GNL3: Difference between revisions

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Latest revision as of 08:53, 31 August 2017

Guanine nucleotide-binding protein-like 3, also known as nucleostemin, is a protein that in humans is encoded by the GNL3 gene.^[1]^[2]^[3] It is found within the nucleolus that binds p53.^[4] Nucleostemin regulates the cell cycle and affects cell differentiation, decreasing in amount as this differentiation progresses.^[4] It is a marker for many stem cells and cancer cells.^[5]

Interactions

GNL3 has been shown to interact with Mdm2^[6] and P53.^[2]

References

↑ Charpentier AH, Bednarek AK, Daniel RL, Hawkins KA, Laflin KJ, Gaddis S, MacLeod MC, Aldaz CM (Nov 2000). "Effects of estrogen on global gene expression: identification of novel targets of estrogen action". Cancer Res. 60 (21): 5977–83. PMID 11085516.
↑ ^2.0 ^2.1 Tsai RY, McKay RD (Dec 2002). "A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells". Genes Dev. 16 (23): 2991–3003. doi:10.1101/gad.55671. PMC 187487. PMID 12464630.
↑ "Entrez Gene: GNL3 guanine nucleotide binding protein-like 3 (nucleolar)".
↑ ^4.0 ^4.1 Ross, Michael H.; Pawlina, Wojciech. (2011). Histology : a text and atlas : with correlated cell and molecular biolog. Philadelphia: Wolters Kluwer/Lippincott Williams Wilkins Health. p. 79. ISBN 0-7817-7200-1.
↑ Niall M. Adams (29 November 2010). Advances in Nuclear Architecture. Springer. p. 31. ISBN 978-90-481-9898-6. Retrieved 27 September 2011.
↑ Dai MS, Sun XX, Lu H (Jul 2008). "Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2". Mol. Cell. Biol. 28 (13): 4365–76. doi:10.1128/MCB.01662-07. PMC 2447154. PMID 18426907.

Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ (2002). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Schwartz PH, Bryant PJ, Fuja TJ, Su H, O'Dowd DK, Klassen H (2003). "Isolation and characterization of neural progenitor cells from post-mortem human cortex". J. Neurosci. Res. 74 (6): 838–51. doi:10.1002/jnr.10854. PMID 14648588.
Liu SJ, Cai ZW, Liu YJ, Dong MY, Sun LQ, Hu GF, Wei YY, Lao WD (2004). "Role of nucleostemin in growth regulation of gastric cancer, liver cancer and other malignancies". World J. Gastroenterol. 10 (9): 1246–9. PMID 15112336.
Sijin L, Ziwei C, Yajun L, Meiyu D, Hongwei Z, Guofa H, Siguo L, Hong G, Zhihong Z, Xiaolei L, Yingyun W, Yan X, Weide L (2004). "The effect of knocking-down nucleostemin gene expression on the in vitro proliferation and in vivo tumorigenesis of HeLa cells". J. Exp. Clin. Cancer Res. 23 (3): 529–38. PMID 15595646.
Tsai RY, McKay RD (2005). "A multistep, GTP-driven mechanism controlling the dynamic cycling of nucleostemin". J. Cell Biol. 168 (2): 179–84. doi:10.1083/jcb.200409053. PMC 2171593. PMID 15657390.
Politz JC, Polena I, Trask I, Bazett-Jones DP, Pederson T (2005). "A nonribosomal landscape in the nucleolus revealed by the stem cell protein nucleostemin". Mol. Biol. Cell. 16 (7): 3401–10. doi:10.1091/mbc.E05-02-0106. PMC 1165421. PMID 15857956.
Han C, Zhang X, Xu W, Wang W, Qian H, Chen Y (2005). "Cloning of the nucleostemin gene and its function in transforming human embryonic bone marrow mesenchymal stem cells into F6 tumor cells". Int. J. Mol. Med. 16 (2): 205–13. doi:10.3892/ijmm.16.2.205. PMID 16012751.
Yang HX, Jin GL, Meng L, Zhang JZ, Liu WB, Shou CC (2005). "Screening and identification of proteins interacting with nucleostemin". World J. Gastroenterol. 11 (31): 4812–4. PMID 16097049.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kafienah W, Mistry S, Williams C, Hollander AP (2006). "Nucleostemin is a marker of proliferating stromal stem cells in adult human bone marrow". Stem Cells. 24 (4): 1113–20. doi:10.1634/stemcells.2005-0416. PMID 16282439.
Fan Y, Liu Z, Zhao S, Lou F, Nilsson S, Ekman P, Xu D, Fang X (2006). "Nucleostemin mRNA is expressed in both normal and malignant renal tissues". Br. J. Cancer. 94 (11): 1658–62. doi:10.1038/sj.bjc.6603145. PMC 2361296. PMID 16670719.
Lacina L, Smetana K, Dvoránková B, Stork J, Plzáková Z, Gabius HJ (2006). "Immunocyto- and histochemical profiling of nucleostemin expression: marker of epidermal stem cells?". J. Dermatol. Sci. 44 (2): 73–80. doi:10.1016/j.jdermsci.2006.08.008. PMID 17000083.
Zhu Q, Yasumoto H, Tsai RY (2006). "Nucleostemin delays cellular senescence and negatively regulates TRF1 protein stability". Mol. Cell. Biol. 26 (24): 9279–90. doi:10.1128/MCB.00724-06. PMC 1698521. PMID 17000763.
Liu SJ, Zhang ZH, Zhang DQ, Sui XM, Liu YJ, Cai ZW, Yuan XY, Sun LQ, Hu GF, Liu RL (2006). "Gene profiling after knocking-down expression of nucleostemin in Hela cells using oligonucleotide DNA microarray". J. Exp. Clin. Cancer Res. 25 (4): 575–83. PMID 17310849.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[pmid11085516-1] Charpentier AH, Bednarek AK, Daniel RL, Hawkins KA, Laflin KJ, Gaddis S, MacLeod MC, Aldaz CM (Nov 2000). "Effects of estrogen on global gene expression: identification of novel targets of estrogen action". Cancer Res. 60 (21): 5977–83. PMID 11085516.

[pmid12464630-2] 2.0 ^2.1 Tsai RY, McKay RD (Dec 2002). "A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells". Genes Dev. 16 (23): 2991–3003. doi:10.1101/gad.55671. PMC 187487. PMID 12464630.

[entrez-3] "Entrez Gene: GNL3 guanine nucleotide binding protein-like 3 (nucleolar)".

[Ross2011-4] 4.0 ^4.1 Ross, Michael H.; Pawlina, Wojciech. (2011). Histology : a text and atlas : with correlated cell and molecular biolog. Philadelphia: Wolters Kluwer/Lippincott Williams Wilkins Health. p. 79. ISBN 0-7817-7200-1.

[Adams2010-5] Niall M. Adams (29 November 2010). Advances in Nuclear Architecture. Springer. p. 31. ISBN 978-90-481-9898-6. Retrieved 27 September 2011.

[pmid18426907-6] Dai MS, Sun XX, Lu H (Jul 2008). "Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2". Mol. Cell. Biol. 28 (13): 4365–76. doi:10.1128/MCB.01662-07. PMC 2447154. PMID 18426907.

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@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Guanine nucleotide-binding protein-like 3''', also known as '''nucleostemin''', is a [[protein]] that in humans is encoded by the ''GNL3'' [[gene]].<ref name="pmid11085516">{{cite journal | vauthors = Charpentier AH, Bednarek AK, Daniel RL, Hawkins KA, Laflin KJ, Gaddis S, MacLeod MC, Aldaz CM | title = Effects of estrogen on global gene expression: identification of novel targets of estrogen action | journal = Cancer Res. | volume = 60 | issue = 21 | pages = 5977–83  | date = Nov 2000 | pmid = 11085516 | pmc =  | doi =  }}</ref><ref name="pmid12464630">{{cite journal | vauthors = Tsai RY, McKay RD | title = A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells | journal = Genes Dev. | volume = 16 | issue = 23 | pages = 2991–3003  | date = Dec 2002 | pmid = 12464630 | pmc = 187487 | doi = 10.1101/gad.55671 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GNL3 guanine nucleotide binding protein-like 3 (nucleolar)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26354| accessdate = }}</ref> It is found within the [[nucleolus]] that binds [[p53]].<ref name="Ross2011">{{Cite book  | last1 = Ross | first1 = Michael H. | last2 = Pawlina | first2 = Wojciech. | title = Histology : a text and atlas : with correlated cell and molecular biolog | year = 2011 | publisher = Wolters Kluwer/Lippincott Williams  Wilkins Health | location = Philadelphia | isbn = 0-7817-7200-1 | pages = 79 }}
-| update_page = yes
+</ref> Nucleostemin regulates the [[cell cycle]] and affects [[cell differentiation]], decreasing in amount as this differentiation progresses.<ref name="Ross2011" /> It is a marker for many [[stem cell]]s and [[cancer cell]]s.<ref name="Adams2010">{{cite book|author=Niall M. Adams|title=Advances in Nuclear Architecture|url=https://books.google.com/books?id=dpceD8fZ1B0C&pg=PA31|accessdate=27 September 2011|date=29 November 2010|publisher=Springer|isbn=978-90-481-9898-6|page=31}}</ref>
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Interactions ==
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Guanine nucleotide binding protein-like 3 (nucleolar)
- | HGNCid = 29931
- | Symbol = GNL3
- | AltSymbols =; NS; C77032; E2IG3; MGC800
- | OMIM = 608011
- | ECnumber =
- | Homologene = 56670
- | MGIid = 1353651
- | GeneAtlas_image1 = PBB_GE_GNL3_217850_at_tn.png
- | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
- | Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005730 |text = nucleolus}}
- | Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0042127 |text = regulation of cell proliferation}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 26354
-    | Hs_Ensembl = ENSG00000163938
-    | Hs_RefseqProtein = NP_055181
-    | Hs_RefseqmRNA = NM_014366
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 3
-    | Hs_GenLoc_start = 52695149
-    | Hs_GenLoc_end = 52703548
-    | Hs_Uniprot = Q9BVP2
-    | Mm_EntrezGene = 30877
-    | Mm_Ensembl = ENSMUSG00000042354
-    | Mm_RefseqmRNA = NM_153547
-    | Mm_RefseqProtein = NP_705775
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 14
-    | Mm_GenLoc_start = 29841445
-    | Mm_GenLoc_end = 29848070
-    | Mm_Uniprot = Q3TK27
-  }}
-}}
-'''Guanine nucleotide binding protein-like 3 (nucleolar)''', also known as '''GNL3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GNL3 guanine nucleotide binding protein-like 3 (nucleolar)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26354| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+GNL3 has been shown to [[Protein-protein interaction|interact]] with [[Mdm2]]<ref name=pmid18426907>{{cite journal | vauthors = Dai MS, Sun XX, Lu H | title = Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2 | journal = Mol. Cell. Biol. | volume = 28 | issue = 13 | pages = 4365–76  | date = Jul 2008 | pmid = 18426907 | pmc = 2447154 | doi = 10.1128/MCB.01662-07 }}</ref> and [[P53]].<ref name="pmid12464630"/>
-{{PBB_Summary
-| section_title =
-| summary_text =
-}}
-==References==
+== References ==
-{{reflist|2}}
+{{reflist}}
-==Further reading==
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI | title = Directed proteomic analysis of the human nucleolus | journal = Curr. Biol. | volume = 12 | issue = 1 | pages = 1–11 | year = 2002 | pmid = 11790298 | doi = 10.1016/S0960-9822(01)00650-9 }}
-| citations =
+* {{cite journal | vauthors = Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ | title = Functional proteomic analysis of human nucleolus | journal = Mol. Biol. Cell | volume = 13 | issue = 11 | pages = 4100–9 | year = 2002 | pmid = 12429849 | pmc = 133617 | doi = 10.1091/mbc.E02-05-0271 }}
-*{{cite journal  | author=Charpentier AH, Bednarek AK, Daniel RL, ''et al.'' |title=Effects of estrogen on global gene expression: identification of novel targets of estrogen action. |journal=Cancer Res. |volume=60 |issue= 21 |pages= 5977-83 |year= 2000 |pmid= 11085516 |doi=  }}
+* {{cite journal | vauthors = Schwartz PH, Bryant PJ, Fuja TJ, Su H, O'Dowd DK, Klassen H | title = Isolation and characterization of neural progenitor cells from post-mortem human cortex | journal = J. Neurosci. Res. | volume = 74 | issue = 6 | pages = 838–51 | year = 2003 | pmid = 14648588 | doi = 10.1002/jnr.10854 }}
-*{{cite journal  | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11790298 |doi=  }}
+* {{cite journal | vauthors = Liu SJ, Cai ZW, Liu YJ, Dong MY, Sun LQ, Hu GF, Wei YY, Lao WD | title = Role of nucleostemin in growth regulation of gastric cancer, liver cancer and other malignancies | journal = World J. Gastroenterol. | volume = 10 | issue = 9 | pages = 1246–9 | year = 2004 | pmid = 15112336 | doi =  }}
-*{{cite journal  | author=Scherl A, Couté Y, Déon C, ''et al.'' |title=Functional proteomic analysis of human nucleolus. |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 4100-9 |year= 2003 |pmid= 12429849 |doi= 10.1091/mbc.E02-05-0271 }}
+* {{cite journal | vauthors = Sijin L, Ziwei C, Yajun L, Meiyu D, Hongwei Z, Guofa H, Siguo L, Hong G, Zhihong Z, Xiaolei L, Yingyun W, Yan X, Weide L | title = The effect of knocking-down nucleostemin gene expression on the in vitro proliferation and in vivo tumorigenesis of HeLa cells | journal = J. Exp. Clin. Cancer Res. | volume = 23 | issue = 3 | pages = 529–38 | year = 2004 | pmid = 15595646 | doi =  }}
-*{{cite journal  | author=Tsai RY, McKay RD |title=A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells. |journal=Genes Dev. |volume=16 |issue= 23 |pages= 2991-3003 |year= 2003 |pmid= 12464630 |doi= 10.1101/gad.55671 }}
+* {{cite journal | vauthors = Tsai RY, McKay RD | title = A multistep, GTP-driven mechanism controlling the dynamic cycling of nucleostemin | journal = J. Cell Biol. | volume = 168 | issue = 2 | pages = 179–84 | year = 2005 | pmid = 15657390 | pmc = 2171593 | doi = 10.1083/jcb.200409053 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+* {{cite journal | vauthors = Politz JC, Polena I, Trask I, Bazett-Jones DP, Pederson T | title = A nonribosomal landscape in the nucleolus revealed by the stem cell protein nucleostemin | journal = Mol. Biol. Cell | volume = 16 | issue = 7 | pages = 3401–10 | year = 2005 | pmid = 15857956 | pmc = 1165421 | doi = 10.1091/mbc.E05-02-0106 }}
-*{{cite journal  | author=Schwartz PH, Bryant PJ, Fuja TJ, ''et al.'' |title=Isolation and characterization of neural progenitor cells from post-mortem human cortex. |journal=J. Neurosci. Res. |volume=74 |issue= 6 |pages= 838-51 |year= 2004 |pmid= 14648588 |doi= 10.1002/jnr.10854 }}
+* {{cite journal | vauthors = Han C, Zhang X, Xu W, Wang W, Qian H, Chen Y | title = Cloning of the nucleostemin gene and its function in transforming human embryonic bone marrow mesenchymal stem cells into F6 tumor cells | journal = Int. J. Mol. Med. | volume = 16 | issue = 2 | pages = 205–13 | year = 2005 | pmid = 16012751 | doi = 10.3892/ijmm.16.2.205 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+* {{cite journal | vauthors = Yang HX, Jin GL, Meng L, Zhang JZ, Liu WB, Shou CC | title = Screening and identification of proteins interacting with nucleostemin | journal = World J. Gastroenterol. | volume = 11 | issue = 31 | pages = 4812–4 | year = 2005 | pmid = 16097049 | doi =  }}
-*{{cite journal  | author=Liu SJ, Cai ZW, Liu YJ, ''et al.'' |title=Role of nucleostemin in growth regulation of gastric cancer, liver cancer and other malignancies. |journal=World J. Gastroenterol. |volume=10 |issue= 9 |pages= 1246-9 |year= 2004 |pmid= 15112336 |doi=  }}
+* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+* {{cite journal | vauthors = Kafienah W, Mistry S, Williams C, Hollander AP | title = Nucleostemin is a marker of proliferating stromal stem cells in adult human bone marrow | journal = Stem Cells | volume = 24 | issue = 4 | pages = 1113–20 | year = 2006 | pmid = 16282439 | doi = 10.1634/stemcells.2005-0416 }}
-*{{cite journal  | author=Sijin L, Ziwei C, Yajun L, ''et al.'' |title=The effect of knocking-down nucleostemin gene expression on the in vitro proliferation and in vivo tumorigenesis of HeLa cells. |journal=J. Exp. Clin. Cancer Res. |volume=23 |issue= 3 |pages= 529-38 |year= 2005 |pmid= 15595646 |doi=  }}
+* {{cite journal | vauthors = Fan Y, Liu Z, Zhao S, Lou F, Nilsson S, Ekman P, Xu D, Fang X | title = Nucleostemin mRNA is expressed in both normal and malignant renal tissues | journal = Br. J. Cancer | volume = 94 | issue = 11 | pages = 1658–62 | year = 2006 | pmid = 16670719 | pmc = 2361296 | doi = 10.1038/sj.bjc.6603145 }}
-*{{cite journal  | author=Tsai RY, McKay RD |title=A multistep, GTP-driven mechanism controlling the dynamic cycling of nucleostemin. |journal=J. Cell Biol. |volume=168 |issue= 2 |pages= 179-84 |year= 2005 |pmid= 15657390 |doi= 10.1083/jcb.200409053 }}
+* {{cite journal | vauthors = Lacina L, Smetana K, Dvoránková B, Stork J, Plzáková Z, Gabius HJ | title = Immunocyto- and histochemical profiling of nucleostemin expression: marker of epidermal stem cells? | journal = J. Dermatol. Sci. | volume = 44 | issue = 2 | pages = 73–80 | year = 2006 | pmid = 17000083 | doi = 10.1016/j.jdermsci.2006.08.008 }}
-*{{cite journal  | author=Politz JC, Polena I, Trask I, ''et al.'' |title=A nonribosomal landscape in the nucleolus revealed by the stem cell protein nucleostemin. |journal=Mol. Biol. Cell |volume=16 |issue= 7 |pages= 3401-10 |year= 2005 |pmid= 15857956 |doi= 10.1091/mbc.E05-02-0106 }}
+* {{cite journal | vauthors = Zhu Q, Yasumoto H, Tsai RY | title = Nucleostemin delays cellular senescence and negatively regulates TRF1 protein stability | journal = Mol. Cell. Biol. | volume = 26 | issue = 24 | pages = 9279–90 | year = 2006 | pmid = 17000763 | pmc = 1698521 | doi = 10.1128/MCB.00724-06 }}
-*{{cite journal  | author=Han C, Zhang X, Xu W, ''et al.'' |title=Cloning of the nucleostemin gene and its function in transforming human embryonic bone marrow mesenchymal stem cells into F6 tumor cells. |journal=Int. J. Mol. Med. |volume=16 |issue= 2 |pages= 205-13 |year= 2005 |pmid= 16012751 |doi=  }}
+* {{cite journal | vauthors = Liu SJ, Zhang ZH, Zhang DQ, Sui XM, Liu YJ, Cai ZW, Yuan XY, Sun LQ, Hu GF, Liu RL | title = Gene profiling after knocking-down expression of nucleostemin in Hela cells using oligonucleotide DNA microarray | journal = J. Exp. Clin. Cancer Res. | volume = 25 | issue = 4 | pages = 575–83 | year = 2006 | pmid = 17310849 | doi =  }}
-*{{cite journal  | author=Yang HX, Jin GL, Meng L, ''et al.'' |title=Screening and identification of proteins interacting with nucleostemin. |journal=World J. Gastroenterol. |volume=11 |issue= 31 |pages= 4812-4 |year= 2005 |pmid= 16097049 |doi=  }}
-*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
-*{{cite journal  | author=Kafienah W, Mistry S, Williams C, Hollander AP |title=Nucleostemin is a marker of proliferating stromal stem cells in adult human bone marrow. |journal=Stem Cells |volume=24 |issue= 4 |pages= 1113-20 |year= 2006 |pmid= 16282439 |doi= 10.1634/stemcells.2005-0416 }}
-*{{cite journal  | author=Fan Y, Liu Z, Zhao S, ''et al.'' |title=Nucleostemin mRNA is expressed in both normal and malignant renal tissues. |journal=Br. J. Cancer |volume=94 |issue= 11 |pages= 1658-62 |year= 2006 |pmid= 16670719 |doi= 10.1038/sj.bjc.6603145 }}
-*{{cite journal  | author=Lacina L, Smetana K, Dvoránková B, ''et al.'' |title=Immunocyto- and histochemical profiling of nucleostemin expression: marker of epidermal stem cells? |journal=J. Dermatol. Sci. |volume=44 |issue= 2 |pages= 73-80 |year= 2006 |pmid= 17000083 |doi= 10.1016/j.jdermsci.2006.08.008 }}
-*{{cite journal  | author=Zhu Q, Yasumoto H, Tsai RY |title=Nucleostemin delays cellular senescence and negatively regulates TRF1 protein stability. |journal=Mol. Cell. Biol. |volume=26 |issue= 24 |pages= 9279-90 |year= 2007 |pmid= 17000763 |doi= 10.1128/MCB.00724-06 }}
-*{{cite journal  | author=Liu SJ, Zhang ZH, Zhang DQ, ''et al.'' |title=Gene profiling after knocking-down expression of nucleostemin in Hela cells using oligonucleotide DNA microarray. |journal=J. Exp. Clin. Cancer Res. |volume=25 |issue= 4 |pages= 575-83 |year= 2007 |pmid= 17310849 |doi=  }}
-}}
 {{refend}}
-{{protein-stub}}
-{{WikiDoc Sources}}
+{{gene-3-stub}}

GNL3: Difference between revisions

Latest revision as of 08:53, 31 August 2017

Interactions

References

Further reading

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