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{{Infobox_gene}}
{{PBB_Controls
'''[[Ectoderm]]-neural cortex protein 1''' is a [[protein]] that in humans is encoded by the ''ENC1'' [[gene]].<ref name="pmid9305847">{{cite journal | vauthors = Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B | title = A model for p53-induced apoptosis | journal = Nature | volume = 389 | issue = 6648 | pages = 300–5 | date = Sep 1997 | pmid = 9305847 | pmc =  | doi = 10.1038/38525 }}</ref><ref name="pmid9566959">{{cite journal | vauthors = Kim TA, Lim J, Ota S, Raja S, Rogers R, Rivnay B, Avraham H, Avraham S | title = NRP/B, a novel nuclear matrix protein, associates with p110(RB) and is involved in neuronal differentiation | journal = The Journal of Cell Biology | volume = 141 | issue = 3 | pages = 553–66 | date = May 1998 | pmid = 9566959 | pmc = 2132755 | doi = 10.1083/jcb.141.3.553 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ENC1 ectodermal-neural cortex (with BTB-like domain)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8507| accessdate = }}</ref>
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| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Ectodermal-neural cortex (with BTB-like domain)
| HGNCid = 3345
| Symbol = ENC1
| AltSymbols =; CCL28; ENC-1; FLJ39259; KLHL35; NRPB; PIG10; TP53I10
| OMIM = 605173
| ECnumber = 
| Homologene = 2694
| MGIid = 109610
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}}
| Process = {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007399 |text = nervous system development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8507
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_003624
    | Hs_RefseqmRNA = NM_003633
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 13803
    | Mm_Ensembl = ENSMUSG00000041773
    | Mm_RefseqmRNA = NM_007930
    | Mm_RefseqProtein = NP_031956
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 98341869
    | Mm_GenLoc_end = 98353733
    | Mm_Uniprot = Q8BRG4
  }}
}}
'''Ectodermal-neural cortex (with BTB-like domain)''', also known as '''ENC1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ENC1 ectodermal-neural cortex (with BTB-like domain)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8507| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
DNA damage and/or hyperproliferative signals activate wildtype p53 tumor suppressor protein (TP53; MIM 191170), inducing cell cycle arrest or apoptosis. Mutations that inactivate p53 occur in 50% of all tumors. Polyak et al. (1997) used serial analysis of gene expression (SAGE) to evaluate cellular mRNA levels in a colorectal cancer cell line transfected with p53. Of 7,202 transcripts identified, only 14 were expressed at levels more than 10-fold higher in p53-expressing cells than in control cells. Polyak et al. (1997) termed these genes 'p53-induced genes,' or PIGs, several of which were predicted to encode redox-controlling proteins. They noted that reactive oxygen species (ROS) are potent inducers of apoptosis. Flow cytometric analysis showed that p53 expression induces ROS production, which increases as apoptosis progresses under some conditions. The authors stated that the PIG10 gene, also called ENC1, encodes an actin-binding protein.[supplied by OMIM]<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = DNA damage and/or hyperproliferative signals activate wildtype p53 tumor suppressor protein (TP53; MIM 191170), inducing cell cycle arrest or apoptosis. Mutations that inactivate p53 occur in 50% of all tumors. Polyak et al. (1997) used serial analysis of gene expression (SAGE) to evaluate cellular mRNA levels in a colorectal cancer cell line transfected with p53. Of 7,202 transcripts identified, only 14 were expressed at levels more than 10-fold higher in p53-expressing cells than in control cells. Polyak et al. (1997) termed these genes 'p53-induced genes,' or PIGs, several of which were predicted to encode redox-controlling proteins. They noted that reactive oxygen species (ROS) are potent inducers of apoptosis. Flow cytometric analysis showed that p53 expression induces ROS production, which increases as apoptosis progresses under some conditions. The authors stated that the PIG10 gene, also called ENC1, encodes an actin-binding protein.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: ENC1 ectodermal-neural cortex (with BTB-like domain)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8507| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
ENC1 has been shown to [[Protein-protein interaction|interact]] with [[Retinoblastoma protein]].<ref name=pmid9566959 />
{{refbegin | 2}}
 
{{PBB_Further_reading
==Model organisms==
| citations =  
[[Model organism]]s have been used in the study of ENC1 function. A conditional [[knockout mouse]] line called ''Enc1<sup>tm1a(EUCOMM)Wtsi</sup>'' was generated at the [[Wellcome Trust Sanger Institute]].<ref name="mgp_reference">{{cite journal |title=The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice |author=Gerdin AK |year=2010 |journal=Acta Ophthalmologica|volume=88 |pages=925–7|doi=10.1111/j.1755-3768.2010.4142.x }}</ref> Male and female animals underwent a standardized [[phenotypic screen]]<ref name="IMPCsearch_ref">{{cite web |url=http://www.mousephenotype.org/data/search?q=Enc1#fq=*:*&facet=gene |title=International Mouse Phenotyping Consortium}}</ref> to determine the effects of deletion.<ref name="pmid21677750">{{cite journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–42 | date = Jun 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}</ref><ref name="mouse_library">{{cite journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | date = Jun 2011 | pmid = 21677718 | doi = 10.1038/474262a }}</ref><ref name="mouse_for_all_reasons">{{cite journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9–13 | date = Jan 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}</ref><ref name="pmid23870131">{{cite journal | vauthors = White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP | title = Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes | journal = Cell | volume = 154 | issue = 2 | pages = 452–64 | date = Jul 2013 | pmid = 23870131 | doi = 10.1016/j.cell.2013.06.022 | pmc=3717207}}</ref> Additional screens performed: - In-depth immunological phenotyping<ref name="iii_ref">{{cite web |url= http://www.immunophenotyping.org/data/search?keys=Enc1&field_gene_construct_tid=All |title=Infection and Immunity Immunophenotyping (3i) Consortium}}</ref>
*{{cite journal | author=Polyak K, Xia Y, Zweier JL, ''et al.'' |title=A model for p53-induced apoptosis. |journal=Nature |volume=389 |issue= 6648 |pages= 300-5 |year= 1997 |pmid= 9305847 |doi= 10.1038/38525 }}
{| class="wikitable sortable collapsible collapsed" border="1" cellpadding="2" style="float: left;" |
*{{cite journal | author=Kim TA, Lim J, Ota S, ''et al.'' |title=NRP/B, a novel nuclear matrix protein, associates with p110(RB) and is involved in neuronal differentiation. |journal=J. Cell Biol. |volume=141 |issue= 3 |pages= 553-66 |year= 1998 |pmid= 9566959 |doi=  }}
|+ ''Enc1'' knockout mouse phenotype
*{{cite journal | author=Hernandez MC, Andres-Barquin PJ, Holt I, Israel MA |title=Cloning of human ENC-1 and evaluation of its expression and regulation in nervous system tumors. |journal=Exp. Cell Res. |volume=242 |issue= 2 |pages= 470-7 |year= 1998 |pmid= 9683534 |doi= 10.1006/excr.1998.4109 }}
|-
*{{cite journal | author=Hernandez MC, Andres-Barquin PJ, Kuo WL, Israel MA |title=Assignment of the ectodermal-neural cortex 1 gene (ENC1) to human chromosome band 5q13 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=87 |issue= 1-2 |pages= 89-90 |year= 2000 |pmid= 10640818 |doi= }}
! Characteristic!! Phenotype
*{{cite journal | author=Zhao L, Gregoire F, Sul HS |title=Transient induction of ENC-1, a Kelch-related actin-binding protein, is required for adipocyte differentiation. |journal=J. Biol. Chem. |volume=275 |issue= 22 |pages= 16845-50 |year= 2000 |pmid= 10828068 |doi= }}
|-
*{{cite journal | author=Kim TA, Ota S, Jiang S, ''et al.'' |title=Genomic organization, chromosomal localization and regulation of expression of the neuronal nuclear matrix protein NRP/B in human brain tumors. |journal=Gene |volume=255 |issue= 1 |pages= 105-16 |year= 2000 |pmid= 10974570 |doi= }}
| colspan=2; style="text-align: center;" | All data available at.<ref name="IMPCsearch_ref"/><ref name="iii_ref" />
*{{cite journal | author=Fujita M, Furukawa Y, Tsunoda T, ''et al.'' |title=Up-regulation of the ectodermal-neural cortex 1 (ENC1) gene, a downstream target of the beta-catenin/T-cell factor complex, in colorectal carcinomas. |journal=Cancer Res. |volume=61 |issue= 21 |pages= 7722-6 |year= 2001 |pmid= 11691783 |doi=  }}
|-
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
| Peripheral blood leukocytes 6 Weeks || bgcolor="#488ED3"|Normal
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
 
*{{cite journal  | author=Hammarsund M, Lerner M, Zhu C, ''et al.'' |title=Disruption of a novel ectodermal neural cortex 1 antisense gene, ENC-1AS and identification of ENC-1 overexpression in hairy cell leukemia. |journal=Hum. Mol. Genet. |volume=13 |issue= 23 |pages= 2925-36 |year= 2005 |pmid= 15459180 |doi= 10.1093/hmg/ddh315 }}
|-
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
| Insulin || bgcolor="#488ED3"|Normal
*{{cite journal  | author=Barrios-Rodiles M, Brown KR, Ozdamar B, ''et al.'' |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621-5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 }}
 
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
|-
*{{cite journal | author=Seng S, Avraham HK, Jiang S, ''et al.'' |title=The nuclear matrix protein, NRP/B, enhances Nrf2-mediated oxidative stress responses in breast cancer cells. |journal=Cancer Res. |volume=67 |issue= 18 |pages= 8596-604 |year= 2007 |pmid= 17875699 |doi= 10.1158/0008-5472.CAN-06-3785 }}
| ''[[Haematology]]'' 6 Weeks || bgcolor="#C40000"|Abnormal
}}
 
|-
| Homozygous viability at P14 || bgcolor="#488ED3"|Normal
 
|-
| Homozygous Fertility || bgcolor="#488ED3"|Normal
 
|-
| Body weight || bgcolor="#488ED3"|Normal
 
|-
| Neurological assessment || bgcolor="#488ED3"|Normal
 
|-
| Grip strength || bgcolor="#488ED3"|Normal
 
|-
| [[Dysmorphology]] || bgcolor="#488ED3"|Normal
 
|-
| [[Indirect calorimetry]] || bgcolor="#488ED3"|Normal
 
|-
| [[Glucose tolerance test]] || bgcolor="#488ED3"|Normal
 
|-
| [[Auditory brainstem response]] || bgcolor="#488ED3"|Normal
 
|-
| [[Dual-energy X-ray absorptiometry|DEXA]] || bgcolor="#488ED3"|Normal
 
|-
| [[Radiography]] || bgcolor="#488ED3"|Normal
 
|-
| Eye morphology || bgcolor="#488ED3"|Normal
 
|-
| [[Clinical chemistry]] || bgcolor="#488ED3"|Normal
 
|-
| ''[[Haematology]]'' 16 Weeks || bgcolor="#488ED3"|Normal
 
|-
| Peripheral blood leukocytes 16 Weeks || bgcolor="#488ED3"|Normal
 
|-
| Heart weight || bgcolor="#488ED3"|Normal
 
|-
| ''[[Salmonella]]'' infection || bgcolor="#488ED3"|Normal
 
|-
| Cytotoxic T Cell Function || bgcolor="#488ED3"|Normal
 
|-
| Spleen Immunophenotyping || bgcolor="#488ED3"|Normal
 
|-
| Mesenteric Lymph Node Immunophenotyping || bgcolor="#488ED3"|Normal
 
|-
| Bone Marrow Immunophenotyping || bgcolor="#488ED3"|Normal
 
|-
| Epidermal Immune Composition || bgcolor="#488ED3"|Normal
 
|-
|}
{{clear}}
 
== References ==
{{reflist|33em}}
 
== Further reading ==
{{refbegin|33em}}
* {{cite journal | vauthors = Hernandez MC, Andres-Barquin PJ, Holt I, Israel MA | title = Cloning of human ENC-1 and evaluation of its expression and regulation in nervous system tumors | journal = Experimental Cell Research | volume = 242 | issue = 2 | pages = 470–7 | date = Aug 1998 | pmid = 9683534 | doi = 10.1006/excr.1998.4109 }}
* {{cite journal | vauthors = Hernandez MC, Andres-Barquin PJ, Kuo WL, Israel MA | title = Assignment of the ectodermal-neural cortex 1 gene (ENC1) to human chromosome band 5q13 by in situ hybridization | journal = Cytogenetics and Cell Genetics | volume = 87 | issue = 1-2 | pages = 89–90 | year = 2000 | pmid = 10640818 | doi = 10.1159/000015398 }}
* {{cite journal | vauthors = Zhao L, Gregoire F, Sul HS | title = Transient induction of ENC-1, a Kelch-related actin-binding protein, is required for adipocyte differentiation | journal = The Journal of Biological Chemistry | volume = 275 | issue = 22 | pages = 16845–50 | date = Jun 2000 | pmid = 10828068 | doi = 10.1074/jbc.275.22.16845 }}
* {{cite journal | vauthors = Kim TA, Ota S, Jiang S, Pasztor LM, White RA, Avraham S | title = Genomic organization, chromosomal localization and regulation of expression of the neuronal nuclear matrix protein NRP/B in human brain tumors | journal = Gene | volume = 255 | issue = 1 | pages = 105–16 | date = Sep 2000 | pmid = 10974570 | doi = 10.1016/S0378-1119(00)00297-3 }}
* {{cite journal | vauthors = Fujita M, Furukawa Y, Tsunoda T, Tanaka T, Ogawa M, Nakamura Y | title = Up-regulation of the ectodermal-neural cortex 1 (ENC1) gene, a downstream target of the beta-catenin/T-cell factor complex, in colorectal carcinomas | journal = Cancer Research | volume = 61 | issue = 21 | pages = 7722–6 | date = Nov 2001 | pmid = 11691783 | doi =  }}
* {{cite journal | vauthors = Hammarsund M, Lerner M, Zhu C, Merup M, Jansson M, Gahrton G, Kluin-Nelemans H, Einhorn S, Grandér D, Sangfelt O, Corcoran M | title = Disruption of a novel ectodermal neural cortex 1 antisense gene, ENC-1AS and identification of ENC-1 overexpression in hairy cell leukemia | journal = Human Molecular Genetics | volume = 13 | issue = 23 | pages = 2925–36 | date = Dec 2004 | pmid = 15459180 | doi = 10.1093/hmg/ddh315 }}
* {{cite journal | vauthors = Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL | title = High-throughput mapping of a dynamic signaling network in mammalian cells | journal = Science | volume = 307 | issue = 5715 | pages = 1621–5 | date = Mar 2005 | pmid = 15761153 | doi = 10.1126/science.1105776 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
* {{cite journal | vauthors = Seng S, Avraham HK, Jiang S, Yang S, Sekine M, Kimelman N, Li H, Avraham S | title = The nuclear matrix protein, NRP/B, enhances Nrf2-mediated oxidative stress responses in breast cancer cells | journal = Cancer Research | volume = 67 | issue = 18 | pages = 8596–604 | date = Sep 2007 | pmid = 17875699 | doi = 10.1158/0008-5472.CAN-06-3785 }}
{{refend}}
{{refend}}


{{protein-stub}}
[[Category:Kelch proteins]]
{{WikiDoc Sources}}

Latest revision as of 02:44, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ectoderm-neural cortex protein 1 is a protein that in humans is encoded by the ENC1 gene.[1][2][3]

Function

DNA damage and/or hyperproliferative signals activate wildtype p53 tumor suppressor protein (TP53; MIM 191170), inducing cell cycle arrest or apoptosis. Mutations that inactivate p53 occur in 50% of all tumors. Polyak et al. (1997) used serial analysis of gene expression (SAGE) to evaluate cellular mRNA levels in a colorectal cancer cell line transfected with p53. Of 7,202 transcripts identified, only 14 were expressed at levels more than 10-fold higher in p53-expressing cells than in control cells. Polyak et al. (1997) termed these genes 'p53-induced genes,' or PIGs, several of which were predicted to encode redox-controlling proteins. They noted that reactive oxygen species (ROS) are potent inducers of apoptosis. Flow cytometric analysis showed that p53 expression induces ROS production, which increases as apoptosis progresses under some conditions. The authors stated that the PIG10 gene, also called ENC1, encodes an actin-binding protein.[supplied by OMIM][3]

Interactions

ENC1 has been shown to interact with Retinoblastoma protein.[2]

Model organisms

Model organisms have been used in the study of ENC1 function. A conditional knockout mouse line called Enc1tm1a(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[4] Male and female animals underwent a standardized phenotypic screen[5] to determine the effects of deletion.[6][7][8][9] Additional screens performed: - In-depth immunological phenotyping[10]

References

  1. ↑ Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B (Sep 1997). "A model for p53-induced apoptosis". Nature. 389 (6648): 300–5. doi:10.1038/38525. PMID 9305847.
  2. ↑ 2.0 2.1 Kim TA, Lim J, Ota S, Raja S, Rogers R, Rivnay B, Avraham H, Avraham S (May 1998). "NRP/B, a novel nuclear matrix protein, associates with p110(RB) and is involved in neuronal differentiation". The Journal of Cell Biology. 141 (3): 553–66. doi:10.1083/jcb.141.3.553. PMC 2132755. PMID 9566959.
  3. ↑ 3.0 3.1 "Entrez Gene: ENC1 ectodermal-neural cortex (with BTB-like domain)".
  4. ↑ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  5. ↑ 5.0 5.1 "International Mouse Phenotyping Consortium".
  6. ↑ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  7. ↑ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  8. ↑ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  9. ↑ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
  10. ↑ 10.0 10.1 "Infection and Immunity Immunophenotyping (3i) Consortium".

Further reading

  • Hernandez MC, Andres-Barquin PJ, Holt I, Israel MA (Aug 1998). "Cloning of human ENC-1 and evaluation of its expression and regulation in nervous system tumors". Experimental Cell Research. 242 (2): 470–7. doi:10.1006/excr.1998.4109. PMID 9683534.
  • Hernandez MC, Andres-Barquin PJ, Kuo WL, Israel MA (2000). "Assignment of the ectodermal-neural cortex 1 gene (ENC1) to human chromosome band 5q13 by in situ hybridization". Cytogenetics and Cell Genetics. 87 (1–2): 89–90. doi:10.1159/000015398. PMID 10640818.
  • Zhao L, Gregoire F, Sul HS (Jun 2000). "Transient induction of ENC-1, a Kelch-related actin-binding protein, is required for adipocyte differentiation". The Journal of Biological Chemistry. 275 (22): 16845–50. doi:10.1074/jbc.275.22.16845. PMID 10828068.
  • Kim TA, Ota S, Jiang S, Pasztor LM, White RA, Avraham S (Sep 2000). "Genomic organization, chromosomal localization and regulation of expression of the neuronal nuclear matrix protein NRP/B in human brain tumors". Gene. 255 (1): 105–16. doi:10.1016/S0378-1119(00)00297-3. PMID 10974570.
  • Fujita M, Furukawa Y, Tsunoda T, Tanaka T, Ogawa M, Nakamura Y (Nov 2001). "Up-regulation of the ectodermal-neural cortex 1 (ENC1) gene, a downstream target of the beta-catenin/T-cell factor complex, in colorectal carcinomas". Cancer Research. 61 (21): 7722–6. PMID 11691783.
  • Hammarsund M, Lerner M, Zhu C, Merup M, Jansson M, Gahrton G, Kluin-Nelemans H, Einhorn S, Grandér D, Sangfelt O, Corcoran M (Dec 2004). "Disruption of a novel ectodermal neural cortex 1 antisense gene, ENC-1AS and identification of ENC-1 overexpression in hairy cell leukemia". Human Molecular Genetics. 13 (23): 2925–36. doi:10.1093/hmg/ddh315. PMID 15459180.
  • Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL (Mar 2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
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