HNRPH1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Heterogeneous nuclear ribonucleoprotein H''' is a [[protein]] <ref>{{Cite journal|last=Penumutchu|first=Srinivasa|last2=Chiu|first2=Liang-Yuan|last3=Meagher|first3=Jennifer L.|last4=Hansen|first4=Alexandar L.|last5=Stuckey|first5=Jeanne A.|last6=Tolbert|first6=Blanton S.|date=2018-08-18|title=Differential Conformational Dynamics Encoded by the Inter-qRRM linker of hnRNP H|journal=Journal of the American Chemical Society|volume=140|issue=37|pages=11661–11673|language=en|doi=10.1021/jacs.8b05366|pmid=30122033|issn=0002-7863}}</ref> that in humans is encoded by the ''HNRNPH1'' [[gene]].<ref name="pmid7499401">{{cite journal |vauthors=Honore B, Rasmussen HH, Vorum H, Dejgaard K, Liu X, Gromov P, Madsen P, Gesser B, Tommerup N, Celis JE | title = Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes | journal = J Biol Chem | volume = 270 | issue = 48 | pages = 28780–9 |date=Jan 1996 | pmid = 7499401 | pmc =  | doi =10.1074/jbc.270.48.28780 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HNRPH1 heterogeneous nuclear ribonucleoprotein H1 (H)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3187| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_HNRPH1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1wez.
| PDB = {{PDB2|1wez}}, {{PDB2|1wg5}}
| Name = Heterogeneous nuclear ribonucleoprotein H1 (H)
| HGNCid = 5041
| Symbol = HNRPH1
| AltSymbols =; DKFZp686A15170; HNRPH; hnRNPH
| OMIM = 601035
| ECnumber =
| Homologene = 31318
| MGIid = 1891925
| GeneAtlas_image1 = PBB_GE_HNRPH1_201031_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_HNRPH1_213470_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008266 |text = poly(U) binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005681 |text = spliceosome}} {{GNF_GO|id=GO:0030530 |text = heterogeneous nuclear ribonucleoprotein complex}}
| Process = {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3187
    | Hs_Ensembl = ENSG00000169045
    | Hs_RefseqProtein = NP_005511
    | Hs_RefseqmRNA = NM_005520
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 178973795
    | Hs_GenLoc_end = 178984276
    | Hs_Uniprot = P31943
    | Mm_EntrezGene = 59013
    | Mm_Ensembl = ENSMUSG00000007850
    | Mm_RefseqmRNA = NM_021510
    | Mm_RefseqProtein = NP_067485
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 50221174
    | Mm_GenLoc_end = 50229318
    | Mm_Uniprot = Q3TNG9
  }}
}}
'''Heterogeneous nuclear ribonucleoprotein H1 (H)''', also known as '''HNRPH1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HNRPH1 heterogeneous nuclear ribonucleoprotein H1 (H)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3187| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. It is very similar to the family member HNRPF. This gene is thought to be potentially involved in hereditary lymphedema type I phenotype.<ref name="entrez">{{cite web | title = Entrez Gene: HNRPH1 heterogeneous nuclear ribonucleoprotein H1 (H)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3187| accessdate = }}</ref>
| summary_text = This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. It is very similar to the family member HNRPF. This gene is thought to be potentially involved in hereditary lymphedema type I phenotype.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Rasmussen HH, van Damme J, Puype M, ''et al.'' |title=Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. |journal=Electrophoresis |volume=13 |issue= 12 |pages= 960-9 |year= 1993 |pmid= 1286667 |doi=  }}
*{{cite journal   |vauthors=Rasmussen HH, van Damme J, Puype M, etal |title=Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. |journal=Electrophoresis |volume=13 |issue= 12 |pages= 960–9 |year= 1993 |pmid= 1286667 |doi=10.1002/elps.11501301199 }}
*{{cite journal  | author=Dawson SJ, White LA |title=Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. |journal=J. Infect. |volume=24 |issue= 3 |pages= 317-20 |year= 1992 |pmid= 1602151 |doi=  }}
*{{cite journal  |vauthors=Dawson SJ, White LA |title=Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. |journal=J. Infect. |volume=24 |issue= 3 |pages= 317–20 |year= 1992 |pmid= 1602151 |doi=10.1016/S0163-4453(05)80037-4 }}
*{{cite journal  | author=Honoré B, Rasmussen HH, Vorum H, ''et al.'' |title=Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes. |journal=J. Biol. Chem. |volume=270 |issue= 48 |pages= 28780-9 |year= 1996 |pmid= 7499401 |doi=  }}
*{{cite journal  |vauthors=Matunis MJ, Xing J, Dreyfuss G |title=The hnRNP F protein: unique primary structure, nucleic acid-binding properties, and subcellular localization. |journal=Nucleic Acids Res. |volume=22 |issue= 6 |pages= 1059–67 |year= 1994 |pmid= 7512260 |doi=10.1093/nar/22.6.1059  | pmc=307930 }}
*{{cite journal  | author=Matunis MJ, Xing J, Dreyfuss G |title=The hnRNP F protein: unique primary structure, nucleic acid-binding properties, and subcellular localization. |journal=Nucleic Acids Res. |volume=22 |issue= 6 |pages= 1059-67 |year= 1994 |pmid= 7512260 |doi=  }}
*{{cite journal  |vauthors=Gamberi C, Izaurralde E, Beisel C, Mattaj IW |title=Interaction between the human nuclear cap-binding protein complex and hnRNP F. |journal=Mol. Cell. Biol. |volume=17 |issue= 5 |pages= 2587–97 |year= 1997 |pmid= 9111328 |doi= | pmc=232108 }}
*{{cite journal  | author=Gamberi C, Izaurralde E, Beisel C, Mattaj IW |title=Interaction between the human nuclear cap-binding protein complex and hnRNP F. |journal=Mol. Cell. Biol. |volume=17 |issue= 5 |pages= 2587-97 |year= 1997 |pmid= 9111328 |doi=  }}
*{{cite journal  |vauthors=Chou MY, Rooke N, Turck CW, Black DL |title=hnRNP H is a component of a splicing enhancer complex that activates a c-src alternative exon in neuronal cells. |journal=Mol. Cell. Biol. |volume=19 |issue= 1 |pages= 69–77 |year= 1999 |pmid= 9858532 |doi= | pmc=83866 }}
*{{cite journal | author=Chou MY, Rooke N, Turck CW, Black DL |title=hnRNP H is a component of a splicing enhancer complex that activates a c-src alternative exon in neuronal cells. |journal=Mol. Cell. Biol. |volume=19 |issue= 1 |pages= 69-77 |year= 1999 |pmid= 9858532 |doi=  }}
*{{cite journal   |vauthors=Evans AL, Brice G, Sotirova V, etal |title=Mapping of primary congenital lymphedema to the 5q35.3 region. |journal=Am. J. Hum. Genet. |volume=64 |issue= 2 |pages= 547–55 |year= 1999 |pmid= 9973292 |doi=10.1086/302248  | pmc=1377764 }}
*{{cite journal  | author=Evans AL, Brice G, Sotirova V, ''et al.'' |title=Mapping of primary congenital lymphedema to the 5q35.3 region. |journal=Am. J. Hum. Genet. |volume=64 |issue= 2 |pages= 547-55 |year= 1999 |pmid= 9973292 |doi=  }}
*{{cite journal  |vauthors=Honoré B, Vorum H, Baandrup U |title=hnRNPs H, H' and F behave differently with respect to posttranslational cleavage and subcellular localization. |journal=FEBS Lett. |volume=456 |issue= 2 |pages= 274–80 |year= 1999 |pmid= 10456323 |doi=10.1016/S0014-5793(99)00911-4 }}
*{{cite journal | author=Honoré B, Vorum H, Baandrup U |title=hnRNPs H, H' and F behave differently with respect to posttranslational cleavage and subcellular localization. |journal=FEBS Lett. |volume=456 |issue= 2 |pages= 274-80 |year= 1999 |pmid= 10456323 |doi= }}
*{{cite journal   |vauthors=Markovtsov V, Nikolic JM, Goldman JA, etal |title=Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein. |journal=Mol. Cell. Biol. |volume=20 |issue= 20 |pages= 7463–79 |year= 2000 |pmid= 11003644 |doi=10.1128/MCB.20.20.7463-7479.2000  | pmc=86300  }}
*{{cite journal | author=Markovtsov V, Nikolic JM, Goldman JA, ''et al.'' |title=Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein. |journal=Mol. Cell. Biol. |volume=20 |issue= 20 |pages= 7463-79 |year= 2000 |pmid= 11003644 |doi= }}
*{{cite journal   |vauthors=Andersen JS, Lyon CE, Fox AH, etal |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=10.1016/S0960-9822(01)00650-9  }}
*{{cite journal | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11790298 |doi=  }}
*{{cite journal   |vauthors=Jurica MS, Licklider LJ, Gygi SR, etal |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426–39 |year= 2002 |pmid= 11991638 |doi=10.1017/S1355838202021088  | pmc=1370266 }}
*{{cite journal | author=Jurica MS, Licklider LJ, Gygi SR, ''et al.'' |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426-39 |year= 2002 |pmid= 11991638 |doi=  }}
*{{cite journal   |vauthors=Angenstein F, Evans AM, Settlage RE, etal |title=A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons. |journal=J. Neurosci. |volume=22 |issue= 20 |pages= 8827–37 |year= 2002 |pmid= 12388589 |doi=  }}
*{{cite journal | author=Angenstein F, Evans AM, Settlage RE, ''et al.'' |title=A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons. |journal=J. Neurosci. |volume=22 |issue= 20 |pages= 8827-37 |year= 2002 |pmid= 12388589 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Li J, Hawkins IC, Harvey CD, etal |title=Regulation of alternative splicing by SRrp86 and its interacting proteins. |journal=Mol. Cell. Biol. |volume=23 |issue= 21 |pages= 7437–47 |year= 2003 |pmid= 14559993 |doi=10.1128/MCB.23.21.7437-7447.2003  | pmc=207616  }}
*{{cite journal | author=Li J, Hawkins IC, Harvey CD, ''et al.'' |title=Regulation of alternative splicing by SRrp86 and its interacting proteins. |journal=Mol. Cell. Biol. |volume=23 |issue= 21 |pages= 7437-47 |year= 2003 |pmid= 14559993 |doi= }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Honoré B, Baandrup U, Vorum H |title=Heterogeneous nuclear ribonucleoproteins F and H/H' show differential expression in normal and selected cancer tissues. |journal=Exp. Cell Res. |volume=294 |issue= 1 |pages= 199–209 |year= 2004 |pmid= 14980514 |doi= 10.1016/j.yexcr.2003.11.011 }}
*{{cite journal | author=Honoré B, Baandrup U, Vorum H |title=Heterogeneous nuclear ribonucleoproteins F and H/H' show differential expression in normal and selected cancer tissues. |journal=Exp. Cell Res. |volume=294 |issue= 1 |pages= 199-209 |year= 2004 |pmid= 14980514 |doi= 10.1016/j.yexcr.2003.11.011 }}
*{{cite journal   |vauthors=Brill LM, Salomon AR, Ficarro SB, etal |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763–72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d }}
*{{cite journal | author=Brill LM, Salomon AR, Ficarro SB, ''et al.'' |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763-72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101  | pmc=514446 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal   |vauthors=Jin J, Smith FD, Stark C, etal |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
*{{cite journal  | author=Jin J, Smith FD, Stark C, ''et al.'' |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436-50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
*{{cite journal  |vauthors=Lin KT, Lu RM, Tarn WY |title=The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo. |journal=Mol. Cell. Biol. |volume=24 |issue= 20 |pages= 9176–85 |year= 2004 |pmid= 15456888 |doi= 10.1128/MCB.24.20.9176-9185.2004 | pmc=517884 }}
*{{cite journal | author=Lin KT, Lu RM, Tarn WY |title=The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo. |journal=Mol. Cell. Biol. |volume=24 |issue= 20 |pages= 9176-85 |year= 2004 |pmid= 15456888 |doi= 10.1128/MCB.24.20.9176-9185.2004 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=3187}}
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Latest revision as of 17:55, 21 December 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Heterogeneous nuclear ribonucleoprotein H is a protein [1] that in humans is encoded by the HNRNPH1 gene.[2][3]

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. It is very similar to the family member HNRPF. This gene is thought to be potentially involved in hereditary lymphedema type I phenotype.[3]

References

  1. ↑ Penumutchu, Srinivasa; Chiu, Liang-Yuan; Meagher, Jennifer L.; Hansen, Alexandar L.; Stuckey, Jeanne A.; Tolbert, Blanton S. (2018-08-18). "Differential Conformational Dynamics Encoded by the Inter-qRRM linker of hnRNP H". Journal of the American Chemical Society. 140 (37): 11661–11673. doi:10.1021/jacs.8b05366. ISSN 0002-7863. PMID 30122033.
  2. ↑ Honore B, Rasmussen HH, Vorum H, Dejgaard K, Liu X, Gromov P, Madsen P, Gesser B, Tommerup N, Celis JE (Jan 1996). "Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes". J Biol Chem. 270 (48): 28780–9. doi:10.1074/jbc.270.48.28780. PMID 7499401.
  3. ↑ 3.0 3.1 "Entrez Gene: HNRPH1 heterogeneous nuclear ribonucleoprotein H1 (H)".

Further reading



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