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{{Infobox_gene}}
{{PBB_Controls
'''Flotillin-1''' is a [[protein]] that in humans is encoded by the ''FLOT1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FLOT1 flotillin 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10211| accessdate = }}</ref>
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| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Caveolae]] are small domains on the inner cell membrane involved in vesicular trafficking and [[signal transduction]].  FLOT1 encodes a caveolae-associated, [[integral membrane protein]].<ref name="pmid9153235">{{cite journal |vauthors=Bickel PE, Scherer PE, Schnitzer JE, Oh P, Lisanti MP, Lodish HF | title = Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins | journal = J. Biol. Chem. | volume = 272 | issue = 21 | pages = 13793–802 |date=May 1997 | pmid = 9153235 | doi = 10.1074/jbc.272.21.13793 }}</ref> The function of flotillin 1 has not been determined.<ref name="entrez"/>
{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Flotillin 1
| HGNCid = 3757
| Symbol = FLOT1
| AltSymbols =;
| OMIM = 606998
| ECnumber =
| Homologene = 31337
| MGIid = 1100500
| GeneAtlas_image1 = PBB_GE_FLOT1_208748_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_FLOT1_208749_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_FLOT1_210142_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}  
  | Component = {{GNF_GO|id=GO:0005901 |text = caveola}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0016600 |text = flotillin complex}} {{GNF_GO|id=GO:0045121 |text = lipid raft}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10211
    | Hs_Ensembl = ENSG00000137312
    | Hs_RefseqProtein = NP_005794
    | Hs_RefseqmRNA = NM_005803
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 30803465
    | Hs_GenLoc_end = 30818443
    | Hs_Uniprot = O75955
    | Mm_EntrezGene = 14251
    | Mm_Ensembl = ENSMUSG00000059714
    | Mm_RefseqmRNA = NM_008027
    | Mm_RefseqProtein = NP_032053
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 35431400
    | Mm_GenLoc_end = 35440840
    | Mm_Uniprot = Q3TJS0
  }}
}}
'''Flotillin 1''', also known as '''FLOT1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FLOT1 flotillin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10211| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{PBB_Summary
 
| section_title =  
FLOT1 has been shown to [[Protein-protein interaction|interact]] with [[SORBS1]].<ref name="pmid15128873">{{cite journal |vauthors=Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I | title = Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites | journal = J. Cell Sci. | volume = 117 | issue = Pt 12 | pages = 2557–68 |date=May 2004 | pmid = 15128873 | doi = 10.1242/jcs.01148 }}</ref><ref name="pmid11001060">{{cite journal |vauthors=Baumann CA, Ribon V, Kanzaki M, Thurmond DC, Mora S, Shigematsu S, Bickel PE, Pessin JE, Saltiel AR | title = CAP defines a second signalling pathway required for insulin-stimulated glucose transport | journal = Nature | volume = 407 | issue = 6801 | pages = 202–7 |date=September 2000 | pmid = 11001060 | doi = 10.1038/35025089 | url = https://deepblue.lib.umich.edu/bitstream/2027.42/62940/1/407202a0.pdf }}</ref><ref name="pmid11481476">{{cite journal |vauthors=Kimura A, Baumann CA, Chiang SH, Saltiel AR | title = The sorbin homology domain: a motif for the targeting of proteins to lipid rafts | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 16 | pages = 9098–103 |date=July 2001 | pmid = 11481476 | pmc = 55379 | doi = 10.1073/pnas.151252898 }}</ref>
| summary_text = Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. FLOT1 encodes a caveolae-associated, integral membrane protein. The function of flotillin 1 has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: FLOT1 flotillin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10211| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
{{Clear}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
| citations =
*{{cite journal  |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  |display-authors=etal}}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  |vauthors=Volonte D, Galbiati F, Li S |title=Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in vivo. Characterization and epitope-mapping of a novel flotillin-1 monoclonal antibody probe. |journal=J. Biol. Chem. |volume=274 |issue= 18 |pages= 12702–9 |year= 1999 |pmid= 10212252 |doi=10.1074/jbc.274.18.12702 |display-authors=etal}}
*{{cite journal  | author=Bickel PE, Scherer PE, Schnitzer JE, ''et al.'' |title=Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins. |journal=J. Biol. Chem. |volume=272 |issue= 21 |pages= 13793-802 |year= 1997 |pmid= 9153235 |doi= }}
*{{cite journal  |vauthors=Hazarika P, Dham N, Patel P |title=Flotillin 2 is distinct from epidermal surface antigen (ESA) and is associated with filopodia formation. |journal=J. Cell. Biochem. |volume=75 |issue= 1 |pages= 147–59 |year= 1999 |pmid= 10462713 |doi=10.1002/(SICI)1097-4644(19991001)75:1<147::AID-JCB15>3.0.CO;2-D |display-authors=etal}}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  |vauthors=Hu RM, Han ZG, Song HD |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543–8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997 | pmc=16901 |display-authors=etal}}
*{{cite journal  | author=Volonte D, Galbiati F, Li S, ''et al.'' |title=Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in vivo. Characterization and epitope-mapping of a novel flotillin-1 monoclonal antibody probe. |journal=J. Biol. Chem. |volume=274 |issue= 18 |pages= 12702-9 |year= 1999 |pmid= 10212252 |doi=  }}
*{{cite journal  |vauthors=Baumann CA, Ribon V, Kanzaki M |title=CAP defines a second signalling pathway required for insulin-stimulated glucose transport. |journal=Nature |volume=407 |issue= 6801 |pages= 202–7 |year= 2000 |pmid= 11001060 |doi= 10.1038/35025089 |display-authors=etal}}
*{{cite journal  | author=Hazarika P, Dham N, Patel P, ''et al.'' |title=Flotillin 2 is distinct from epidermal surface antigen (ESA) and is associated with filopodia formation. |journal=J. Cell. Biochem. |volume=75 |issue= 1 |pages= 147-59 |year= 1999 |pmid= 10462713 |doi=  }}
*{{cite journal  |vauthors=Zhang QH, Ye M, Wu XY |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=10.1101/gr.140200  | pmc=310934  |display-authors=etal}}
*{{cite journal  | author=Hu RM, Han ZG, Song HD, ''et al.'' |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543-8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997 }}
*{{cite journal  |vauthors=Salzer U, Prohaska R |title=Stomatin, flotillin-1, and flotillin-2 are major integral proteins of erythrocyte lipid rafts. |journal=Blood |volume=97 |issue= 4 |pages= 1141–3 |year= 2001 |pmid= 11159550 |doi=10.1182/blood.V97.4.1141 }}
*{{cite journal  | author=Baumann CA, Ribon V, Kanzaki M, ''et al.'' |title=CAP defines a second signalling pathway required for insulin-stimulated glucose transport. |journal=Nature |volume=407 |issue= 6801 |pages= 202-7 |year= 2000 |pmid= 11001060 |doi= 10.1038/35025089 }}
*{{cite journal  |vauthors=Edgar AJ, Polak JM |title=Flotillin-1: gene structure: cDNA cloning from human lung and the identification of alternative polyadenylation signals. |journal=Int. J. Biochem. Cell Biol. |volume=33 |issue= 1 |pages= 53–64 |year= 2001 |pmid= 11167132 |doi=10.1016/S1357-2725(00)00069-8 }}
*{{cite journal  | author=Zhang QH, Ye M, Wu XY, ''et al.'' |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546-60 |year= 2001 |pmid= 11042152 |doi=  }}
*{{cite journal  |vauthors=Kimura A, Baumann CA, Chiang SH, Saltiel AR |title=The sorbin homology domain: a motif for the targeting of proteins to lipid rafts. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 16 |pages= 9098–103 |year= 2001 |pmid= 11481476 |doi= 10.1073/pnas.151252898 | pmc=55379 }}
*{{cite journal  | author=Salzer U, Prohaska R |title=Stomatin, flotillin-1, and flotillin-2 are major integral proteins of erythrocyte lipid rafts. |journal=Blood |volume=97 |issue= 4 |pages= 1141-3 |year= 2001 |pmid= 11159550 |doi=  }}
*{{cite journal  |vauthors=Stuermer CA, Lang DM, Kirsch F |title=Glycosylphosphatidyl inositol-anchored proteins and fyn kinase assemble in noncaveolar plasma membrane microdomains defined by reggie-1 and -2. |journal=Mol. Biol. Cell |volume=12 |issue= 10 |pages= 3031–45 |year= 2002 |pmid= 11598189 |doi= 10.1091/mbc.12.10.3031| pmc=60153  |display-authors=etal}}
*{{cite journal  | author=Edgar AJ, Polak JM |title=Flotillin-1: gene structure: cDNA cloning from human lung and the identification of alternative polyadenylation signals. |journal=Int. J. Biochem. Cell Biol. |volume=33 |issue= 1 |pages= 53-64 |year= 2001 |pmid= 11167132 |doi=  }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Kimura A, Baumann CA, Chiang SH, Saltiel AR |title=The sorbin homology domain: a motif for the targeting of proteins to lipid rafts. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 16 |pages= 9098-103 |year= 2001 |pmid= 11481476 |doi= 10.1073/pnas.151252898 }}
*{{cite journal  |vauthors=Girardot N, Allinquant B, Duyckaerts C |title=[Lipid rafts, flotillin-1 and Alzheimer disease] |journal=J. Soc. Biol. |volume=197 |issue= 3 |pages= 223–9 |year= 2004 |pmid= 14708344 |doi= }}
*{{cite journal  | author=Stuermer CA, Lang DM, Kirsch F, ''et al.'' |title=Glycosylphosphatidyl inositol-anchored proteins and fyn kinase assemble in noncaveolar plasma membrane microdomains defined by reggie-1 and -2. |journal=Mol. Biol. Cell |volume=12 |issue= 10 |pages= 3031-45 |year= 2002 |pmid= 11598189 |doi=  }}
*{{cite journal  |vauthors=Wakasugi K, Nakano T, Kitatsuji C, Morishima I |title=Human neuroglobin interacts with flotillin-1, a lipid raft microdomain-associated protein. |journal=Biochem. Biophys. Res. Commun. |volume=318 |issue= 2 |pages= 453–60 |year= 2004 |pmid= 15120622 |doi= 10.1016/j.bbrc.2004.04.045 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Haglund K, Ivankovic-Dikic I, Shimokawa N |title=Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites. |journal=J. Cell Sci. |volume=117 |issue= Pt 12 |pages= 2557–68 |year= 2004 |pmid= 15128873 |doi= 10.1242/jcs.01148 |display-authors=etal}}
*{{cite journal  | author=Girardot N, Allinquant B, Duyckaerts C |title=[Lipid rafts, flotillin-1 and Alzheimer disease] |journal=J. Soc. Biol. |volume=197 |issue= 3 |pages= 223-9 |year= 2004 |pmid= 14708344 |doi= }}
*{{cite journal  |vauthors=Bared SM, Buechler C, Boettcher A |title=Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells. |journal=Mol. Biol. Cell |volume=15 |issue= 12 |pages= 5399–407 |year= 2005 |pmid= 15469992 |doi= 10.1091/mbc.E04-03-0182  | pmc=532019 |display-authors=etal}}
*{{cite journal  | author=Wakasugi K, Nakano T, Kitatsuji C, Morishima I |title=Human neuroglobin interacts with flotillin-1, a lipid raft microdomain-associated protein. |journal=Biochem. Biophys. Res. Commun. |volume=318 |issue= 2 |pages= 453-60 |year= 2004 |pmid= 15120622 |doi= 10.1016/j.bbrc.2004.04.045 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Haglund K, Ivankovic-Dikic I, Shimokawa N, ''et al.'' |title=Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites. |journal=J. Cell. Sci. |volume=117 |issue= Pt 12 |pages= 2557-68 |year= 2004 |pmid= 15128873 |doi= 10.1242/jcs.01148 }}
*{{cite journal  |vauthors=Jacobowitz DM, Kallarakal AT |title=Flotillin-1 in the substantia nigra of the Parkinson brain and a predominant localization in catecholaminergic nerves in the rat brain. |journal=Neurotoxicity research |volume=6 |issue= 4 |pages= 245–57 |year= 2005 |pmid= 15545008 |doi=10.1007/BF03033435  }}
*{{cite journal  | author=Bared SM, Buechler C, Boettcher A, ''et al.'' |title=Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells. |journal=Mol. Biol. Cell |volume=15 |issue= 12 |pages= 5399-407 |year= 2005 |pmid= 15469992 |doi= 10.1091/mbc.E04-03-0182 }}
*{{cite journal  |vauthors=Pope SN, Lee IR |title=Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin. |journal=J. Steroid Biochem. Mol. Biol. |volume=94 |issue= 1-3 |pages= 203–8 |year= 2005 |pmid= 15862967 |doi= 10.1016/j.jsbmb.2005.01.007 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Glebov OO, Bright NA, Nichols BJ |title=Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells. |journal=Nat. Cell Biol.|volume=8 |issue= 1 |pages= 46–54 |year= 2006 |pmid= 16341206 |doi=10.1038/ncb1342  }}
*{{cite journal  | author=Jacobowitz DM, Kallarakal AT |title=Flotillin-1 in the substantia nigra of the Parkinson brain and a predominant localization in catecholaminergic nerves in the rat brain. |journal=Neurotoxicity research |volume=6 |issue= 4 |pages= 245-57 |year= 2005 |pmid= 15545008 |doi= }}
*{{cite journal  | author=Pope SN, Lee IR |title=Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin. |journal=J. Steroid Biochem. Mol. Biol. |volume=94 |issue= 1-3 |pages= 203-8 |year= 2005 |pmid= 15862967 |doi= 10.1016/j.jsbmb.2005.01.007 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC genome browser|FLOT1}}
* {{UCSC gene details|FLOT1}}
 
 
{{gene-6-stub}}

Latest revision as of 13:09, 4 November 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Flotillin-1 is a protein that in humans is encoded by the FLOT1 gene.[1]

Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. FLOT1 encodes a caveolae-associated, integral membrane protein.[2] The function of flotillin 1 has not been determined.[1]

Interactions

FLOT1 has been shown to interact with SORBS1.[3][4][5]

References

  1. ↑ 1.0 1.1 "Entrez Gene: FLOT1 flotillin 1".
  2. ↑ Bickel PE, Scherer PE, Schnitzer JE, Oh P, Lisanti MP, Lodish HF (May 1997). "Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins". J. Biol. Chem. 272 (21): 13793–802. doi:10.1074/jbc.272.21.13793. PMID 9153235.
  3. ↑ Haglund K, Ivankovic-Dikic I, Shimokawa N, Kruh GD, Dikic I (May 2004). "Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites". J. Cell Sci. 117 (Pt 12): 2557–68. doi:10.1242/jcs.01148. PMID 15128873.
  4. ↑ Baumann CA, Ribon V, Kanzaki M, Thurmond DC, Mora S, Shigematsu S, Bickel PE, Pessin JE, Saltiel AR (September 2000). "CAP defines a second signalling pathway required for insulin-stimulated glucose transport" (PDF). Nature. 407 (6801): 202–7. doi:10.1038/35025089. PMID 11001060.
  5. ↑ Kimura A, Baumann CA, Chiang SH, Saltiel AR (July 2001). "The sorbin homology domain: a motif for the targeting of proteins to lipid rafts". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 9098–103. doi:10.1073/pnas.151252898. PMC 55379. PMID 11481476.

Further reading

External links


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