EML4: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Echinoderm microtubule-associated protein-like 4''' is a [[protein]] that in humans is encoded by the ''EML4'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EML4 echinoderm microtubule associated protein like 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27436| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
This protein is involved in cancers when spliced with the [[anaplastic lymphoma kinase]].<ref name="pmid18593892">{{cite journal | vauthors = Choi YL, Takeuchi K, Soda M, Inamura K, Togashi Y, Hatano S, Enomoto M, Hamada T, Haruta H, Watanabe H, Kurashina K, Hatanaka H, Ueno T, Takada S, Yamashita Y, Sugiyama Y, Ishikawa Y, Mano H | title = Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer | journal = Cancer Res. | volume = 68 | issue = 13 | pages = 4971–6 |date=July 2008 | pmid = 18593892 | doi = 10.1158/0008-5472.CAN-07-6158 }}</ref>
{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Echinoderm microtubule associated protein like 4
| HGNCid = 1316
| Symbol = EML4
| AltSymbols =; C2orf2; DKFZp686P18118; ELP120; FLJ10942; FLJ32318; ROPP120
| OMIM = 607442
| ECnumber = 
| Homologene = 56841
| MGIid = 1926048
| GeneAtlas_image1 = PBB_GE_EML4_220386_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005874 |text = microtubule}}
| Process = {{GNF_GO|id=GO:0007017 |text = microtubule-based process}} {{GNF_GO|id=GO:0007067 |text = mitosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 27436
    | Hs_Ensembl = ENSG00000143924
    | Hs_RefseqProtein = NP_061936
    | Hs_RefseqmRNA = NM_019063
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 42249997
    | Hs_GenLoc_end = 42413192
    | Hs_Uniprot = Q9HC35
    | Mm_EntrezGene = 78798
    | Mm_Ensembl = ENSMUSG00000032624
    | Mm_RefseqmRNA = NM_199466
    | Mm_RefseqProtein = NP_955760
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 83313529
    | Mm_GenLoc_end = 83388677
    | Mm_Uniprot = 
  }}
}}
'''Echinoderm microtubule associated protein like 4''', also known as '''EML4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EML4 echinoderm microtubule associated protein like 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27436| accessdate = }}</ref>


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==References==
{{PBB_Summary
{{reflist}}
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| summary_text =
}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Andersson B, Wentland MA, Ricafrente JY |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 |display-authors=etal}}
| citations =
*{{cite journal  | vauthors=Yu W, Andersson B, Worley KC |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=  10.1101/gr.7.4.353| pmc=139146  |display-authors=etal}}
*{{cite journal  | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal  | vauthors=Heidebrecht HJ, Buck F, Pollmann M |title=Cloning and localization of C2orf2(ropp120), a previously unknown WD repeat protein. |journal=Genomics |volume=68 |issue= 3 |pages= 348–50 |year= 2000 |pmid= 10995578 |doi= 10.1006/geno.2000.6301 |display-authors=etal}}
*{{cite journal  | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Heidebrecht HJ, Buck F, Pollmann M, ''et al.'' |title=Cloning and localization of C2orf2(ropp120), a previously unknown WD repeat protein. |journal=Genomics |volume=68 |issue= 3 |pages= 348-50 |year= 2000 |pmid= 10995578 |doi= 10.1006/geno.2000.6301 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal  | vauthors=Rush J, Moritz A, Lee KA |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Hillier LW, Graves TA, Fulton RS |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 |display-authors=etal}}
*{{cite journal  | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal  | vauthors=Pollmann M, Parwaresch R, Adam-Klages S |title=Human EML4, a novel member of the EMAP family, is essential for microtubule formation. |journal=Exp. Cell Res. |volume=312 |issue= 17 |pages= 3241–51 |year= 2006 |pmid= 16890222 |doi= 10.1016/j.yexcr.2006.06.035 |display-authors=etal}}
*{{cite journal  | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724-31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
*{{cite journal  | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
*{{cite journal  | author=Pollmann M, Parwaresch R, Adam-Klages S, ''et al.'' |title=Human EML4, a novel member of the EMAP family, is essential for microtubule formation. |journal=Exp. Cell Res. |volume=312 |issue= 17 |pages= 3241-51 |year= 2006 |pmid= 16890222 |doi= 10.1016/j.yexcr.2006.06.035 }}
*{{cite journal  | vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 |display-authors=etal}}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Echinoderm microtubule-associated protein-likes}}
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{{gene-2-stub}}

Latest revision as of 00:29, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

n/a

RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Echinoderm microtubule-associated protein-like 4 is a protein that in humans is encoded by the EML4 gene.[1]

This protein is involved in cancers when spliced with the anaplastic lymphoma kinase.[2]

References

  1. ↑ "Entrez Gene: EML4 echinoderm microtubule associated protein like 4".
  2. ↑ Choi YL, Takeuchi K, Soda M, Inamura K, Togashi Y, Hatano S, Enomoto M, Hamada T, Haruta H, Watanabe H, Kurashina K, Hatanaka H, Ueno T, Takada S, Yamashita Y, Sugiyama Y, Ishikawa Y, Mano H (July 2008). "Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer". Cancer Res. 68 (13): 4971–6. doi:10.1158/0008-5472.CAN-07-6158. PMID 18593892.

Further reading


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