FSCN1: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: HTTP→HTTPS (v470))
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Fascin''' is a [[protein]] that in humans is encoded by the ''FSCN1'' [[gene]].<ref name="pmid8068206">{{cite journal | vauthors = Duh FM, Latif F, Weng Y, Geil L, Modi W, Stackhouse T, Matsumura F, Duan DR, Linehan WM, Lerman MI | title = cDNA cloning and expression of the human homolog of the sea urchin fascin and Drosophila singed genes which encodes an actin-bundling protein | journal = DNA Cell Biol | volume = 13 | issue = 8 | pages = 821–7 | date = Sep 1994 | pmid = 8068206 | pmc =  | doi = 10.1089/dna.1994.13.821 }}</ref><ref name="pmid10783262">{{cite journal | vauthors = Tubb BE, Bardien-Kruger S, Kashork CD, Shaffer LG, Ramagli LS, Xu J, Siciliano MJ, Bryan J | title = Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes | journal = Genomics | volume = 65 | issue = 2 | pages = 146–56 | date = Jul 2000 | pmid = 10783262 | pmc =  | doi = 10.1006/geno.2000.6156 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FSCN1 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6624| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_FSCN1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1dfc.
| PDB = {{PDB2|1dfc}}
| Name = Fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
| HGNCid = 11148
| Symbol = FSCN1
| AltSymbols =; p55; FLJ38511; SNL
| OMIM = 602689
| ECnumber = 
| Homologene = 48164
| MGIid = 1352745
| GeneAtlas_image1 = PBB_GE_FSCN1_201564_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_FSCN1_210933_s_at_tn.png
| Function = {{GNF_GO|id=GO:0030674 |text = protein binding, bridging}} {{GNF_GO|id=GO:0051015 |text = actin filament binding}}
| Component = {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}}
| Process = {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0030036 |text = actin cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0051017 |text = actin filament bundle formation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6624
    | Hs_Ensembl = ENSG00000075618
    | Hs_RefseqProtein = NP_003079
    | Hs_RefseqmRNA = NM_003088
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 5598980
    | Hs_GenLoc_end = 5612805
    | Hs_Uniprot = Q16658
    | Mm_EntrezGene = 14086
    | Mm_Ensembl = ENSMUSG00000029581
    | Mm_RefseqmRNA = NM_007984
    | Mm_RefseqProtein = NP_032010
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 143225496
    | Mm_GenLoc_end = 143238322
    | Mm_Uniprot = Q05DK3
  }}
}}
'''Fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)''', also known as '''FSCN1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FSCN1 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6624| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
FSCN1 has been shown to [[Protein-protein interaction|interact]] with [[Low affinity nerve growth factor receptor]]<ref name=pmid12789270>{{cite journal | vauthors = Shonukan O, Bagayogo I, McCrea P, Chao M, Hempstead B | title = Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin | language =  | journal = Oncogene | volume = 22 | issue = 23 | pages = 3616–23 | date = Jun 2003 | pmid = 12789270 | doi = 10.1038/sj.onc.1206561 }}</ref> and [[PKC alpha]].<ref name=pmid14532112>{{cite journal | vauthors = Anilkumar N, Parsons M, Monk R, Ng T, Adams JC | title = Interaction of fascin and protein kinase Cα: a novel intersection in cell adhesion and motility | language =  | journal = EMBO J. | volume = 22 | issue = 20 | pages = 5390–402 | date = Oct 2003 | pmid = 14532112 | pmc = 213775 | doi = 10.1093/emboj/cdg521 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Dawson SJ, White LA | title = Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin | journal = J. Infect. | volume = 24 | issue = 3 | pages = 317–20 | year = 1992 | pmid = 1602151 | doi = 10.1016/S0163-4453(05)80037-4 }}
| citations =
* {{cite journal | vauthors = Yamashiro-Matsumura S, Matsumura F | title = Purification and characterization of an F-actin-bundling 55-kilodalton protein from HeLa cells | journal = J. Biol. Chem. | volume = 260 | issue = 8 | pages = 5087–97 | year = 1985 | pmid = 3886649 | doi =  }}
*{{cite journal | author=Dawson SJ, White LA |title=Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. |journal=J. Infect. |volume=24 |issue= 3 |pages= 317-20 |year= 1992 |pmid= 1602151 |doi= }}
* {{cite journal | vauthors = Mosialos G, Yamashiro S, Baughman RW, Matsudaira P, Vara L, Matsumura F, Kieff E, Birkenbach M | title = Epstein-Barr virus infection induces expression in B lymphocytes of a novel gene encoding an evolutionarily conserved 55-kilodalton actin-bundling protein | journal = J. Virol. | volume = 68 | issue = 11 | pages = 7320–8 | year = 1994 | pmid = 7933116 | pmc = 237173 | doi =  }}
*{{cite journal | author=Yamashiro-Matsumura S, Matsumura F |title=Purification and characterization of an F-actin-bundling 55-kilodalton protein from HeLa cells. |journal=J. Biol. Chem. |volume=260 |issue= 8 |pages= 5087-97 |year= 1985 |pmid= 3886649 |doi=  }}
* {{cite journal | vauthors = Mosialos G, Birkenbach M, Ayehunie S, Matsumura F, Pinkus GS, Kieff E, Langhoff E | title = Circulating human dendritic cells differentially express high levels of a 55-kd actin-bundling protein | journal = Am. J. Pathol. | volume = 148 | issue = 2 | pages = 593–600 | year = 1996 | pmid = 8579121 | pmc = 1861678 | doi =  }}
*{{cite journal | author=Mosialos G, Yamashiro S, Baughman RW, ''et al.'' |title=Epstein-Barr virus infection induces expression in B lymphocytes of a novel gene encoding an evolutionarily conserved 55-kilodalton actin-bundling protein. |journal=J. Virol. |volume=68 |issue= 11 |pages= 7320-8 |year= 1994 |pmid= 7933116 |doi=  }}
* {{cite journal | vauthors = Yamakita Y, Ono S, Matsumura F, Yamashiro S | title = Phosphorylation of human fascin inhibits its actin binding and bundling activities | journal = J. Biol. Chem. | volume = 271 | issue = 21 | pages = 12632–8 | year = 1996 | pmid = 8647875 | doi = 10.1074/jbc.271.21.12632 }}
*{{cite journal | author=Duh FM, Latif F, Weng Y, ''et al.'' |title=cDNA cloning and expression of the human homolog of the sea urchin fascin and Drosophila singed genes which encodes an actin-bundling protein. |journal=DNA Cell Biol. |volume=13 |issue= 8 |pages= 821-7 |year= 1994 |pmid= 8068206 |doi=  }}
* {{cite journal | vauthors = Lin XH, Grako KA, Burg MA, Stallcup WB | title = NG2 proteoglycan and the actin-binding protein fascin define separate populations of actin-containing filopodia and lamellipodia during cell spreading and migration | journal = Mol. Biol. Cell | volume = 7 | issue = 12 | pages = 1977–93 | year = 1997 | pmid = 8970159 | pmc = 276044 | doi = 10.1091/mbc.7.12.1977 }}
*{{cite journal | author=Mosialos G, Birkenbach M, Ayehunie S, ''et al.'' |title=Circulating human dendritic cells differentially express high levels of a 55-kd actin-bundling protein. |journal=Am. J. Pathol. |volume=148 |issue= 2 |pages= 593-600 |year= 1996 |pmid= 8579121 |doi= }}
* {{cite journal | vauthors = Ono S, Yamakita Y, Yamashiro S, Matsudaira PT, Gnarra JR, Obinata T, Matsumura F | title = Identification of an actin binding region and a protein kinase C phosphorylation site on human fascin | journal = J. Biol. Chem. | volume = 272 | issue = 4 | pages = 2527–33 | year = 1997 | pmid = 8999969 | doi = 10.1074/jbc.272.4.2527 }}
*{{cite journal | author=Yamakita Y, Ono S, Matsumura F, Yamashiro S |title=Phosphorylation of human fascin inhibits its actin binding and bundling activities. |journal=J. Biol. Chem. |volume=271 |issue= 21 |pages= 12632-8 |year= 1996 |pmid= 8647875 |doi= }}
* {{cite journal | vauthors = Pinkus GS, Pinkus JL, Langhoff E, Matsumura F, Yamashiro S, Mosialos G, Said JW | title = Fascin, a sensitive new marker for Reed-Sternberg cells of hodgkin's disease. Evidence for a dendritic or B cell derivation? | journal = Am. J. Pathol. | volume = 150 | issue = 2 | pages = 543–62 | year = 1997 | pmid = 9033270 | pmc = 1858289 | doi =  }}
*{{cite journal | author=Lin XH, Grako KA, Burg MA, Stallcup WB |title=NG2 proteoglycan and the actin-binding protein fascin define separate populations of actin-containing filopodia and lamellipodia during cell spreading and migration. |journal=Mol. Biol. Cell |volume=7 |issue= 12 |pages= 1977-93 |year= 1997 |pmid= 8970159 |doi= }}
* {{cite journal | vauthors = Ross R, Ross XL, Schwing J, Längin T, Reske-Kunz AB | title = The actin-bundling protein fascin is involved in the formation of dendritic processes in maturing epidermal Langerhans cells | journal = J. Immunol. | volume = 160 | issue = 8 | pages = 3776–82 | year = 1998 | pmid = 9558080 | doi =  }}
*{{cite journal | author=Ono S, Yamakita Y, Yamashiro S, ''et al.'' |title=Identification of an actin binding region and a protein kinase C phosphorylation site on human fascin. |journal=J. Biol. Chem. |volume=272 |issue= 4 |pages= 2527-33 |year= 1997 |pmid= 8999969 |doi=  }}
* {{cite journal | vauthors = Sonderbye L, Meehan S, Palsson R, Ahsan N, Ladefoged J, Langhoff E | title = Immunohistochemical study of actin binding protein (p55) in the human kidney | journal = Transplantation | volume = 65 | issue = 7 | pages = 1004–8 | year = 1998 | pmid = 9565110 | doi = 10.1097/00007890-199804150-00025 }}
*{{cite journal | author=Pinkus GS, Pinkus JL, Langhoff E, ''et al.'' |title=Fascin, a sensitive new marker for Reed-Sternberg cells of hodgkin's disease. Evidence for a dendritic or B cell derivation? |journal=Am. J. Pathol. |volume=150 |issue= 2 |pages= 543-62 |year= 1997 |pmid= 9033270 |doi=  }}
* {{cite journal | vauthors = Kempf W, Levi E, Kamarashev J, Kutzner H, Pfeifer W, Petrogiannis-Haliotis T, Burg G, Kadin ME | title = Fascin expression in CD30-positive cutaneous lymphoproliferative disorders | journal = J. Cutan. Pathol. | volume = 29 | issue = 5 | pages = 295–300 | year = 2003 | pmid = 12100631 | doi = 10.1034/j.1600-0560.2002.290507.x }}
*{{cite journal | author=Ross R, Ross XL, Schwing J, ''et al.'' |title=The actin-bundling protein fascin is involved in the formation of dendritic processes in maturing epidermal Langerhans cells. |journal=J. Immunol. |volume=160 |issue= 8 |pages= 3776-82 |year= 1998 |pmid= 9558080 |doi= }}
* {{cite journal | vauthors = Goncharuk VN, Ross JS, Carlson JA | title = Actin-binding protein fascin expression in skin neoplasia | journal = J. Cutan. Pathol. | volume = 29 | issue = 7 | pages = 430–8 | year = 2003 | pmid = 12139639 | doi = 10.1034/j.1600-0560.2002.290708.x }}
*{{cite journal | author=Sonderbye L, Meehan S, Palsson R, ''et al.'' |title=Immunohistochemical study of actin binding protein (p55) in the human kidney. |journal=Transplantation |volume=65 |issue= 7 |pages= 1004-8 |year= 1998 |pmid= 9565110 |doi= }}
* {{cite journal | vauthors = Pelosi G, Pastorino U, Pasini F, Maissoneuve P, Fraggetta F, Iannucci A, Sonzogni A, De Manzoni G, Terzi A, Durante E, Bresaola E, Pezzella F, Viale G | title = Independent prognostic value of fascin immunoreactivity in stage I nonsmall cell lung cancer | journal = Br. J. Cancer | volume = 88 | issue = 4 | pages = 537–47 | year = 2003 | pmid = 12592367 | pmc = 2377175 | doi = 10.1038/sj.bjc.6600731 }}
*{{cite journal | author=Tubb BE, Bardien-Kruger S, Kashork CD, ''et al.'' |title=Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes. |journal=Genomics |volume=65 |issue= 2 |pages= 146-56 |year= 2000 |pmid= 10783262 |doi= 10.1006/geno.2000.6156 }}
* {{cite journal | vauthors = Shonukan O, Bagayogo I, McCrea P, Chao M, Hempstead B | title = Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin | journal = Oncogene | volume = 22 | issue = 23 | pages = 3616–23 | year = 2003 | pmid = 12789270 | doi = 10.1038/sj.onc.1206561 }}
*{{cite journal | author=Kempf W, Levi E, Kamarashev J, ''et al.'' |title=Fascin expression in CD30-positive cutaneous lymphoproliferative disorders. |journal=J. Cutan. Pathol. |volume=29 |issue= 5 |pages= 295-300 |year= 2003 |pmid= 12100631 |doi= }}
* {{cite journal | vauthors = Bros M, Ross XL, Pautz A, Reske-Kunz AB, Ross R | title = The human fascin gene promoter is highly active in mature dendritic cells due to a stage-specific enhancer | journal = J. Immunol. | volume = 171 | issue = 4 | pages = 1825–34 | year = 2003 | pmid = 12902483 | doi = 10.4049/jimmunol.171.4.1825 }}
*{{cite journal | author=Goncharuk VN, Ross JS, Carlson JA |title=Actin-binding protein fascin expression in skin neoplasia. |journal=J. Cutan. Pathol. |volume=29 |issue= 7 |pages= 430-8 |year= 2003 |pmid= 12139639 |doi= }}
* {{cite journal | vauthors = Anilkumar N, Parsons M, Monk R, Ng T, Adams JC | title = Interaction of fascin and protein kinase Cα: a novel intersection in cell adhesion and motility | journal = EMBO J. | volume = 22 | issue = 20 | pages = 5390–402 | year = 2004 | pmid = 14532112 | pmc = 213775 | doi = 10.1093/emboj/cdg521 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Ishikawa R, Sakamoto T, Ando T, Higashi-Fujime S, Kohama K | title = Polarized actin bundles formed by human fascin-1: their sliding and disassembly on myosin II and myosin V in vitro | journal = J. Neurochem. | volume = 87 | issue = 3 | pages = 676–85 | year = 2003 | pmid = 14535950 | doi = 10.1046/j.1471-4159.2003.02058.x }}
*{{cite journal | author=Pelosi G, Pastorino U, Pasini F, ''et al.'' |title=Independent prognostic value of fascin immunoreactivity in stage I nonsmall cell lung cancer. |journal=Br. J. Cancer |volume=88 |issue= 4 |pages= 537-47 |year= 2003 |pmid= 12592367 |doi= 10.1038/sj.bjc.6600731 }}
*{{cite journal | author=Shonukan O, Bagayogo I, McCrea P, ''et al.'' |title=Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin. |journal=Oncogene |volume=22 |issue= 23 |pages= 3616-23 |year= 2003 |pmid= 12789270 |doi= 10.1038/sj.onc.1206561 }}
*{{cite journal  | author=Bros M, Ross XL, Pautz A, ''et al.'' |title=The human fascin gene promoter is highly active in mature dendritic cells due to a stage-specific enhancer. |journal=J. Immunol. |volume=171 |issue= 4 |pages= 1825-34 |year= 2003 |pmid= 12902483 |doi=  }}
*{{cite journal  | author=Anilkumar N, Parsons M, Monk R, ''et al.'' |title=Interaction of fascin and protein kinase Calpha: a novel intersection in cell adhesion and motility. |journal=EMBO J. |volume=22 |issue= 20 |pages= 5390-402 |year= 2004 |pmid= 14532112 |doi= 10.1093/emboj/cdg521 }}
*{{cite journal  | author=Ishikawa R, Sakamoto T, Ando T, ''et al.'' |title=Polarized actin bundles formed by human fascin-1: their sliding and disassembly on myosin II and myosin V in vitro. |journal=J. Neurochem. |volume=87 |issue= 3 |pages= 676-85 |year= 2003 |pmid= 14535950 |doi=  }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=6624}}
{{WikiDoc Sources}}
 
 
{{gene-7-stub}}

Latest revision as of 01:51, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Fascin is a protein that in humans is encoded by the FSCN1 gene.[1][2][3]

Interactions

FSCN1 has been shown to interact with Low affinity nerve growth factor receptor[4] and PKC alpha.[5]

References

  1. ↑ Duh FM, Latif F, Weng Y, Geil L, Modi W, Stackhouse T, Matsumura F, Duan DR, Linehan WM, Lerman MI (Sep 1994). "cDNA cloning and expression of the human homolog of the sea urchin fascin and Drosophila singed genes which encodes an actin-bundling protein". DNA Cell Biol. 13 (8): 821–7. doi:10.1089/dna.1994.13.821. PMID 8068206.
  2. ↑ Tubb BE, Bardien-Kruger S, Kashork CD, Shaffer LG, Ramagli LS, Xu J, Siciliano MJ, Bryan J (Jul 2000). "Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes". Genomics. 65 (2): 146–56. doi:10.1006/geno.2000.6156. PMID 10783262.
  3. ↑ "Entrez Gene: FSCN1 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)".
  4. ↑ Shonukan O, Bagayogo I, McCrea P, Chao M, Hempstead B (Jun 2003). "Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin". Oncogene. 22 (23): 3616–23. doi:10.1038/sj.onc.1206561. PMID 12789270.
  5. ↑ Anilkumar N, Parsons M, Monk R, Ng T, Adams JC (Oct 2003). "Interaction of fascin and protein kinase Cα: a novel intersection in cell adhesion and motility". EMBO J. 22 (20): 5390–402. doi:10.1093/emboj/cdg521. PMC 213775. PMID 14532112.

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=FSCN1&oldid=1421601"