EIF2A: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Eukaryotic translation initiation factor 2A''' ('''eIF2A''') is a [[protein]] that in humans is encoded by the ''EIF2A'' [[gene]].<ref name="pmid12133843">{{cite journal | vauthors = Zoll WL, Horton LE, Komar AA, Hensold JO, Merrick WC | title = Characterization of mammalian eIF2A and identification of the yeast homolog | journal = The Journal of Biological Chemistry | volume = 277 | issue = 40 | pages = 37079–87 | date = Oct 2002 | pmid = 12133843 | pmc =  | doi = 10.1074/jbc.M207109200 }}</ref><ref name="pmid1620067">{{cite journal | vauthors = Merrick WC | title = Mechanism and regulation of eukaryotic protein synthesis | journal = Microbiological Reviews | volume = 56 | issue = 2 | pages = 291–315 | date = Jun 1992 | pmid = 1620067 | pmc = 372869 | doi = }}</ref><ref name="entrez"/> The eIF2A protein is not to be confused with [[EIF2S1|eIF2α]], a subunit of the heterotrimeric [[eIF2]] complex. Instead, eIF2A functions by a separate mechanism in [[eukaryotic translation]].
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Eukaryotic translation initiation factor 2A, 65kDa
| HGNCid = 3254
| Symbol = EIF2A
| AltSymbols =; EIF-2A; CDA02; MST089; MSTP004; MSTP089
| OMIM = 609234
| ECnumber = 
| Homologene = 5969
| MGIid = 1098684
| GeneAtlas_image1 = PBB_GE_EIF2A_gnf1h00584_at_tn.png
| Function = {{GNF_GO|id=GO:0000049 |text = tRNA binding}} {{GNF_GO|id=GO:0003743 |text = translation initiation factor activity}} {{GNF_GO|id=GO:0043022 |text = ribosome binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005850 |text = eukaryotic translation initiation factor 2 complex}}
| Process = {{GNF_GO|id=GO:0006417 |text = regulation of translation}} {{GNF_GO|id=GO:0042255 |text = ribosome assembly}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 83939
    | Hs_Ensembl = ENSG00000144895
    | Hs_RefseqProtein = NP_114414
    | Hs_RefseqmRNA = NM_032025
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 151747206
    | Hs_GenLoc_end = 151784717
    | Hs_Uniprot = 
    | Mm_EntrezGene = 229317
    | Mm_Ensembl = ENSMUSG00000027810
    | Mm_RefseqmRNA = NM_001005509
    | Mm_RefseqProtein = NP_001005509
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 58613945
    | Mm_GenLoc_end = 58645430
    | Mm_Uniprot = 
  }}
}}
'''Eukaryotic translation initiation factor 2A, 65kDa''', also known as '''EIF2A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EIF2A eukaryotic translation initiation factor 2A, 65kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83939| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
eIF2A is a 65 kDa protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: EIF2A eukaryotic translation initiation factor 2A, 38kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83939| accessdate = }}</ref> It may be important for translation initiation mediated by the [[HCV IRES]] under stress conditions, but this result has been debated.<ref name="pmid21556050">{{cite journal | vauthors = Kim JH, Park SM, Park JH, Keum SJ, Jang SK | title = eIF2A mediates translation of hepatitis C viral mRNA under stress conditions | journal = The EMBO Journal | volume = 30 | issue = 12 | pages = 2454–64 | date = Jun 2011 | pmid = 21556050 | pmc =  3116280| doi = 10.1038/emboj.2011.146 }}</ref><ref name="Jaafar Oguro Nakamura Kieft p. ">{{cite journal | vauthors = Jaafar ZA, Oguro A, Nakamura Y, Kieft JS | title = Translation initiation by the hepatitis C virus IRES requires eIF1A and ribosomal complex remodeling | journal = eLife | volume = 5 | pages = e21198 | date = December 2016 | pmid = 28009256 | doi = 10.7554/elife.21198 }}</ref>
{{PBB_Summary
| section_title =
| summary_text = EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: EIF2A eukaryotic translation initiation factor 2A, 65kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83939| accessdate = }}</ref>
}}


==References==
== See also ==
{{reflist|2}}
* [[eIF2]]
==Further reading==
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Koumenis C, Naczki C, Koritzinsky M, Rastani S, Diehl A, Sonenberg N, Koromilas A, Wouters BG | title = Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha | journal = Molecular and Cellular Biology | volume = 22 | issue = 21 | pages = 7405–16 | date = Nov 2002 | pmid = 12370288 | pmc = 135664 | doi = 10.1128/MCB.22.21.7405-7416.2002 }}
| citations =
* {{cite journal | vauthors = Page AB, Owen CR, Kumar R, Miller JM, Rafols JA, White BC, DeGracia DJ, Krause GS | title = Persistent eIF2alpha(P) is colocalized with cytoplasmic cytochrome c in vulnerable hippocampal neurons after 4 hours of reperfusion following 10-minute complete brain ischemia | journal = Acta Neuropathologica | volume = 106 | issue = 1 | pages = 8–16 | date = Jul 2003 | pmid = 12687390 | doi = 10.1007/s00401-003-0693-2 }}
*{{cite journal  | author=Merrick WC |title=Mechanism and regulation of eukaryotic protein synthesis. |journal=Microbiol. Rev. |volume=56 |issue= 2 |pages= 291-315 |year= 1992 |pmid= 1620067 |doi=  }}
* {{cite journal | vauthors = Ito T, Marintchev A, Wagner G | title = Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B | journal = Structure | volume = 12 | issue = 9 | pages = 1693–704 | date = Sep 2004 | pmid = 15341733 | doi = 10.1016/j.str.2004.07.010 }}
*{{cite journal  | author=Zoll WL, Horton LE, Komar AA, ''et al.'' |title=Characterization of mammalian eIF2A and identification of the yeast homolog. |journal=J. Biol. Chem. |volume=277 |issue= 40 |pages= 37079-87 |year= 2002 |pmid= 12133843 |doi= 10.1074/jbc.M207109200 }}
* {{cite journal | vauthors = Weiser DC, Sikes S, Li S, Shenolikar S | title = The inhibitor-1 C terminus facilitates hormonal regulation of cellular protein phosphatase-1: functional implications for inhibitor-1 isoforms | journal = The Journal of Biological Chemistry | volume = 279 | issue = 47 | pages = 48904–14 | date = Nov 2004 | pmid = 15345721 | doi = 10.1074/jbc.M404416200 }}
*{{cite journal | author=Koumenis C, Naczki C, Koritzinsky M, ''et al.'' |title=Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha. |journal=Mol. Cell. Biol. |volume=22 |issue= 21 |pages= 7405-16 |year= 2002 |pmid= 12370288 |doi=  }}
* {{cite journal | vauthors = Komar AA, Gross SR, Barth-Baus D, Strachan R, Hensold JO, Goss Kinzy T, Merrick WC | title = Novel characteristics of the biological properties of the yeast Saccharomyces cerevisiae eukaryotic initiation factor 2A | journal = The Journal of Biological Chemistry | volume = 280 | issue = 16 | pages = 15601–11 | date = Apr 2005 | pmid = 15718232 | doi = 10.1074/jbc.M413728200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Wang J, Laschinger C, Zhao XH, Mak B, Seth A, McCulloch CA | title = Mechanical force activates eIF-2alpha phospho-kinases in fibroblast | journal = Biochemical and Biophysical Research Communications | volume = 330 | issue = 1 | pages = 123–30 | date = Apr 2005 | pmid = 15781241 | doi = 10.1016/j.bbrc.2005.02.140 }}
*{{cite journal | author=Page AB, Owen CR, Kumar R, ''et al.'' |title=Persistent eIF2alpha(P) is colocalized with cytoplasmic cytochrome c in vulnerable hippocampal neurons after 4 hours of reperfusion following 10-minute complete brain ischemia. |journal=Acta Neuropathol. |volume=106 |issue= 1 |pages= 8-16 |year= 2003 |pmid= 12687390 |doi= 10.1007/s00401-003-0693-2 }}
* {{cite journal | vauthors = Gorrini C, Loreni F, Gandin V, Sala LA, Sonenberg N, Marchisio PC, Biffo S | title = Fibronectin controls cap-dependent translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 102 | issue = 26 | pages = 9200–5 | date = Jun 2005 | pmid = 15961545 | pmc = 1166589 | doi = 10.1073/pnas.0409513102 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Su Q, Wang S, Baltzis D, Qu LK, Wong AH, Koromilas AE | title = Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 1 | pages = 63–8 | date = Jan 2006 | pmid = 16373505 | pmc = 1324992 | doi = 10.1073/pnas.0508207103 }}
*{{cite journal  | author=Ito T, Marintchev A, Wagner G |title=Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B. |journal=Structure |volume=12 |issue= 9 |pages= 1693-704 |year= 2005 |pmid= 15341733 |doi= 10.1016/j.str.2004.07.010 }}
* {{cite journal | vauthors = Squatrito M, Mancino M, Sala L, Draetta GF | title = Ebp1 is a dsRNA-binding protein associated with ribosomes that modulates eIF2alpha phosphorylation | journal = Biochemical and Biophysical Research Communications | volume = 344 | issue = 3 | pages = 859–68 | date = Jun 2006 | pmid = 16631606 | doi = 10.1016/j.bbrc.2006.03.205 }}
*{{cite journal | author=Weiser DC, Sikes S, Li S, Shenolikar S |title=The inhibitor-1 C terminus facilitates hormonal regulation of cellular protein phosphatase-1: functional implications for inhibitor-1 isoforms. |journal=J. Biol. Chem. |volume=279 |issue= 47 |pages= 48904-14 |year= 2005 |pmid= 15345721 |doi= 10.1074/jbc.M404416200 }}
* {{cite journal | vauthors = Scheuner D, Patel R, Wang F, Lee K, Kumar K, Wu J, Nilsson A, Karin M, Kaufman RJ | title = Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis | journal = The Journal of Biological Chemistry | volume = 281 | issue = 30 | pages = 21458–68 | date = Jul 2006 | pmid = 16717090 | doi = 10.1074/jbc.M603784200 }}
*{{cite journal | author=Komar AA, Gross SR, Barth-Baus D, ''et al.'' |title=Novel characteristics of the biological properties of the yeast Saccharomyces cerevisiae eukaryotic initiation factor 2A. |journal=J. Biol. Chem. |volume=280 |issue= 16 |pages= 15601-11 |year= 2005 |pmid= 15718232 |doi= 10.1074/jbc.M413728200 }}
* {{cite journal | vauthors = Mazroui R, Sukarieh R, Bordeleau ME, Kaufman RJ, Northcote P, Tanaka J, Gallouzi I, Pelletier J | title = Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2alpha phosphorylation | journal = Molecular Biology of the Cell | volume = 17 | issue = 10 | pages = 4212–9 | date = Oct 2006 | pmid = 16870703 | pmc = 1635342 | doi = 10.1091/mbc.E06-04-0318 }}
*{{cite journal | author=Wang J, Laschinger C, Zhao XH, ''et al.'' |title=Mechanical force activates eIF-2alpha phospho-kinases in fibroblast. |journal=Biochem. Biophys. Res. Commun. |volume=330 |issue= 1 |pages= 123-30 |year= 2005 |pmid= 15781241 |doi= 10.1016/j.bbrc.2005.02.140 }}
* {{cite journal | vauthors = Fribley AM, Evenchik B, Zeng Q, Park BK, Guan JY, Zhang H, Hale TJ, Soengas MS, Kaufman RJ, Wang CY | title = Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa | journal = The Journal of Biological Chemistry | volume = 281 | issue = 42 | pages = 31440–7 | date = Oct 2006 | pmid = 16928686 | doi = 10.1074/jbc.M604356200 }}
*{{cite journal | author=Gorrini C, Loreni F, Gandin V, ''et al.'' |title=Fibronectin controls cap-dependent translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 26 |pages= 9200-5 |year= 2005 |pmid= 15961545 |doi= 10.1073/pnas.0409513102 }}
* {{cite journal | vauthors = Fritsch RM, Schneider G, Saur D, Scheibel M, Schmid RM | title = Translational repression of MCL-1 couples stress-induced eIF2 alpha phosphorylation to mitochondrial apoptosis initiation | journal = The Journal of Biological Chemistry | volume = 282 | issue = 31 | pages = 22551–62 | date = Aug 2007 | pmid = 17553788 | doi = 10.1074/jbc.M702673200 }}
*{{cite journal | author=Su Q, Wang S, Baltzis D, ''et al.'' |title=Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 1 |pages= 63-8 |year= 2006 |pmid= 16373505 |doi= 10.1073/pnas.0508207103 }}
* {{cite journal | vauthors = Nayak R, Pintel DJ | title = Adeno-associated viruses can induce phosphorylation of eIF2alpha via PKR activation, which can be overcome by helper adenovirus type 5 virus-associated RNA | journal = Journal of Virology | volume = 81 | issue = 21 | pages = 11908–16 | date = Nov 2007 | pmid = 17715234 | pmc = 2168773 | doi = 10.1128/JVI.01132-07 }}
*{{cite journal | author=Squatrito M, Mancino M, Sala L, Draetta GF |title=Ebp1 is a dsRNA-binding protein associated with ribosomes that modulates eIF2alpha phosphorylation. |journal=Biochem. Biophys. Res. Commun. |volume=344 |issue= 3 |pages= 859-68 |year= 2006 |pmid= 16631606 |doi= 10.1016/j.bbrc.2006.03.205 }}
*{{cite journal | author=Scheuner D, Patel R, Wang F, ''et al.'' |title=Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis. |journal=J. Biol. Chem. |volume=281 |issue= 30 |pages= 21458-68 |year= 2006 |pmid= 16717090 |doi= 10.1074/jbc.M603784200 }}
*{{cite journal | author=Mazroui R, Sukarieh R, Bordeleau ME, ''et al.'' |title=Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2alpha phosphorylation. |journal=Mol. Biol. Cell |volume=17 |issue= 10 |pages= 4212-9 |year= 2007 |pmid= 16870703 |doi= 10.1091/mbc.E06-04-0318 }}
*{{cite journal | author=Fribley AM, Evenchik B, Zeng Q, ''et al.'' |title=Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa. |journal=J. Biol. Chem. |volume=281 |issue= 42 |pages= 31440-7 |year= 2006 |pmid= 16928686 |doi= 10.1074/jbc.M604356200 }}
*{{cite journal | author=Fritsch RM, Schneider G, Saur D, ''et al.'' |title=Translational repression of MCL-1 couples stress-induced eIF2 alpha phosphorylation to mitochondrial apoptosis initiation. |journal=J. Biol. Chem. |volume=282 |issue= 31 |pages= 22551-62 |year= 2007 |pmid= 17553788 |doi= 10.1074/jbc.M702673200 }}
*{{cite journal | author=Nayak R, Pintel DJ |title=Adeno-associated viruses can induce phosphorylation of eIF2alpha via PKR activation, which can be overcome by helper adenovirus type 5 virus-associated RNA. |journal=J. Virol. |volume=81 |issue= 21 |pages= 11908-16 |year= 2007 |pmid= 17715234 |doi= 10.1128/JVI.01132-07 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 09:13, 3 January 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Eukaryotic translation initiation factor 2A (eIF2A) is a protein that in humans is encoded by the EIF2A gene.[1][2][3] The eIF2A protein is not to be confused with eIF2α, a subunit of the heterotrimeric eIF2 complex. Instead, eIF2A functions by a separate mechanism in eukaryotic translation.

Function

eIF2A is a 65 kDa protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002).[supplied by OMIM][3] It may be important for translation initiation mediated by the HCV IRES under stress conditions, but this result has been debated.[4][5]

See also

References

  1. ↑ Zoll WL, Horton LE, Komar AA, Hensold JO, Merrick WC (Oct 2002). "Characterization of mammalian eIF2A and identification of the yeast homolog". The Journal of Biological Chemistry. 277 (40): 37079–87. doi:10.1074/jbc.M207109200. PMID 12133843.
  2. ↑ Merrick WC (Jun 1992). "Mechanism and regulation of eukaryotic protein synthesis". Microbiological Reviews. 56 (2): 291–315. PMC 372869. PMID 1620067.
  3. ↑ 3.0 3.1 "Entrez Gene: EIF2A eukaryotic translation initiation factor 2A, 38kDa".
  4. ↑ Kim JH, Park SM, Park JH, Keum SJ, Jang SK (Jun 2011). "eIF2A mediates translation of hepatitis C viral mRNA under stress conditions". The EMBO Journal. 30 (12): 2454–64. doi:10.1038/emboj.2011.146. PMC 3116280. PMID 21556050.
  5. ↑ Jaafar ZA, Oguro A, Nakamura Y, Kieft JS (December 2016). "Translation initiation by the hepatitis C virus IRES requires eIF1A and ribosomal complex remodeling". eLife. 5: e21198. doi:10.7554/elife.21198. PMID 28009256.

Further reading


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