GPS1: Difference between revisions

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{{Infobox_gene}}
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'''COP9 signalosome complex subunit 1''' is a [[protein]] that in humans is encoded by the ''GPS1'' [[gene]].<ref name="pmid9535219">{{cite journal |vauthors=Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, Gordon C, Naumann M, Dubiel W | title = A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits | journal = FASEB J | volume = 12 | issue = 6 | pages = 469–78 |date=Apr 1998 | pmid = 9535219 | pmc = | doi = }}</ref><ref name="entrez"/>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = G protein pathway suppressor 1
| HGNCid = 4549
| Symbol = GPS1
| AltSymbols =; CSN1; COPS1; MGC71287
| OMIM = 601934
| ECnumber = 
| Homologene = 3046
| MGIid = 2384801
| GeneAtlas_image1 = PBB_GE_GPS1_217782_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005095 |text = GTPase inhibitor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0008180 |text = signalosome}}
| Process = {{GNF_GO|id=GO:0000188 |text = inactivation of MAPK activity}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007254 |text = JNK cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2873
    | Hs_Ensembl = ENSG00000169727
    | Hs_RefseqProtein = NP_004118
    | Hs_RefseqmRNA = NM_004127
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 77603067
    | Hs_GenLoc_end = 77608618
    | Hs_Uniprot = Q13098
    | Mm_EntrezGene = 209318
    | Mm_Ensembl = ENSMUSG00000025156
    | Mm_RefseqmRNA = XM_001002541
    | Mm_RefseqProtein = XP_001002541
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 120600365
    | Mm_GenLoc_end = 120605192
    | Mm_Uniprot = Q99LD4
  }}
}}
'''G protein pathway suppressor 1''', also known as '''GPS1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPS1 G protein pathway suppressor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2873| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: GPS1 G protein pathway suppressor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2873| accessdate = }}</ref>
| summary_text = This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: GPS1 G protein pathway suppressor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2873| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Wolf DA, Zhou C, Wee S |title=The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases? |journal=Nat. Cell Biol. |volume=5 |issue= 12 |pages= 1029-33 |year= 2004 |pmid= 14647295 |doi= 10.1038/ncb1203-1029 }}
*{{cite journal  |vauthors=Wolf DA, Zhou C, Wee S |title=The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases? |journal=Nat. Cell Biol. |volume=5 |issue= 12 |pages= 1029–33 |year= 2004 |pmid= 14647295 |doi= 10.1038/ncb1203-1029 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Spain BH, Bowdish KS, Pacal AR, ''et al.'' |title=Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells. |journal=Mol. Cell. Biol. |volume=16 |issue= 12 |pages= 6698-706 |year= 1997 |pmid= 8943324 |doi=  }}
*{{cite journal   |vauthors=Spain BH, Bowdish KS, Pacal AR, etal |title=Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells |journal=Mol. Cell. Biol. |volume=16 |issue= 12 |pages= 6698–706 |year= 1997 |pmid= 8943324 |doi= 10.1128/mcb.16.12.6698| pmc=231672 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  }}
*{{cite journal | author=Seeger M, Kraft R, Ferrell K, ''et al.'' |title=A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. |journal=FASEB J. |volume=12 |issue= 6 |pages= 469-78 |year= 1998 |pmid= 9535219 |doi=  }}
*{{cite journal   |vauthors=Wei N, Tsuge T, Serino G, etal |title=The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex |journal=Curr. Biol. |volume=8 |issue= 16 |pages= 919–22 |year= 1998 |pmid= 9707402 |doi=10.1016/S0960-9822(07)00372-7 }}
*{{cite journal  | author=Wei N, Tsuge T, Serino G, ''et al.'' |title=The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. |journal=Curr. Biol. |volume=8 |issue= 16 |pages= 919-22 |year= 1998 |pmid= 9707402 |doi= }}
*{{cite journal  |vauthors=Tsuge T, Matsui M, Wei N |title=The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain |journal=J. Mol. Biol. |volume=305 |issue= 1 |pages= 1–9 |year= 2001 |pmid= 11114242 |doi= 10.1006/jmbi.2000.4288 }}
*{{cite journal | author=Tsuge T, Matsui M, Wei N |title=The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain. |journal=J. Mol. Biol. |volume=305 |issue= 1 |pages= 1-9 |year= 2001 |pmid= 11114242 |doi= 10.1006/jmbi.2000.4288 }}
*{{cite journal   |vauthors=Bech-Otschir D, Kraft R, Huang X, etal |title=COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system |journal=EMBO J. |volume=20 |issue= 7 |pages= 1630–9 |year= 2001 |pmid= 11285227 |doi= 10.1093/emboj/20.7.1630  | pmc=145508 }}
*{{cite journal | author=Bech-Otschir D, Kraft R, Huang X, ''et al.'' |title=COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. |journal=EMBO J. |volume=20 |issue= 7 |pages= 1630-9 |year= 2001 |pmid= 11285227 |doi= 10.1093/emboj/20.7.1630 }}
*{{cite journal   |vauthors=Lyapina S, Cope G, Shevchenko A, etal |title=Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome |journal=Science |volume=292 |issue= 5520 |pages= 1382–5 |year= 2001 |pmid= 11337588 |doi= 10.1126/science.1059780 }}
*{{cite journal  | author=Lyapina S, Cope G, Shevchenko A, ''et al.'' |title=Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. |journal=Science |volume=292 |issue= 5520 |pages= 1382-5 |year= 2001 |pmid= 11337588 |doi= 10.1126/science.1059780 }}
*{{cite journal  |vauthors=Hoareau Alves K, Bochard V, Réty S, Jalinot P |title=Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome |journal=FEBS Lett. |volume=527 |issue= 1–3 |pages= 15–21 |year= 2002 |pmid= 12220626 |doi=10.1016/S0014-5793(02)03147-2  }}
*{{cite journal  | author=Hoareau Alves K, Bochard V, Réty S, Jalinot P |title=Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome. |journal=FEBS Lett. |volume=527 |issue= 1-3 |pages= 15-21 |year= 2002 |pmid= 12220626 |doi= }}
*{{cite journal  |vauthors=Sun Y, Wilson MP, Majerus PW |title=Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1 |journal=J. Biol. Chem. |volume=277 |issue= 48 |pages= 45759–64 |year= 2003 |pmid= 12324474 |doi= 10.1074/jbc.M208709200 }}
*{{cite journal | author=Sun Y, Wilson MP, Majerus PW |title=Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1. |journal=J. Biol. Chem. |volume=277 |issue= 48 |pages= 45759-64 |year= 2003 |pmid= 12324474 |doi= 10.1074/jbc.M208709200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Serino G, Su H, Peng Z, etal |title=Characterization of the Last Subunit of the Arabidopsis COP9 Signalosome: Implications for the Overall Structure and Origin of the Complex |journal=Plant Cell |volume=15 |issue= 3 |pages= 719–31 |year= 2003 |pmid= 12615944 |doi=10.1105/tpc.009092  | pmc=150025  }}
*{{cite journal | author=Serino G, Su H, Peng Z, ''et al.'' |title=Characterization of the last subunit of the Arabidopsis COP9 signalosome: implications for the overall structure and origin of the complex. |journal=Plant Cell |volume=15 |issue= 3 |pages= 719-31 |year= 2003 |pmid= 12615944 |doi=  }}
*{{cite journal   |vauthors=Uhle S, Medalia O, Waldron R, etal |title=Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome |journal=EMBO J. |volume=22 |issue= 6 |pages= 1302–12 |year= 2003 |pmid= 12628923 |doi= 10.1093/emboj/cdg127 | pmc=151059 }}
*{{cite journal | author=Uhle S, Medalia O, Waldron R, ''et al.'' |title=Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. |journal=EMBO J. |volume=22 |issue= 6 |pages= 1302-12 |year= 2003 |pmid= 12628923 |doi= 10.1093/emboj/cdg127 }}
*{{cite journal   |vauthors=Groisman R, Polanowska J, Kuraoka I, etal |title=The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage |journal=Cell |volume=113 |issue= 3 |pages= 357–67 |year= 2003 |pmid= 12732143 |doi=10.1016/S0092-8674(03)00316-7  }}
*{{cite journal | author=Groisman R, Polanowska J, Kuraoka I, ''et al.'' |title=The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. |journal=Cell |volume=113 |issue= 3 |pages= 357-67 |year= 2003 |pmid= 12732143 |doi= }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Wang Y, Lu C, Wei H, etal |title=Hepatopoietin interacts directly with COP9 signalosome and regulates AP-1 activity |journal=FEBS Lett. |volume=572 |issue= 1–3 |pages= 85–91 |year= 2004 |pmid= 15304329 |doi= 10.1016/j.febslet.2004.07.012 }}
*{{cite journal | author=Wang Y, Lu C, Wei H, ''et al.'' |title=Hepatopoietin interacts directly with COP9 signalosome and regulates AP-1 activity. |journal=FEBS Lett. |volume=572 |issue= 1-3 |pages= 85-91 |year= 2004 |pmid= 15304329 |doi= 10.1016/j.febslet.2004.07.012 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Beausoleil SA, Villén J, Gerber SA, etal |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
}}
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Latest revision as of 09:03, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

COP9 signalosome complex subunit 1 is a protein that in humans is encoded by the GPS1 gene.[1][2]

This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.[2]

References

  1. ↑ Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, Gordon C, Naumann M, Dubiel W (Apr 1998). "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits". FASEB J. 12 (6): 469–78. PMID 9535219.
  2. ↑ 2.0 2.1 "Entrez Gene: GPS1 G protein pathway suppressor 1".

Further reading



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