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{{ | '''Histidine triad nucleotide-binding protein 1''' is a [[protein]] that in humans is encoded by the ''HINT1'' [[gene]].<ref name="pmid8812426">{{cite journal |vauthors=Brzoska PM, Chen H, Levin NA, Kuo WL, Collins C, Fu KK, Gray JW, Christman MF | title = Cloning, mapping, and in vivo localization of a human member of the PKCI-1 protein family (PRKCNH1) | journal = Genomics | volume = 36 | issue = 1 | pages = 151–6 |date=Feb 1997 | pmid = 8812426 | pmc = | doi = 10.1006/geno.1996.0435 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HINT1 histidine triad nucleotide binding protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3094| accessdate = }}</ref> It is a [[haploinsufficient]] tumor suppressor gene that inhibits the [[Wnt signaling pathway|Wnt/β-catenin pathway]] in colon cancer cells and [[microphthalmia-associated transcription factor]] (MITF) activity in human mast cells.<ref name="pmid19089909">{{cite journal |vauthors=Wang L, Li H, Zhang Y, Santella RM, Weinstein IB | title = HINT1 inhibits beta-catenin/TCF4, USF2 and NFkappaB activity in human hepatoma cells| journal = Int J Cancer | volume = 124 | issue = 7 | pages = 1526–34|date=Apr 2009 | pmid = 19089909 | pmc = 2667231 | doi = 10.1002/ijc.24072 }}</ref><ref name="pmid14975237">{{cite journal |vauthors=Lee YN, Nechushtan H, Figov N, Razin E | title = The function of lysyl-tRNA synthetase and Ap4A as signaling regulators of MITF activity in FcepsilonRI-activated mast cells | journal = Immunity| volume = 20 | issue = 2 | pages = 145–51 |date=Feb 2004 | pmid = 14975237 | pmc = | doi =10.1016/S1074-7613(04)00020-2 }}</ref> In the LysRS-Ap4A-MITF signaling pathway, HINT1 inhibits the MITF transcriptional activity by direct association. Upon pathway activation, HINT1 is released from MITF by [[diadenosine tetraphosphate]] (Ap4A), produced by [[KARS (gene)|LysRS]].<ref name="pmid14975237"/><ref name="pmid19524539">{{cite journal |vauthors=Yannay-Cohen N, Carmi-Levy I, Kay G, Yang CM, Han JM, Kemeny DM, Kim S, Nechushtan H, Razin E | title = LysRS serves as a key signaling molecule in the immune response by regulating gene expression | journal = Mol Cell| volume = 34 | issue = 5 | pages = 603–11 |date=June 2009 | pmid = 19524539 | pmc = | doi =10.1016/j.molcel.2009.05.019 }}</ref> | ||
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==See also== | |||
* [[Histidine triad nucleotide-binding protein 2]] (HINT2) | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | *{{cite journal |vauthors=Brzoska PM, Chen H, Zhu Y, etal |title=The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 17 |pages= 7824–8 |year= 1995 |pmid= 7644499 |doi=10.1073/pnas.92.17.7824 | pmc=41238 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Lima CD, Klein MG, Weinstein IB, Hendrickson WA |title=Three-dimensional structure of human protein kinase C interacting protein 1, a member of the HIT family of proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 11 |pages= 5357–62 |year= 1996 |pmid= 8643579 |doi=10.1073/pnas.93.11.5357 | pmc=39250 }} | ||
*{{cite journal |vauthors=Lima CD, Klein MG, Hendrickson WA |title=Structure-based analysis of catalysis and substrate definition in the HIT protein family. |journal=Science |volume=278 |issue= 5336 |pages= 286–90 |year= 1997 |pmid= 9323207 |doi=10.1126/science.278.5336.286 }} | |||
*{{cite journal | | *{{cite journal |vauthors=Klein MG, Yao Y, Slosberg ED, etal |title=Characterization of PKCI and comparative studies with FHIT, related members of the HIT protein family. |journal=Exp. Cell Res. |volume=244 |issue= 1 |pages= 26–32 |year= 1998 |pmid= 9770345 |doi= 10.1006/excr.1998.4153 }} | ||
*{{cite journal | *{{cite journal |vauthors=Weitzdoerfer R, Stolzlechner D, Dierssen M, etal |title=Reduction of nucleoside diphosphate kinase B, Rab GDP-dissociation inhibitor beta and histidine triad nucleotide-binding protein in fetal Down syndrome brain. |journal=J. Neural Transm. Suppl. |volume= |issue= 61 |pages= 347–59 |year= 2002 |pmid= 11771757 |doi= 10.1007/978-3-7091-6262-0_29}} | ||
*{{cite journal | *{{cite journal |vauthors=Bieganowski P, Garrison PN, Hodawadekar SC, etal |title=Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3. |journal=J. Biol. Chem. |volume=277 |issue= 13 |pages= 10852–60 |year= 2002 |pmid= 11805111 |doi= 10.1074/jbc.M111480200 | pmc=2556056 }} | ||
*{{cite journal | *{{cite journal | author=Brenner C |title=Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases. |journal=Biochemistry |volume=41 |issue= 29 |pages= 9003–14 |year= 2002 |pmid= 12119013 |doi=10.1021/bi025942q | pmc=2571077 }} | ||
*{{cite journal | author=Brenner C |title=Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases. |journal=Biochemistry |volume=41 |issue= 29 |pages= | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | ||
*{{cite journal | *{{cite journal |vauthors=Gevaert K, Goethals M, Martens L, etal |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }} | ||
*{{cite journal | *{{cite journal |vauthors=Galey D, Becker K, Haughey N, etal |title=Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes. |journal=J. Neurovirol. |volume=9 |issue= 3 |pages= 358–71 |year= 2003 |pmid= 12775419 |doi=10.1080/13550280390201119 }} | ||
*{{cite journal | *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }} | ||
*{{cite journal | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
*{{cite journal | *{{cite journal |vauthors=Weiske J, Huber O |title=The histidine triad protein Hint1 triggers apoptosis independent of its enzymatic activity. |journal=J. Biol. Chem. |volume=281 |issue= 37 |pages= 27356–66 |year= 2006 |pmid= 16835243 |doi= 10.1074/jbc.M513452200 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Ajit SK, Ramineni S, Edris W, etal |title=RGSZ1 interacts with protein kinase C interacting protein PKCI-1 and modulates mu opioid receptor signaling. |journal=Cell. Signal. |volume=19 |issue= 4 |pages= 723–30 |year= 2007 |pmid= 17126529 |doi= 10.1016/j.cellsig.2006.09.008 }} | ||
*{{cite journal | *{{cite journal | vauthors= Symes AJ, Eilertsen M, Millar M| last-author-amp= yes|title=Quantitative Analysis of BTF3, HINT1, NDRG1 and ODC1 Protein Over-Expression in Human Prostate Cancer Tissue |journal=PLoS ONE |volume=8 |issue=12 |pages= e84295 |year= 2013 |pmid= 24386364|doi= 10.1371/journal.pone.0084295 |pmc=3874000|display-authors=etal}} | ||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{PDB Gallery|geneid=3094}} | |||
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
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Histidine triad nucleotide-binding protein 1 is a protein that in humans is encoded by the HINT1 gene.[1][2] It is a haploinsufficient tumor suppressor gene that inhibits the Wnt/β-catenin pathway in colon cancer cells and microphthalmia-associated transcription factor (MITF) activity in human mast cells.[3][4] In the LysRS-Ap4A-MITF signaling pathway, HINT1 inhibits the MITF transcriptional activity by direct association. Upon pathway activation, HINT1 is released from MITF by diadenosine tetraphosphate (Ap4A), produced by LysRS.[4][5]
See also
References
- ↑ Brzoska PM, Chen H, Levin NA, Kuo WL, Collins C, Fu KK, Gray JW, Christman MF (Feb 1997). "Cloning, mapping, and in vivo localization of a human member of the PKCI-1 protein family (PRKCNH1)". Genomics. 36 (1): 151–6. doi:10.1006/geno.1996.0435. PMID 8812426.
- ↑ "Entrez Gene: HINT1 histidine triad nucleotide binding protein 1".
- ↑ Wang L, Li H, Zhang Y, Santella RM, Weinstein IB (Apr 2009). "HINT1 inhibits beta-catenin/TCF4, USF2 and NFkappaB activity in human hepatoma cells". Int J Cancer. 124 (7): 1526–34. doi:10.1002/ijc.24072. PMC 2667231. PMID 19089909.
- ↑ 4.0 4.1 Lee YN, Nechushtan H, Figov N, Razin E (Feb 2004). "The function of lysyl-tRNA synthetase and Ap4A as signaling regulators of MITF activity in FcepsilonRI-activated mast cells". Immunity. 20 (2): 145–51. doi:10.1016/S1074-7613(04)00020-2. PMID 14975237.
- ↑ Yannay-Cohen N, Carmi-Levy I, Kay G, Yang CM, Han JM, Kemeny DM, Kim S, Nechushtan H, Razin E (June 2009). "LysRS serves as a key signaling molecule in the immune response by regulating gene expression". Mol Cell. 34 (5): 603–11. doi:10.1016/j.molcel.2009.05.019. PMID 19524539.
Further reading
- Brzoska PM, Chen H, Zhu Y, et al. (1995). "The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7824–8. doi:10.1073/pnas.92.17.7824. PMC 41238. PMID 7644499.
- Lima CD, Klein MG, Weinstein IB, Hendrickson WA (1996). "Three-dimensional structure of human protein kinase C interacting protein 1, a member of the HIT family of proteins". Proc. Natl. Acad. Sci. U.S.A. 93 (11): 5357–62. doi:10.1073/pnas.93.11.5357. PMC 39250. PMID 8643579.
- Lima CD, Klein MG, Hendrickson WA (1997). "Structure-based analysis of catalysis and substrate definition in the HIT protein family". Science. 278 (5336): 286–90. doi:10.1126/science.278.5336.286. PMID 9323207.
- Klein MG, Yao Y, Slosberg ED, et al. (1998). "Characterization of PKCI and comparative studies with FHIT, related members of the HIT protein family". Exp. Cell Res. 244 (1): 26–32. doi:10.1006/excr.1998.4153. PMID 9770345.
- Weitzdoerfer R, Stolzlechner D, Dierssen M, et al. (2002). "Reduction of nucleoside diphosphate kinase B, Rab GDP-dissociation inhibitor beta and histidine triad nucleotide-binding protein in fetal Down syndrome brain". J. Neural Transm. Suppl. (61): 347–59. doi:10.1007/978-3-7091-6262-0_29. PMID 11771757.
- Bieganowski P, Garrison PN, Hodawadekar SC, et al. (2002). "Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3". J. Biol. Chem. 277 (13): 10852–60. doi:10.1074/jbc.M111480200. PMC 2556056. PMID 11805111.
- Brenner C (2002). "Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases". Biochemistry. 41 (29): 9003–14. doi:10.1021/bi025942q. PMC 2571077. PMID 12119013.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
- Galey D, Becker K, Haughey N, et al. (2003). "Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes". J. Neurovirol. 9 (3): 358–71. doi:10.1080/13550280390201119. PMID 12775419.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Weiske J, Huber O (2006). "The histidine triad protein Hint1 triggers apoptosis independent of its enzymatic activity". J. Biol. Chem. 281 (37): 27356–66. doi:10.1074/jbc.M513452200. PMID 16835243.
- Ajit SK, Ramineni S, Edris W, et al. (2007). "RGSZ1 interacts with protein kinase C interacting protein PKCI-1 and modulates mu opioid receptor signaling". Cell. Signal. 19 (4): 723–30. doi:10.1016/j.cellsig.2006.09.008. PMID 17126529.
- Symes AJ, Eilertsen M, Millar M, et al. (2013). "Quantitative Analysis of BTF3, HINT1, NDRG1 and ODC1 Protein Over-Expression in Human Prostate Cancer Tissue". PLoS ONE. 8 (12): e84295. doi:10.1371/journal.pone.0084295. PMC 3874000. PMID 24386364.
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