GYPE: Difference between revisions

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{{Infobox_gene}}
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'''Glycophorin-E''' is a [[protein]] that in humans is encoded by the ''GYPE'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GYPE glycophorin E| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2996| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Glycophorin E
| HGNCid = 4705
| Symbol = GYPE
| AltSymbols =; MNS; GPE; MiIX
| OMIM = 138590
| ECnumber = 
| Homologene = 88655
| MGIid = 
| GeneAtlas_image1 = PBB_GE_GYPE_207854_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2996
    | Hs_Ensembl = ENSG00000197465
    | Hs_RefseqProtein = NP_002093
    | Hs_RefseqmRNA = NM_002102
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 145011470
    | Hs_GenLoc_end = 145046166
    | Hs_Uniprot = P15421
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Glycophorin E''', also known as '''GYPE''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GYPE glycophorin E| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2996| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a sialoglycoprotein and a type I membrane protein. It is a member of a gene family with GPA and GPB genes. This encoded protein might carry the M blood group antigen. GYPA, GYPB, and GYPE are organized in tandem on chromosome 4. This gene might have derived from an ancestral gene common to the GPB gene by gene duplication. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: GYPE glycophorin E| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2996| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a sialoglycoprotein and a type I membrane protein. It is a member of a gene family with GPA and GPB genes. This encoded protein might carry the M blood group antigen. GYPA, GYPB, and GYPE are organized in tandem on chromosome 4. This gene might have derived from an ancestral gene common to the GPB gene by gene duplication. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Cartron JP, Rahuel C |title=Human erythrocyte glycophorins: protein and gene structure analyses. |journal=Transfusion medicine reviews |volume=6 |issue= 2 |pages= 63-92 |year= 1992 |pmid= 1591491 |doi=  }}
*{{cite journal  |vauthors=Cartron JP, Rahuel C |title=Human erythrocyte glycophorins: protein and gene structure analyses |journal=Transfusion medicine reviews |volume=6 |issue= 2 |pages= 63–92 |year= 1992 |pmid= 1591491 |doi=10.1016/S0887-7963(92)70158-8 }}
*{{cite journal  | author=Huang CH, Skov F, Daniels G, ''et al.'' |title=Molecular analysis of human glycophorin MiIX gene shows a silent segment transfer and untemplated mutation resulting from gene conversion via sequence repeats. |journal=Blood |volume=80 |issue= 9 |pages= 2379-87 |year= 1992 |pmid= 1421409 |doi=  }}
*{{cite journal  | author=Huang CH |title=Molecular analysis of human glycophorin MiIX gene shows a silent segment transfer and untemplated mutation resulting from gene conversion via sequence repeats |journal=Blood |volume=80 |issue= 9 |pages= 2379–87 |year= 1992 |pmid= 1421409 |doi= |name-list-format=vanc| author2=Skov F  | author3=Daniels G  | display-authors=3  | last4=Tippett  | first4=P  | last5=Blumenfeld  | first5=OO }}
*{{cite journal  | author=Vignal A, London J, Rahuel C, Cartron JP |title=Promoter sequence and chromosomal organization of the genes encoding glycophorins A, B and E. |journal=Gene |volume=95 |issue= 2 |pages= 289-93 |year= 1991 |pmid= 2249783 |doi=  }}
*{{cite journal  |vauthors=Vignal A, London J, Rahuel C, Cartron JP |title=Promoter sequence and chromosomal organization of the genes encoding glycophorins A, B and E |journal=Gene |volume=95 |issue= 2 |pages= 289–293 |year= 1991 |pmid= 2249783 |doi=10.1016/0378-1119(90)90374-Z }}
*{{cite journal  | author=Kudo S, Fukuda M |title=Identification of a novel human glycophorin, glycophorin E, by isolation of genomic clones and complementary DNA clones utilizing polymerase chain reaction. |journal=J. Biol. Chem. |volume=265 |issue= 2 |pages= 1102-10 |year= 1990 |pmid= 2295603 |doi=  }}
*{{cite journal  |vauthors=Kudo S, Fukuda M |title=Identification of a novel human glycophorin, glycophorin E, by isolation of genomic clones and complementary DNA clones utilizing polymerase chain reaction |journal=J. Biol. Chem. |volume=265 |issue= 2 |pages= 1102–10 |year= 1990 |pmid= 2295603 |doi=  }}
*{{cite journal  | author=Vignal A, Rahuel C, London J, ''et al.'' |title=A novel gene member of the human glycophorin A and B gene family. Molecular cloning and expression. |journal=Eur. J. Biochem. |volume=191 |issue= 3 |pages= 619-25 |year= 1990 |pmid= 2390989 |doi=  }}
*{{cite journal  | author=Vignal A |title=A novel gene member of the human glycophorin A and B gene family. Molecular cloning and expression |journal=Eur. J. Biochem. |volume=191 |issue= 3 |pages= 619–625 |year= 1990 |pmid= 2390989 |doi=10.1111/j.1432-1033.1990.tb19166.x  |name-list-format=vanc| author2=Rahuel C  | author3=London J  | display-authors=3  | last4=Cherif Zahar  | first4=Baya  | last5=Schaff  | first5=Sophie  | last6=Hattab  | first6=Claude  | last7=Okubo  | first7=Yasuko  | last8=Cartron  | first8=Jean-Pierre }}
*{{cite journal  | author=Kudo S, Fukuda M |title=Contribution of gene conversion to the retention of the sequence for M blood group type determinant in glycophorin E gene. |journal=J. Biol. Chem. |volume=269 |issue= 37 |pages= 22969-74 |year= 1994 |pmid= 7521873 |doi=  }}
*{{cite journal  |vauthors=Kudo S, Fukuda M |title=Contribution of gene conversion to the retention of the sequence for M blood group type determinant in glycophorin E gene |journal=J. Biol. Chem. |volume=269 |issue= 37 |pages= 22969–74 |year= 1994 |pmid= 7521873 |doi=  }}
*{{cite journal  | author=Onda M, Fukuda M |title=Detailed physical mapping of the genes encoding glycophorins A, B and E, as revealed by P1 plasmids containing human genomic DNA. |journal=Gene |volume=159 |issue= 2 |pages= 225-30 |year= 1995 |pmid= 7622054 |doi=  }}
*{{cite journal  |vauthors=Onda M, Fukuda M |title=Detailed physical mapping of the genes encoding glycophorins A, B and E, as revealed by P1 plasmids containing human genomic DNA |journal=Gene |volume=159 |issue= 2 |pages= 225–230 |year= 1995 |pmid= 7622054 |doi=10.1016/0378-1119(95)00075-H }}
*{{cite journal  | author=Kudo S, Onda M, Fukuda M |title=Characterization of glycophorin A transcripts: control by the common erythroid-specific promoter and alternative usage of different polyadenylation signals. |journal=J. Biochem. |volume=116 |issue= 1 |pages= 183-92 |year= 1995 |pmid= 7798177 |doi=  }}
*{{cite journal  |vauthors=Kudo S, Onda M, Fukuda M |title=Characterization of glycophorin A transcripts: control by the common erythroid-specific promoter and alternative usage of different polyadenylation signals |journal=J. Biochem. |volume=116 |issue= 1 |pages= 183–92 |year= 1995 |pmid= 7798177 |doi=  }}
*{{cite journal  | author=Huang CH, Chen Y, Blumenfeld OO |title=A novel St(a) glycophorin produced via gene conversion of pseudoexon III from glycophorin E to glycophorin A gene. |journal=Hum. Mutat. |volume=15 |issue= 6 |pages= 533-40 |year= 2000 |pmid= 10862083 |doi= 10.1002/1098-1004(200006)15:6<533::AID-HUMU5>3.0.CO;2-R }}
*{{cite journal  |vauthors=Huang CH, Chen Y, Blumenfeld OO |title=A novel St(a) glycophorin produced via gene conversion of pseudoexon III from glycophorin E to glycophorin A gene |journal=Hum. Mutat. |volume=15 |issue= 6 |pages= 533–540 |year= 2000 |pmid= 10862083 |doi= 10.1002/1098-1004(200006)15:6<533::AID-HUMU5>3.0.CO;2-R }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Wang HY, Tang H, Shen CK, Wu CI |title=Rapidly evolving genes in human. I. The glycophorins and their possible role in evading malaria parasites. |journal=Mol. Biol. Evol. |volume=20 |issue= 11 |pages= 1795-804 |year= 2004 |pmid= 12949139 |doi= 10.1093/molbev/msg185 }}
*{{cite journal  |vauthors=Wang HY, Tang H, Shen CK, Wu CI |title=Rapidly evolving genes in human. I. The glycophorins and their possible role in evading malaria parasites |journal=Mol. Biol. Evol. |volume=20 |issue= 11 |pages= 1795–1804 |year= 2004 |pmid= 12949139 |doi= 10.1093/molbev/msg185 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 09:11, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Glycophorin-E is a protein that in humans is encoded by the GYPE gene.[1]

The protein encoded by this gene is a sialoglycoprotein and a type I membrane protein. It is a member of a gene family with GPA and GPB genes. This encoded protein might carry the M blood group antigen. GYPA, GYPB, and GYPE are organized in tandem on chromosome 4. This gene might have derived from an ancestral gene common to the GPB gene by gene duplication. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.[1]

References

  1. 1.0 1.1 "Entrez Gene: GYPE glycophorin E".

Further reading