IGFALS: Difference between revisions

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{{Infobox_gene}}
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'''Insulin-like growth factor binding protein, acid labile subunit''', also known as '''IGFALS''', is a [[protein]] which in humans is encoded by the ''IGFALS''  [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: IGFALS insulin-like growth factor binding protein, acid labile subunit| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3483| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Insulin-like growth factor binding protein, acid labile subunit
| HGNCid = 5468
| Symbol = IGFALS
| AltSymbols =; ALS
| OMIM = 601489
| ECnumber = 
| Homologene = 37987
| MGIid = 107973
| GeneAtlas_image1 = PBB_GE_IGFALS_215712_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005520 |text = insulin-like growth factor binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3483
    | Hs_Ensembl = ENSG00000099769
    | Hs_RefseqProtein = NP_004961
    | Hs_RefseqmRNA = NM_004970
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 1780417
    | Hs_GenLoc_end = 1783735
    | Hs_Uniprot = P35858
    | Mm_EntrezGene = 16005
    | Mm_Ensembl = ENSMUSG00000046070
    | Mm_RefseqmRNA = NM_008340
    | Mm_RefseqProtein = NP_032366
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 24607540
    | Mm_GenLoc_end = 24609348
    | Mm_Uniprot = Q3KQP3
  }}
}}
'''Insulin-like growth factor binding protein, acid labile subunit''', also known as '''IGFALS''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: IGFALS insulin-like growth factor binding protein, acid labile subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3483| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a serum protein that binds [[insulin-like growth factor]]s, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty [[leucine-rich repeat]]s, is stimulated by growth hormone. Three transcript variants encoding two different isoforms have been found for this gene.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text =
}}


==References==
== Clinical significance ==
{{reflist|2}}
 
==Further reading==
Defects in this gene are a cause of [[acid-labile subunit deficiency]], which manifests itself in a delayed and slow puberty.{{citation needed|reason=This claim needs a reference.|date=June 2015}}
 
== Interactions ==
 
IGFALS has been shown to [[Protein-protein interaction|interact]] with [[IGFBP3]].<ref name=pmid9497324>{{cite journal | vauthors = Twigg SM, Baxter RC | title = Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit | journal = J. Biol. Chem. | volume = 273 | issue = 11 | pages = 6074–9 | date = Mar 1998 | pmid = 9497324 | doi = 10.1074/jbc.273.11.6074 }}</ref><ref name=pmid9446566>{{cite journal | vauthors = Firth SM, Ganeshprasad U, Baxter RC | title = Structural determinants of ligand and cell surface binding of insulin-like growth factor-binding protein-3 | journal = J. Biol. Chem. | volume = 273 | issue = 5 | pages = 2631–8 | date = Jan 1998 | pmid = 9446566 | doi = 10.1074/jbc.273.5.2631 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Domené HM, Bengolea SV, Jasper HG, Boisclair YR | title = Acid-labile subunit deficiency: phenotypic similarities and differences between human and mouse.. | journal = J. Endocrinol. Invest. | volume = 28 | issue = 5 Suppl | pages = 43–6 | year = 2005 | pmid = 16114275 | doi =  }}
| citations =
* {{cite journal | vauthors = Leong SR, Baxter RC, Camerato T, Dai J, Wood WI | title = Structure and functional expression of the acid-labile subunit of the insulin-like growth factor-binding protein complex. | journal = Mol. Endocrinol. | volume = 6 | issue = 6 | pages = 870–6 | year = 1992 | pmid = 1379671 | doi = 10.1210/me.6.6.870 }}
*{{cite journal | author=Domené HM, Bengolea SV, Jasper HG, Boisclair YR |title=Acid-labile subunit deficiency: phenotypic similarities and differences between human and mouse. |journal=J. Endocrinol. Invest. |volume=28 |issue= 5 Suppl |pages= 43-6 |year= 2005 |pmid= 16114275 |doi=  }}
* {{cite journal | vauthors = Dai J, Baxter RC | title = Molecular cloning of the acid-labile subunit of the rat insulin-like growth factor binding protein complex. | journal = Biochem. Biophys. Res. Commun. | volume = 188 | issue = 1 | pages = 304–9 | year = 1992 | pmid = 1384485 | doi = 10.1016/0006-291X(92)92385-B }}
*{{cite journal | author=Leong SR, Baxter RC, Camerato T, ''et al.'' |title=Structure and functional expression of the acid-labile subunit of the insulin-like growth factor-binding protein complex. |journal=Mol. Endocrinol. |volume=6 |issue= 6 |pages= 870-6 |year= 1992 |pmid= 1379671 |doi= }}
* {{cite journal | vauthors = Baxter RC, Martin JL, Beniac VA | title = High molecular weight insulin-like growth factor binding protein complex. Purification and properties of the acid-labile subunit from human serum. | journal = J. Biol. Chem. | volume = 264 | issue = 20 | pages = 11843–8 | year = 1989 | pmid = 2473065 | doi =  }}
*{{cite journal | author=Dai J, Baxter RC |title=Molecular cloning of the acid-labile subunit of the rat insulin-like growth factor binding protein complex. |journal=Biochem. Biophys. Res. Commun. |volume=188 |issue= 1 |pages= 304-9 |year= 1992 |pmid= 1384485 |doi= }}
* {{cite journal | vauthors = Firth SM, Ganeshprasad U, Baxter RC | title = Structural determinants of ligand and cell surface binding of insulin-like growth factor-binding protein-3. | journal = J. Biol. Chem. | volume = 273 | issue = 5 | pages = 2631–8 | year = 1998 | pmid = 9446566 | doi = 10.1074/jbc.273.5.2631 }}
*{{cite journal | author=Baxter RC, Martin JL, Beniac VA |title=High molecular weight insulin-like growth factor binding protein complex. Purification and properties of the acid-labile subunit from human serum. |journal=J. Biol. Chem. |volume=264 |issue= 20 |pages= 11843-8 |year= 1989 |pmid= 2473065 |doi=  }}
* {{cite journal | vauthors = Twigg SM, Baxter RC | title = Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit. | journal = J. Biol. Chem. | volume = 273 | issue = 11 | pages = 6074–9 | year = 1998 | pmid = 9497324 | doi = 10.1074/jbc.273.11.6074 }}
*{{cite journal | author=Firth SM, Ganeshprasad U, Baxter RC |title=Structural determinants of ligand and cell surface binding of insulin-like growth factor-binding protein-3. |journal=J. Biol. Chem. |volume=273 |issue= 5 |pages= 2631-8 |year= 1998 |pmid= 9446566 |doi= }}
* {{cite journal | vauthors = Twigg SM, Kiefer MC, Zapf J, Baxter RC | title = Insulin-like growth factor-binding protein 5 complexes with the acid-labile subunit. Role of the carboxyl-terminal domain. | journal = J. Biol. Chem. | volume = 273 | issue = 44 | pages = 28791–8 | year = 1998 | pmid = 9786878 | doi = 10.1074/jbc.273.44.28791 }}
*{{cite journal | author=Twigg SM, Baxter RC |title=Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit. |journal=J. Biol. Chem. |volume=273 |issue= 11 |pages= 6074-9 |year= 1998 |pmid= 9497324 |doi= }}
* {{cite journal | vauthors = Suwanichkul A, Boisclair YR, Olney RC, Durham SK, Powell DR | title = Conservation of a growth hormone-responsive promoter element in the human and mouse acid-labile subunit genes. | journal = Endocrinology | volume = 141 | issue = 2 | pages = 833–8 | year = 2000 | pmid = 10650966 | doi = 10.1210/en.141.2.833 }}
*{{cite journal | author=Twigg SM, Kiefer MC, Zapf J, Baxter RC |title=Insulin-like growth factor-binding protein 5 complexes with the acid-labile subunit. Role of the carboxyl-terminal domain. |journal=J. Biol. Chem. |volume=273 |issue= 44 |pages= 28791-8 |year= 1998 |pmid= 9786878 |doi= }}
* {{cite journal | vauthors = Ueki I, Ooi GT, Tremblay ML, Hurst KR, Bach LA, Boisclair YR | title = Inactivation of the acid labile subunit gene in mice results in mild retardation of postnatal growth despite profound disruptions in the circulating insulin-like growth factor system. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 12 | pages = 6868–73 | year = 2000 | pmid = 10823924 | pmc = 18767 | doi = 10.1073/pnas.120172697 }}
*{{cite journal | author=Suwanichkul A, Boisclair YR, Olney RC, ''et al.'' |title=Conservation of a growth hormone-responsive promoter element in the human and mouse acid-labile subunit genes. |journal=Endocrinology |volume=141 |issue= 2 |pages= 833-8 |year= 2000 |pmid= 10650966 |doi= }}
* {{cite journal | vauthors = Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y | title = Protein-protein interaction panel using mouse full-length cDNAs. | journal = Genome Res. | volume = 11 | issue = 10 | pages = 1758–65 | year = 2001 | pmid = 11591653 | pmc = 311163 | doi = 10.1101/gr.180101 }}
*{{cite journal | author=Ueki I, Ooi GT, Tremblay ML, ''et al.'' |title=Inactivation of the acid labile subunit gene in mice results in mild retardation of postnatal growth despite profound disruptions in the circulating insulin-like growth factor system. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 12 |pages= 6868-73 |year= 2000 |pmid= 10823924 |doi= 10.1073/pnas.120172697 }}
* {{cite journal | vauthors = Sneppen SB, Lange M, Pedersen LM, Kristensen L LØ, Main KM, Juul A, Skakkebaek NE, Feldt-Rasmussen U | title = Total and free insulin-like growth factor I, insulin-like growth factor binding protein 3 and acid-labile subunit reflect clinical activity in acromegaly. | journal = Growth Horm. IGF Res. | volume = 11 | issue = 6 | pages = 384–91 | year = 2002 | pmid = 11914026 | doi = 10.1054/ghir.2001.0254 }}
*{{cite journal | author=Suzuki H, Fukunishi Y, Kagawa I, ''et al.'' |title=Protein-protein interaction panel using mouse full-length cDNAs. |journal=Genome Res. |volume=11 |issue= 10 |pages= 1758-65 |year= 2001 |pmid= 11591653 |doi= 10.1101/gr.180101 }}
* {{cite journal | vauthors = Cisternino M, Draghi M, Lauriola S, Scarcella D, Bernasconi S, Cavallo L, De Luca F, Lomeo A, Tatò L | title = The acid-labile subunit of human ternary insulin-like growth factor-binding protein complex in girls with central precocious puberty before and during gonadotropin-releasing hormone analog therapy. | journal = J. Clin. Endocrinol. Metab. | volume = 87 | issue = 10 | pages = 4629–33 | year = 2002 | pmid = 12364447 | doi = 10.1210/jc.2002-020308 }}
*{{cite journal | author=Sneppen SB, Lange M, Pedersen LM, ''et al.'' |title=Total and free insulin-like growth factor I, insulin-like growth factor binding protein 3 and acid-labile subunit reflect clinical activity in acromegaly. |journal=Growth Horm. IGF Res. |volume=11 |issue= 6 |pages= 384-91 |year= 2002 |pmid= 11914026 |doi= 10.1054/ghir.2001.0254 }}
* {{cite journal | vauthors = Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, Veenstra TD, Adkins JN, Pounds JG, Fagan R, Lobley A | title = The human plasma proteome: a nonredundant list developed by combination of four separate sources. | journal = Mol. Cell. Proteomics | volume = 3 | issue = 4 | pages = 311–26 | year = 2004 | pmid = 14718574 | doi = 10.1074/mcp.M300127-MCP200 }}
*{{cite journal | author=Cisternino M, Draghi M, Lauriola S, ''et al.'' |title=The acid-labile subunit of human ternary insulin-like growth factor-binding protein complex in girls with central precocious puberty before and during gonadotropin-releasing hormone analog therapy. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 10 |pages= 4629-33 |year= 2002 |pmid= 12364447 |doi= }}
* {{cite journal | vauthors = Domené HM, Bengolea SV, Martínez AS, Ropelato MG, Pennisi P, Scaglia P, Heinrich JJ, Jasper HG | title = Deficiency of the circulating insulin-like growth factor system associated with inactivation of the acid-labile subunit gene. | journal = N. Engl. J. Med. | volume = 350 | issue = 6 | pages = 570–7 | year = 2004 | pmid = 14762184 | doi = 10.1056/NEJMoa013100 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Payet LD, Firth SM, Baxter RC | title = The role of the acid-labile subunit in regulating insulin-like growth factor transport across human umbilical vein endothelial cell monolayers. | journal = J. Clin. Endocrinol. Metab. | volume = 89 | issue = 5 | pages = 2382–9 | year = 2004 | pmid = 15126567 | doi = 10.1210/jc.2003-031880 }}
*{{cite journal | author=Anderson NL, Polanski M, Pieper R, ''et al.'' |title=The human plasma proteome: a nonredundant list developed by combination of four separate sources. |journal=Mol. Cell Proteomics |volume=3 |issue= 4 |pages= 311-26 |year= 2004 |pmid= 14718574 |doi= 10.1074/mcp.M300127-MCP200 }}
* {{cite journal | vauthors = Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD | title = Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. | journal = J. Proteome Res. | volume = 4 | issue = 6 | pages = 2070–80 | year = 2006 | pmid = 16335952 | pmc = 1850943 | doi = 10.1021/pr0502065 }}
*{{cite journal | author=Domené HM, Bengolea SV, Martínez AS, ''et al.'' |title=Deficiency of the circulating insulin-like growth factor system associated with inactivation of the acid-labile subunit gene. |journal=N. Engl. J. Med. |volume=350 |issue= 6 |pages= 570-7 |year= 2004 |pmid= 14762184 |doi= 10.1056/NEJMoa013100 }}
* {{cite journal | vauthors = Deming SL, Ren Z, Wen W, Shu XO, Cai Q, Gao YT, Zheng W | title = Genetic variation in IGF1, IGF-1R, IGFALS, and IGFBP3 in breast cancer survival among Chinese women: a report from the Shanghai Breast Cancer Study. | journal = Breast Cancer Res. Treat. | volume = 104 | issue = 3 | pages = 309–19 | year = 2007 | pmid = 17063263 | doi = 10.1007/s10549-006-9420-8 }}
*{{cite journal | author=Payet LD, Firth SM, Baxter RC |title=The role of the acid-labile subunit in regulating insulin-like growth factor transport across human umbilical vein endothelial cell monolayers. |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 5 |pages= 2382-9 |year= 2004 |pmid= 15126567 |doi= }}
*{{cite journal | author=Martin J, Han C, Gordon LA, ''et al.'' |title=The sequence and analysis of duplication-rich human chromosome 16. |journal=Nature |volume=432 |issue= 7020 |pages= 988-94 |year= 2005 |pmid= 15616553 |doi= 10.1038/nature03187 }}
*{{cite journal  | author=Liu T, Qian WJ, Gritsenko MA, ''et al.'' |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070-80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 }}
*{{cite journal  | author=Deming SL, Ren Z, Wen W, ''et al.'' |title=Genetic variation in IGF1, IGF-1R, IGFALS, and IGFBP3 in breast cancer survival among Chinese women: a report from the Shanghai Breast Cancer Study. |journal=Breast Cancer Res. Treat. |volume=104 |issue= 3 |pages= 309-19 |year= 2007 |pmid= 17063263 |doi= 10.1007/s10549-006-9420-8 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 02:11, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

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Ensembl

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UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Insulin-like growth factor binding protein, acid labile subunit, also known as IGFALS, is a protein which in humans is encoded by the IGFALS gene.[1]

Function

The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Three transcript variants encoding two different isoforms have been found for this gene.[1]

Clinical significance

Defects in this gene are a cause of acid-labile subunit deficiency, which manifests itself in a delayed and slow puberty.[citation needed]

Interactions

IGFALS has been shown to interact with IGFBP3.[2][3]

References

  1. ↑ 1.0 1.1 "Entrez Gene: IGFALS insulin-like growth factor binding protein, acid labile subunit".
  2. ↑ Twigg SM, Baxter RC (Mar 1998). "Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit". J. Biol. Chem. 273 (11): 6074–9. doi:10.1074/jbc.273.11.6074. PMID 9497324.
  3. ↑ Firth SM, Ganeshprasad U, Baxter RC (Jan 1998). "Structural determinants of ligand and cell surface binding of insulin-like growth factor-binding protein-3". J. Biol. Chem. 273 (5): 2631–8. doi:10.1074/jbc.273.5.2631. PMID 9446566.

Further reading


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