IHPK2: Difference between revisions

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{{Infobox_gene}}
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'''Inositol hexakisphosphate kinase 2''' is an [[enzyme]] that in humans is encoded by the ''IP6K2'' [[gene]].<ref name="pmid10574768">{{cite journal |vauthors=Saiardi A, Erdjument-Bromage H, Snowman AM, Tempst P, Snyder SH | title = Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases | journal = Curr Biol | volume = 9 | issue = 22 | pages = 1323–6 |date=May 2000 | pmid = 10574768 | pmc =  | doi =10.1016/S0960-9822(00)80055-X }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: IHPK2 inositol hexaphosphate kinase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51447| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Inositol hexaphosphate kinase 2
| HGNCid = 17313
| Symbol = IHPK2
| AltSymbols =; PiUS; IP6K2
| OMIM = 606992
| ECnumber = 
| Homologene = 56929
| MGIid = 1923750
| GeneAtlas_image1 = PBB_GE_IHPK2_218192_at_tn.png
| Function = {{GNF_GO|id=GO:0008440 |text = inositol trisphosphate 3-kinase activity}} {{GNF_GO|id=GO:0008976 |text = polyphosphate kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0050517 |text = inositol hexakisphosphate kinase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
  | Process = {{GNF_GO|id=GO:0030308 |text = negative regulation of cell growth}} {{GNF_GO|id=GO:0043065 |text = positive regulation of apoptosis}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51447
    | Hs_Ensembl = ENSG00000068745
    | Hs_RefseqProtein = NP_001005912
    | Hs_RefseqmRNA = NM_001005912
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 48700441
    | Hs_GenLoc_end = 48729710
    | Hs_Uniprot = Q9UHH9
    | Mm_EntrezGene = 76500
    | Mm_Ensembl = ENSMUSG00000032599
    | Mm_RefseqmRNA = XM_977756
    | Mm_RefseqProtein = XP_982850
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 108641019
    | Mm_GenLoc_end = 108663560
    | Mm_Uniprot = Q80V72
  }}
}}
'''Inositol hexaphosphate kinase 2''', also known as '''IHPK2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: IHPK2 inositol hexaphosphate kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51447| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants encoding different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: IHPK2 inositol hexaphosphate kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51447| accessdate = }}</ref>
| summary_text = This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants encoding different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: IHPK2 inositol hexaphosphate kinase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51447| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal   |vauthors=Andersson B, Wentland MA, Ricafrente JY, etal |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=  }}
*{{cite journal   |vauthors=Yu W, Andersson B, Worley KC, etal |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 }}
*{{cite journal  | author=White KE, Econs MJ |title=Localization of PiUS, a stimulator of cellular phosphate uptake to human chromosome 3p21.3. |journal=Somat. Cell Mol. Genet. |volume=24 |issue= 1 |pages= 71-4 |year= 1998 |pmid= 9776982 |doi= }}
*{{cite journal  |vauthors=White KE, Econs MJ |title=Localization of PiUS, a stimulator of cellular phosphate uptake to human chromosome 3p21.3. |journal=Somat. Cell Mol. Genet. |volume=24 |issue= 1 |pages= 71–4 |year= 1998 |pmid= 9776982 |doi=10.1007/BF02677496 }}
*{{cite journal  | author=Saiardi A, Erdjument-Bromage H, Snowman AM, ''et al.'' |title=Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases. |journal=Curr. Biol. |volume=9 |issue= 22 |pages= 1323-6 |year= 2000 |pmid= 10574768 |doi= }}
*{{cite journal  |vauthors=Saiardi A, Caffrey JJ, Snyder SH, Shears SB |title=The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesis. |journal=J. Biol. Chem. |volume=275 |issue= 32 |pages= 24686–92 |year= 2000 |pmid= 10827188 |doi= 10.1074/jbc.M002750200 }}
*{{cite journal  | author=Saiardi A, Caffrey JJ, Snyder SH, Shears SB |title=The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesis. |journal=J. Biol. Chem. |volume=275 |issue= 32 |pages= 24686-92 |year= 2000 |pmid= 10827188 |doi= 10.1074/jbc.M002750200 }}
*{{cite journal  |vauthors=Morrison BH, Bauer JA, Kalvakolanu DV, Lindner DJ |title=Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cells. |journal=J. Biol. Chem. |volume=276 |issue= 27 |pages= 24965–70 |year= 2001 |pmid= 11337497 |doi= 10.1074/jbc.M101161200 | pmc=2025680 }}
*{{cite journal  | author=Morrison BH, Bauer JA, Kalvakolanu DV, Lindner DJ |title=Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cells. |journal=J. Biol. Chem. |volume=276 |issue= 27 |pages= 24965-70 |year= 2001 |pmid= 11337497 |doi= 10.1074/jbc.M101161200 }}
*{{cite journal   |vauthors=Saiardi A, Nagata E, Luo HR, etal |title=Identification and characterization of a novel inositol hexakisphosphate kinase. |journal=J. Biol. Chem. |volume=276 |issue= 42 |pages= 39179–85 |year= 2001 |pmid= 11502751 |doi= 10.1074/jbc.M106842200 }}
*{{cite journal | author=Saiardi A, Nagata E, Luo HR, ''et al.'' |title=Identification and characterization of a novel inositol hexakisphosphate kinase. |journal=J. Biol. Chem. |volume=276 |issue= 42 |pages= 39179-85 |year= 2001 |pmid= 11502751 |doi= 10.1074/jbc.M106842200 }}
*{{cite journal   |vauthors=Morrison BH, Bauer JA, Hu J, etal |title=Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics. |journal=Oncogene |volume=21 |issue= 12 |pages= 1882–9 |year= 2002 |pmid= 11896621 |doi= 10.1038/sj.onc.1205265 | pmc=2043497 }}
*{{cite journal | author=Morrison BH, Bauer JA, Hu J, ''et al.'' |title=Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics. |journal=Oncogene |volume=21 |issue= 12 |pages= 1882-9 |year= 2002 |pmid= 11896621 |doi= 10.1038/sj.onc.1205265 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Nagata E, Luo HR, Saiardi A, etal |title=Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death. |journal=J. Biol. Chem. |volume=280 |issue= 2 |pages= 1634–40 |year= 2005 |pmid= 15533939 |doi= 10.1074/jbc.M409416200 }}
*{{cite journal | author=Nagata E, Luo HR, Saiardi A, ''et al.'' |title=Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death. |journal=J. Biol. Chem. |volume=280 |issue= 2 |pages= 1634-40 |year= 2005 |pmid= 15533939 |doi= 10.1074/jbc.M409416200 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Morrison BH, Bauer JA, Lupica JA, etal |title=Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation. |journal=J. Biol. Chem. |volume=282 |issue= 21 |pages= 15349–56 |year= 2007 |pmid= 17379600 |doi= 10.1074/jbc.M700156200 | pmc=2048714 }}
*{{cite journal | author=Morrison BH, Bauer JA, Lupica JA, ''et al.'' |title=Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation. |journal=J. Biol. Chem. |volume=282 |issue= 21 |pages= 15349-56 |year= 2007 |pmid= 17379600 |doi= 10.1074/jbc.M700156200 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== See also ==
{{WikiDoc Sources}}
* [[Inositol-hexakisphosphate kinase]]
 
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Latest revision as of 23:43, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Inositol hexakisphosphate kinase 2 is an enzyme that in humans is encoded by the IP6K2 gene.[1][2]

This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants encoding different isoforms.[2]

References

  1. ↑ Saiardi A, Erdjument-Bromage H, Snowman AM, Tempst P, Snyder SH (May 2000). "Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases". Curr Biol. 9 (22): 1323–6. doi:10.1016/S0960-9822(00)80055-X. PMID 10574768.
  2. ↑ 2.0 2.1 "Entrez Gene: IHPK2 inositol hexaphosphate kinase 2".

Further reading

See also



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