HPR (gene): Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''laxman ''' is a [[protein]] that in humans is encoded by the ''HPR'' [[gene]].<ref name="pmid2987228">{{cite journal | author = Maeda N | title = Nucleotide sequence of the haptoglobin and haptoglobin-related gene pair. The haptoglobin-related gene contains a retrovirus-like element | journal = J Biol Chem | volume = 260 | issue = 11 | pages = 6698–709 |date=Jul 1985 | pmid = 2987228 | pmc =  | doi =  }}</ref><ref name="pmid16778136">{{cite journal |vauthors=Nielsen MJ, Petersen SV, Jacobsen C, Oxvig C, Rees D, Moller HJ, Moestrup SK | title = Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein | journal = Blood | volume = 108 | issue = 8 | pages = 2846–9 |date=Oct 2006 | pmid = 16778136 | pmc =  | doi = 10.1182/blood-2006-05-022327 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HPR haptoglobin-related protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3250| accessdate = }}</ref> The HPR gene affects hereditary immunity to a non-pathogenic species of African [[Trypanosoma|trypanosomes]].<ref name="pmid7716520">{{cite journal  |vauthors=Smith AB, Esko JD, Hajduk SL |title=Killing of trypanosomes by the human haptoglobin-related protein. |journal=Science |volume=268 |issue= 5208 |pages= 284–6 |year= 1995 |pmid= 7716520 |doi=10.1126/science.7716520  }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==See also==
{{GNF_Protein_box
* [[Haptoglobin]]
| image =
* [[Trypanosoma brucei#Killing by human serum and resistance to human serum killing|''Trypanosoma brucei'': Killing by human serum and resistance to human serum killing]]
| image_source =
| PDB =
| Name = Haptoglobin-related protein
| HGNCid = 5156
| Symbol = HPR
| AltSymbols =; HP; A-259H10.2
| OMIM = 140210
| ECnumber = 
| Homologene = 8273
| MGIid = 96211
| GeneAtlas_image1 = PBB_GE_HPR_208471_at_tn.png
| GeneAtlas_image2 = PBB_GE_HPR_208470_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004252 |text = serine-type endopeptidase activity}} {{GNF_GO|id=GO:0030492 |text = hemoglobin binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3250
    | Hs_Ensembl = ENSG00000205103
    | Hs_RefseqProtein = NP_066275
    | Hs_RefseqmRNA = NM_020995
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 70665176
    | Hs_GenLoc_end = 70668596
    | Hs_Uniprot = P00739
    | Mm_EntrezGene = 15439
    | Mm_Ensembl = ENSMUSG00000031722
    | Mm_RefseqmRNA = NM_017370
    | Mm_RefseqProtein = NP_059066
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 112464400
    | Mm_GenLoc_end = 112466693
    | Mm_Uniprot = Q3UBS3
  }}
}}
'''Haptoglobin-related protein''', also known as '''HPR''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HPR haptoglobin-related protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3250| accessdate = }}</ref>


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==References==
{{PBB_Summary
{{reflist}}
| section_title =
| summary_text =
}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  |vauthors=Erickson LM, Kim HS, Maeda N |title=Junctions between genes in the haptoglobin gene cluster of primates. |journal=Genomics |volume=14 |issue= 4 |pages= 948–58 |year= 1993 |pmid= 1478675 |doi=10.1016/S0888-7543(05)80116-8 }}
| citations =
*{{cite journal   |vauthors=Maeda N, McEvoy SM, Harris HF, etal |title=Polymorphisms in the human haptoglobin gene cluster: chromosomes with multiple haptoglobin-related (Hpr) genes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 19 |pages= 7395–9 |year= 1986 |pmid= 2876426 |doi=10.1073/pnas.83.19.7395  | pmc=386724 }}
*{{cite journal  | author=Erickson LM, Kim HS, Maeda N |title=Junctions between genes in the haptoglobin gene cluster of primates. |journal=Genomics |volume=14 |issue= 4 |pages= 948-58 |year= 1993 |pmid= 1478675 |doi=  }}
*{{cite journal  |vauthors=Bensi G, Raugei G, Klefenz H, Cortese R |title=Structure and expression of the human haptoglobin locus. |journal=EMBO J. |volume=4 |issue= 1 |pages= 119–26 |year= 1985 |pmid= 4018023 |doi=  | pmc=554159 }}
*{{cite journal | author=Maeda N, McEvoy SM, Harris HF, ''et al.'' |title=Polymorphisms in the human haptoglobin gene cluster: chromosomes with multiple haptoglobin-related (Hpr) genes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 19 |pages= 7395-9 |year= 1986 |pmid= 2876426 |doi= }}
*{{cite journal   |vauthors=Hillier LD, Lennon G, Becker M, etal |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=10.1101/gr.6.9.807 }}
*{{cite journal  | author=Maeda N |title=Nucleotide sequence of the haptoglobin and haptoglobin-related gene pair. The haptoglobin-related gene contains a retrovirus-like element. |journal=J. Biol. Chem. |volume=260 |issue= 11 |pages= 6698-709 |year= 1985 |pmid= 2987228 |doi=  }}
*{{cite journal   |vauthors=Tabak S, Lev A, Valansi C, etal |title=Transcriptionally active haptoglobin-related (Hpr) gene in hepatoma G2 and leukemia molt-4 cells. |journal=DNA Cell Biol. |volume=15 |issue= 11 |pages= 1001–7 |year= 1997 |pmid= 8945641 |doi=10.1089/dna.1996.15.1001 }}
*{{cite journal  | author=Bensi G, Raugei G, Klefenz H, Cortese R |title=Structure and expression of the human haptoglobin locus. |journal=EMBO J. |volume=4 |issue= 1 |pages= 119-26 |year= 1985 |pmid= 4018023 |doi= }}
*{{cite journal  |vauthors=Muranjan M, Nussenzweig V, Tomlinson S |title=Characterization of the human serum trypanosome toxin, haptoglobin-related protein. |journal=J. Biol. Chem. |volume=273 |issue= 7 |pages= 3884–7 |year= 1998 |pmid= 9461571 |doi=10.1074/jbc.273.7.3884 }}
*{{cite journal | author=Smith AB, Esko JD, Hajduk SL |title=Killing of trypanosomes by the human haptoglobin-related protein. |journal=Science |volume=268 |issue= 5208 |pages= 284-6 |year= 1995 |pmid= 7716520 |doi=  }}
*{{cite journal   |vauthors=Raper J, Fung R, Ghiso J, etal |title=Characterization of a novel trypanosome lytic factor from human serum. |journal=Infect. Immun. |volume=67 |issue= 4 |pages= 1910–6 |year= 1999 |pmid= 10085035 |doi= | pmc=96545 }}
*{{cite journal | author=Hillier LD, Lennon G, Becker M, ''et al.'' |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807-28 |year= 1997 |pmid= 8889549 |doi=  }}
*{{cite journal   |vauthors=Loftus BJ, Kim UJ, Sneddon VP, etal |title=Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. |journal=Genomics |volume=60 |issue= 3 |pages= 295–308 |year= 1999 |pmid= 10493829 |doi= 10.1006/geno.1999.5927 }}
*{{cite journal | author=Tabak S, Lev A, Valansi C, ''et al.'' |title=Transcriptionally active haptoglobin-related (Hpr) gene in hepatoma G2 and leukemia molt-4 cells. |journal=DNA Cell Biol. |volume=15 |issue= 11 |pages= 1001-7 |year= 1997 |pmid= 8945641 |doi=  }}
*{{cite journal   |vauthors=Xu XR, Huang J, Xu ZG, etal |title=Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 26 |pages= 15089–94 |year= 2002 |pmid= 11752456 |doi= 10.1073/pnas.241522398 | pmc=64988 }}
*{{cite journal  | author=Muranjan M, Nussenzweig V, Tomlinson S |title=Characterization of the human serum trypanosome toxin, haptoglobin-related protein. |journal=J. Biol. Chem. |volume=273 |issue= 7 |pages= 3884-7 |year= 1998 |pmid= 9461571 |doi=  }}
*{{cite journal   |vauthors=Hatada S, Seed JR, Barker C, etal |title=No trypanosome lytic activity in the sera of mice producing human haptoglobin-related protein. |journal=Mol. Biochem. Parasitol. |volume=119 |issue= 2 |pages= 291–4 |year= 2002 |pmid= 11814582 |doi=10.1016/S0166-6851(01)00420-0  }}
*{{cite journal | author=Raper J, Fung R, Ghiso J, ''et al.'' |title=Characterization of a novel trypanosome lytic factor from human serum. |journal=Infect. Immun. |volume=67 |issue= 4 |pages= 1910-6 |year= 1999 |pmid= 10085035 |doi=  }}
*{{cite journal   |vauthors=Vanhollebeke B, Nielsen MJ, Watanabe Y, etal |title=Distinct roles of haptoglobin-related protein and apolipoprotein L-I in trypanolysis by human serum. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 10 |pages= 4118–23 |year= 2007 |pmid= 17360487 |doi= 10.1073/pnas.0609902104 | pmc=1820718 }}
*{{cite journal | author=Loftus BJ, Kim UJ, Sneddon VP, ''et al.'' |title=Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. |journal=Genomics |volume=60 |issue= 3 |pages= 295-308 |year= 1999 |pmid= 10493829 |doi= 10.1006/geno.1999.5927 }}
*{{cite journal   |vauthors=Widener J, Nielsen MJ, Shiflett A, etal |title=Hemoglobin is a co-factor of human trypanosome lytic factor. |journal=PLoS Pathog. |volume=3 |issue= 9 |pages= 1250–61 |year= 2007 |pmid= 17845074 |doi= 10.1371/journal.ppat.0030129 | pmc=1971115 }}
*{{cite journal | author=Xu XR, Huang J, Xu ZG, ''et al.'' |title=Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 26 |pages= 15089-94 |year= 2002 |pmid= 11752456 |doi= 10.1073/pnas.241522398 }}
*{{cite journal | author=Hatada S, Seed JR, Barker C, ''et al.'' |title=No trypanosome lytic activity in the sera of mice producing human haptoglobin-related protein. |journal=Mol. Biochem. Parasitol. |volume=119 |issue= 2 |pages= 291-4 |year= 2002 |pmid= 11814582 |doi=  }}
*{{cite journal  | author=Nielsen MJ, Petersen SV, Jacobsen C, ''et al.'' |title=Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein. |journal=Blood |volume=108 |issue= 8 |pages= 2846-9 |year= 2006 |pmid= 16778136 |doi= 10.1182/blood-2006-05-022327 }}
*{{cite journal | author=Vanhollebeke B, Nielsen MJ, Watanabe Y, ''et al.'' |title=Distinct roles of haptoglobin-related protein and apolipoprotein L-I in trypanolysis by human serum. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 10 |pages= 4118-23 |year= 2007 |pmid= 17360487 |doi= 10.1073/pnas.0609902104 }}
*{{cite journal | author=Widener J, Nielsen MJ, Shiflett A, ''et al.'' |title=Hemoglobin is a co-factor of human trypanosome lytic factor. |journal=PLoS Pathog. |volume=3 |issue= 9 |pages= 1250-61 |year= 2007 |pmid= 17845074 |doi= 10.1371/journal.ppat.0030129 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 05:19, 31 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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n/a

Ensembl

n/a

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UniProt

n/a

n/a

RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

laxman is a protein that in humans is encoded by the HPR gene.[1][2][3] The HPR gene affects hereditary immunity to a non-pathogenic species of African trypanosomes.[4]

See also

References

  1. ↑ Maeda N (Jul 1985). "Nucleotide sequence of the haptoglobin and haptoglobin-related gene pair. The haptoglobin-related gene contains a retrovirus-like element". J Biol Chem. 260 (11): 6698–709. PMID 2987228.
  2. ↑ Nielsen MJ, Petersen SV, Jacobsen C, Oxvig C, Rees D, Moller HJ, Moestrup SK (Oct 2006). "Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein". Blood. 108 (8): 2846–9. doi:10.1182/blood-2006-05-022327. PMID 16778136.
  3. ↑ "Entrez Gene: HPR haptoglobin-related protein".
  4. ↑ Smith AB, Esko JD, Hajduk SL (1995). "Killing of trypanosomes by the human haptoglobin-related protein". Science. 268 (5208): 284–6. doi:10.1126/science.7716520. PMID 7716520.

Further reading


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