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{{Infobox_gene}}
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'''Flotillin-2''' is a [[protein]] that in humans is encoded by the ''FLOT2'' [[gene]].<ref name="pmid1769667">{{cite journal |vauthors=Schroeder WT, Siciliano MJ, Stewart-Galetka SL, Duvic M | title = The human gene for an epidermal surface antigen (M17S1) is located at 17q11-12 | journal = Genomics | volume = 11 | issue = 2 | pages = 481–2 |date=Feb 1992 | pmid = 1769667 | pmc =  | doi =10.1016/0888-7543(91)90166-C }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FLOT2 flotillin 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2319| accessdate = }}</ref>
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Flotillin 2 (flot-2) is a highly conserved protein isolated from caveolae/lipid raft domains that tether growth factor receptors linked to signal transduction pathways. Flot-2 binds to [[PAR-1]], a known upstream mediator of major signal transduction pathways implicated in cell growth and [[metastasis]], and may influence [[tumour]] progression.<ref name="pmid15492257">{{cite journal |vauthors=Hazarika P, McCarty MF, Prieto VG, George S, Babu D, Koul D, Bar-Eli M, Duvic M | title = Up-regulation of Flotillin-2 is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1. | journal = Cancer Res. | volume = 64 | issue = 20 | pages = 7361–9 |date=Oct 2004 | pmid = 15492257 | pmc =  | doi =10.1158/0008-5472.CAN-04-0823  }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_FLOT2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1win.
| PDB = {{PDB2|1win}}
| Name = Flotillin 2
| HGNCid = 3758
| Symbol = FLOT2
| AltSymbols =; ECS-1; ECS1; ESA; ESA1; M17S1
| OMIM = 131560
| ECnumber = 
| Homologene = 3293
| MGIid = 103309
| GeneAtlas_image1 = PBB_GE_FLOT2_201350_at_tn.png
| GeneAtlas_image2 = PBB_GE_FLOT2_211299_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0016600 |text = flotillin complex}} {{GNF_GO|id=GO:0045121 |text = lipid raft}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0008544 |text = epidermis development}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2319
    | Hs_Ensembl = ENSG00000132589
    | Hs_RefseqProtein = NP_004466
    | Hs_RefseqmRNA = NM_004475
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 24230484
    | Hs_GenLoc_end = 24248696
    | Hs_Uniprot = Q14254
    | Mm_EntrezGene = 14252
    | Mm_Ensembl = ENSMUSG00000061981
    | Mm_RefseqmRNA = NM_001040403
    | Mm_RefseqProtein = NP_001035493
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 77854174
    | Mm_GenLoc_end = 77876626
    | Mm_Uniprot = Q5SS82
  }}
}}
'''Flotillin 2''', also known as '''FLOT2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FLOT2 flotillin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2319| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in neuronal signaling.<ref name="entrez">{{cite web | title = Entrez Gene: FLOT2 flotillin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2319| accessdate = }}</ref>
| summary_text = Caveolae are small domains on the inner [[cell membrane]] involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in [[neuronal signaling]].<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Schroeder WT, Siciliano MJ, Stewart-Galetka SL, Duvic M |title=The human gene for an epidermal surface antigen (M17S1) is located at 17q11-12. |journal=Genomics |volume=11 |issue= 2 |pages= 481-2 |year= 1992 |pmid= 1769667 |doi=  }}
*{{cite journal  |vauthors=Schroeder WT, Stewart-Galetka S, Mandavilli S |title=Cloning and characterization of a novel epidermal cell surface antigen (ESA) |journal=J. Biol. Chem. |volume=269 |issue= 31 |pages= 19983–91 |year= 1994 |pmid= 8051082 |doi=  |display-authors=etal}}
*{{cite journal  | author=Schroeder WT, Stewart-Galetka S, Mandavilli S, ''et al.'' |title=Cloning and characterization of a novel epidermal cell surface antigen (ESA). |journal=J. Biol. Chem. |volume=269 |issue= 31 |pages= 19983-91 |year= 1994 |pmid= 8051082 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  |vauthors=Volonte D, Galbiati F, Li S |title=Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in vivo. Characterization and epitope-mapping of a novel flotillin-1 monoclonal antibody probe |journal=J. Biol. Chem. |volume=274 |issue= 18 |pages= 12702–9 |year= 1999 |pmid= 10212252 |doi=10.1074/jbc.274.18.12702 |display-authors=etal}}
*{{cite journal  | author=Volonte D, Galbiati F, Li S, ''et al.'' |title=Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in vivo. Characterization and epitope-mapping of a novel flotillin-1 monoclonal antibody probe. |journal=J. Biol. Chem. |volume=274 |issue= 18 |pages= 12702-9 |year= 1999 |pmid= 10212252 |doi=  }}
*{{cite journal  |vauthors=Hazarika P, Dham N, Patel P |title=Flotillin 2 is distinct from epidermal surface antigen (ESA) and is associated with filopodia formation |journal=J. Cell. Biochem. |volume=75 |issue= 1 |pages= 147–59 |year= 1999 |pmid= 10462713 |doi=10.1002/(SICI)1097-4644(19991001)75:1<147::AID-JCB15>3.0.CO;2-D |display-authors=etal}}
*{{cite journal  | author=Hazarika P, Dham N, Patel P, ''et al.'' |title=Flotillin 2 is distinct from epidermal surface antigen (ESA) and is associated with filopodia formation. |journal=J. Cell. Biochem. |volume=75 |issue= 1 |pages= 147-59 |year= 1999 |pmid= 10462713 |doi=  }}
*{{cite journal  |vauthors=Salzer U, Prohaska R |title=Stomatin, flotillin-1, and flotillin-2 are major integral proteins of erythrocyte lipid rafts |journal=Blood |volume=97 |issue= 4 |pages= 1141–3 |year= 2001 |pmid= 11159550 |doi=10.1182/blood.V97.4.1141 }}
*{{cite journal  | author=Salzer U, Prohaska R |title=Stomatin, flotillin-1, and flotillin-2 are major integral proteins of erythrocyte lipid rafts. |journal=Blood |volume=97 |issue= 4 |pages= 1141-3 |year= 2001 |pmid= 11159550 |doi= }}
*{{cite journal  |vauthors=Solomon S, Masilamani M, Rajendran L |title=The lipid raft microdomain-associated protein reggie-1/flotillin-2 is expressed in human B cells and localized at the plasma membrane and centrosome in PBMCs |journal=Immunobiology |volume=205 |issue= 1 |pages= 108–19 |year= 2002 |pmid= 11999340 |doi=10.1078/0171-2985-00114  |display-authors=etal}}
*{{cite journal  | author=Solomon S, Masilamani M, Rajendran L, ''et al.'' |title=The lipid raft microdomain-associated protein reggie-1/flotillin-2 is expressed in human B cells and localized at the plasma membrane and centrosome in PBMCs. |journal=Immunobiology |volume=205 |issue= 1 |pages= 108-19 |year= 2002 |pmid= 11999340 |doi=  }}
*{{cite journal  |vauthors=Wistow G, Bernstein SL, Wyatt MK |title=Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants |journal=Mol. Vis. |volume=8 |issue= |pages= 205–20 |year= 2002 |pmid= 12107410 |doi=  |display-authors=etal}}
*{{cite journal  | author=Wistow G, Bernstein SL, Wyatt MK, ''et al.'' |title=Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants. |journal=Mol. Vis. |volume=8 |issue= |pages= 205-20 |year= 2002 |pmid= 12107410 |doi=  }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Shin BK, Wang H, Yim AM |title=Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7607–16 |year= 2003 |pmid= 12493773 |doi= 10.1074/jbc.M210455200 |display-authors=etal}}
*{{cite journal  | author=Shin BK, Wang H, Yim AM, ''et al.'' |title=Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function. |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7607-16 |year= 2003 |pmid= 12493773 |doi= 10.1074/jbc.M210455200 }}
*{{cite journal  |vauthors=Lehner B, Semple JI, Brown SE |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region |journal=Genomics |volume=83 |issue= 1 |pages= 153–67 |year= 2004 |pmid= 14667819 |doi=10.1016/S0888-7543(03)00235-0  |display-authors=etal}}
*{{cite journal  | author=Lehner B, Semple JI, Brown SE, ''et al.'' |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. |journal=Genomics |volume=83 |issue= 1 |pages= 153-67 |year= 2004 |pmid= 14667819 |doi=  }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Hazarika P, McCarty MF, Prieto VG |title=Up-regulation of Flotillin-2 is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1 |journal=Cancer Res. |volume=64 |issue= 20 |pages= 7361–9 |year= 2004 |pmid= 15492257 |doi= 10.1158/0008-5472.CAN-04-0823 |display-authors=etal}}
*{{cite journal  | author=Hazarika P, McCarty MF, Prieto VG, ''et al.'' |title=Up-regulation of Flotillin-2 is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1. |journal=Cancer Res. |volume=64 |issue= 20 |pages= 7361-9 |year= 2004 |pmid= 15492257 |doi= 10.1158/0008-5472.CAN-04-0823 }}
*{{cite journal  |vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  |vauthors=Bracho C, Dunia I, Romano M |title=Caveolins and flotillin-2 are present in the blood stages of Plasmodium vivax |journal=Parasitol. Res. |volume=99 |issue= 2 |pages= 153–9 |year= 2006 |pmid= 16521037 |doi= 10.1007/s00436-006-0139-6 |display-authors=etal}}
*{{cite journal  | author=Bracho C, Dunia I, Romano M, ''et al.'' |title=Caveolins and flotillin-2 are present in the blood stages of Plasmodium vivax. |journal=Parasitol. Res. |volume=99 |issue= 2 |pages= 153-9 |year= 2006 |pmid= 16521037 |doi= 10.1007/s00436-006-0139-6 }}
*{{cite journal  |vauthors=Doherty SD, Prieto VG, George S |title=High flotillin-2 expression is associated with lymph node metastasis and Breslow depth in melanoma |journal=Melanoma Res. |volume=16 |issue= 5 |pages= 461–3 |year= 2007 |pmid= 17013097 |doi= 10.1097/01.cmr.0000222592.75858.20 |display-authors=etal}}
*{{cite journal  | author=Doherty SD, Prieto VG, George S, ''et al.'' |title=High flotillin-2 expression is associated with lymph node metastasis and Breslow depth in melanoma. |journal=Melanoma Res. |volume=16 |issue= 5 |pages= 461-3 |year= 2007 |pmid= 17013097 |doi= 10.1097/01.cmr.0000222592.75858.20 }}
*{{cite journal  |vauthors=Jiang M, Ding Y, Su Y |title=Arginase-flotillin interaction brings arginase to red blood cell membrane |journal=FEBS Lett. |issue= 28–29 |pages= 6561–4 |year= 2007 |pmid= 17113085 |doi= 10.1016/j.febslet.2006.11.003 |volume=580|display-authors=etal}}
*{{cite journal  | author=Jiang M, Ding Y, Su Y, ''et al.'' |title=Arginase-flotillin interaction brings arginase to red blood cell membrane. |journal=FEBS Lett. |volume=580 |issue= 28-29 |pages= 6561-4 |year= 2007 |pmid= 17113085 |doi= 10.1016/j.febslet.2006.11.003 }}
*{{cite journal  |vauthors=Sugawara Y, Nishii H, Takahashi T |title=The lipid raft proteins flotillins/reggies interact with Galphaq and are involved in Gq-mediated p38 mitogen-activated protein kinase activation through tyrosine kinase |journal=Cell. Signal. |volume=19 |issue= 6 |pages= 1301–8 |year= 2007 |pmid= 17307333 |doi= 10.1016/j.cellsig.2007.01.012 |display-authors=etal}}
*{{cite journal  | author=Sugawara Y, Nishii H, Takahashi T, ''et al.'' |title=The lipid raft proteins flotillins/reggies interact with Galphaq and are involved in Gq-mediated p38 mitogen-activated protein kinase activation through tyrosine kinase. |journal=Cell. Signal. |volume=19 |issue= 6 |pages= 1301-8 |year= 2007 |pmid= 17307333 |doi= 10.1016/j.cellsig.2007.01.012 }}
*{{cite journal  |vauthors=Langhorst MF, Solis GP, Hannbeck S |title=Linking membrane microdomains to the cytoskeleton: regulation of the lateral mobility of reggie-1/flotillin-2 by interaction with actin |journal=FEBS Lett. |volume=581 |issue= 24 |pages= 4697–703 |year= 2007 |pmid= 17854803 |doi= 10.1016/j.febslet.2007.08.074 |display-authors=etal}}
*{{cite journal  | author=Langhorst MF, Solis GP, Hannbeck S, ''et al.'' |title=Linking membrane microdomains to the cytoskeleton: regulation of the lateral mobility of reggie-1/flotillin-2 by interaction with actin. |journal=FEBS Lett. |volume=581 |issue= 24 |pages= 4697-703 |year= 2007 |pmid= 17854803 |doi= 10.1016/j.febslet.2007.08.074 }}
*{{cite journal  |vauthors=Rajendran L, Beckmann J, Magenau A |title=Flotillins are involved in the polarization of primitive and mature hematopoietic cells. |journal=PLoS ONE |volume=4 |issue= 12 |year= 2009 |pmid= 20027317 |doi=  10.1371/journal.pone.0008290 |pmc=2794375 |pages=e8290|display-authors=etal}}
*{{cite journal  |vauthors=Pust S, Dyve AB, Torgersen ML |title=Interplay between toxin transport and flotillin localization. |journal=PLoS ONE |volume=5 |issue= 1 |year= 2010 |pmid= 20107503 |doi=  10.1371/journal.pone.0008844 |pmc=2809741 |pages=e8844|display-authors=etal}}
*{{cite journal  | author=Stuermer CA |title=The reggie/flotillin connection to growth. |journal=Trends Cell Biol. |volume=20 |issue= 1 |pages= 6–13 |year= 2010 |pmid= 19896850 |doi=  10.1016/j.tcb.2009.10.003}}
*{{cite journal  |vauthors=Solis GP, Malaga-Trillo E, Plattner H |title=Cellular roles of the prion protein in association with reggie/flotillin microdomains. |journal=Front. Biosci. |volume=15 |pages= 1075–85 |year= 2010 |pmid= 20515742 |doi=  10.2741/3662|display-authors=etal}}
*{{cite journal  |vauthors=Ludwig A, Otto GP, Riento K |title=Flotillin microdomains interact with the cortical cytoskeleton to control uropod formation and neutrophil recruitment |journal=J. Cell Biol. |volume=191 |issue= 4 |pages= 771–84 |year= 2010 |pmid= 21059848 |doi=10.1083/jcb.201005140  | pmc=2983060  |display-authors=etal}}
*{{cite journal  |vauthors=Cornfine S, Himmel M, Kopp P |title=The kinesin KIF9 and reggie/flotillin proteins regulate matrix degradation by macrophage podosomes |journal=Mol Biol Cell  |volume=22 |issue= 2 |pages= 202–15 |year= 2011 |pmid= 21119006 |doi=10.1091/mbc.E10-05-0394  | pmc=3020916  |display-authors=etal}}
*{{cite journal  |vauthors=Ge L, Qi W, Wang LJ, Miao HH |title=Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake |journal=Proc Natl Acad Sci U S A |volume=108 |issue= 2 |pages= 551–6 |year= 2011 |pmid= 21187433 |doi=10.1073/pnas.1014434108  | pmc=3021008  |display-authors=etal}}
*{{cite journal  |vauthors=Song J, Chen W, Lu Z |title=Soluble expression, purification, and characterization of recombinant human flotillin-2 (reggie-1) in Escherichia coli. |journal=Mol Biol Rep  |volume=38 |issue= 3 |pages= 2091–8 |year= 2011 |pmid= 20857209 |doi= 10.1007/s11033-010-0335-4|display-authors=etal}}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=2319}}


{{protein-stub}}
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Latest revision as of 21:10, 12 December 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

n/a

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Flotillin-2 is a protein that in humans is encoded by the FLOT2 gene.[1][2] Flotillin 2 (flot-2) is a highly conserved protein isolated from caveolae/lipid raft domains that tether growth factor receptors linked to signal transduction pathways. Flot-2 binds to PAR-1, a known upstream mediator of major signal transduction pathways implicated in cell growth and metastasis, and may influence tumour progression.[3]

Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in neuronal signaling.[2]

References

  1. ↑ Schroeder WT, Siciliano MJ, Stewart-Galetka SL, Duvic M (Feb 1992). "The human gene for an epidermal surface antigen (M17S1) is located at 17q11-12". Genomics. 11 (2): 481–2. doi:10.1016/0888-7543(91)90166-C. PMID 1769667.
  2. ↑ 2.0 2.1 "Entrez Gene: FLOT2 flotillin 2".
  3. ↑ Hazarika P, McCarty MF, Prieto VG, George S, Babu D, Koul D, Bar-Eli M, Duvic M (Oct 2004). "Up-regulation of Flotillin-2 is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1". Cancer Res. 64 (20): 7361–9. doi:10.1158/0008-5472.CAN-04-0823. PMID 15492257.

Further reading


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