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{{Infobox_gene}}
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'''Histone H1.1''' is a [[protein]] that in humans is encoded by the ''HIST1H1A'' [[gene]].<ref name="pmid2759094">{{cite journal |vauthors=Eick S, Nicolai M, Mumberg D, Doenecke D | title = Human H1 histones: conserved and varied sequence elements in two H1 subtype genes | journal = Eur J Cell Biol | volume = 49 | issue = 1 | pages = 110–5 |date=Sep 1989 | pmid = 2759094 | pmc =  | doi =  }}</ref><ref name="pmid12408966">{{cite journal |vauthors=Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ | title = The human and mouse replication-dependent histone genes | journal = Genomics | volume = 80 | issue = 5 | pages = 487–98 |date=Oct 2002 | pmid = 12408966 | pmc =  | doi =10.1016/S0888-7543(02)96850-3 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HIST1H1A histone cluster 1, H1a| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3024| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Histone cluster 1, H1a
| HGNCid = 4715
| Symbol = HIST1H1A
| AltSymbols =; H1.1; H1F1; HIST1; MGC126642; MGC138345
| OMIM = 142709
| ECnumber =
| Homologene = 68460
| MGIid = 1931523
  | GeneAtlas_image1 = PBB_GE_HIST1H1A_208484_at_tn.png
  | Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}}  
| Component = {{GNF_GO|id=GO:0000786 |text = nucleosome}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005694 |text = chromosome}}
| Process = {{GNF_GO|id=GO:0006334 |text = nucleosome assembly}} {{GNF_GO|id=GO:0007283 |text = spermatogenesis}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3024
    | Hs_Ensembl = ENSG00000124610
    | Hs_RefseqProtein = NP_005316
    | Hs_RefseqmRNA = NM_005325
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 26125292
    | Hs_GenLoc_end = 26125939
    | Hs_Uniprot = Q02539
    | Mm_EntrezGene = 80838
    | Mm_Ensembl = ENSMUSG00000049539
    | Mm_RefseqmRNA = NM_030609
    | Mm_RefseqProtein = NP_085112
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 23771133
    | Mm_GenLoc_end = 23771879
    | Mm_Uniprot = Q5SZ98
  }}
}}
'''Histone cluster 1, H1a''', also known as '''HIST1H1A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HIST1H1A histone cluster 1, H1a| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3024| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.<ref name="entrez">{{cite web | title = Entrez Gene: HIST1H1A histone cluster 1, H1a| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3024| accessdate = }}</ref>
| summary_text = Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Du Clos TW, Zlock LT, Marnell L |title=Definition of a C-reactive protein binding determinant on histones. |journal=J. Biol. Chem. |volume=266 |issue= 4 |pages= 2167-71 |year= 1991 |pmid= 1989977 |doi=  }}
*{{cite journal  |vauthors=Du Clos TW, Zlock LT, Marnell L |title=Definition of a C-reactive protein binding determinant on histones. |journal=J. Biol. Chem. |volume=266 |issue= 4 |pages= 2167–71 |year= 1991 |pmid= 1989977 |doi=  }}
*{{cite journal  | author=Eick S, Nicolai M, Mumberg D, Doenecke D |title=Human H1 histones: conserved and varied sequence elements in two H1 subtype genes. |journal=Eur. J. Cell Biol. |volume=49 |issue= 1 |pages= 110-5 |year= 1989 |pmid= 2759094 |doi=  }}
*{{cite journal  |vauthors=Gurley LR, Valdez JG, Buchanan JS |title=Characterization of the mitotic specific phosphorylation site of histone H1. Absence of a consensus sequence for the p34cdc2/cyclin B kinase. |journal=J. Biol. Chem. |volume=270 |issue= 46 |pages= 27653–60 |year= 1996 |pmid= 7499230 |doi=  10.1074/jbc.270.46.27653}}
*{{cite journal | author=Gurley LR, Valdez JG, Buchanan JS |title=Characterization of the mitotic specific phosphorylation site of histone H1. Absence of a consensus sequence for the p34cdc2/cyclin B kinase. |journal=J. Biol. Chem. |volume=270 |issue= 46 |pages= 27653-60 |year= 1996 |pmid= 7499230 |doi=  }}
*{{cite journal   |vauthors=Burfeind P, Hoyer-Fender S, Doenecke D, etal |title=Expression and chromosomal mapping of the gene encoding the human histone H1.1. |journal=Hum. Genet. |volume=94 |issue= 6 |pages= 633–9 |year= 1995 |pmid= 7989039 |doi=  10.1007/bf00206957}}
*{{cite journal | author=Burfeind P, Hoyer-Fender S, Doenecke D, ''et al.'' |title=Expression and chromosomal mapping of the gene encoding the human histone H1.1. |journal=Hum. Genet. |volume=94 |issue= 6 |pages= 633-9 |year= 1995 |pmid= 7989039 |doi= }}
*{{cite journal   |vauthors=Albig W, Drabent B, Kunz J, etal |title=All known human H1 histone genes except the H1(0) gene are clustered on chromosome 6. |journal=Genomics |volume=16 |issue= 3 |pages= 649–54 |year= 1993 |pmid= 8325638 |doi= 10.1006/geno.1993.1243 }}
*{{cite journal | author=Albig W, Drabent B, Kunz J, ''et al.'' |title=All known human H1 histone genes except the H1(0) gene are clustered on chromosome 6. |journal=Genomics |volume=16 |issue= 3 |pages= 649-54 |year= 1993 |pmid= 8325638 |doi= 10.1006/geno.1993.1243 }}
*{{cite journal   |vauthors=O'Connor PM, Ferris DK, Pagano M, etal |title=G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. |journal=J. Biol. Chem. |volume=268 |issue= 11 |pages= 8298–308 |year= 1993 |pmid= 8463339 |doi= }}
*{{cite journal  | author=O'Connor PM, Ferris DK, Pagano M, ''et al.'' |title=G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. |journal=J. Biol. Chem. |volume=268 |issue= 11 |pages= 8298-308 |year= 1993 |pmid= 8463339 |doi=  }}
*{{cite journal  |vauthors=Díaz-Jullien C, Pérez-Estévez A, Covelo G, Freire M |title=Prothymosin alpha binds histones in vitro and shows activity in nucleosome assembly assay. |journal=Biochim. Biophys. Acta |volume=1296 |issue= 2 |pages= 219–27 |year= 1996 |pmid= 8814229 |doi=  10.1016/0167-4838(96)00072-6}}
*{{cite journal | author=Díaz-Jullien C, Pérez-Estévez A, Covelo G, Freire M |title=Prothymosin alpha binds histones in vitro and shows activity in nucleosome assembly assay. |journal=Biochim. Biophys. Acta |volume=1296 |issue= 2 |pages= 219-27 |year= 1996 |pmid= 8814229 |doi= }}
*{{cite journal   |vauthors=Albig W, Kioschis P, Poustka A, etal |title=Human histone gene organization: nonregular arrangement within a large cluster. |journal=Genomics |volume=40 |issue= 2 |pages= 314–22 |year= 1997 |pmid= 9119399 |doi= 10.1006/geno.1996.4592 }}
*{{cite journal  | author=Albig W, Kioschis P, Poustka A, ''et al.'' |title=Human histone gene organization: nonregular arrangement within a large cluster. |journal=Genomics |volume=40 |issue= 2 |pages= 314-22 |year= 1997 |pmid= 9119399 |doi= 10.1006/geno.1996.4592 }}
*{{cite journal  |vauthors=Meergans T, Albig W, Doenecke D |title=Conserved sequence elements in human main type-H1 histone gene promoters: their role in H1 gene expression. |journal=Eur. J. Biochem. |volume=256 |issue= 2 |pages= 436–46 |year= 1998 |pmid= 9760185 |doi=10.1046/j.1432-1327.1998.2560436.x  }}
*{{cite journal | author=Meergans T, Albig W, Doenecke D |title=Conserved sequence elements in human main type-H1 histone gene promoters: their role in H1 gene expression. |journal=Eur. J. Biochem. |volume=256 |issue= 2 |pages= 436-46 |year= 1998 |pmid= 9760185 |doi=  }}
*{{cite journal   |vauthors=Carrier F, Georgel PT, Pourquier P, etal |title=Gadd45, a p53-Responsive Stress Protein, Modifies DNA Accessibility on Damaged Chromatin |journal=Mol. Cell. Biol. |volume=19 |issue= 3 |pages= 1673–85 |year= 1999 |pmid= 10022855 |doi= | pmc=83961 }}
*{{cite journal | author=Carrier F, Georgel PT, Pourquier P, ''et al.'' |title=Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin. |journal=Mol. Cell. Biol. |volume=19 |issue= 3 |pages= 1673-85 |year= 1999 |pmid= 10022855 |doi=  }}
*{{cite journal   |vauthors=Silljé HH, Takahashi K, Tanaka K, etal |title=Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication |journal=EMBO J. |volume=18 |issue= 20 |pages= 5691–702 |year= 1999 |pmid= 10523312 |doi= 10.1093/emboj/18.20.5691 | pmc=1171636 }}
*{{cite journal | author=Silljé HH, Takahashi K, Tanaka K, ''et al.'' |title=Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication. |journal=EMBO J. |volume=18 |issue= 20 |pages= 5691-702 |year= 1999 |pmid= 10523312 |doi= 10.1093/emboj/18.20.5691 }}
*{{cite journal   |vauthors=Richardson RT, Batova IN, Widgren EE, etal |title=Characterization of the histone H1-binding protein, NASP, as a cell cycle-regulated somatic protein |journal=J. Biol. Chem. |volume=275 |issue= 39 |pages= 30378–86 |year= 2000 |pmid= 10893414 |doi= 10.1074/jbc.M003781200 }}
*{{cite journal  | author=Richardson RT, Batova IN, Widgren EE, ''et al.'' |title=Characterization of the histone H1-binding protein, NASP, as a cell cycle-regulated somatic protein. |journal=J. Biol. Chem. |volume=275 |issue= 39 |pages= 30378-86 |year= 2000 |pmid= 10893414 |doi= 10.1074/jbc.M003781200 }}
*{{cite journal  |vauthors=Lever MA, Th'ng JP, Sun X, Hendzel MJ |title=Rapid exchange of histone H1.1 on chromatin in living human cells |journal=Nature |volume=408 |issue= 6814 |pages= 873–6 |year= 2001 |pmid= 11130728 |doi= 10.1038/35048603 }}
*{{cite journal  | author=Lever MA, Th'ng JP, Sun X, Hendzel MJ |title=Rapid exchange of histone H1.1 on chromatin in living human cells. |journal=Nature |volume=408 |issue= 6814 |pages= 873-6 |year= 2001 |pmid= 11130728 |doi= 10.1038/35048603 }}
*{{cite journal  |vauthors=Chadwick BP, Willard HF |title=A Novel Chromatin Protein, Distantly Related to Histone H2a, Is Largely Excluded from the Inactive X Chromosome |journal=J. Cell Biol. |volume=152 |issue= 2 |pages= 375–84 |year= 2001 |pmid= 11266453 |doi=10.1083/jcb.152.2.375  | pmc=2199617  }}
*{{cite journal | author=Chadwick BP, Willard HF |title=A novel chromatin protein, distantly related to histone H2A, is largely excluded from the inactive X chromosome. |journal=J. Cell Biol. |volume=152 |issue= 2 |pages= 375-84 |year= 2001 |pmid= 11266453 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Marzluff WF, Gongidi P, Woods KR, ''et al.'' |title=The human and mouse replication-dependent histone genes. |journal=Genomics |volume=80 |issue= 5 |pages= 487-98 |year= 2003 |pmid= 12408966 |doi= }}
*{{cite journal   |vauthors=Coleman MA, Miller KA, Beernink PT, etal |title=Identification of chromatin-related protein interactions using protein microarrays |journal=Proteomics |volume=3 |issue= 11 |pages= 2101–7 |year= 2004 |pmid= 14595808 |doi= 10.1002/pmic.200300593 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Hendzel MJ, Lever MA, Crawford E, Th'ng JP |title=The C-terminal domain is the primary determinant of histone H1 binding to chromatin in vivo |journal=J. Biol. Chem. |volume=279 |issue= 19 |pages= 20028–34 |year= 2004 |pmid= 14985337 |doi= 10.1074/jbc.M400070200 }}
*{{cite journal | author=Coleman MA, Miller KA, Beernink PT, ''et al.'' |title=Identification of chromatin-related protein interactions using protein microarrays. |journal=Proteomics |volume=3 |issue= 11 |pages= 2101-7 |year= 2004 |pmid= 14595808 |doi= 10.1002/pmic.200300593 }}
*{{cite journal   |vauthors=Cohen-Armon M, Visochek L, Katzoff A, etal |title=Long-term memory requires polyADP-ribosylation |journal=Science |volume=304 |issue= 5678 |pages= 1820–2 |year= 2004 |pmid= 15205535 |doi= 10.1126/science.1096775 }}
*{{cite journal | author=Hendzel MJ, Lever MA, Crawford E, Th'ng JP |title=The C-terminal domain is the primary determinant of histone H1 binding to chromatin in vivo. |journal=J. Biol. Chem. |volume=279 |issue= 19 |pages= 20028-34 |year= 2004 |pmid= 14985337 |doi= 10.1074/jbc.M400070200 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Cohen-Armon M, Visochek L, Katzoff A, ''et al.'' |title=Long-term memory requires polyADP-ribosylation. |journal=Science |volume=304 |issue= 5678 |pages= 1820-2 |year= 2004 |pmid= 15205535 |doi= 10.1126/science.1096775 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 13:37, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Histone H1.1 is a protein that in humans is encoded by the HIST1H1A gene.[1][2][3]

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[3]

References

  1. ↑ Eick S, Nicolai M, Mumberg D, Doenecke D (Sep 1989). "Human H1 histones: conserved and varied sequence elements in two H1 subtype genes". Eur J Cell Biol. 49 (1): 110–5. PMID 2759094.
  2. ↑ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  3. ↑ 3.0 3.1 "Entrez Gene: HIST1H1A histone cluster 1, H1a".

Further reading



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