12687390.
Ito T, Marintchev A, Wagner G (Sep 2004). "Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B". Structure. 12 (9): 1693–704. doi:10.1016/j.str.2004.07.010. PMID 15341733.
Weiser DC, Sikes S, Li S, Shenolikar S (Nov 2004). "The inhibitor-1 C terminus facilitates hormonal regulation of cellular protein phosphatase-1: functional implications for inhibitor-1 isoforms". The Journal of Biological Chemistry. 279 (47): 48904–14. doi:10.1074/jbc.M404416200. PMID 15345721.
Komar AA, Gross SR, Barth-Baus D, Strachan R, Hensold JO, Goss Kinzy T, Merrick WC (Apr 2005). "Novel characteristics of the biological properties of the yeast Saccharomyces cerevisiae eukaryotic initiation factor 2A". The Journal of Biological Chemistry. 280 (16): 15601–11. doi:10.1074/jbc.M413728200. PMID 15718232.
Wang J, Laschinger C, Zhao XH, Mak B, Seth A, McCulloch CA (Apr 2005). "Mechanical force activates eIF-2alpha phospho-kinases in fibroblast". Biochemical and Biophysical Research Communications. 330 (1): 123–30. doi:10.1016/j.bbrc.2005.02.140. PMID 15781241.
Gorrini C, Loreni F, Gandin V, Sala LA, Sonenberg N, Marchisio PC, Biffo S (Jun 2005). "Fibronectin controls cap-dependent translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways". Proceedings of the National Academy of Sciences of the United States of America. 102 (26): 9200–5. doi:10.1073/pnas.0409513102. PMC 1166589. PMID 15961545.
Su Q, Wang S, Baltzis D, Qu LK, Wong AH, Koromilas AE (Jan 2006). "Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase". Proceedings of the National Academy of Sciences of the United States of America. 103 (1): 63–8. doi:10.1073/pnas.0508207103. PMC 1324992. PMID 16373505.
Squatrito M, Mancino M, Sala L, Draetta GF (Jun 2006). "Ebp1 is a dsRNA-binding protein associated with ribosomes that modulates eIF2alpha phosphorylation". Biochemical and Biophysical Research Communications. 344 (3): 859–68. doi:10.1016/j.bbrc.2006.03.205. PMID 16631606.
Scheuner D, Patel R, Wang F, Lee K, Kumar K, Wu J, Nilsson A, Karin M, Kaufman RJ (Jul 2006). "Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis". The Journal of Biological Chemistry. 281 (30): 21458–68. doi:10.1074/jbc.M603784200. PMID 16717090.
Mazroui R, Sukarieh R, Bordeleau ME, Kaufman RJ, Northcote P, Tanaka J, Gallouzi I, Pelletier J (Oct 2006). "Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2alpha phosphorylation". Molecular Biology of the Cell. 17 (10): 4212–9. doi:10.1091/mbc.E06-04-0318. PMC 1635342. PMID 16870703.
Fribley AM, Evenchik B, Zeng Q, Park BK, Guan JY, Zhang H, Hale TJ, Soengas MS, Kaufman RJ, Wang CY (Oct 2006). "Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa". The Journal of Biological Chemistry. 281 (42): 31440–7. doi:10.1074/jbc.M604356200. PMID 16928686.
Fritsch RM, Schneider G, Saur D, Scheibel M, Schmid RM (Aug 2007). "Translational repression of MCL-1 couples stress-induced eIF2 alpha phosphorylation to mitochondrial apoptosis initiation". The Journal of Biological Chemistry. 282 (31): 22551–62. doi:10.1074/jbc.M702673200. PMID 17553788.
Nayak R, Pintel DJ (Nov 2007). "Adeno-associated viruses can induce phosphorylation of eIF2alpha via PKR activation, which can be overcome by helper adenovirus type 5 virus-associated RNA". Journal of Virology. 81 (21): 11908–16. doi:10.1128/JVI.01132-07. PMC 2168773. PMID 17715234.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[pmid12133843-1] Zoll WL, Horton LE, Komar AA, Hensold JO, Merrick WC (Oct 2002). "Characterization of mammalian eIF2A and identification of the yeast homolog". The Journal of Biological Chemistry. 277 (40): 37079–87. doi:10.1074/jbc.M207109200. PMID 12133843.

[pmid1620067-2] Merrick WC (Jun 1992). "Mechanism and regulation of eukaryotic protein synthesis". Microbiological Reviews. 56 (2): 291–315. PMC 372869. PMID 1620067.

[entrez-3] 3.0 ^3.1 "Entrez Gene: EIF2A eukaryotic translation initiation factor 2A, 38kDa".

[pmid21556050-4] Kim JH, Park SM, Park JH, Keum SJ, Jang SK (Jun 2011). "eIF2A mediates translation of hepatitis C viral mRNA under stress conditions". The EMBO Journal. 30 (12): 2454–64. doi:10.1038/emboj.2011.146. PMC 3116280. PMID 21556050.

[Jaafar_Oguro_Nakamura_Kieft_p.-5] Jaafar ZA, Oguro A, Nakamura Y, Kieft JS (December 2016). "Translation initiation by the hepatitis C virus IRES requires eIF1A and ribosomal complex remodeling". eLife. 5: e21198. doi:10.7554/elife.21198. PMID 28009256.

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[5]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Eukaryotic translation initiation factor 2A''' ('''eIF2A''') is a [[protein]] that in humans is encoded by the ''EIF2A'' [[gene]].<ref name="pmid12133843">{{cite journal | vauthors = Zoll WL, Horton LE, Komar AA, Hensold JO, Merrick WC | title = Characterization of mammalian eIF2A and identification of the yeast homolog | journal = The Journal of Biological Chemistry | volume = 277 | issue = 40 | pages = 37079–87 | date = Oct 2002 | pmid = 12133843 | pmc =  | doi = 10.1074/jbc.M207109200 }}</ref><ref name="pmid1620067">{{cite journal | vauthors = Merrick WC | title = Mechanism and regulation of eukaryotic protein synthesis | journal = Microbiological Reviews | volume = 56 | issue = 2 | pages = 291–315 | date = Jun 1992 | pmid = 1620067 | pmc = 372869 | doi =  }}</ref><ref name="entrez"/> The eIF2A protein is not to be confused with [[EIF2S1|eIF2α]], a subunit of the heterotrimeric [[eIF2]] complex. Instead, eIF2A functions by a separate mechanism in [[eukaryotic translation]].
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Eukaryotic translation initiation factor 2A, 65kDa
- | HGNCid = 3254
- | Symbol = EIF2A
- | AltSymbols =; EIF-2A; CDA02; MST089; MSTP004; MSTP089
- | OMIM = 609234
- | ECnumber =
- | Homologene = 5969
- | MGIid = 1098684
- | GeneAtlas_image1 = PBB_GE_EIF2A_gnf1h00584_at_tn.png
- | Function = {{GNF_GO|id=GO:0000049 |text = tRNA binding}} {{GNF_GO|id=GO:0003743 |text = translation initiation factor activity}} {{GNF_GO|id=GO:0043022 |text = ribosome binding}}
- | Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005850 |text = eukaryotic translation initiation factor 2 complex}}
- | Process = {{GNF_GO|id=GO:0006417 |text = regulation of translation}} {{GNF_GO|id=GO:0042255 |text = ribosome assembly}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 83939
-    | Hs_Ensembl = ENSG00000144895
-    | Hs_RefseqProtein = NP_114414
-    | Hs_RefseqmRNA = NM_032025
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 3
-    | Hs_GenLoc_start = 151747206
-    | Hs_GenLoc_end = 151784717
-    | Hs_Uniprot =
-    | Mm_EntrezGene = 229317
-    | Mm_Ensembl = ENSMUSG00000027810
-    | Mm_RefseqmRNA = NM_001005509
-    | Mm_RefseqProtein = NP_001005509
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 3
-    | Mm_GenLoc_start = 58613945
-    | Mm_GenLoc_end = 58645430
-    | Mm_Uniprot =
-  }}
-}}
-'''Eukaryotic translation initiation factor 2A, 65kDa''', also known as '''EIF2A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EIF2A eukaryotic translation initiation factor 2A, 65kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83939| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+eIF2A is a 65 kDa protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: EIF2A eukaryotic translation initiation factor 2A, 38kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83939| accessdate = }}</ref> It may be important for translation initiation mediated by the [[HCV IRES]] under stress conditions, but this result has been debated.<ref name="pmid21556050">{{cite journal | vauthors = Kim JH, Park SM, Park JH, Keum SJ, Jang SK | title = eIF2A mediates translation of hepatitis C viral mRNA under stress conditions | journal = The EMBO Journal | volume = 30 | issue = 12 | pages = 2454–64 | date = Jun 2011 | pmid = 21556050 | pmc =  3116280| doi = 10.1038/emboj.2011.146 }}</ref><ref name="Jaafar Oguro Nakamura Kieft p. ">{{cite journal | vauthors = Jaafar ZA, Oguro A, Nakamura Y, Kieft JS | title = Translation initiation by the hepatitis C virus IRES requires eIF1A and ribosomal complex remodeling | journal = eLife | volume = 5 | pages = e21198 | date = December 2016 | pmid = 28009256 | doi = 10.7554/elife.21198 }}</ref>
-{{PBB_Summary
-| section_title =
-| summary_text = EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: EIF2A eukaryotic translation initiation factor 2A, 65kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83939| accessdate = }}</ref>
-}}
-==References==
+== See also ==
-{{reflist|2}}
+* [[eIF2]]
-==Further reading==
+== References ==
+{{reflist}}
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Koumenis C, Naczki C, Koritzinsky M, Rastani S, Diehl A, Sonenberg N, Koromilas A, Wouters BG | title = Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha | journal = Molecular and Cellular Biology | volume = 22 | issue = 21 | pages = 7405–16 | date = Nov 2002 | pmid = 12370288 | pmc = 135664 | doi = 10.1128/MCB.22.21.7405-7416.2002 }}
-| citations =
+* {{cite journal | vauthors = Page AB, Owen CR, Kumar R, Miller JM, Rafols JA, White BC, DeGracia DJ, Krause GS | title = Persistent eIF2alpha(P) is colocalized with cytoplasmic cytochrome c in vulnerable hippocampal neurons after 4 hours of reperfusion following 10-minute complete brain ischemia | journal = Acta Neuropathologica | volume = 106 | issue = 1 | pages = 8–16 | date = Jul 2003 | pmid = 12687390 | doi = 10.1007/s00401-003-0693-2 }}
-*{{cite journal  | author=Merrick WC |title=Mechanism and regulation of eukaryotic protein synthesis. |journal=Microbiol. Rev. |volume=56 |issue= 2 |pages= 291-315 |year= 1992 |pmid= 1620067 |doi=  }}
+* {{cite journal | vauthors = Ito T, Marintchev A, Wagner G | title = Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B | journal = Structure | volume = 12 | issue = 9 | pages = 1693–704 | date = Sep 2004 | pmid = 15341733 | doi = 10.1016/j.str.2004.07.010 }}
-*{{cite journal  | author=Zoll WL, Horton LE, Komar AA, ''et al.'' |title=Characterization of mammalian eIF2A and identification of the yeast homolog. |journal=J. Biol. Chem. |volume=277 |issue= 40 |pages= 37079-87 |year= 2002 |pmid= 12133843 |doi= 10.1074/jbc.M207109200 }}
+* {{cite journal | vauthors = Weiser DC, Sikes S, Li S, Shenolikar S | title = The inhibitor-1 C terminus facilitates hormonal regulation of cellular protein phosphatase-1: functional implications for inhibitor-1 isoforms | journal = The Journal of Biological Chemistry | volume = 279 | issue = 47 | pages = 48904–14 | date = Nov 2004 | pmid = 15345721 | doi = 10.1074/jbc.M404416200 }}
-*{{cite journal  | author=Koumenis C, Naczki C, Koritzinsky M, ''et al.'' |title=Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha. |journal=Mol. Cell. Biol. |volume=22 |issue= 21 |pages= 7405-16 |year= 2002 |pmid= 12370288 |doi=  }}
+* {{cite journal | vauthors = Komar AA, Gross SR, Barth-Baus D, Strachan R, Hensold JO, Goss Kinzy T, Merrick WC | title = Novel characteristics of the biological properties of the yeast Saccharomyces cerevisiae eukaryotic initiation factor 2A | journal = The Journal of Biological Chemistry | volume = 280 | issue = 16 | pages = 15601–11 | date = Apr 2005 | pmid = 15718232 | doi = 10.1074/jbc.M413728200 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+* {{cite journal | vauthors = Wang J, Laschinger C, Zhao XH, Mak B, Seth A, McCulloch CA | title = Mechanical force activates eIF-2alpha phospho-kinases in fibroblast | journal = Biochemical and Biophysical Research Communications | volume = 330 | issue = 1 | pages = 123–30 | date = Apr 2005 | pmid = 15781241 | doi = 10.1016/j.bbrc.2005.02.140 }}
-*{{cite journal  | author=Page AB, Owen CR, Kumar R, ''et al.'' |title=Persistent eIF2alpha(P) is colocalized with cytoplasmic cytochrome c in vulnerable hippocampal neurons after 4 hours of reperfusion following 10-minute complete brain ischemia. |journal=Acta Neuropathol. |volume=106 |issue= 1 |pages= 8-16 |year= 2003 |pmid= 12687390 |doi= 10.1007/s00401-003-0693-2 }}
+* {{cite journal | vauthors = Gorrini C, Loreni F, Gandin V, Sala LA, Sonenberg N, Marchisio PC, Biffo S | title = Fibronectin controls cap-dependent translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 102 | issue = 26 | pages = 9200–5 | date = Jun 2005 | pmid = 15961545 | pmc = 1166589 | doi = 10.1073/pnas.0409513102 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+* {{cite journal | vauthors = Su Q, Wang S, Baltzis D, Qu LK, Wong AH, Koromilas AE | title = Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 1 | pages = 63–8 | date = Jan 2006 | pmid = 16373505 | pmc = 1324992 | doi = 10.1073/pnas.0508207103 }}
-*{{cite journal  | author=Ito T, Marintchev A, Wagner G |title=Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B. |journal=Structure |volume=12 |issue= 9 |pages= 1693-704 |year= 2005 |pmid= 15341733 |doi= 10.1016/j.str.2004.07.010 }}
+* {{cite journal | vauthors = Squatrito M, Mancino M, Sala L, Draetta GF | title = Ebp1 is a dsRNA-binding protein associated with ribosomes that modulates eIF2alpha phosphorylation | journal = Biochemical and Biophysical Research Communications | volume = 344 | issue = 3 | pages = 859–68 | date = Jun 2006 | pmid = 16631606 | doi = 10.1016/j.bbrc.2006.03.205 }}
-*{{cite journal  | author=Weiser DC, Sikes S, Li S, Shenolikar S |title=The inhibitor-1 C terminus facilitates hormonal regulation of cellular protein phosphatase-1: functional implications for inhibitor-1 isoforms. |journal=J. Biol. Chem. |volume=279 |issue= 47 |pages= 48904-14 |year= 2005 |pmid= 15345721 |doi= 10.1074/jbc.M404416200 }}
+* {{cite journal | vauthors = Scheuner D, Patel R, Wang F, Lee K, Kumar K, Wu J, Nilsson A, Karin M, Kaufman RJ | title = Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis | journal = The Journal of Biological Chemistry | volume = 281 | issue = 30 | pages = 21458–68 | date = Jul 2006 | pmid = 16717090 | doi = 10.1074/jbc.M603784200 }}
-*{{cite journal  | author=Komar AA, Gross SR, Barth-Baus D, ''et al.'' |title=Novel characteristics of the biological properties of the yeast Saccharomyces cerevisiae eukaryotic initiation factor 2A. |journal=J. Biol. Chem. |volume=280 |issue= 16 |pages= 15601-11 |year= 2005 |pmid= 15718232 |doi= 10.1074/jbc.M413728200 }}
+* {{cite journal | vauthors = Mazroui R, Sukarieh R, Bordeleau ME, Kaufman RJ, Northcote P, Tanaka J, Gallouzi I, Pelletier J | title = Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2alpha phosphorylation | journal = Molecular Biology of the Cell | volume = 17 | issue = 10 | pages = 4212–9 | date = Oct 2006 | pmid = 16870703 | pmc = 1635342 | doi = 10.1091/mbc.E06-04-0318 }}
-*{{cite journal  | author=Wang J, Laschinger C, Zhao XH, ''et al.'' |title=Mechanical force activates eIF-2alpha phospho-kinases in fibroblast. |journal=Biochem. Biophys. Res. Commun. |volume=330 |issue= 1 |pages= 123-30 |year= 2005 |pmid= 15781241 |doi= 10.1016/j.bbrc.2005.02.140 }}
+* {{cite journal | vauthors = Fribley AM, Evenchik B, Zeng Q, Park BK, Guan JY, Zhang H, Hale TJ, Soengas MS, Kaufman RJ, Wang CY | title = Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa | journal = The Journal of Biological Chemistry | volume = 281 | issue = 42 | pages = 31440–7 | date = Oct 2006 | pmid = 16928686 | doi = 10.1074/jbc.M604356200 }}
-*{{cite journal  | author=Gorrini C, Loreni F, Gandin V, ''et al.'' |title=Fibronectin controls cap-dependent translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 26 |pages= 9200-5 |year= 2005 |pmid= 15961545 |doi= 10.1073/pnas.0409513102 }}
+* {{cite journal | vauthors = Fritsch RM, Schneider G, Saur D, Scheibel M, Schmid RM | title = Translational repression of MCL-1 couples stress-induced eIF2 alpha phosphorylation to mitochondrial apoptosis initiation | journal = The Journal of Biological Chemistry | volume = 282 | issue = 31 | pages = 22551–62 | date = Aug 2007 | pmid = 17553788 | doi = 10.1074/jbc.M702673200 }}
-*{{cite journal  | author=Su Q, Wang S, Baltzis D, ''et al.'' |title=Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 1 |pages= 63-8 |year= 2006 |pmid= 16373505 |doi= 10.1073/pnas.0508207103 }}
+* {{cite journal | vauthors = Nayak R, Pintel DJ | title = Adeno-associated viruses can induce phosphorylation of eIF2alpha via PKR activation, which can be overcome by helper adenovirus type 5 virus-associated RNA | journal = Journal of Virology | volume = 81 | issue = 21 | pages = 11908–16 | date = Nov 2007 | pmid = 17715234 | pmc = 2168773 | doi = 10.1128/JVI.01132-07 }}
-*{{cite journal  | author=Squatrito M, Mancino M, Sala L, Draetta GF |title=Ebp1 is a dsRNA-binding protein associated with ribosomes that modulates eIF2alpha phosphorylation. |journal=Biochem. Biophys. Res. Commun. |volume=344 |issue= 3 |pages= 859-68 |year= 2006 |pmid= 16631606 |doi= 10.1016/j.bbrc.2006.03.205 }}
-*{{cite journal  | author=Scheuner D, Patel R, Wang F, ''et al.'' |title=Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis. |journal=J. Biol. Chem. |volume=281 |issue= 30 |pages= 21458-68 |year= 2006 |pmid= 16717090 |doi= 10.1074/jbc.M603784200 }}
-*{{cite journal  | author=Mazroui R, Sukarieh R, Bordeleau ME, ''et al.'' |title=Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2alpha phosphorylation. |journal=Mol. Biol. Cell |volume=17 |issue= 10 |pages= 4212-9 |year= 2007 |pmid= 16870703 |doi= 10.1091/mbc.E06-04-0318 }}
-*{{cite journal  | author=Fribley AM, Evenchik B, Zeng Q, ''et al.'' |title=Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa. |journal=J. Biol. Chem. |volume=281 |issue= 42 |pages= 31440-7 |year= 2006 |pmid= 16928686 |doi= 10.1074/jbc.M604356200 }}
-*{{cite journal  | author=Fritsch RM, Schneider G, Saur D, ''et al.'' |title=Translational repression of MCL-1 couples stress-induced eIF2 alpha phosphorylation to mitochondrial apoptosis initiation. |journal=J. Biol. Chem. |volume=282 |issue= 31 |pages= 22551-62 |year= 2007 |pmid= 17553788 |doi= 10.1074/jbc.M702673200 }}
-*{{cite journal  | author=Nayak R, Pintel DJ |title=Adeno-associated viruses can induce phosphorylation of eIF2alpha via PKR activation, which can be overcome by helper adenovirus type 5 virus-associated RNA. |journal=J. Virol. |volume=81 |issue= 21 |pages= 11908-16 |year= 2007 |pmid= 17715234 |doi= 10.1128/JVI.01132-07 }}
-}}
 {{refend}}
-{{protein-stub}}
-{{WikiDoc Sources}}
+{{gene-3-stub}}

EIF2A: Difference between revisions

Latest revision as of 09:13, 3 January 2018

Contents

Function

See also

References

Further reading

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