FOLR2: Difference between revisions

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{{Infobox_gene}}
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'''Folate receptor beta''' is a [[protein]] that in humans is encoded by the ''FOLR2'' [[gene]].<ref name="pmid1133088">{{cite journal |vauthors=Kawasaki K, Fearnhead RW | title = On the relationship between tetracycline and the incremental lines in dentine | journal = J Anat | volume = 119 | issue = Pt 1 | pages = 49–59 |date=Sep 1975 | pmid = 1133088 | pmc = 1231614 | doi =  }}</ref><ref name="pmid7698003">{{cite journal |vauthors=van Heyningen V, Little PF | title = Report of the fourth international workshop on human chromosome 11 mapping 1994 | journal = Cytogenet Cell Genet | volume = 69 | issue = 3-4 | pages = 127–58 |date=May 1995 | pmid = 7698003 | pmc =  | doi =10.1159/000133953 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FOLR2 folate receptor 2 (fetal)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2350| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Folate receptor 2 (fetal)
| HGNCid = 3793
| Symbol = FOLR2
| AltSymbols =; FBP/PL-1; FR-P3; FR-beta; beta-hFR
| OMIM = 136425
| ECnumber =
| Homologene = 627
| MGIid = 95569
| GeneAtlas_image1 = PBB_GE_FOLR2_204829_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005542 |text = folic acid binding}} {{GNF_GO|id=GO:0048503 |text = GPI anchor binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0015884 |text = folic acid transport}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2350
    | Hs_Ensembl = ENSG00000165457
    | Hs_RefseqProtein = NP_000794
    | Hs_RefseqmRNA = NM_000803
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 71605476
    | Hs_GenLoc_end = 71610632
    | Hs_Uniprot = P14207
    | Mm_EntrezGene = 14276
    | Mm_Ensembl = ENSMUSG00000032725
    | Mm_RefseqmRNA = NM_008035
    | Mm_RefseqProtein = NP_032061
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 101713809
    | Mm_GenLoc_end = 101730833
    | Mm_Uniprot = Q05685
  }}
}}
'''Folate receptor 2 (fetal)''', also known as '''FOLR2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FOLR2 folate receptor 2 (fetal)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2350| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells.  This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus.<ref name="entrez">{{cite web | title = Entrez Gene: FOLR2 folate receptor 2 (fetal)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2350| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for [[folic acid]] and for several reduced folic acid derivatives, and mediate delivery of [[Levomefolic acid|5-methyltetrahydrofolate]] to the interior of cells.  This protein has a 68% and 79% sequence [[Homology (biology)|homology]] with the [[Folate receptor 1|FOLR1]] and [[FOLR3]] proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus.<ref name="entrez">{{cite web | title = Entrez Gene: FOLR2 folate receptor 2 (fetal)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2350| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Henderson GB |title=Folate-binding proteins. |journal=Annu. Rev. Nutr. |volume=10 |issue=  |pages= 319-35 |year= 1990 |pmid= 2166548 |doi= 10.1146/annurev.nu.10.070190.001535 }}
*{{cite journal  | author=Henderson GB |title=Folate-binding proteins. |journal=Annu. Rev. Nutr. |volume=10 |issue=  |pages= 319–35 |year= 1990 |pmid= 2166548 |doi= 10.1146/annurev.nu.10.070190.001535 }}
*{{cite journal  | author=Kawasaki K, Fearnhead RW |title=On the relationship between tetracycline and the incremental lines in dentine. |journal=J. Anat. |volume=119 |issue= Pt 1 |pages= 49-59 |year= 1975 |pmid= 1133088 |doi=  }}
*{{cite journal  |vauthors=Ragoussis J, Senger G, Trowsdale J, Campbell IG |title=Genomic organization of the human folate receptor genes on chromosome 11q13. |journal=Genomics |volume=14 |issue= 2 |pages= 423–30 |year= 1992 |pmid= 1330883 |doi=10.1016/S0888-7543(05)80236-8 }}
*{{cite journal  | author=Ragoussis J, Senger G, Trowsdale J, Campbell IG |title=Genomic organization of the human folate receptor genes on chromosome 11q13. |journal=Genomics |volume=14 |issue= 2 |pages= 423-30 |year= 1992 |pmid= 1330883 |doi=  }}
*{{cite journal  |vauthors=Freisheim JH, Price EM, Ratnam M |title=Folate coenzyme and antifolate transport proteins in normal and neoplastic cells. |journal=Adv. Enzyme Regul. |volume=29 |issue=  |pages= 13–26 |year= 1990 |pmid= 2561247 |doi=10.1016/0065-2571(89)90091-5 }}
*{{cite journal  | author=Freisheim JH, Price EM, Ratnam M |title=Folate coenzyme and antifolate transport proteins in normal and neoplastic cells. |journal=Adv. Enzyme Regul. |volume=29 |issue=  |pages= 13-26 |year= 1990 |pmid= 2561247 |doi=  }}
*{{cite journal  |vauthors=Ratnam M, Marquardt H, Duhring JL, Freisheim JH |title=Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA. |journal=Biochemistry |volume=28 |issue= 20 |pages= 8249–54 |year= 1990 |pmid= 2605182 |doi=10.1021/bi00446a042 }}
*{{cite journal  | author=Ratnam M, Marquardt H, Duhring JL, Freisheim JH |title=Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA. |journal=Biochemistry |volume=28 |issue= 20 |pages= 8249-54 |year= 1990 |pmid= 2605182 |doi=  }}
*{{cite journal  |vauthors=Yan W, Ratnam M |title=Preferred sites of glycosylphosphatidylinositol modification in folate receptors and constraints in the primary structure of the hydrophobic portion of the signal. |journal=Biochemistry |volume=34 |issue= 44 |pages= 14594–600 |year= 1995 |pmid= 7578066 |doi=10.1021/bi00044a039 }}
*{{cite journal  | author=Yan W, Ratnam M |title=Preferred sites of glycosylphosphatidylinositol modification in folate receptors and constraints in the primary structure of the hydrophobic portion of the signal. |journal=Biochemistry |volume=34 |issue= 44 |pages= 14594-600 |year= 1995 |pmid= 7578066 |doi= }}
*{{cite journal  |vauthors=Sadasivan E, Cedeno MM, Rothenberg SP |title=Characterization of the gene encoding a folate-binding protein expressed in human placenta. Identification of promoter activity in a G-rich SP1 site linked with the tandemly repeated GGAAG motif for the ets encoded GA-binding protein. |journal=J. Biol. Chem. |volume=269 |issue= 7 |pages= 4725–35 |year= 1994 |pmid= 8106441 |doi=  }}
*{{cite journal  | author=van Heyningen V, Little PF |title=Report of the fourth international workshop on human chromosome 11 mapping 1994. |journal=Cytogenet. Cell Genet. |volume=69 |issue= 3-4 |pages= 127-58 |year= 1995 |pmid= 7698003 |doi= }}
*{{cite journal  |vauthors=Shen F, Ross JF, Wang X, Ratnam M |title=Identification of a novel folate receptor, a truncated receptor, and receptor type beta in hematopoietic cells: cDNA cloning, expression, immunoreactivity, and tissue specificity. |journal=Biochemistry |volume=33 |issue= 5 |pages= 1209–15 |year= 1994 |pmid= 8110752 |doi=10.1021/bi00171a021 }}
*{{cite journal  | author=Sadasivan E, Cedeno MM, Rothenberg SP |title=Characterization of the gene encoding a folate-binding protein expressed in human placenta. Identification of promoter activity in a G-rich SP1 site linked with the tandemly repeated GGAAG motif for the ets encoded GA-binding protein. |journal=J. Biol. Chem. |volume=269 |issue= 7 |pages= 4725-35 |year= 1994 |pmid= 8106441 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Shen F, Ross JF, Wang X, Ratnam M |title=Identification of a novel folate receptor, a truncated receptor, and receptor type beta in hematopoietic cells: cDNA cloning, expression, immunoreactivity, and tissue specificity. |journal=Biochemistry |volume=33 |issue= 5 |pages= 1209-15 |year= 1994 |pmid= 8110752 |doi=  }}
*{{cite journal  |vauthors=Page ST, Owen WC, Price K, Elwood PC |title=Expression of the human placental folate receptor transcript is regulated in human tissues. Organization and full nucleotide sequence of the gene. |journal=J. Mol. Biol. |volume=229 |issue= 4 |pages= 1175–83 |year= 1993 |pmid= 8445646 |doi= 10.1006/jmbi.1993.1116 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
*{{cite journal  | author=Page ST, Owen WC, Price K, Elwood PC |title=Expression of the human placental folate receptor transcript is regulated in human tissues. Organization and full nucleotide sequence of the gene. |journal=J. Mol. Biol. |volume=229 |issue= 4 |pages= 1175-83 |year= 1993 |pmid= 8445646 |doi= 10.1006/jmbi.1993.1116 }}
*{{cite journal  |vauthors=Wang J, Shen F, Yan W |title=Proteolysis of the carboxyl-terminal GPI signal independent of GPI modification as a mechanism for selective protein secretion. |journal=Biochemistry |volume=36 |issue= 47 |pages= 14583–92 |year= 1998 |pmid= 9398177 |doi= 10.1021/bi970845w |display-authors=etal}}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  |vauthors=Nakashima-Matsushita N, Homma T, Yu S |title=Selective expression of folate receptor beta and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis. |journal=Arthritis Rheum. |volume=42 |issue= 8 |pages= 1609–16 |year= 1999 |pmid= 10446858 |doi= 10.1002/1529-0131(199908)42:8<1609::AID-ANR7>3.0.CO;2-L |display-authors=etal}}
*{{cite journal  | author=Wang J, Shen F, Yan W, ''et al.'' |title=Proteolysis of the carboxyl-terminal GPI signal independent of GPI modification as a mechanism for selective protein secretion. |journal=Biochemistry |volume=36 |issue= 47 |pages= 14583-92 |year= 1998 |pmid= 9398177 |doi= 10.1021/bi970845w }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Nakashima-Matsushita N, Homma T, Yu S, ''et al.'' |title=Selective expression of folate receptor beta and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis. |journal=Arthritis Rheum. |volume=42 |issue= 8 |pages= 1609-16 |year= 1999 |pmid= 10446858 |doi= 10.1002/1529-0131(199908)42:8<1609::AID-ANR7>3.0.CO;2-L }}
*{{cite journal  |vauthors=Hao H, Qi H, Ratnam M |title=Modulation of the folate receptor type beta gene by coordinate actions of retinoic acid receptors at activator Sp1/ets and repressor AP-1 sites. |journal=Blood |volume=101 |issue= 11 |pages= 4551–60 |year= 2003 |pmid= 12543860 |doi= 10.1182/blood-2002-10-3174 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Hao H, Qi H, Ratnam M |title=Modulation of the folate receptor type beta gene by coordinate actions of retinoic acid receptors at activator Sp1/ets and repressor AP-1 sites. |journal=Blood |volume=101 |issue= 11 |pages= 4551-60 |year= 2003 |pmid= 12543860 |doi= 10.1182/blood-2002-10-3174 }}
}}
}}
{{refend}}
{{refend}}


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{{gene-11-stub}}

Latest revision as of 04:53, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Folate receptor beta is a protein that in humans is encoded by the FOLR2 gene.[1][2][3]

The protein encoded by this gene is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus.[3]

References

  1. ↑ Kawasaki K, Fearnhead RW (Sep 1975). "On the relationship between tetracycline and the incremental lines in dentine". J Anat. 119 (Pt 1): 49–59. PMC 1231614. PMID 1133088.
  2. ↑ van Heyningen V, Little PF (May 1995). "Report of the fourth international workshop on human chromosome 11 mapping 1994". Cytogenet Cell Genet. 69 (3–4): 127–58. doi:10.1159/000133953. PMID 7698003.
  3. ↑ 3.0 3.1 "Entrez Gene: FOLR2 folate receptor 2 (fetal)".

Further reading

  • Henderson GB (1990). "Folate-binding proteins". Annu. Rev. Nutr. 10: 319–35. doi:10.1146/annurev.nu.10.070190.001535. PMID 2166548.
  • Ragoussis J, Senger G, Trowsdale J, Campbell IG (1992). "Genomic organization of the human folate receptor genes on chromosome 11q13". Genomics. 14 (2): 423–30. doi:10.1016/S0888-7543(05)80236-8. PMID 1330883.
  • Freisheim JH, Price EM, Ratnam M (1990). "Folate coenzyme and antifolate transport proteins in normal and neoplastic cells". Adv. Enzyme Regul. 29: 13–26. doi:10.1016/0065-2571(89)90091-5. PMID 2561247.
  • Ratnam M, Marquardt H, Duhring JL, Freisheim JH (1990). "Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA". Biochemistry. 28 (20): 8249–54. doi:10.1021/bi00446a042. PMID 2605182.
  • Yan W, Ratnam M (1995). "Preferred sites of glycosylphosphatidylinositol modification in folate receptors and constraints in the primary structure of the hydrophobic portion of the signal". Biochemistry. 34 (44): 14594–600. doi:10.1021/bi00044a039. PMID 7578066.
  • Sadasivan E, Cedeno MM, Rothenberg SP (1994). "Characterization of the gene encoding a folate-binding protein expressed in human placenta. Identification of promoter activity in a G-rich SP1 site linked with the tandemly repeated GGAAG motif for the ets encoded GA-binding protein". J. Biol. Chem. 269 (7): 4725–35. PMID 8106441.
  • Shen F, Ross JF, Wang X, Ratnam M (1994). "Identification of a novel folate receptor, a truncated receptor, and receptor type beta in hematopoietic cells: cDNA cloning, expression, immunoreactivity, and tissue specificity". Biochemistry. 33 (5): 1209–15. doi:10.1021/bi00171a021. PMID 8110752.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Page ST, Owen WC, Price K, Elwood PC (1993). "Expression of the human placental folate receptor transcript is regulated in human tissues. Organization and full nucleotide sequence of the gene". J. Mol. Biol. 229 (4): 1175–83. doi:10.1006/jmbi.1993.1116. PMID 8445646.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Wang J, Shen F, Yan W, et al. (1998). "Proteolysis of the carboxyl-terminal GPI signal independent of GPI modification as a mechanism for selective protein secretion". Biochemistry. 36 (47): 14583–92. doi:10.1021/bi970845w. PMID 9398177.
  • Nakashima-Matsushita N, Homma T, Yu S, et al. (1999). "Selective expression of folate receptor beta and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis". Arthritis Rheum. 42 (8): 1609–16. doi:10.1002/1529-0131(199908)42:8<1609::AID-ANR7>3.0.CO;2-L. PMID 10446858.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Hao H, Qi H, Ratnam M (2003). "Modulation of the folate receptor type beta gene by coordinate actions of retinoic acid receptors at activator Sp1/ets and repressor AP-1 sites". Blood. 101 (11): 4551–60. doi:10.1182/blood-2002-10-3174. PMID 12543860.



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