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{{Infobox_gene}}
{{GNF_Protein_box
'''Insulin-like growth factor 2 mRNA-binding protein 1''' is a [[protein]] that in humans is encoded by the ''IGF2BP1'' [[gene]].<ref name="pmid9891060">{{cite journal |vauthors=Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC | title = A Family of Insulin-Like Growth Factor II mRNA-Binding Proteins Represses Translation in Late Development | journal = Mol Cell Biol | volume = 19 | issue = 2 | pages = 1262–70 |date=Feb 1999 | pmid = 9891060 | pmc = 116055 | doi = }}</ref><ref name="pmid11992722">{{cite journal |vauthors=Yaniv K, Yisraeli JK | title = The involvement of a conserved family of RNA binding proteins in embryonic development and carcinogenesis | journal = Gene | volume = 287 | issue = 1–2 | pages = 49–54 |date=May 2002 | pmid = 11992722 | pmc =  | doi =10.1016/S0378-1119(01)00866-6 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10642| accessdate = }}</ref>
| image = 
| image_source = 
| PDB =
| Name = Insulin-like growth factor 2 mRNA binding protein 1
| HGNCid = 28866
| Symbol = IGF2BP1
| AltSymbols =; CRD-BP; CRDBP; IMP-1; IMP1; VICKZ1; ZBP1
| OMIM = 608288
| ECnumber =
| Homologene = 4772
| MGIid = 1890357
| GeneAtlas_image1 = PBB_GE_IGF2BP1_gnf1h00091_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}}
| Component =  
| Process = {{GNF_GO|id=GO:0006417 |text = regulation of translation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10642
    | Hs_Ensembl = ENSG00000159217
    | Hs_RefseqProtein = NP_006537
    | Hs_RefseqmRNA = NM_006546
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 44429773
    | Hs_GenLoc_end = 44488506
    | Hs_Uniprot = 
    | Mm_EntrezGene = 140486
    | Mm_Ensembl = ENSMUSG00000013415
    | Mm_RefseqmRNA = NM_009951
    | Mm_RefseqProtein = NP_034081
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 95778822
    | Mm_GenLoc_end = 95822002
    | Mm_Uniprot =   
  }}
}}
'''Insulin-like growth factor 2 mRNA binding protein 1''', also known as '''IGF2BP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10642| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation.<ref name="entrez">{{cite web | title = Entrez Gene: IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10642| accessdate = }}</ref>
| summary_text = This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four K homology domains and two [[RNA]] recognition motifs. It functions by binding to the 5' UTR of the [[insulin-like growth factor 2]] (IGF2) [[mRNA]] and regulating IGF2 translation.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Yaniv K, Yisraeli JK |title=The involvement of a conserved family of RNA binding proteins in embryonic development and carcinogenesis. |journal=Gene |volume=287 |issue= 1-2 |pages= 49-54 |year= 2002 |pmid= 11992722 |doi= }}
*{{cite journal  |vauthors=Perycz M, Urbanska AS, Krawczyk P, Parobczak K, Jaworski J |title=Zipcode binding protein 1 regulates the development of dendritic arbors in hippocampal neurons |journal=J. Neurosci. |volume=31 |issue= 14 |pages= 5271–85 |year= 2011 |pmid= 21471362 |doi= 10.1523/JNEUROSCI.2387-10.2011 }}
*{{cite journal  | author=Yisraeli JK |title=VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins. |journal=Biol. Cell |volume=97 |issue= 1 |pages= 87-96 |year= 2005 |pmid= 15601260 |doi= 10.1042/BC20040151 }}
*{{cite journal  | author=Yisraeli JK |title=VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins |journal=Biol. Cell |volume=97 |issue= 1 |pages= 87–96 |year= 2005 |pmid= 15601260 |doi= 10.1042/BC20040151 }}
*{{cite journal  | author=Prokipcak RD, Herrick DJ, Ross J |title=Purification and properties of a protein that binds to the C-terminal coding region of human c-myc mRNA. |journal=J. Biol. Chem. |volume=269 |issue= 12 |pages= 9261-9 |year= 1994 |pmid= 8132663 |doi=  }}
*{{cite journal  |vauthors=Prokipcak RD, Herrick DJ, Ross J |title=Purification and properties of a protein that binds to the C-terminal coding region of human c-myc mRNA |journal=J. Biol. Chem. |volume=269 |issue= 12 |pages= 9261–9 |year= 1994 |pmid= 8132663 |doi=  }}
*{{cite journal  | author=Doyle GA, Betz NA, Leeds PF, ''et al.'' |title=The c-myc coding region determinant-binding protein: a member of a family of KH domain RNA-binding proteins. |journal=Nucleic Acids Res. |volume=26 |issue= 22 |pages= 5036-44 |year= 1999 |pmid= 9801297 |doi= }}
*{{cite journal  | author=Doyle GA |title=The c-myc coding region determinant-binding protein: a member of a family of KH domain RNA-binding proteins |journal=Nucleic Acids Res. |volume=26 |issue= 22 |pages= 5036–44 |year= 1999 |pmid= 9801297 |doi=10.1093/nar/26.22.5036  | pmc=147974 |name-list-format=vanc| author2=Betz NA  | author3=Leeds PF  | display-authors=3  | last4=Fleisig  | first4=AJ  | last5=Prokipcak  | first5=RD  | last6=Ross  | first6=J }}
*{{cite journal | author=Nielsen J, Christiansen J, Lykke-Andersen J, ''et al.'' |title=A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development. |journal=Mol. Cell. Biol. |volume=19 |issue= 2 |pages= 1262-70 |year= 1999 |pmid= 9891060 |doi=  }}
*{{cite journal  | author=Runge S |title=H19 RNA binds four molecules of insulin-like growth factor II mRNA-binding protein |journal=J. Biol. Chem. |volume=275 |issue= 38 |pages= 29562–9 |year= 2000 |pmid= 10875929 |doi= 10.1074/jbc.M001156200  |name-list-format=vanc| author2=Nielsen FC | author3=Nielsen J | display-authors=3  | last4=Lykke-Andersen  | first4=J  | last5=Wewer  | first5=UM  | last6=Christiansen  | first6=J }}
*{{cite journal  | author=Runge S, Nielsen FC, Nielsen J, ''et al.'' |title=H19 RNA binds four molecules of insulin-like growth factor II mRNA-binding protein. |journal=J. Biol. Chem. |volume=275 |issue= 38 |pages= 29562-9 |year= 2000 |pmid= 10875929 |doi= 10.1074/jbc.M001156200 }}
*{{cite journal  | author=Nielsen FC |title=Cytoplasmic trafficking of IGF-II mRNA-binding protein by conserved KH domains |journal=J. Cell Sci. |volume=115 |issue= Pt 10 |pages= 2087–97 |year= 2003 |pmid= 11973350 |doi=  |name-list-format=vanc| author2=Nielsen J | author3=Kristensen MA  | display-authors=3  | last4=Koch  | first4=G  | last5=Christiansen  | first5=J  }}
*{{cite journal | author=Nielsen FC, Nielsen J, Kristensen MA, ''et al.'' |title=Cytoplasmic trafficking of IGF-II mRNA-binding protein by conserved KH domains. |journal=J. Cell. Sci. |volume=115 |issue= Pt 10 |pages= 2087-97 |year= 2003 |pmid= 11973350 |doi=  }}
*{{cite journal  |vauthors=Lemm I, Ross J |title=Regulation of c-myc mRNA Decay by Translational Pausing in a Coding Region Instability Determinant |journal=Mol. Cell. Biol. |volume=22 |issue= 12 |pages= 3959–69 |year= 2002 |pmid= 12024010 |doi=10.1128/MCB.22.12.3959-3969.2002  | pmc=133878  }}
*{{cite journal  | author=Lemm I, Ross J |title=Regulation of c-myc mRNA decay by translational pausing in a coding region instability determinant. |journal=Mol. Cell. Biol. |volume=22 |issue= 12 |pages= 3959-69 |year= 2002 |pmid= 12024010 |doi=  }}
*{{cite journal  | author=Ioannidis P |title=8q24 Copy number gains and expression of the c-myc mRNA stabilizing protein CRD-BP in primary breast carcinomas |journal=Int. J. Cancer |volume=104 |issue= 1 |pages= 54–9 |year= 2003 |pmid= 12532419 |doi= 10.1002/ijc.10794 |name-list-format=vanc| author2=Mahaira L | author3=Papadopoulou A  | display-authors=3  | last4=Teixeira  | first4=Manuel R.  | last5=Heim  | first5=Sverre  | last6=Andersen  | first6=Johan A.  | last7=Evangelou  | first7=Evangelos | last8=Dafni  | first8=Urania  | last9=Pandis  | first9=Nikos }}
*{{cite journal | author=Ioannidis P, Mahaira L, Papadopoulou A, ''et al.'' |title=8q24 Copy number gains and expression of the c-myc mRNA stabilizing protein CRD-BP in primary breast carcinomas. |journal=Int. J. Cancer |volume=104 |issue= 1 |pages= 54-9 |year= 2003 |pmid= 12532419 |doi= 10.1002/ijc.10794 }}
*{{cite journal  | author=Nielsen J |title=Nuclear transit of human zipcode-binding protein IMP1 |journal=Biochem. J. |volume=376 |issue= Pt 2 |pages= 383–91 |year= 2003 |pmid= 12921532 |doi= 10.1042/BJ20030943 | pmc=1223771 |name-list-format=vanc| author2=Adolph SK  | author3=Rajpert-De Meyts E  | display-authors=3  | last4=Lykke-Andersen  | first4=Jens  | last5=Koch  | first5=Grete  | last6=Christiansen  | first6=Jan  | last7=Nielsen  | first7=Finn C. }}
*{{cite journal  | author=Nielsen J, Adolph SK, Rajpert-De Meyts E, ''et al.'' |title=Nuclear transit of human zipcode-binding protein IMP1. |journal=Biochem. J. |volume=376 |issue= Pt 2 |pages= 383-91 |year= 2003 |pmid= 12921532 |doi= 10.1042/BJ20030943 }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Gu L, Shigemasa K, Ohama K |title=Increased expression of IGF II mRNA-binding protein 1 mRNA is associated with an advanced clinical stage and poor prognosis in patients with ovarian cancer |journal=Int. J. Oncol. |volume=24 |issue= 3 |pages= 671–8 |year= 2004 |pmid= 14767552 |doi= 10.3892/ijo.24.3.671}}
*{{cite journal | author=Gu L, Shigemasa K, Ohama K |title=Increased expression of IGF II mRNA-binding protein 1 mRNA is associated with an advanced clinical stage and poor prognosis in patients with ovarian cancer. |journal=Int. J. Oncol. |volume=24 |issue= 3 |pages= 671-8 |year= 2004 |pmid= 14767552 |doi=  }}
*{{cite journal  | author=Hansen TV |title=Dwarfism and Impaired Gut Development in Insulin-Like Growth Factor II mRNA-Binding Protein 1-Deficient Mice |journal=Mol. Cell. Biol. |volume=24 |issue= 10 |pages= 4448–64 |year= 2004 |pmid= 15121863 |doi=10.1128/MCB.24.10.4448-4464.2004  | pmc=400488  |name-list-format=vanc| author2=Hammer NA  | author3=Nielsen J  | display-authors=3  | last4=Madsen  | first4=M.  | last5=Dalbaeck  | first5=C.  | last6=Wewer  | first6=U. M.  | last7=Christiansen  | first7=J.  | last8=Nielsen  | first8=F. C.  }}
*{{cite journal  | author=Hansen TV, Hammer NA, Nielsen J, ''et al.'' |title=Dwarfism and impaired gut development in insulin-like growth factor II mRNA-binding protein 1-deficient mice. |journal=Mol. Cell. Biol. |volume=24 |issue= 10 |pages= 4448-64 |year= 2004 |pmid= 15121863 |doi=  }}
*{{cite journal  | author=Ioannidis P |title=Expression of the RNA-binding protein CRD-BP in brain and non-small cell lung tumors |journal=Cancer Lett. |volume=209 |issue= 2 |pages= 245–50 |year= 2004 |pmid= 15159028 |doi= 10.1016/j.canlet.2003.12.015  |name-list-format=vanc| author2=Kottaridi C  | author3=Dimitriadis E  | display-authors=3  | last4=Courtis  | first4=Nelly  | last5=Mahaira  | first5=Louiza  | last6=Talieri  | first6=Maroulio  | last7=Giannopoulos  | first7=Andreas  | last8=Iliadis  | first8=Kosmas  | last9=Papaioannou  | first9=Dimitrios }}
*{{cite journal | author=Ioannidis P, Kottaridi C, Dimitriadis E, ''et al.'' |title=Expression of the RNA-binding protein CRD-BP in brain and non-small cell lung tumors. |journal=Cancer Lett. |volume=209 |issue= 2 |pages= 245-50 |year= 2004 |pmid= 15159028 |doi= 10.1016/j.canlet.2003.12.015 }}
*{{cite journal  |vauthors=Rackham O, Brown CM |title=Visualization of RNA–protein interactions in living cells: FMRP and IMP1 interact on mRNAs |journal=EMBO J. |volume=23 |issue= 16 |pages= 3346–55 |year= 2005 |pmid= 15282548 |doi= 10.1038/sj.emboj.7600341  | pmc=514514 }}
*{{cite journal  | author=Rackham O, Brown CM |title=Visualization of RNA-protein interactions in living cells: FMRP and IMP1 interact on mRNAs. |journal=EMBO J. |volume=23 |issue= 16 |pages= 3346-55 |year= 2005 |pmid= 15282548 |doi= 10.1038/sj.emboj.7600341 }}
*{{cite journal  | author=Nielsen J |title=Sequential dimerization of human zipcode-binding protein IMP1 on RNA: a cooperative mechanism providing RNP stability |journal=Nucleic Acids Res. |volume=32 |issue= 14 |pages= 4368–76 |year= 2004 |pmid= 15314207 |doi= 10.1093/nar/gkh754  | pmc=514376  |name-list-format=vanc| author2=Kristensen MA  | author3=Willemoës M  | display-authors=3  | last4=Nielsen  | first4=FC  | last5=Christiansen  | first5=J }}
*{{cite journal  | author=Nielsen J, Kristensen MA, Willemoës M, ''et al.'' |title=Sequential dimerization of human zipcode-binding protein IMP1 on RNA: a cooperative mechanism providing RNP stability. |journal=Nucleic Acids Res. |volume=32 |issue= 14 |pages= 4368-76 |year= 2004 |pmid= 15314207 |doi= 10.1093/nar/gkh754 }}
*{{cite journal  | author=Suzuki Y |title=Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604  | pmc=515316  |name-list-format=vanc| author2=Yamashita R  | author3=Shirota M  | display-authors=3  | last4=Sakakibara  | first4=Y  | last5=Chiba  | first5=J  | last6=Mizushima-Sugano  | first6=J  | last7=Nakai  | first7=K  | last8=Sugano  | first8=S }}
*{{cite journal  | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
*{{cite journal  | author=Liao B |title=Targeted knockdown of the RNA-binding protein CRD-BP promotes cell proliferation via an insulin-like growth factor II-dependent pathway in human K562 leukemia cells |journal=J. Biol. Chem. |volume=279 |issue= 47 |pages= 48716–24 |year= 2005 |pmid= 15355996 |doi= 10.1074/jbc.M405853200 |name-list-format=vanc| author2=Patel M  | author3=Hu Y  | display-authors=3  | last4=Charles  | first4=S  | last5=Herrick  | first5=DJ  | last6=Brewer  | first6=G }}
*{{cite journal  | author=Liao B, Patel M, Hu Y, ''et al.'' |title=Targeted knockdown of the RNA-binding protein CRD-BP promotes cell proliferation via an insulin-like growth factor II-dependent pathway in human K562 leukemia cells. |journal=J. Biol. Chem. |volume=279 |issue= 47 |pages= 48716-24 |year= 2005 |pmid= 15355996 |doi= 10.1074/jbc.M405853200 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 13:21, 16 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Insulin-like growth factor 2 mRNA-binding protein 1 is a protein that in humans is encoded by the IGF2BP1 gene.[1][2][3]

This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation.[3]

References

  1. ↑ Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC (Feb 1999). "A Family of Insulin-Like Growth Factor II mRNA-Binding Proteins Represses Translation in Late Development". Mol Cell Biol. 19 (2): 1262–70. PMC 116055. PMID 9891060.
  2. ↑ Yaniv K, Yisraeli JK (May 2002). "The involvement of a conserved family of RNA binding proteins in embryonic development and carcinogenesis". Gene. 287 (1–2): 49–54. doi:10.1016/S0378-1119(01)00866-6. PMID 11992722.
  3. ↑ 3.0 3.1 "Entrez Gene: IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1".

Further reading



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